Patents Assigned to Bios Corporation
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Patent number: 8362238Abstract: The present invention relates to a process of preparing a highly pure tacrolimus, which comprising a pre-purification process carried out by means of crystallization, and particularly to a process of preparing a highly pure tacrolimus, which comprises a pre-purification process comprising the steps of (a) extracting mycelia cake collected by filtering a tacrolimus-containing oily compound with an organic solvent, (b) concentrating the extract under reduced pressure and (c) crystallizing the concentrate. In addition, a highly pure tacrolimus can be obtained by dissolving the pre-purified crystals in an organic solvent, passing through the solution in an adsorption resin and concentrating the eluate under reduced pressure, followed by crystallization. According to a process of the present invention, Tacrolimus as pure as appropriate for a pharmaceutical purpose can be prepared by a simple process and at a relatively low cost.Type: GrantFiled: February 25, 2009Date of Patent: January 29, 2013Assignee: Chongkundang Bio CorporationInventors: Byoung-Taek Choi, Yun-Beom Ham, Seong-Seon Yu, Kyung-Il Jeong, Byung-Sik Kim
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Publication number: 20120230922Abstract: Embodiments of this invention encompass a method for producing and purifying rebaudioside C. In particular, this invention relates to a method for purifying rebaudioside C compositions to obtain a substantially pure rebaudioside C product using one or more crystallization steps. Resulting polymorphic forms of rebaudioside C, substantially pure rebaudioside C compositions and their uses are disclosed.Type: ApplicationFiled: September 22, 2010Publication date: September 13, 2012Applicant: Redpoint Bio CorporationInventors: F. Raymond Salemme, Robert A. Daines
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Publication number: 20120164083Abstract: The present invention is directed to the use of rebaudioside A or rebaudioside D in combination with one or more compounds of Formula (I), or a stereoisomer thereof, wherein R2 is rhamnose, and R and R1 are each independently selected from the group consisting of hydrogen, glucose, and beta-sophorose, for enhancing the sweet taste of carbohydrate sweeteners, such as sucrose and fructose. The present invention is also directed to consumables which include a combination of a carbohydrate sweetener, rebaudioside A or rebaudioside D, and one or more compounds of Formula (I), or a stereoisomer thereof.Type: ApplicationFiled: August 31, 2010Publication date: June 28, 2012Applicant: Redpoint Bio CorporationInventors: R. Kyle Palmer, F. Raymond Salemme
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Patent number: 8193168Abstract: The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.Type: GrantFiled: February 4, 2008Date of Patent: June 5, 2012Assignee: Redpoint Bio CorporationInventors: S. Paul Lee, Peihong Zhou, M. N. Tulu Buber, Rok Cerne, Robert Bryant, F. Raymond Salemme, Gillian Morgan
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Publication number: 20120065393Abstract: The present invention relates to a process of preparing a highly pure tacrolimus, which comprising a pre-purification process carried out by means of crystallization, and particularly to a process of preparing a highly pure tacrolimus, which comprises a pre-purification process comprising the steps of (a) extracting mycelia cake collected by filtering a tacrolimus-containing oily compound with an organic solvent, (b) concentrating the extract under reduced pressure and (c) crystallizing the concentrate. In addition, a highly pure tacrolimus can be obtained by dissolving the pre-purified crystals in an organic solvent, passing through the solution in an adsorption resin and concentrating the eluate under reduced pressure, followed by crystallization. According to a process of the present invention, Tacrolimus as pure as appropriate for a pharmaceutical purpose can be prepared by a simple process and at a relatively low cost.Type: ApplicationFiled: February 25, 2009Publication date: March 15, 2012Applicant: Chongkundang Bio CorporationInventors: Byoung-Taek Choi, Yun-Beom Ham, Seong-Seon Yu, Kyung-II Jeong, Byung-Sik Kim
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Patent number: 7875452Abstract: There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods, especially electrophysiological, suffer from a lack of sensitivity, rapid signal loss, low throughput, and are labor intensive. The claimed methods and compositions provide electrophysiology methods that allow prolonged sample testing and fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.Type: GrantFiled: September 30, 2008Date of Patent: January 25, 2011Assignee: Redpoint Bio CorporationInventors: Robert W. Bryant, S. Paul Lee, Rok Cerne, M. N. Tulu Buber, Ivona Bakaj, Roy Kyle Palmer
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Publication number: 20100248988Abstract: There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods suffer from a lack of sensitivity, low throughput, and are labor intensive. The claimed methods provide fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.Type: ApplicationFiled: May 28, 2010Publication date: September 30, 2010Applicant: Redpoint Bio CorporationInventors: Robert W. BRYANT, S. Paul Lee, R. Kyle Palmer, Qifeng Yang, M.N. Tulu Buber
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Publication number: 20100248987Abstract: The invention relates an assay useful for screening and identifying compounds as modulators of lower alkyl phenol activation of TRPA1. Thymol, a lower alkyl phenol anti-infective and the active ingredient in, e.g., mouthwashes, is stringent and has an objectionable burning taste sensation. Thymol activates the transient receptor potential like ion channel TRPA1. The assay described and claimed herein involves measurement of activation of TRPA1 and enables the screening of compounds that inhibit lower alkyl phenol, or thymol activation of TRPA1. Inhibitors of thymol activation of TRPA1 can be used to prevent the objectionable taste of thymol in medical uses where taste limits acceptance.Type: ApplicationFiled: February 4, 2010Publication date: September 30, 2010Applicant: Redpoint Bio CorporationInventors: Seunghun Paul Lee, Qifeng Yang, Robert W. Bryant, Tulu Buber
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Publication number: 20100203176Abstract: A method is provided for reducing weight in a subject by administering an effective amount of a composition comprising omega-3 polyunsaturated fatty acid (PUFA), at least one of L-arginine, L-ornithine, an L-arginine precursor and an L-ornithine precursor, and at least one of a nucleobase, a nucleoside and a nucleic acid. The method can also be used to treat obesity, hyperlipidemia, diabetes and/or hypertension and for improving diathesis, or treating adult disease or disposition to adult disease.Type: ApplicationFiled: April 16, 2010Publication date: August 12, 2010Applicant: BBK Bio CorporationInventor: Masafumi KOIDE
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Publication number: 20100197813Abstract: The present invention is directed to the use of a compound of Formula I and physiologically acceptable salts thereof wherein G1, G2, G3, R1, R2, R7, R3, R4, and R5 are defined herein. Compounds according to Formula I can be used to enhance a sweet taste produced by a tastant. The invention is also directed to compositions comprising a compound according to the above formula. Other aspects of the invention provide methods, compounds, and compositions for improved food products wherein the food product comprises a compound according to Formula I and a reduced amount of a sweet tastant.Type: ApplicationFiled: February 9, 2010Publication date: August 5, 2010Applicant: Redpoint Bio CorporationInventors: Karnail S. ATWAL, Anita B. Atwal, Robert W. Bryant, Ivona Bakaj, Roy Kyle Palmer, Rok Cerne
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Patent number: 7749730Abstract: There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods suffer from a lack of sensitivity, low throughput, and are labor intensive. The claimed methods provide fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.Type: GrantFiled: November 3, 2006Date of Patent: July 6, 2010Assignee: Redpoint Bio CorporationInventors: Robert W. Bryant, S. Paul Lee, R. Kyle Palmer, Qifeng Yang, M. N. Tulu Buber
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Patent number: 7674831Abstract: The present invention is directed to the use of a compound of Formula I and physiologically acceptable salts thereof wherein G1, G2, G3, R1, R2, R7, R3, R4, and R5 are defined herein. Compounds according to Formula I can be used to enhance a sweet taste produced by a tastant. The invention is also directed to compositions comprising a compound according to the above formula. Other aspects of the invention provide methods, compounds, and compositions for improved food products wherein the food product comprises a compound according to Formula I and a reduced amount of a sweet tastant.Type: GrantFiled: August 22, 2007Date of Patent: March 9, 2010Assignee: Redpoint Bio CorporationInventors: Karnail S. Atwal, Anita B. Atwal, legal representative, Robert W. Bryant, Ivona Bakaj, Roy Kyle Palmer, Rok Cerne
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Patent number: 7674594Abstract: The invention relates an assay useful for screening and identifying compounds as modulators of lower alkyl phenol activation of TRPA1. Thymol, a lower alkyl phenol anti-infective and the active ingredient in, e.g., mouthwashes, is stringent and has an objectionable burning taste sensation. Thymol activates the transient receptor potential like ion channel TRPA1. The assay described and claimed herein involves measurement of activation of TRPA1 and enables the screening of compounds that inhibit lower alkyl phenol, or thymol activation of TRPA1. Inhibitors of thymol activation of TRPA1 can be used to prevent the objectionable taste of thymol in medical uses where taste limits acceptance.Type: GrantFiled: July 26, 2007Date of Patent: March 9, 2010Assignee: Redpoint Bio CorporationInventors: Seunghun Paul Lee, Qifeng Yang, Robert W. Bryant, Tulu Buber
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Publication number: 20090205581Abstract: Described herein are various apparatus and systems useful in sensory discrimination. Through the use of a multi-well sample plate, the high-throughput analysis apparatus and method allow for rapid sensory discrimination of a large number of samples.Type: ApplicationFiled: February 15, 2008Publication date: August 20, 2009Applicant: REDPOINT BIO CORPORATIONInventors: R. Kyle Palmer, Francis X. Brennan, Heather R. Devantier, Daniel J. Long
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Publication number: 20090202601Abstract: The intermolecular mutual recognition between a disease-state inducing substance (e.g., allergen group, pathogen et cetera) and a living body which functions at the time when such a disease-state inducing substance reaches the living body is inhibited by making use of pectins and nucleic acids.Type: ApplicationFiled: April 13, 2009Publication date: August 13, 2009Applicant: BBK BIO CORPORATIONInventors: Masafumi Koide, Ryutaro Tsuda, Kenji Fujisawa
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Publication number: 20090041917Abstract: The present invention provides compositions containing bitterness inhibitors that reduce the bitter taste of KCl that is used in foods or beverages as a substitute for sodium chloride. The compositions contain as bitterness inhibitors taurine and 5?-adenosinic acid, and 5?-inosinic acid, and/or 5?-guanylic acid. Furthermore, the present invention provides methods of using these compositions and methods for preparing them.Type: ApplicationFiled: October 20, 2008Publication date: February 12, 2009Applicant: Redpoint Bio CorporationInventors: Francis Raymond SALEMME, Richard Barndt
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Publication number: 20090035444Abstract: The present invention provides flavored seasoning compositions containing low-salt substitutes that reduce the quantify of common salt used to flavor foods. More specifically, the compositions contain (a) a flavored seasoning mixture comprising flavoring agents, and flow agents, bulking agents, binding agents and/or preservatives, and (b) a salt substitute containing potassium chloride and bitterness inhibitors taurine and 5?-adenosinic acid, 5?-inosinic acid and/or 5?-guanylic acid. Furthermore, the present invention provides foods containing these compositions, methods of using these compositions and methods for preparing them.Type: ApplicationFiled: October 16, 2008Publication date: February 5, 2009Applicant: Redpoint Bio CorporationInventors: Francis Raymond Salemme, Abraham I. Bakal, Richard Barndt
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Publication number: 20080306030Abstract: The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.Type: ApplicationFiled: February 4, 2008Publication date: December 11, 2008Applicant: Redpoint Bio CorporationInventors: S. Paul Lee, Peihong Zhou, M.N. Tulu Buber, Rok Cerne, Robert Bryant, F. Raymond Salemme, Gillian Morgan
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Patent number: 7455872Abstract: The present invention provides compositions containing bitterness inhibitors that reduce the bitter taste of KCl that is used in foods or beverages as a substitute for sodium chloride. The compositions contain as bitterness inhibitors taurine and 5?-adenosinic acid, and 5?-inosinic acid, and/or 5?-guanylic acid. Furthermore, the present invention provides methods of using these compositions and methods for preparing them.Type: GrantFiled: June 20, 2005Date of Patent: November 25, 2008Assignee: Redpoint Bio CorporationInventors: Francis Raymond Salemme, Richard Barndt
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Patent number: 7452563Abstract: The present invention provides flavored seasoning compositions containing low-salt substitutes that reduce the quantity of common salt used to flavor foods. More specifically, the compositions contain (a) a flavored seasoning mixture comprising flavoring agents, and flow agents, bulking agents, binding agents and/or preservatives, and (b) a salt substitute containing potassium chloride and bitterness inhibitors taurine and 5?-adenosinic acid, 5?-inosinic acid and/or 5?-guanylic acid. Furthermore, the present invention provides foods containing these compositions, methods of using these compositions and methods for preparing them.Type: GrantFiled: June 20, 2005Date of Patent: November 18, 2008Assignee: Redpoint Bio CorporationInventors: Francis Raymond Salemme, Abraham I. Bakal, Richard Barndt