Abstract: An extravascular system is provided which includes a catheter adapter having a blood control septum configured to control flow of a fluid through the catheter adapter, the catheter adapter further having a catheter configured for intravenous insertion. The extravascular system further includes a septum activator slidably inserted within the catheter adapter and configured for advancement through the blood control septum to provide a fluid pathway through the blood control septum. Further still, the extravascular system includes an external safety mechanism comprising a needle hub and a needle shield interconnected via a tether, wherein the needle shield includes a safety clip that is configured to retain a sharpened end of the introducer needle within the needle shield. Some implementations further comprise an access port forming a portion of the catheter adapter and providing selective access to the lumen of the catheter adapter.

Abstract: Disinfection cap includes housing comprising closed top, essentially cylindrical sidewall, and open bottom formed by the sidewall with opening to inner cavity within the housing for receiving tip including mating feature of needleless connector. Disinfection sponge can be configured within inner cavity, removable cover sealing opening to inner cavity to seal sponge within inner cavity prior to cap use. Inner cavity includes at least one thread on inner surface of its sidewall that does not correspond to the mating feature of needleless connector, but is sufficient to interlock with mating feature of needleless connector. Plurality of disinfection caps are disposed on strip of IV pole hanging device such that each cap can be peeled off the strip unsealed for immediate use, or separated from the strip sealed for later use.

Abstract: Aspects of the present disclosure include methods for spectrally resolving light from fluorophores having overlapping fluorescence spectra in a sample. Methods according to certain embodiments include detecting light with a light detection system from a sample having a plurality of fluorophores having overlapping fluorescence spectra and spectrally resolving light from each fluorophore in the sample. In some embodiments, methods include estimating the abundance of one or more of the fluorophores in the sample, such as on a particle. In certain instances, methods include identifying the particle in the sample based on the abundance of each fluorophore and sorting the particle. Methods according to some embodiments includes spectrally resolving the light from each fluorophore by calculating a spectral unmixing matrix for the fluorescence spectra of each fluorophore. Systems and integrated circuit devices (e.g., a field programmable gate array) for practicing the subject methods are also provided.

Abstract: A catheter system to protect against needle stick injuries and environmental contamination from exposure to residual blood. The catheter system may include a catheter assembly, a needle assembly, and a housing. The needle assembly may be coupled to the catheter assembly and include a needle hub and an introducer needle. The housing may be secured within a lumen of the catheter adapter and may include a distal end, a proximal end, and a cavity. The introducer needle may extend through the housing. A safety clip within the cavity may include an elongated arm portion and a barrier feature. The introducer needle may bias the barrier feature outwardly away from a longitudinal axis of the introducer needle. In response to proximal retraction of the introducer needle, the barrier feature may be configured to move toward the longitudinal axis of the needle and shield the sharp distal tip.

Abstract: A needle is provided that can be used for introducing or aspirating fluids to a patient or as an introducer needle for positioning and inserting a catheter, such as a peripheral IV catheter into a patient. The needle can be an introducer needle that extends from the distal end of the catheter during insertion. The needle has an insertion tip with a configuration to assist penetration into a vein with a reduced incidence of injuring the inner surface of the vein or inadvertently passing through side wall of the vein. The needle tip can be farmed with a curved distal end surface where the pointed tip is spaced radially inward relative to the outer surface of the needle. In another embodiment the needle tip can have a reverse beveled surface having an axial length, angle, and curvature to assist in penetrating the vein with a reduced incidence of transfixing the vein.

Abstract: Methods and systems for a deep-learning platform for sorting cell populations. An example method includes executing a software-platform associated with analyzing received flow cytometry data obtained via an acquisition device in communication with the computing system, and the software-platform sorting cell populations indicated in the flow cytometry data. User input is received indicating selection of a deep-learning module, the deep-learning module being obtained via a network to supplement the software-platform. The flow cytometry data is analyzed and a machine learning model is selected which was trained based on similar phenotype information as indicated in the flow cytometry data. The machine learning model is applied based on the flow cytometry data, the information being normalized based on the UMI counts associated with the flow cytometry data.

Abstract: A nest and tub arrangement for the storage of medical device components including a tub and at least one nest. The tub includes four side surfaces and a plurality of guide ribs extending vertically along the side surfaces, wherein the plurality of guide ribs are inwardly directed and include a friction surface extending vertically thereon. The at least one nest includes a top surface, a bottom surface, a plurality of receptacles for the storage of a plurality of medical device components therein, and a plurality of deflectable clips positioned on side surfaces of the at least one nest.

Abstract: Aspects of the present disclosure include systems for detecting light from a particle in a flow stream by spectral discrimination. Systems according to certain embodiments include a light source configured to irradiate a particle propagating along a flow stream through an interrogation region, a light detection system that includes a wavelength separator component configured to pass light having a predetermined spectral range across the wavelength separator, a light adjustment component configured to continuously convey light from the irradiated particle across the wavelength separator as the particle is propagated along the flow stream through the interrogation region and a photodetector configured to detect light conveyed across the wavelength separator. Systems also include a processor for generating a photodetector signal pulse in response to light detected from the wavelength separator. Methods and kits for detecting light with the subject systems are also described.

Abstract: Flush syringe assemblies are described herein. Such flush syringe assembly may include a barrel including a side wall defining a chamber, a collar mounted on a distal wall of the barrel and surrounding an elongate tip. A cap may be attached to the collar via a hinge. The flush syringe assembly may also include a cap attached to the collar via a hinge. A ring may be disposed around the collar with a locking element that engages with a corresponding mating locking projection on the cap. The cap may include a slanted surface. The slanted surface of the cap may include one or more ribs made of an elastomeric material.

Abstract: A delivery device to deliver a tubular instrument into a catheter extending distally from a catheter adapter. The delivery device may include a housing configured to couple to the catheter adapter. The delivery device may include a tubular instrument configured to insert through the catheter. The tubular instrument may include a distal end, a proximal end, and a lumen extending between the distal end and the proximal end. The distal end may include a distal tip, which may be closed. The proximal end may be secured within the housing. The tubular instrument may be configured to advance distally with respect to the housing. A portion of the distal end proximate the distal tip may include a first material and maybe stiffer than the distal tip, which may include a second material. A durometer of the first material may be greater than a durometer of the second material.

Abstract: A syringe having two variable volumes are described herein. The syringe includes a first stopper and a second stopper, the first stopper being connected to a plunger. A first variable volume of the two variable volumes is disposed between the first stopper and the second stopper and a second variable volume of the two variable volumes is between the second stopper and a distal end of a barrel of the syringe. A flow path structure is disposed at the distal end of the barrel, the flow path structure extending from the distal end of the barrel along an inner sidewall of the barrel.

Abstract: Systems for detecting light (e.g., in a flow stream) are described. Light detection systems according to certain embodiments include a wavelength separator configured to generate first, second and third predetermined spectral ranges of light from a light source and first, second and third light detection modules configured to receive each of the first, second and third predetermined spectral ranges of light, the light detection modules having a plurality of photodetectors and an optical component that conveys light having a predetermined sub-spectral range to the photodetectors. Systems and methods for measuring light emitted by a sample (e.g., in a flow stream) and kits having three or more wavelength separators, a plurality of photodetectors and an optical component are also provided.

Abstract: A blood collection system may include a needle assembly, which may include a needle configured to receive an evacuated blood collection tube. The blood collection system may include a tubing, which may include a distal end and a proximal end. The proximal end may be coupled to the needle assembly. The tubing may include a first flow channel and a second flow channel. The first flow channel may be configured to collapse at a lower pressure differential than the second flow channel.

Abstract: A system for preparing and administering a prescribed fluidic pharmaceutical compound, such as a chemotherapy compound, includes a scale having a platen. The scale is in communication with a user display for displaying an output of the scale. An image capture device having a field of view for capturing at least one image of an object placed on the platen is provided in communication with the user display for displaying the captured image. The platen may include a visual identifier for identifying a portion of the field of view of the image capture device. The platen may also include a tackifier or absorbent material. The platen may be formed of a light-transmissible material.

Abstract: A gripper for a picking device for storing small piece goods and a method for operating a picking device having a gripper are provided. The gripper simplifies dispensing and includes a drop table extending in first and second horizontal directions, and has at least one end portion having a dispensing end face, wherein the drop table and the end portion define an upper support surface. A transport device for moving small piece goods is arranged above the drop table and sensor device(s) are arranged in the at least one end portion having detection regions associated therewith, the sensor device being arranged along a vertical axis in such a way that the detection regions cover a vertically extending space in front of the dispensing end face.

Abstract: In one aspect, a method of sorting cells in a flow cytometry system is disclosed, which includes illuminating a cell with radiation having at least two optical frequencies shifted from one another by a radiofrequency to elicit fluorescent radiation from the cell, detecting the fluorescent radiation to generate temporal fluorescence data, and processing the temporal fluorescence data to arrive at a sorting decision regarding the cell without generating an image (i.e., a pixel-by-pixel image) of the cell based on the fluorescence data. In other words, while the fluorescence data can contain image data that would allow generating a pixel-by-pixel fluorescence intensity map, the method arrives at the sorting decision without generating such a map. In some cases, the sorting decision can be made with a latency less than about 100 microseconds. In some embodiments, the above method of sorting cells can have a sub-cellular resolution, e.g.

Abstract: Inserts can be formed with elution characteristics to cause the inserts to elute an antimicrobial agent when subject to a fluid within a medical device. An insert can be formed with a desired geometry to allow the insert to be compression fit within a medical device to prevent the insert from moving or becoming dislodged once inserted into the medical device. The material may also be hygroscopic so that the insert swells when subject to a fluid thereby enhancing the compression fit of the device within the medical device. In some cases, the material can be reinforced using an internal structure. Inserts can be formed in many ways including by casting, thermoforming, or extrusion. In some cases, the inserts can be formed using a peel-away sleeve or material. The peel-away sleeves can be formed of a non-sticky material which facilitates removal of the inserts once the inserts have cured.

Abstract: The disclosure provides driver components and methods of operating same that provide a reduced form factor for pen-type injection devices. In particular, various multi-piece telescoping plunger rod configurations are disclosed that can be implemented within pen-type injection devices to achieve such improvements. Driver components replace a single plunger rod having fixed length with telescoping pieces that are controlled to at least partially extend axially to dispense fluid from the reservoir or cartridge.

Abstract: Methods of determining an ideal gain for a detector in a light detection system of a flow cytometer are provided. Methods of interest include irradiating a flow stream with light from a light source, incrementally increasing the gain of the detector such that the detector collects light from the flow stream at each of a plurality of successively increasing gains, obtaining a baseline noise level from the detector at each gain in the plurality of successively increasing gains, calculating a limit of detection (LoD) for each gain in the plurality of successively increasing gains, and assessing the calculated LoDs to determine the ideal gain. Systems and computer readable storage media for practicing the invention are also provided.

Abstract: A picking device for storing bottles and a corresponding method are provided. The picking device includes a storage locations for bottles, a control device and an operating device having a gripper with two prongs, the operating device displaceable adjacent the storage location in first and second directions. The control device causes the operating device to lift a bottle from the storage location and move the bottle in a third direction away from the storage location by one of a frictional connection and a positive connection between the bottle and the two prongs or move a bottle in a third direction towards the storage location and lower the bottle to rest in the storage location by one of a frictional connection and a positive connection between the bottle and the two prongs. A method for retrieving bottles and an operating device for use with a picking device are also provided.