Abstract: Capillary-based pressure threshold sensors are provided for liquids that exploit the properties of hydrophobic, superhydrophobic, oleophobic and amphiphobic porous membranes to detect when fluid passes through the membrane in the event of the pressure across the membrane rising above the breakthrough pressure of a fluid. Example implementations are provided of different configurations for a capillary-based pressure threshold sensor, and of how a capillary-based pressure threshold sensor is used in a medication delivery device or other fluid delivery devices to detect occlusion or other fluid flow condition.

Abstract: An infusion device system includes a base (12) for removably coupling to a delivery device, a needle hub (22) supporting an insertion needle (20) and a catheter (18) for delivering a substance to a patient. The infusion device includes a needle shield (24) for covering the insertion needle (20) after inserting the catheter (18) into the patient. The needle hub (22) includes a least one leg (70) extending from the needle shield (24) to stabilize the needle shield (24) and needle hub (12) relative to the base. In one embodiment, the legs (70) can include a latching tab (74) to couple to the needle hub (22) to resist separation of the needle hub from the base (12) until the legs are deflected outward to release the needle hub (22).

Abstract: Universal disinfecting connector, connector or cap can interface with male, female, female stopcock, and female hemodialysis threaded fittings, therefore encompassing an entire spectrum of disinfecting connectors. Disinfecting connector or cap includes a configuration of structural elements that provide a universal rotary cap incorporating rotary-activated interfaces and design features allowing the cap to be configured to selectively present any one of a plurality of connection types, or interfaces, for engaging, coupling, or capping, a corresponding type of a male or a female connector or luer.

Abstract: A system for facilitating instrument delivery through a peripheral intravenous catheter (“PIVC”) may include a catheter assembly having a catheter adapter, an extension tube extending from a side port of the catheter adapter, a septum disposed in a lumen of the catheter adapter, and a PIVC extending distally from the catheter adapter. The septum may include a first piece and a second piece and may be least partially disposed within a canister. The system may include an extension set, which may include a distal end and a proximal end. The distal end may include a distal connector and a rigid tube. The proximal end may include a proximal connector. The distal connector may be coupled to the proximal end of the catheter adapter. The rigid tube may penetrate the septum in response to the distal connector being coupled to the proximal end of the catheter adapter.

Abstract: An integrated catheter assembly for rapid vascular insertion including a catheter configured for receipt of a needle and a guidewire; a catheter assembly comprising an integrated assembly comprising a catheter, needle, and guidewire; and a method of rapidly inserting a catheter to obtain vascular access. The catheter includes a central lumen for receiving the needle and guidewire. The lumen includes a distal port and a transverse side port adjacent an intermediate portion thereof which provide open vascular communication from two ports between the central lumen and the vasculature. The needle and guidewire, when integrated with the catheter, extend through the transverse side port wherein a proximal end of the needle extends contiguous to and exterior of a proximal portion of the catheter.

Abstract: A cap is described for connection to a medical connector, the cap includes a housing having a top wall and sidewall forming a first cavity, and a removable or integrally formed protrusion. The protrusion includes an inner thread on an inner surface, the inner thread being sufficient to interlock with a mating feature of a female needleless connector. The inner surface of the protrusion defines a second cavity. The protrusion includes an outer thread on an outer surface, the outer thread being sufficient to interlock with a mating feature of a male needleless connector. The second cavity configured to define a chamber to contain an absorbent material and disinfectant or antimicrobial agent. The cap may also include a peel seal and/or septum to prevent the disinfectant or the antimicrobial agent from exiting the second cavity. An exterior sidewall surface of the housing may include a plurality of grip members.

Abstract: Droplet sorting modules for sorting droplets of a flow stream are described. Droplet sorting modules according to certain embodiments include a plurality of droplet sort decision units and a processor with memory operably coupled to the processor, where the memory includes instructions stored thereon, which when executed by the processor, cause the processor to determine an optimal droplet sort decision unit from the plurality of sort decision units for sorting each droplet of the flow stream. Particle (e.g., cells) sorting systems and methods for sorting droplets of a flow stream are also described. Kits having one or more of the subject droplet sorting modules are also provided.

Abstract: A catheter system may include a catheter adapter, which may include a distal end, a proximal end, and a lumen extending through the distal end of the catheter adapter and the proximal end of the catheter adapter. The catheter system may include a septum assembly disposed within the lumen of the catheter adapter. The catheter system may include a catheter extending from the distal end of the catheter adapter. The catheter system may include an introducer needle, which may include a proximal end, a sharp distal tip, and a bump disposed between the proximal end and the sharp distal tip. The proximal end of the introducer needle may be secured within a needle hub of the catheter system. In response to the bump contacting the septum assembly, the sharp distal tip of the introducer needle is disposed distal to a distal end of the catheter.

Abstract: Systems, methods and devices are described including a medical device subassembly including a magnetic feature. Systems include such a catheter adapter subassembly or needle subassembly or guidewire introducer subassembly and a wire including a magnetic feature, and relative movement of the catheter adapter subassembly or needle subassembly or guidewire introducer subassembly and the wire can be determined using a magnetometer.

Abstract: An automated apparatus can provide pre-analytical processing of samples, racking and forwarding to an adjacent analyzer for analysis. The apparatus may have a controller that implements an auto-learn process to teach robotic handlers the locations within the workspace(s) of the apparatus. A robotic sample handler may include a sensor configured to generate a detection signal when in a near vicinity of a fiducial beacon in the workspace of the apparatus for biological sample preparation, preprocessing and/or diagnostic assay performed by one or more analyzers of the automated apparatus. The controller may control the robotic sample handler to conduct a search pattern so that a location of the fiducial beacon may be detected and thereafter calculated to obtain a more accurate location of the beacon. The calculated positions may then serve as a basis for the controlled movement of samples by the robot to and from locations of the workspace.

Abstract: A syringe adapter including a housing, a cannula having a first end and second end with the second end of the cannula positioned within the housing, and a seal arrangement positioned within the housing with the seal arrangement movable within the housing between a first position where the seal arrangement is disengaged from a mating connector and a second position where the seal arrangement is engaged with a mating connector, the seal arrangement comprising a membrane. The syringe adapter including a lock mechanism, where the seal arrangement includes a lock interface that is configured to engage the lock mechanism when the seal arrangement is in the second position and when the lock mechanism is in the locked position, and where the lock mechanism is disengaged from the lock interface when the seal arrangement is in the second position and when the lock mechanism is in the unlocked position.

Abstract: An injection device for injecting a substance into a body, including a syringe having: a needle, a barrel, a stopper, a plunger rod, moveable from an initial position to a final position, a needle shield, moveable at least from a retracted position to a safety position, a locking unit, arranged to lock the needle shield into the safety position, a locking actuator moveable at least: from a non-actuating position, into which the locking unit is in an open mode, to an actuating position, into which the locking actuator is arranged to put the locking unit in closed mode so that the needle shield can be locked into the safety position.

Abstract: A mechanical separator for separating a fluid sample into first and second phases within a collection container is disclosed. The mechanical separator may have a separator body having a through-hole defined therein, with the through-hole adapted for allowing fluid to pass therethrough. The separator body includes a float, having a first density, and a ballast, having a second density greater than the first density. A portion of the float is connected to a portion of the ballast. Optionally, the float may include a first extended tab adjacent a first opening of the through-hole and a second extended tab adjacent the second opening of the through-hole. In certain configurations, the separator body also includes an extended tab band disposed about an outer surface of the float. The separator body may also include an engagement band circumferentially disposed about at least a portion of the separator body.

Abstract: A catheter assembly and a method of manufacturing are described. A catheter assembly comprises a catheter body comprising a proximal end, a distal end, and a lumen formed by an inner wall of the catheter body that extends between the proximal end and the distal end along a longitudinal axis. A device may include the catheter body further comprising an external surface that extends between the proximal end and the distal end, the external surface comprising a first portion and a second portion. A device may include the second portion of the external surface including a micro-textured surface configured to spread drops of a liquid tissue adhesive across the second portion of the external surface by capillary action to form a thin film and/or micro-droplets of the liquid tissue adhesive to achieve faster curing and hence adhesion between catheter to skin.

Abstract: A clip used in a catheter assembly, the clip comprising a first leg and a second leg angularly connected to the first leg, wherein the second leg includes a substantially U-shaped spade configured to engage a needle housing of the catheter assembly to secure the clip to the needle housing.

Abstract: A disinfection cap is described for connection to a medical connector; the disinfection cap includes a housing having a top wall and sidewall forming a cavity. In one or more embodiments, a retention rod forming a fluid reservoir is disposed within the cavity for retaining disinfectant. In one or more embodiments, a corrugated capsule is disposed within the cavity for retaining disinfectant. Pressure buildup within the cavity due to insertion of a luer connector causes expulsion of disinfectant, thereby disinfecting the luer connector.

Abstract: A fluid delivery device has a syringe barrel-type reservoir with plunger, and plunger driver assembly comprising double-acting, telescoping lead screws that is located behind and outside of the barrel. Simultaneously and counter-rotating sleeve screw and center screw telescope out of a nested configuration of the plunger driver assembly and into the reservoir at a rate of double their individual and equal pitch and lead parameters when the sleeve screw is rotated. A threaded nut and gear anchor disposed on an end of the barrel receive the sleeve screw and the threaded nut causes the sleeve screw to translate and rotate in response to motor operation. A distal end of the center screw can be keyed to a plunger pusher for anti-rotation constraint when the motor is imparting rotation on the threaded nut and sleeve screw.

Abstract: Drug delivery safety devices having trigger activation systems activated by pressure against the skin of a patient and which automatically shield the needle after withdrawing the needle from the skin of the patient.

Abstract: A catheter system may include a catheter adapter and a needle shield device coupled to the catheter adapter. The needle shield device may include a needle housing and a needle assembly slideably coupled to the needle housing. The needle housing may include an elongated body and a nose portion coupled to the elongated body. The elongated body may include a distal end, a proximal end, and a slot disposed between the distal end and the proximal end of the elongated body. The needle assembly may include a needle grip and a needle hub having a protuberance coupled to the needle grip and slideably fit within the slot. To facilitate securement between the catheter adapter and the needle shield device, a flexible arm of the needle shield device may couple to the catheter adapter and/or multiple protrusions of the nose portion may contact an internal wall of the catheter adapter.

Abstract: Disclosed herein include systems, methods, compositions, and kits for sample identification. A sample indexing composition can comprise, for example, a protein binding reagent associated with a sample indexing oligonucleotide. Different sample indexing compositions can include sample indexing oligonucleotides with different sequences. Sample origin of cells can be identified based on the sequences of the sample indexing oligonucleotides. Sample indexing oligonucleotides can be barcoded using barcoded and lengthened using daisy-chaining primers.