Abstract: Pharmaceutical compositions are provided comprising an active agent and a dextran polymer derivative. The compositions include from 0.01 to 99 wt % of an active agent and from 1 to 99.99 wt % of a dextran polymer derivative. The dextran polymer derivative is selected from dextran acetate, dextran propionate, dextran succinate, dextran acetate propionate, dextran acetate succinate, dextran propionate succinate, dextran acetate propionate succinate, and mixtures thereof.
Type:
Grant
Filed:
February 12, 2014
Date of Patent:
September 12, 2017
Assignee:
Bend Research, Inc.
Inventors:
Warren K. Miller, David T. Vodak, Daniel E. Dobry, David K. Lyon, Dwayne T. Friesen, Michael M. Morgen, Corey J. Bloom, Daniel T. Smithey
Abstract: Disclosed are compositions including a solid dispersion comprising a dispersion polymer, a basic low-water solubility active, and an anionic counterion, as well as methods of making and using the compositions.
Abstract: A pharmaceutical composition comprises nanoparticles comprising a poorly water-soluble drug and a poorly aqueous soluble polymer, and a resuspending material selected from the group consisting of hydroxypropyl methyl cellulose acetate succinate, carboxymethyl ethylcellulose, and pharmaceutically acceptable salt forms thereof.
Type:
Grant
Filed:
December 5, 2008
Date of Patent:
August 8, 2017
Assignee:
Bend Research, Inc.
Inventors:
Warren Kenyon Miller, Daniel Smithey, Benjamin Lee Frankamp, Ralph Tadday
Abstract: The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T2, wherein T2 is greater than T1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T2, such that the active agent and matrix material are soluble in the organic solvent at T2.
Type:
Grant
Filed:
March 19, 2010
Date of Patent:
August 8, 2017
Assignee:
Bend Research, Inc.
Inventors:
Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. Dubose, Douglas L. Millard
Abstract: Disclosed are compositions including nanoparticles comprising a poorly aqueous soluble polymer, an ionizable active agent, and a counterion having an opposite charge as the ionizable active agent, as well as methods of making and using the compositions.
Type:
Application
Filed:
July 15, 2015
Publication date:
July 27, 2017
Applicant:
Bend Research, Inc.
Inventors:
Warren Kenyon Miller, Michael Mark Morgen
Abstract: An exemplary method comprises providing a spray-dried dispersion comprising particles, the particles comprising an active agent and a polymer, the dispersion particles having an average particle diameter of less than 50 ?m. An ordered mixture is formed by high-shear mixing the dispersion with a powdered glidant, wherein the average particle diameter of the glidant is less than or equal to one fifth the average particle diameter of the dispersion after high-shear mixing. The dosage forms are formed by at least one of directly compressing the ordered mixture to form a tablet and encapsulating the ordered mixture to form a capsule.
Type:
Grant
Filed:
September 5, 2013
Date of Patent:
July 25, 2017
Assignee:
Bend Research, Inc.
Inventors:
Jason A. Everett, Randy J. Wald, Sanjay Konagurthu
Abstract: A sample can be collected from an enclosed container by opening a sample collection valve and drawing the sample from the enclosed container. After delivery of the sample out of a fluid flow path, a sanitizing fluid can be directed along the fluid flow path to sanitize the fluid flow path.
Type:
Application
Filed:
November 18, 2016
Publication date:
March 9, 2017
Applicant:
Bend Research, Inc.
Inventors:
David D. Newbold, Douglas L. Millard, Erwin Y. Yu, Paul T. Jeffers, Jeffrey W. Weber
Abstract: Methods and apparatus are disclosed for correcting measurements received by applying a frequency-varying signal with a measuring device (e.g., a permittivity probe) to a population of living cells (e.g., contained in a bioreactor) and correcting measurement divergences using data acquired using an alternate analytical method (e.g., trypan blue exclusion). In one example, a method comprises receiving electrical property data for a first population of cells, the data obtained by applying a first frequency-varying signal to the population with a measuring device, receiving biological property data obtained using an alternate analytical technique, generating at least one value representative of the frequency dependence of the electrical property data, and determining a relationship between the biological property data and the representative value. In some examples, measurements of apoptosis are predicted using the electrical property data.
Type:
Grant
Filed:
January 4, 2013
Date of Patent:
February 14, 2017
Assignee:
Bend Research, Inc.
Inventors:
Brandon J. Downey, Jeffery F. Breit, Lisa Graham, Adam S. Carroll
Abstract: A pharmaceutical composition comprises a solid amorphous dispersion comprising a low-solubility drug and a concentration-enhancing polymer and a lipophilic microphase-forming material. Alternatively, a solid amorphous dispersion comprising a low-solubility drug and a concentration-enhancing polymer is co-administered with a lipophilic microphase-forming material to an in vivo use environment.
Type:
Application
Filed:
September 16, 2016
Publication date:
January 5, 2017
Applicant:
Bend Research, Inc.
Inventors:
Michael E. Perlman, Ravi M. Shanker, Walter C. Babcock, Dwayne Thomas Friesen, Mark D. Rabenstein, Daniel Tod Smithey
Abstract: In one aspect, pharmaceutical compositions comprising dispersions of an acid-sensitive drug and a neutral dispersion polymer are disclosed. The acid-sensitive drug has improved chemical stability relative to dispersions of the drug and acidic polymers. In another aspect, pharmaceutical compositions of low-solubility drugs and amphiphilic, hydroxy-functional vinyl copolymers are disclosed.
Type:
Application
Filed:
September 7, 2016
Publication date:
December 29, 2016
Applicant:
Bend Research, Inc.
Inventors:
Dwayne T. Friesen, Michael J. Gumkowski, Rodney James Ketner, Douglas A. Lorenz, James A. S. Nightingale, Ravi M. Shanker, James B. West
Abstract: A sample can be collected from an enclosed container by opening a sample collection valve and drawing the sample from the enclosed container. After delivery of the sample out of a fluid flow path, a sanitizing fluid can be directed along the fluid flow path to sanitize the fluid flow path.
Type:
Grant
Filed:
May 4, 2012
Date of Patent:
November 22, 2016
Assignee:
Bend Research, Inc.
Inventors:
David D. Newbold, Douglas L. Millard, Erwin Y. Yu, Paul T. Jeffers, Jeffrey W. Weber
Abstract: A pharmaceutical composition comprises a solid amorphous dispersion comprising a low-solubility drug and a concentration-enhancing polymer and a lipophilic microphase-forming material. Alternatively, a solid amorphous dispersion comprising a low-solubility drug and a concentration-enhancing polymer is co-administered with a lipophilic microphase-forming material to an in vivo use environment.
Type:
Grant
Filed:
October 26, 2007
Date of Patent:
November 8, 2016
Assignee:
Bend Research, Inc.
Inventors:
Michael E. Perlman, Ravi M. Shanker, Walter C. Babcock, Dwayne Thomas Friesen, Mark D. Rabenstein, Dan Tod Smithey
Abstract: In one aspect, pharmaceutical compositions comprising dispersions of an acid-sensitive drug and a neutral dispersion polymer are disclosed. The acid-sensitive drug has improved chemical stability relative to dispersions of the drug and acidic polymers. In another aspect, pharmaceutical compositions of low-solubility drugs and amphiphilic, hydroxy-functional vinyl copolymers are disclosed.
Type:
Grant
Filed:
April 1, 2014
Date of Patent:
October 18, 2016
Assignee:
Bend Research, Inc.
Inventors:
Dwayne T. Friesen, Michael J. Gumkowski, Rodney James Ketner, Douglas A. Lorenz, James A. S. Nightingale, Ravi M. Shanker, James B. West
Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
Type:
Grant
Filed:
March 16, 2015
Date of Patent:
October 4, 2016
Assignee:
Bend Research, Inc.
Inventors:
William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
Abstract: A dosage form comprises a low-solubility drug, and a precipitation-inhibiting polymer. The drug is in a solubility-improved form and in the form of particles at least partially coated with the precipitation-inhibiting polymer.
Type:
Grant
Filed:
November 7, 2014
Date of Patent:
September 20, 2016
Assignee:
Bend Research, Inc.
Inventors:
Leah E. Appel, Walter C. Babcock, Dwayne T. Friesen, Roderick J. Ray, Daniel T. Smithey, Sheri L. Shamblin, Ravi M. Shanker
Abstract: A sample can be collected from an enclosed container by opening a sample collection valve and drawing the sample from the enclosed container. After delivery of the sample out of a fluid flow path, a sanitizing fluid can be directed along the fluid flow path to sanitize the fluid flow path.
Type:
Grant
Filed:
November 5, 2013
Date of Patent:
July 12, 2016
Assignee:
Bend Research, Inc.
Inventors:
David Dixon Newbold, Douglas Lee Millard, Erwin Yaokui Yu, Paul T. Jeffers, Jeffrey W. Weber
Abstract: Pharmaceutical compositions of a low-solubility drug and lower alkanoate-, phthalate- and trimellitate esters of hydroxypropyl methyl cellulose and lower alkanoate- and succinate esters of cellulose and methyl cellulose are disclosed that provide enhanced concentrations of the drug in a use environment.
Type:
Grant
Filed:
December 17, 2013
Date of Patent:
July 12, 2016
Assignee:
Bend Research, Inc.
Inventors:
Walter C. Babcock, Dwayne T. Friesen, Warren K. Miller, Daniel T. Smithey, David K. Lyon
Abstract: A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.
Type:
Grant
Filed:
June 12, 2015
Date of Patent:
June 7, 2016
Assignee:
Bend Research, Inc.
Inventors:
Daniel E. Dobry, James M. Mullin, Douglas L. Millard, Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. Dubose
Abstract: Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
Type:
Grant
Filed:
August 5, 2014
Date of Patent:
May 17, 2016
Assignee:
Bend Research, Inc.
Inventors:
Ronald A. Beyerinck, Heather L. M. Deibele, Dan E. Dobry, Roderick J. Ray, Dana M. Settell, Ken R. Spence