Patents Assigned to Biosystems Inc.
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Patent number: 11412959Abstract: The present invention provides a biofluid sensing device capable of concentrating a biofluid sample with respect to a target analyte, so that the analyte can be accurately detected or measured by EAB sensors. Methods for using such a device provide qualitative information about the presence of the analyte, and/or quantitative information about relative concentrations of the analyte in the biofluid. The disclosed device includes a concentration channel for concentrating the biofluid sample, as well as a selectively permeable membrane, one or more EAB sensors, and one or more secondary sensors carried on a water-impermeable substrate. A method for using the disclosed device to collect a biofluid sample, concentrate the sample relative to a target analyte, and measure the target analyte is also disclosed.Type: GrantFiled: February 7, 2018Date of Patent: August 16, 2022Assignee: Epicore Biosystems, Inc.Inventors: Robert Beech, Gavi Begtrup, Jason Heikenfeld, Jacob A. Bertrand
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Publication number: 20220248738Abstract: This disclosure describes compositions of one or more components including milk fat globule membranes (MFGM) complexes, milk fat globules (MFG), commensal organisms, SlgA, recombinant SlgA (rSlgA), triglycerides or oils, and mammalian milk oligosaccharides (MMO) and the use of such compositions. The reconstituted MFGM component of the disclosed invention may come from an animal source, particularly from a mammalian source, including from the processing of buttermilk.Type: ApplicationFiled: July 27, 2020Publication date: August 11, 2022Applicant: Evolve BioSystems, Inc.Inventors: David KYLE, Samara FREEMAN-SHARKEY, Bethany HENRICK
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Patent number: 11406321Abstract: A sweat sensing device includes a flexible body having a first, outwardly facing surface and a second, skin facing surface and a sweat channel formed in the body, the sweat channel having a first end defining a fluid inlet and a second end. A biochemical assay well formed in the sweat channel and an assay material is disposed in the biochemical assay well, the assay material positioned to react with sweat traveling through the sweat channel and to provide one of a visual indicator and an indicator detectable by a camera and connected processor of the flow of the sweat in the sweat channel.Type: GrantFiled: July 24, 2018Date of Patent: August 9, 2022Assignee: Epicore Biosystems, Inc.Inventors: Jeffrey B. Model, Roozbeh Ghaffari, Alexander J. Aranyosi, Stephen P. Lee, Milan S. Raj
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Patent number: 11366303Abstract: A particle detection method detects presence and location of particles on a target using measured signals from a plurality of structured illumination patterns. The particle detection method uses measured signals obtained by illuminating the target with structured illumination patterns to detect particles. Specifically, the degree of variation in these measured signals in raw images is calculated to determine whether a particle is present on the target at a particular area of interest.Type: GrantFiled: January 30, 2019Date of Patent: June 21, 2022Assignee: Rebus Biosystems, Inc.Inventors: Jekwan Ryu, Hojin Lee, Ahreum Oh
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Patent number: 11337681Abstract: A sweat collection device includes a flexible body having a first, outwardly facing surface and a second, skin-facing surface, and a sweat collection channel formed in the body, the sweat collection channel having a first end defining a sweat inlet port, and a second end defining a sweat outlet port. The sweat inlet port and the sweat outlet port are configured to be closed and sealed such that the sweat collection device and the collected sweat therein may be stored and shipped.Type: GrantFiled: November 21, 2018Date of Patent: May 24, 2022Assignee: Epicore Biosystems, Inc.Inventors: Jeffrey B. Model, Roozbeh Ghaffari, Alexander J. Aranyosi, Stephen P. Lee, Milan S. Raj
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Publication number: 20220154297Abstract: The invention features compositions and methods for the detection of Candida species in biological samples, such as human tissue samples. The invention features species specific nucleic acid probes that can hybridize to target nucleic acid molecules in Candida species and can be used in a variety of detection assays, such as fluorescence based assays or NMR based assays. The compositions and methods of the invention can be used to rapidly and accurately detect one or more Candida species in patients and can be used to assist in point-of care-decisions for treating Candida infections.Type: ApplicationFiled: August 24, 2021Publication date: May 19, 2022Applicant: T2 Biosystems, Inc.Inventor: Lori Anne NEELY
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Patent number: 11324534Abstract: Disclosed herein are apparatuses, systems, kits, and methods for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and/or skin repositioning and/or for generally improving skin function or appearance (e.g., the removal of unwanted skin features or irregularities such as sebaceous glands, sweat glands, hair follicles, necrosis, and fibrosis). Such apparatuses, systems, kits, and methods comprise an apparatus having a handheld main body and a detachably attachable tip comprising one or more needles.Type: GrantFiled: November 13, 2015Date of Patent: May 10, 2022Assignee: Cytrellis Biosystems, Inc.Inventors: Alec Ginggen, Douglas Levinson
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Patent number: 11326213Abstract: The invention features methods, systems, and panels for rapid detection of tick-borne pathogens in a sample (including Borrelia spp. such as B. burgdorferi, B. afzelii, and B. garinii) and for diagnosis and monitoring of tick-transmitted diseases, including Lyme disease, Rocky Mountain spotted fever, Q-fever, babesiosis, ehrlichiosis, tularemia, and anaplasmosis.Type: GrantFiled: January 21, 2016Date of Patent: May 10, 2022Assignee: T2 Biosystems, Inc.Inventors: Ulrich Hans Thomann, Lori Anne Neely, Rahul Krishan Dhanda, Frédéric Sweeney, Thomas Jay Lowery, Jr., Jessica Ann Townsend, Jessica Lee Snyder, Heidi Susanne Giese, Cheryl Ann Bandoski-Gralinski, Daniella Lynn Logan
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Patent number: 11300801Abstract: A synthetic aperture optics (SAO) imaging method minimizes the number of selective excitation patterns used to illuminate the imaging target, based on the objects' physical characteristics corresponding to spatial frequency content from the illuminated target and/or one or more parameters of the optical imaging system used for SAO. With the minimized number of selective excitation patterns, the time required to perform SAO is reduced dramatically, thereby allowing SAO to be used with DNA sequencing applications that require massive parallelization for cost reduction and high throughput. In addition, an SAO apparatus optimized to perform the SAO method is provided. The SAO apparatus includes a plurality of interference pattern generation modules that can be arranged in a half-ring shape.Type: GrantFiled: September 14, 2020Date of Patent: April 12, 2022Assignee: Rebus Biosystems, Inc.Inventors: Chun-Sheu Lee, Jong Buhm Park
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Patent number: 11254970Abstract: This document provides methods and materials for detecting target nucleic acid. For example, methods and materials for detecting the presence or absence of target nucleic acid, methods and materials for detecting the amount of target nucleic acid present within a sample, kits for detecting the presence or absence of target nucleic acid, kits for detecting the amount of target nucleic acid present within a sample, and methods for making such kits are provided.Type: GrantFiled: April 13, 2020Date of Patent: February 22, 2022Assignee: Cascade Biosystems, Inc.Inventors: Kenneth D. Smith, Nina Yazvenko, Mariya Smit
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Patent number: 11254969Abstract: This document provides methods and materials for assessing RNA expression. For example, methods and materials for detecting the presence, absence, or amount of target nucleic acid (e.g., target RNA or target cDNA produced from target RNA), kits for detecting the presence, absence, or amount of target nucleic acid (e.g., target RNA or target cDNA produced from target RNA), and methods for making such kits are provided.Type: GrantFiled: February 20, 2015Date of Patent: February 22, 2022Assignee: Cascade Biosystems, Inc.Inventors: Kenneth D. Smith, Nina Yazvenko, Mariya Smit
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Publication number: 20220048025Abstract: Systems and methods are disclosed for enhancing the consistency of performance of assays, such as multiplexed assays, by printing features in a particular pattern, such that the outer edge of the pattern has a shape that is substantially similar to the shape of the test well. For example, the pattern is a ring pattern, such that the outer edge of the ring pattern is circular or oval along the bottom of multiplexed wells. The assay substrates prepared according to the methods described result in more accurate, precise, and sensitive chemical and/or biological analyses.Type: ApplicationFiled: August 26, 2021Publication date: February 17, 2022Applicant: Aushon Biosystems, Inc.Inventors: Peter Honkanen, Scott Douglas, Travis Sullivan, Scott Orencole
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Publication number: 20220017950Abstract: The present disclosure provides compositions, methods and kits for Omega amplification technologies. In addition, the present disclosure provides compositions, methods and kits for universal FQ probe and for G-quadruplex detection methods for use in isothermal amplification technologies.Type: ApplicationFiled: October 5, 2021Publication date: January 20, 2022Applicant: Atila Biosystems, Inc.Inventors: Youxiang WANG, Xin CHEN, Rong WANG, Zhijie YANG, Yu ZHAO
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Publication number: 20210369150Abstract: The present invention generally relates, in certain aspects, to relatively small devices applied to the skin, modular systems, and methods of use thereof. In some aspects, the device is constructed and arranged to have more than one module. For instance, the device may have a module for delivering to and/or withdrawing fluid from the skin and/or beneath the skin of a subject and a module for transmitting a signal indicative of the fluid delivered to and/or withdrawn from the skin and/or beneath the skin of the subject, a module for analyzing a fluid withdrawn from the skin and/or beneath the skin of the subject, or the like. In some embodiments, the modules are connectable and/or detachable from each other, and in some cases, the connections and/or detachments may be performed while the device is in contact with the subject, e.g., while affixed to the subject.Type: ApplicationFiled: August 13, 2021Publication date: December 2, 2021Applicant: Seventh Sense Biosystems, Inc.Inventors: Howard Bernstein, Donald E. Chickering, III, Douglas A. Levinson, David R. Walt, Shawn Davis, Ramin Haghgooie
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Patent number: 11166743Abstract: Disclosed herein are apparatuses, kits, and methods for treating skin, such as skin tightening, e.g., reducing skin laxity, for treating conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and/or skin repositioning, and/or for generally improving skin function or appearance. Such apparatuses, kits, and methods include one or more hollow needles each having at least one prong and a mechanism for removing skin tissue portion(s) from the hollow needle(s).Type: GrantFiled: March 29, 2017Date of Patent: November 9, 2021Assignee: Cytrellis Biosystems, Inc.Inventors: Douglas Levinson, Alec Ginggen, Kristian DiMatteo, Robert Brik, Jose Lizardi, Nicholas Anderson, Oivind Brockmeier
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Patent number: 11168357Abstract: The present disclosure provides compositions, methods and kits for Omega amplification technologies. In addition, the present disclosure provides compositions, methods and kits for universal FQ probe and for G-quadruplex detection methods for use in isothermal amplification technologies.Type: GrantFiled: May 24, 2017Date of Patent: November 9, 2021Assignee: Atila Biosystems, Inc.Inventors: Youxiang Wang, Xin Chen, Rong Wang, Zhijie Yang, Yu Zhao
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Publication number: 20210330227Abstract: The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.Type: ApplicationFiled: February 1, 2021Publication date: October 28, 2021Applicant: Seventh Sense Biosystems, Inc.Inventors: Douglas A. Levinson, Howard Bernstein, Donald E. Chickering, III, Shawn Davis, Ramin Haghgooie, Mark Michelman
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Patent number: 11147844Abstract: The present disclosure relates generally to compositions, dosage forms, and methods for preventing and treating infections. The compositions include intact and substantially non-viable Gram-negative bacterial cells which have been treated to reduce lipopolysaccharide (LPS)-associated endotoxin activity, which surprisingly have increased activity to trigger immune cell production of cytokines.Type: GrantFiled: September 26, 2019Date of Patent: October 19, 2021Assignee: Decoy Biosystems, Inc.Inventor: Michael J. Newman
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Patent number: 11137454Abstract: Example embodiments of the present invention provide a magnetic relaxometry measurement apparatus, comprising: a magnetizing system configured to supply a pulsed magnetic fields to a sample; a sensor system configured to detect magnetic fields produced by induced magnetization of the sample after a magnetic field pulse from the magnetizing system; one or more compensating coils configured to suppress generation of eddy currents in an environment surrounding the apparatus due to the pulsed magnetic fields.Type: GrantFiled: April 2, 2018Date of Patent: October 5, 2021Assignee: Imagion Biosystems, Inc.Inventors: Todor Karaulanov, Giulio D Paciotti
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Patent number: 11130136Abstract: Systems and methods are disclosed for enhancing the consistency of performance of assays, such as multiplexed assays, by printing features in a particular pattern, such that the outer edge of the pattern has a shape that is substantially similar to the shape of the test well. For example, the pattern is a ring pattern, such that the outer edge of the ring pattern is circular or oval along the bottom of multiplexed wells. The assay substrates prepared according to the methods described result in more accurate, precise, and sensitive chemical and/or biological analyses.Type: GrantFiled: November 14, 2012Date of Patent: September 28, 2021Assignee: Aushon Biosystems, Inc.Inventors: Peter Honkanen, Scott Douglas, Travis Sullivan, Scott Orencole