Patents Assigned to Biosystems Inc.
  • Publication number: 20210259599
    Abstract: Systems and methods for delivering to and/or receiving fluids or other materials, such as blood or interstitial fluid, from subjects, e.g., from the skin. Beading disruptors and/or capillaries may be used for facilitating the transport of fluids from a subject into a device. Beading disruptors may disrupt the “pooling” of bodily fluids such as blood on the surface of the skin and help influence flow in a desired way. A capillary may conduct flow of fluid in the device, e.g., to an inlet of a channel or other flow path that leads to a storage chamber. A vacuum (reduced pressure relative to ambient) may be used to receive fluid into the device, e.g., by using relatively low pressure to draw fluid into the inlet of a channel leading to a storage chamber. The vacuum source may be part of the device and have a volume that is larger than a recess of the fluid transporter that receives fluid from a surface.
    Type: Application
    Filed: October 7, 2020
    Publication date: August 26, 2021
    Applicant: Seventh Sense Biosystems, Inc.
    Inventors: Ramin Haghgooie, Donald E. Chickering, III, Shawn Davis, Mark Michelman, Li Yang Chu
  • Patent number: 11098378
    Abstract: The invention features compositions and methods for the detection of Candida species in biological samples, such as human tissue samples. The invention features species specific nucleic acid probes that can hybridize to target nucleic acid molecules in Candida species and can be used in a variety of detection assays, such as fluorescence based assays or NMR based assays. The compositions and methods of the invention can be used to rapidly and accurately detect one or more Candida species in patients and can be used to assist in point-of care-decisions for treating Candida infections.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: August 24, 2021
    Assignee: T2 Biosystems, Inc.
    Inventor: Lori Anne Neely
  • Patent number: 11083740
    Abstract: The present invention is directed to compositions and methods for the treatment of cancers, particularly cancers of epithelial origin. Therapy with a plurality of nutraceutical, non-chemotherapeutic and chemotherapeutic agents, that together target a plurality of cancer-supportive processes in a patient are disclosed. Among other things, the present invention encompasses the insight that redundant targeting of multiple such pathways provides effective treatment of various cancer, including late-stage cancers, metastasized cancers, and/or cancers that have failed treatment with traditional chemotherapy and/or other therapeutic modalities.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: August 10, 2021
    Assignee: NED Biosystems, Inc.
    Inventor: Rebecca Lambert Bent
  • Publication number: 20210228124
    Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.
    Type: Application
    Filed: September 8, 2020
    Publication date: July 29, 2021
    Applicant: Seventh Sense Biosystems, Inc.
    Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse, Howard Bernstein, Douglas A. Levinson
  • Patent number: 11045504
    Abstract: Provided herein are compositions comprising substantially non-viable Gram-negative bacterial organisms that have a substantial reduction in endotoxin activity and/or pyrogenicity and methods for treating a cancer using the same. Also provided are methods for treating cancer provided herein, comprising administering to a mammal diagnosed with cancer, substantially non-viable Gram-negative bacteria having a substantial reduction in endotoxin activity and/or pyrogenicity, in an amount sufficient to inhibit growth or metastasis of the cancer. An additional method is provided comprising administering viable or non-viable Gram-negative bacterial organisms that have a genetic defect that results in a substantial loss of lipopolysaccharide within the outer membrane of the bacteria. Further provided are methods for reducing endotoxin activity and/or pyrogenicity in Gram-negative bacteria comprising treatment with polymyxin and glutaraldehyde.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: June 29, 2021
    Assignee: Decoy Biosystems, Inc.
    Inventor: Michael J. Newman
  • Publication number: 20210189465
    Abstract: This document provides methods and materials for detecting target nucleic acid. For example, methods and materials for detecting the presence or absence of target nucleic acid, methods and materials for detecting the amount of target nucleic acid present within a sample, kits for detecting the presence or absence of target nucleic acid, kits for detecting the amount of target nucleic acid present within a sample, and methods for making such kits are provided.
    Type: Application
    Filed: January 21, 2021
    Publication date: June 24, 2021
    Applicant: Cascade Biosystems, Inc.
    Inventors: Kenneth D. Smith, Nina Yazvenko, Mariya Smit
  • Publication number: 20210186470
    Abstract: A sweat collection device includes a flexible body having a first, outwardly facing surface and a second, skin-facing surface, and a sweat collection channel formed in the body, the sweat collection channel having a first end defining a sweat inlet port, and a second end defining a sweat outlet port. The sweat inlet port and the sweat outlet port are configured to be closed and sealed such that the sweat collection device and the collected sweat therein may be stored and shipped.
    Type: Application
    Filed: November 21, 2018
    Publication date: June 24, 2021
    Applicant: Epicore Biosystems, Inc.
    Inventors: Jeffrey B. Model, Roozbeh Ghaffari, Alexander J. Aranyosi, Stephen P. Lee, Milan S. Raj
  • Patent number: 11041150
    Abstract: The present disclosure relates to fluidic systems and devices for processing, extracting, or purifying one or more analytes. These systems and devices can be used for processing samples and extracting nucleic acids, for example by isotachophoresis. In particular, the systems and related methods can allow for extraction of nucleic acids, including non-crosslinked nucleic acids, from samples such as tissue or cells. The systems and devices can also be used for multiplex parallel sample processing.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: June 22, 2021
    Assignee: Purigen Biosystems, Inc.
    Inventors: Lewis A. Marshall, Amy L. Hiddessen, Nathan P. Hoverter, Klint A. Rose, Juan G. Santiago, Matthew S. Munson, Janine Mok, Sean Arin, Yatian Qu, Andrew Lee, Michael Christopher DeRenzi
  • Patent number: 11000488
    Abstract: There is disclosed a method for treating pain, comprising administering an analgesic oral dosage form comprising desmetramadol substantially free of tramadol.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: May 11, 2021
    Assignee: Syntrix Biosystems Inc.
    Inventor: John A. Zebala
  • Patent number: 10993953
    Abstract: What is described is a method for treating cancer in a patient assaying levels of (a) CXCR1 and/or CXCR2 ligands or (b) myeloid derived suppressor cells (MDSCs) and/or neutrophils in the patient, and if the patient has increased levels of (a) or (b), then administering a therapeutically effective amount of a compound having a structure selected from the group consisting of formulas SX-517, SX-576, and SX-682
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: May 4, 2021
    Assignee: Syntrix Biosystems Inc.
    Inventors: John A. Zebala, Dean Y. Maeda, Aaron D. Schuler
  • Patent number: 10989662
    Abstract: The present disclosure provides devices and methods enabling the analysis of biomolecules. In some embodiments, the biomolecules may be DNA, RNA, protein, peptide, small molecule, catalyst, precursor, nucleotide, antibodies, or other biomolecules of interest.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: April 27, 2021
    Assignee: Azure Biosystems, Inc.
    Inventors: Diping Che, Zhefu Zhang
  • Patent number: 10989703
    Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: April 27, 2021
    Assignee: Axion BioSystems, Inc.
    Inventors: Isaac Perry Clements, Amanda Jervis Preyer, Swaminathan Rajaraman, Daniel Christopher Millard, James David Ross
  • Patent number: 10988725
    Abstract: Provided herein are tubular membrane filter elements, tangential flow filtration systems comprising such filter elements and methods of using such filter elements and filtration systems.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: April 27, 2021
    Assignee: Artemis Biosystems, Inc.
    Inventors: Maurizio V. Cattaneo, Remco A. Spanjaard
  • Patent number: 10975361
    Abstract: The present invention provides improved DNA polymerases that may be better suited for applications in recombinant DNA technologies, in particular technologies involving plant-derived samples. Among other things, the present invention provides modified DNA polymerases derived from directed evolution experiments designed to select mutations that confer advantageous phenotypes under conditions used in industrial or research applications.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: April 13, 2021
    Assignee: Kapa Biosystems, Inc.
    Inventors: Wolfgang Schafer, Paul McEwan, Eric Van Der Walt, John Foskett, William Bourn
  • Patent number: 10968483
    Abstract: This document provides methods and materials for detecting genetic and/or epigenetic elements. For example, methods and materials for detecting the presence or absence of target nucleic acid containing a genetic or epigenetic element, methods and materials for detecting the amount of target nucleic acid containing a genetic or epigenetic element within a sample, kits for detecting the presence or absence of target nucleic acid containing a genetic or epigenetic element, kits for detecting the amount of target nucleic acid containing a genetic or epigenetic element present within a sample, and methods for making such kits are provided.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: April 6, 2021
    Assignee: Cascade Biosystems, Inc.
    Inventors: Kenneth D. Smith, Nina Yazvenko, Mariya Smit
  • Patent number: 10961555
    Abstract: The present invention provides improved DNA polymerases, in particular, type A DNA polymerases, that may be better suited for applications in recombinant DNA technologies. Among other things, the present invention provides modified DNA polymerases derived from directed evolution experiments designed to select mutations that confer advantageous phenotypes under conditions used in industrial or research applications.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: March 30, 2021
    Assignee: Kapa Biosystems, Inc.
    Inventors: William Bourn, Maryke Appel, Gavin Rush, John Foskett, Paul J. McEwan
  • Patent number: 10953143
    Abstract: The present invention features methods of manipulating subdermal fat in a treatment area. Such methods include inserting a needle (e.g., a micro-coring needle) through the dermis to the subdermal fat layer in order to excise a portion of tissue from the treatment area. These insertions result in a portion of the dermis and a portion of subdermal fat to enter into the needle. Removal of the needle results in excision of the portion of dermis and subdermal fat that entered into the needle.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: March 23, 2021
    Assignee: Cytrellis Biosystems, Inc.
    Inventors: Alec Ginggen, Douglas Levinson, David Stone
  • Publication number: 20210069268
    Abstract: The inventions described herein relate generally to the use of compositions to increase output of particular metabolites in the gut of a nursing infant mammal including humans. These compositions generally comprise one or more bacterial strains selected for their growth on mammalian milk oligosaccharides, a source of mammalian milk oligosaccharides, and, optionally, nutritive components required for the growth of that infant mammal.
    Type: Application
    Filed: September 13, 2018
    Publication date: March 11, 2021
    Applicant: Evolve Biosystems, Inc.
    Inventors: Bethany HENRICK, Steven FRESE, David KYLE, Samara FREEMAN-SHARKEY, Giorgio CASABURI
  • Patent number: 10939860
    Abstract: The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: March 9, 2021
    Assignee: Seventh Sense Biosystems, Inc.
    Inventors: Douglas A. Levinson, Howard Bernstein, Donald E. Chickering, III, Shawn Davis, Ramin Haghgooie, Mark Michelman
  • Patent number: RE48547
    Abstract: There are disclosed aminopyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include aminopyrimidinecarboxamides compounds. More specifically, there is disclosed a genus of CXCR2 inhibitor compounds that are useful for treating a variety of inflammatory and neoplastic disorders.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: May 11, 2021
    Assignee: Syntrix Biosystems Inc.
    Inventors: Dean Y. Maeda, John A. Zebala, Aaron D. Schuler