Abstract: A labile disulfide-containing compound under physiological conditions, comprising: the disulfide-containing compound having a labile disulfide bond that is either a disulfide bond that is cleaved more rapidly than oxidized glutathione or a disulfide bond constructed from thiols in which one of the constituent thiols has a lower pKa than glutathione or a disulfide bond that is activated by intramolecular attack from a free thiol.

Abstract: Disclosed is a complex for providing nucleic acid expression in a cell. A polynucleotide and a polymer are mixed together to form the complex wherein the zeta potential of the complex is not positive. Then the complex is delivered to the cell wherein the nucleic acid is expressed.

Abstract: A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.

Abstract: The present invention relates to compositions and methods for the selection and use of surface exposed epitopes. The present invention includes in vivo and in vitro phage peptide diplay methods for the identification and selection of peptides and peptide associated factors with desired properties (e.g., targeting specificity, stability, etc.). The present invention further provides methods and compositions for the isolation and identification of peptide-specific antibodies. The present invention also includes methods and compositions employing nuclear localization signals for enhanced nuclear transport and expression of DNA.

Abstract: A process for delivering a nucleic acid to a cardiac tissue cell in a mammal is described, comprising introducing a composition consisting of a nucleic acid to a blood vessel, which subsequently delivers the nucleic acid to the cardiac tissue cell. The nucleic acid can be DNA or RNA or plasmid DNA or viral. This process is for purposes of gene therapy, and research.

Abstract: An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.

Abstract: The present invention provides a system and method for medical analysis treatment. The system includes a computer system for storing a plurality of databases. The databases maintain medical research data regarding analyte characteristics and vitamin/nutrient characteristics. A first database maintains a plurality of analyte records, wherein each record holds information regarding a particular analyte that was determined from the results of testing a human test group. Each analyte record includes a low value, a high value and a target value. A second database maintains a plurality of vitamin/nutrient records wherein each vitamin/nutrient record includes analytes associated with the particular vitamin/nutrient and an analyte level indicative of vitamin/nutrient that may have supportive effect.

Abstract: The present invention provides a system and method for medical diagnostic analysis. The system includes a computer system for storing a plurality of databases. The databases maintain medical research data regarding analyte characteristics and bodily function characteristics. A first database maintains a plurality of analyte records, wherein each record holds information regarding a particular analyte that was determined from the results of testing a human test group. Each analyte record includes a low value, a high value and a mode value. A second database maintains a plurality of bodily function records wherein each bodily function record includes analytes associated with the particular bodily function and an analyte level indicative of the bodily function.

Abstract: A dry pesticide applicator is disclosed. The applicator includes a fluidizing medium secured within a housing. A blower mechanism generates a flow of air through the fluidizing medium to establish a fluidized bed within the housing. This fluidized bed is drawn into a dusting by means of a venturi to create a powdered stream. Whenever the dispensing mechanism is inoperative, the fluid flow which creates the powdered stream (by drawing the fluidized bed through a powder inlet) is directed into the housing through the powder inlet to purge any accumulation of powdered material therein.

Abstract: A method and apparatus is disclosed for supporting and handling blot membranes during the course of blotting, analysis and storage.

Abstract: A method is disclosed for molding thin gel slabs horizontally having deep, large volume sample wells molded integrally and in communication with the thin gel slab. The disclosure includes a method for molding at least two contiguous thin gel slabs horizontally.

Abstract: A rapid and effective method and apparatus or blotting is provided whereby a relatively thin gel slab containing electrophoresed, electrostatically charged material is transferred to a porous membrane of opposite charge by means of simple electrostatic attraction free of any external influence or inducement.

Abstract: A method and apparatus is disclosed for supporting and handling blot membranes during the course of blotting, analysis and storage.

Abstract: A method and apparatus is disclosed for molding thin gel slabs horizontally having deep, large volume sample wells molded integrally and in communication with the thin gel slab. The disclosure includes a method and apparatus for molding at least two contiguous thin gel slabs horizontally.

Abstract: The apparatus and process of the present invention resolves sample species in an electrolyte solution containing two or more types of ions, wherein the sample species to be resolved will move in response to fluid flow of the electrolyte and a non-linear voltage gradient such that the non-linear voltage gradient serves to counteract forces of diffusion as the sample travels along the electrophoresis chamber good resolution is obtained in species of widely divergent electrophoretic mobility.

Abstract: A method and apparatus for removing appendage tissue from avian species such as domestic fowl and principally from commercial chickens and turkeys is disclosed. When the appendage is the beak, the method is known as debeaking and the invention is a method comprised of the step of burning and simultaneously cauterizing a hole through a portion of a bird's beak in order to damage the tissue and precipitate eventual rejection thereof outwardly from the point of damage, and apparatus which includes a face mask for positioning the bird's beak between and in contact with opposing electrodes projecting into the apparatus which effect the burning as aforesaid. A power source for the electrodes provides an open circuit voltage of sufficient magnitude to initiate current flow through the beak when opposing sides of the beak contact the electrodes.

Abstract: A method and apparatus for removing appendage tissue from avian species such as domestic fowl and principally from commercial chickens and turkeys is disclosed. When the appendage is the beak, the method is known as debeaking and the invention is a method comprised of the step of burning and simultaneously cauterizing a hole through a portion of a bird's beak in order to damage the tissue and precipitate eventual rejection thereof outwardly from the point of damage, and apparatus which includes a face mask for positioning the bird's beak between and in contact with opposing electrodes projecting into the apparatus which effect the burning as aforesaid. A power source for the electrodes provides an open circuit voltage of sufficient magnitude to initiate current flow through the beak when opposing sides of the beak contact the electrodes.

Abstract: A method and apparatus for removing appendage tissue from avian species such as domestic fowl and principally from commercial chickens and turkeys is disclosed. When the appendage is the beak, the method is known as debeaking and the invention is a method comprised of the step of burning and simultaneously cauterizing a hole through a portion of a bird's beak in order to damage the tissue and precipitate eventual rejection thereof outwardly from the point of damage, and apparatus which includes means adapted to position the bird's beak between and in contact with opposing electrodes projecting into the apparatus which effect the burning as aforesaid. A power source for the electrodes providing an open circuit voltage of sufficient magnitude to initiate current flow through the beak when opposing sides of the beak contact the electrodes.

Abstract: An automatic injection device for small animals. The device comprises a work plate on which an animal to be injected can be positioned, a syringe mounted on the opposite side of the work plate from the side on which the animal to be injected is positioned during use of the device, first means for moving the syringe back and forth between a first position in which the syringe needle is entirely withdrawn on said opposite side of the work plate and a second position in which the syringe needle protrudes through an aperture in the work plate, and second means for detecting the presence of an animal to be injected in position on the work plate and for activating the first means. The first means comprises a single-action pneumatic motor and means for retaining the syringe in its second position while the mounting of the syringe is adjusted.