Patents Assigned to Board of Trustees, Michigan State University
  • Patent number: 10332616
    Abstract: Disclosed herein is a method of estimating the pose of a ligand in a receptor comprising identifying all possible atom pairs of protein-ligand complexes in a given configuration space for a system that comprises proteins; creating a first database and a second database; where the first database comprises associated pairwise distant dependent energies and where the second database comprises all probabilities that include how the atom pairs can combine; combining the first database with the second database via statistical mechanics to accurately estimate binding free energies as well as a pose of a ligand in a receptor; and selecting a protein-ligand complex for further study.
    Type: Grant
    Filed: April 30, 2016
    Date of Patent: June 25, 2019
    Assignees: Board of Trustees of Michigan State University, University of Florida Research Foundation, Inc.
    Inventors: Zheng Zheng, Kenneth M. Merz, Jr.
  • Patent number: 10330610
    Abstract: An imaging system images near-field objects with focused microwave or terahertz radiation. Multiple antennas emit microwave or terahertz radiation, such that the radiation varies in frequency over time, illuminates a near-field object, reflects from the near-field object, and travels to a passive aperture. For example, the passive aperture may comprise a dielectric lens or a parabolic reflector. The passive aperture focuses, onto a spatial region, the microwave or terahertz radiation that reflected from the near-field object. One or more antennas take measurements, in the spatial region, of the microwave or terahertz radiation that reflected from the near-field object. A computer calculates, based on the measurements, an image of the near-field object and depth information regarding the near-field object.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: June 25, 2019
    Assignees: Massachusetts Institute of Technology, Board of Trustees of Michigan State University
    Inventors: Gregory Charvat, Andrew Temme, Micha Feigin-Almon, Ramesh Raskar, Hisham Bedri
  • Patent number: 10323074
    Abstract: The disclosure features, among other things, polypeptides comprising a Cryptic polypeptide, a functional fragment thereof, or variants of any of the foregoing. Also featured are nucleic acids encoding the polypeptides, methods for producing of the polypeptides, and a variety of diagnostic and therapeutic applications in which the polypeptides are useful. For example, the polypeptides can be used to treat a subject having a condition associated with bone loss.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: June 18, 2019
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Erik Martinez-Hackert, Senem Aykul
  • Patent number: 10296988
    Abstract: An electric power system or power grid is optimized using a computer-implemented tool the represents in computer memory the optimization function and at least one constraint, which the processor operates upon using a linear programming solver algorithm. The constraints are represented in memory as data structures that include both real and reactive power terms, corresponding to at least one of a power flow model and a transmission line model. The transmission line model is represented using a piecewise linear representation. The power flow model may also include for each node in the power system a real power loss term representing transmission line loss allocated to that node.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: May 21, 2019
    Assignee: Board of Trustees of Michigan State University
    Inventor: Joydeep Mitra
  • Patent number: 10291680
    Abstract: The streaming media encoding and routing system employs an encoder circuit that constructs a streaming media sequence as a plurality of sequential frames, each frame comprising a plurality of segments. The encoder circuit has a processor that is programmed to place media information into the plurality of segments of each frame according to a predefined priority and further programmed to order the sequence of said segments within each frame such that the segments are progressively priority-ranked from high priority to low priority to define an EPIQ-encoded packet. A processor tests an incoming packet to determine whether it is EPIQ-encoded.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: May 14, 2019
    Assignee: Board of Trustees of Michigan State University
    Inventor: Hayder Radha
  • Publication number: 20190137436
    Abstract: The disclosure relates to textile biosensors and related systems that can be used for in situ health monitoring and disease detection. The biosensors include a flexible or textile substrate, a working electrode embroidered thereon, a reference electrode embroidered thereon, optionally a counter electrode embroidered thereon, and an enzyme probe bound to the working electrode. The biosensors can be integrated directly onto fabrics and garments to provide lightweight, unobtrusive wearable sensing systems that do not compromise wearer mobility, comfort or attention.
    Type: Application
    Filed: April 28, 2017
    Publication date: May 9, 2019
    Applicant: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Peter B. Lillehoj, Xiyuan Liu
  • Publication number: 20190133438
    Abstract: A visual neuromodulation system includes a processor and a transition function determination module configured to determine a spatial frequency transition function corresponding to a spatial frequency based on user input. The user input includes: (i) a quantity of illusions perceived in response to viewing a spatial frequency pattern associated with the spatial frequency and (ii) a level of discomfort sensed in response to viewing the spatial frequency pattern associated with the spatial frequency. The system also includes a threshold determination module configured to determine a threshold spatial frequency based on the spatial frequency transition function. The system includes, in response to the threshold determination module determining the threshold spatial frequency, a control module that selects a display spatial frequency pattern from a set of spatial frequency patterns.
    Type: Application
    Filed: November 6, 2018
    Publication date: May 9, 2019
    Applicant: Board of Trustees of Michigan State University
    Inventors: Jie HUANG, David C. ZHU
  • Patent number: 10280432
    Abstract: The invention relates to genetically modified agricultural plants with increased oil content in vegetative tissues, as well as to expression systems, plant cells, seeds and vegetative tissues related thereto.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: May 7, 2019
    Assignee: Board of Trustees of Michigan State University
    Inventors: Christoph Benning, Sanjaya
  • Publication number: 20190125242
    Abstract: A surgical tool includes opposing jaws, handles and at least one pressure sensor. Another aspect of a surgical tool includes opposing jaws with each having an organ-contacting surface area of at least 50 mm2. A further aspect of a surgical tool includes an electronic controller connected to at least one pressure sensor and automatically adapted to calculate or determine an organ-hardness from a sensor when jaws are moved to an organ-compressing position. In yet another aspect of a surgical tool, a pressure sensor is mounted to a pancreas-compressing surface and a displacement transducer or sensor is mounted to and/or located within a handle coupled to the surface, and an electronic controller is mounted to and/or located within the handle for calculating a hardness of a pancreas and/or other organ.
    Type: Application
    Filed: October 30, 2018
    Publication date: May 2, 2019
    Applicant: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Srinivas Kavuturu, Ranjan Mukherjee
  • Patent number: 10269464
    Abstract: A method of assisting with authenticating a workpiece is provided. In another aspect, ions are generated, accelerated in an accelerator, an isotope is created, and then the isotope is implanted within a workpiece to assist with authenticating of the workpiece. A further aspect includes a workpiece substrate, a visual marker and an isotope internally located within the substrate adjacent the visual marker.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: April 23, 2019
    Assignee: Board of Trustees of Michigan State University
    Inventors: Wolfgang Bauer, Bradley Sherrill
  • Patent number: 10267739
    Abstract: A laser system and method employing stimulated Raman scattering using a main laser pulse and a delayed replica reference pulse are provided. A further aspect calculates stimulated Raman loss and stimulated Raman gain from a reflected laser light scatter collected from a fabric or paper specimen. In another aspect, a laser system receives a low energy portion of a spectrum of main and reference laser pulses with a first photodetector, receives a higher energy portion of the spectrum of the main and reference pulses with a second photodetector, and uses a controller to determine a Raman active phonon transfer of energy manifested as an increase in the reflected laser scatter in a lower energy portion of the spectrum and a decrease in a higher energy portion of the spectrum. In yet another aspect, the controller automatically determines if a hazardous particle or substance such as an explosive, is present on a specimen.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: April 23, 2019
    Assignee: Board of Trustees of Michigan State University
    Inventors: Marcos Dantus, Marshall Thomas Bremer
  • Patent number: 10259768
    Abstract: A method of recycling a polyester includes the steps of providing the polyester, preparing a solution containing water and an alcohol, submerging the polyester in the solution, and hydrolytically depolymerizing the polyester while the polyester is submerged in the solution.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: April 16, 2019
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Rafael Auras, Fabiola Maria Iñiguez-Franco, Maria Rubino, Daniel Holmes, Susan E. Selke, Xiaoyi Fang
  • Patent number: 10251566
    Abstract: A method is provided for determining a central aortic pressure (AP) wave-form for a subject. The method includes measuring a peripheral artery pressure (PAP) waveform from the subject, employing a distributed model to define a pressure-to-pressure transfer function relating PAP to AP and a pressure-to-flow transfer function relating PAP to a central arterial flow in terms of the same unknown parameters, estimating the unknown parameters by finding the pressure-to-flow transfer function, which when applied to the measured PAP waveform, minimizes the magnitude of the central arterial flow waveform during diastole, and applying the pressure-to-pressure transfer function with the estimated parameters to determine an AP waveform for the subject.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: April 9, 2019
    Assignee: Board of Trustees of Michigan State University
    Inventors: Ramakrishna Mukkamala, Gokul Swamy, Nicholas Bari Olivier
  • Patent number: 10253146
    Abstract: The disclosure relates to a nanocomposite polymeric film including a thermoplastic polymer matrix such as polypropylene or other polyolefin, a coupling agent-modified organoclay reinforcement, and a polymeric compatibilizer bound to the coupling agent-modified organoclay, in particular as a thin film with controllable thicknesses. The disclosure further relates to masterbatch additives formed from the coupling agent-modified organoclay and the polymeric compatibilizer bound to the coupling agent-modified organoclay as well as related methods for making the nanocomposite polymeric film and/or processing recycled plastics. The inclusion of the coupling agent-modified organoclay reinforcement improves the mechanical properties of the nanocomposite polymeric film and the rheological properties of polymer melts including the nanocomposite polymeric film components.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: April 9, 2019
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Krishnamurthy Jayaraman, Weijie Ren, Rahul H. Rane
  • Patent number: 10253329
    Abstract: The present invention relates to compositions and methods for identifying and using new germplasm providing aphid resistant in soybean plants, particularly for use in breeding soybean plant lines and cultivars representing specific set(s) of germplasm. In particular, aphid resistant soybean plants comprising new sources of germplasm and stacked germplasm/genes conferring enhanced aphid resistance are provided. These enhanced aphid resistant plants find use in breeding soybean plant lines (cultivars) including lines having superior aphid resistance. Further, the inventions relate to providing new aphid resistant germplasm identified by markers associated with plants having decreased damage from aphid feeding, as well as plants having enhanced tolerance to aphid infestation.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: April 9, 2019
    Assignee: Board of Trustees of Michigan State University
    Inventors: Dechun Wang, Carmille Bales-Arcelo, Zhongnan Zhang, Cuihua Gu, Christina D. DiFonzo, Guorong Zhang, Zhenyu Yang, Menghan Liu, Clarice Mensah
  • Patent number: PP30473
    Abstract: A new cherry tree variety suitable for use as rootstock.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: May 7, 2019
    Assignee: Board of Trustees of Michigan State University
    Inventor: Amy Iezzoni
  • Patent number: PP30491
    Abstract: A new and distinct Fragaria x ananassa plant named ‘Redstart’, particularly characterized as a weak day-neutral long fruiting variety.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: May 14, 2019
    Assignee: Board of Trustees of Michigan State University
    Inventor: James Hancock
  • Patent number: PP30492
    Abstract: A new and distinct Fragaria x ananassa plant named ‘Wasatch’, particularly characterized as a strong day-neutral.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: May 14, 2019
    Assignee: Board of Trustees of Michigan State University
    Inventor: James Hancock
  • Patent number: PP30538
    Abstract: A new cherry tree variety suitable for use as rootstock.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: May 28, 2019
    Assignee: Board of Trustees of Michigan State University
    Inventor: Amy Iezzoni
  • Patent number: PP30553
    Abstract: A new cherry tree variety suitable for use as rootstock.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: June 4, 2019
    Assignee: Board of Trustees of Michigan State University
    Inventor: Amy Iezzoni