Abstract: A device for obtaining a biological sample, such as a capillary blood collection device, that has the ability to lance and squeeze the finger, collect the sample, stabilize the sample, and subsequently dispense the sample in a controlled manner is disclosed. The device also simplifies and streamlines the capillary blood collection by eliminating workflow variabilities which are typically associated with low sample quality including hemolysis and micro-clots.

Abstract: A method to manage flushing of a catheter assembly a clamp configured to clamp an extension tube of a catheter assembly. The clamp may include an acoustic sensor configured to detect fluid flowing through the extension tube. The clamp and the acoustic sensor may be disposed outside of the extension tube. The clamp may include a pinch clamp or a non-pinch clamp. The acoustic sensor may be embedded in the clamp. The method may include detecting, via the acoustic sensor, fluid flowing through the extension tube.

Abstract: A catheter assembly may include a catheter adapter. A body of the catheter adapter may include a distal end, a proximal end, and a lumen extending through the distal end and the proximal end. A catheter may extend distally from the distal end of the body. The catheter adapter may include a side port, which may extend outwardly from the body. The catheter assembly may include a valve disposed within the lumen. The valve may include a channel extending through the valve. The catheter assembly may include a cannula fixed within the side port and disposed within the channel. The cannula may include an opening, and the valve may be configured to compress to expose the opening from within the valve.

Abstract: A blood sampling transfer device that includes a lancing tape having a flow channel and a transfer cartridge removably connected to the lancing tape is disclosed. The blood sampling transfer device provides a closed system that reduces the exposure of a blood sample to both skin and environment and provides fast mixing of a blood sample with a sample stabilizer.

Abstract: A connector assembly disclosed herein includes a male part and a female part. The female part includes a cylindrical body extending about a central axis, a fitting portion configured to be sealingly fitted to a medical injection device, and a spike. An annular gap is formed between the cylindrical body and the spike to at least partly accommodate the male part. The female part further includes at least two ribs formed on an inner surface of the cylindrical body and protruding radially inwardly. Each ribs extends straight in parallel to the central axis and has an innermost fitting surface configured to be detachably fitted to corresponding threaded portions of the male part.

Abstract: In one aspect, a method of sorting cells in a flow cytometry system is disclosed, which includes illuminating a cell with radiation having at least two optical frequencies shifted from one another by a radiofrequency to elicit fluorescent radiation from the cell, detecting the fluorescent radiation to generate temporal fluorescence data, and processing the temporal fluorescence data to arrive at a sorting decision regarding the cell without generating an image (i.e., a pixel-by-pixel image) of the cell based on the fluorescence data. In some cases, the sorting decision can be made with a latency less than about 100 microseconds. In some embodiments, the above method of sorting cells can have a sub-cellular resolution. In some embodiments, a single radiofrequency shift is employed to separate the optical frequencies while in other such embodiments a plurality of different radiofrequency shifts are employed.

Abstract: An automatic picking machine for pharmaceutical drug packages includes at least one storage rack, at least one storage and retrieval machine, a control apparatus for controlling the storage and retrieval machine, and a filling apparatus for successively filling each of a plurality of transport containers with a group of pharmaceutical drug packages corresponding to one order, wherein the filling apparatus includes a plurality of collection containers, first transport apparatuses, each having a transport channel for conveying the pharmaceutical drug packages towards the respective collection container, and a receiving apparatus for receiving a transport container to be filled at a filling location of the filing apparatus.

Abstract: A device for connection to a medical connector, the device includes an outer cap, an inner cap and a peelable seal. The outer cap configured to define a chamber to contain an absorbent material and disinfectant or antimicrobial agent. The outer cap including one or more threads adapted to engage with a female luer connector. The inner cap including one or more thread-tabs adapted to engage a male luer connector. The peelable seal prevents the disinfectant or the antimicrobial agent from exiting the chamber.

Abstract: A plunger stopper (12) configured for attachment with a plunger rod (14) for use with a within a syringe barrel for high dose accuracy drug delivery. The stopper having a first portion (40) formed from a first material and a second portion (42) formed from a second material, wherein the second material has a greater rigidity than the first material and wherein the second portion is configured to be attached to a plunger rod. The second material can be in the form of an insert (44) which functions to reduce the amount of distortion of the stopper during use, reduce air bubble size variation from fill to fill, maintain a seal with the inner wall of the syringe barrel with lower contact pressure in a resting state and reduce the amount of hysteresis of the stopper. The stopper can be adapted for use with infusers, pens, and other types of auto-injectors.

Abstract: A medical stopcock includes a main body having an input port and an output port, a valve body having a handle and a syringe port, with the valve body moveable relative to the main body and defining a valve passageway. The valve body includes a first position where the input port and the output port are in fluid communication via the valve passageway, a second position where the syringe port and the output port are in fluid communication via the valve passageway, and a third position where the syringe port and the input port are in fluid communication via the valve passageway. Rotation of the syringe port is configured to move the valve body relative to the main body.

Abstract: Catheter systems comprising independent fluid paths are disclosed. The catheter systems can include a catheter adapter that has a catheter hub with a chamber. A catheter extends from a distal end of the catheter hub and is in fluid communication with the chamber. A stabilization platform with a first wing and a soft push tab are also part of the catheter hub. The catheter system includes a needle hub with a needle that slidably fits within the catheter. In an insertion configuration, a proximal extension of the catheter hub is removably coupled within a distal opening of the needle hub. After the catheter is placed, the needle hub is retracted from the catheter adapter to slidably remove the needle from the catheter.

Abstract: A blood separation device that decouples and separates the blood collection process from the plasma separation process is disclosed. The blood separation device includes a sample collection module, an activation module, and a separation module. Because the plasma separation happens after the blood separation device is disconnected from a patient, the device performance is no longer affected by patient blood pressure and needle gauge, and patient discomfort is greatly reduced.

Abstract: A syringe and syringe package system comprises a syringe barrel having an open proximal end and a distal end and a syringe stopper placed in the open proximal end of the syringe barrel. The system includes a shape-changeable package, the syringe barrel and the syringe stopper contained within the shape-changeable package, wherein the shape-changeable package comprises a web of material sized and arranged to contain the syringe barrel and the syringe stopper and configured to be converted to a plunger rod that engages the syringe stopper and is translatable within the open proximal end of the barrel.

Abstract: A universal cap for connection to medical connectors facilitates easier cap alignment and engagement with threaded male or female Luer medical connectors and enhanced connector disinfection. A split-collar protrusion projects axially from a closed end wall of the cap towards the open bottom and comprises at least an opposed pair of parallel, sector-shaped, collet fingers/prongs that terminate in protrusion tips. The inner wall of each collet finger respectively defines a split-flange cantilever. Inner and outer walls of each collet finger define split threads, which are respectively sized for mating engagement with respective corresponding threads of Luer connectors. An antibacterial infused absorbent material is oriented between the split flanges and the cap bottom. As the cap is affixed to a Luer connector, absorbent material compression biases the split flanges and deflects the collet fingers/prongs, for easier cap alignment and engagement with Luer medical connectors and enhanced connector disinfection.

Abstract: A fluid delivery device has a syringe barrel-type reservoir with plunger and plunger driver assembly comprising a spiral zipper-driven pump mechanism. A flexible band in the spiral zipper-driven pump mechanism is transformed from a collapsed, nested configuration to an extended configuration by controllably unfurling and recoiling the band into a spiral column of interlocking revolutions of the band. The column has sufficient stiffness to impart translational motion to a plunger along a longitudinal reservoir axis that is precisely controllable by rotation of gears by a motor. The collapsed, non-extended configuration of the spiral zipper-driven pump mechanism reduces reservoir and fluid delivery device length.

Abstract: A PIVC includes a catheter adapter having a catheter that extends distally from the catheter adapter, and an introducer needle that inserts through the catheter. The introducer needle has a grip component at a proximal end of the introducer needle. The grip component extends outwardly and distally to form a winged grip adjacent the catheter adapter when the introducer needle is inserted within the catheter. The grip component can be rotatable within the catheter adapter to allow repositioning of the winged grip with respect to the catheter adapter.

Abstract: Disclosed herein include systems, methods, compositions, and kits for the labeling of nucleic acids targets. In some embodiments, the methods comprise the use of target-specific primers and target-non-specific primers during library preparation (e.g., hybrid library preparation). In some embodiments, the methods increase the abundance of select low abundance targets during cDNA library preparation and/or sequencing library preparation.

Abstract: A catheter configured to release nitric oxide and chlorhexidine providing anti-platelet and antimicrobial properties is manufactured by impregnating a thermoplastic polyurethane catheter extrusion with a nitric oxide releasing compound and with chlorhexidine. Thereafter, the impregnated catheter extrusion is coated with a polyurethane coating comprising chlorhexidine and/or a nitric oxide releasing compound. In the impregnating step, the catheter extrusion may be exposed to a solvent having the nitric oxide releasing compound and chlorhexidine dissolved therein. The solvent is removed from the catheter extrusion. In the coating step, the impregnated catheter extrusion may be dip coated in a polymer solution comprising polyurethane and chlorhexidine and/or a nitric oxide releasing compound in a suitable solvent. The nitric oxide releasing compound, impregnated and/or coated, may be selected from s-nitroso-n-acetylpenicillamine (SNAP), s-nitrosoglutathione (GSNO), and mixtures thereof.

Abstract: A method for readying a fluid sensor associated with a medical device includes attaching a flow restrictor to a fluid outlet of the fluid sensor. The fluid sensor includes a fluid channel, a fluid inlet at a first end of the fluid channel configured to couple to an outlet of an administrable fluid source, and the fluid outlet at a second end of the fluid channel. Fluid is delivered from the administrable fluid source to the fluid channel through the fluid inlet. A syringe actuation device including a force limiting device may be used to deliver the fluid. The fluid is pressurized in the fluid channel between the fluid inlet and the flow restrictor to wet an interior surface of the fluid channel with the fluid. The flow restrictor is removed from the fluid outlet.