Patents Assigned to Board of Trustees, Michigan State University
  • Patent number: 10144932
    Abstract: Methods of treating movement disorders by reducing the activity of Nurr1 are disclosed. These methods are particularly applicable to subjects suffering from Parkinson's disease who have either developed levodopa-induced dyskinesia (LID) or are at risk of developing LID. In some aspects, the invention relates to a method for treating a movement disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition, wherein said composition reduces the activity of a nuclea receptor related 1 protein (“Nurr1”). In some embodiments, the movement disorder is a dyskinesia. The movement disorder may be a levodopa-induced dyskinesia.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: December 4, 2018
    Assignee: Board of Trustees of Michigan State University
    Inventors: Fredric P. Manfredsson, Jack W. Lipton, Nicholas Kanaan, Timothy Collier, Kathy Steece-Collier, Caryl E. Sortwell
  • Patent number: 10136823
    Abstract: A method is provided for determining blood pressure for a subject using a sphygmomanometer. The method includes: measuring an oscillometric cuff pressure waveform of the subject using the sphygmomanometer; representing the measured waveform with a physical model accounting for mechanics of the cuff, an artery and coupling between the cuff and the artery; determining the model unknowns from the measured waveform; and determining blood pressure for the subject using the determined model.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: November 27, 2018
    Assignee: Board of Trustees of Michigan State University
    Inventors: Ramakrishna Mukkamala, Jiankun Liu, Jin-Oh Hahn
  • Patent number: 10130511
    Abstract: An adaptive laser system for ophthalmic use is provided. In another aspect, a relatively inexpensive laser is employed. In another aspect of the present system, non-linear optical imaging uses multiphoton fluorescences and/or second harmonic generation, to create three-dimensional mapping of a portion of the eye in combination with automated feedback to assist with a surgical operation. In a further aspect of the present system, the patient interface uses laser induced markings or indicia to aid in focusing and/or calibration. Still another aspect employs temporal focusing of the laser beam pulse.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: November 20, 2018
    Assignee: Board of Trustees of Michigan State University
    Inventor: Marcos Dantus
  • Patent number: 10106813
    Abstract: Drought-inducible plant promoters are described herein that are useful for expressing drought tolerance factors in plants.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: October 23, 2018
    Assignee: Board of Trustees of Michigan State University
    Inventors: Kyung-Hwan Han, Won-Chan Kim, Joo-Yeol Kim, Jae-Heung Ko
  • Patent number: 10099458
    Abstract: The disclosure relates to reversible bonded structural joints using active adhesive compositions that can allow for dis-assembly, repair, and re-assembly. The disclosure is particularly directed to the adhesive composition material, irrespective of the type of the substrate(s) being joined. The adhesive composition can include any thermoplastic adhesive material that can be remotely activated for targeted heating of just the adhesive composition (e.g., and not the surrounding substrates being joined) via the inclusion of electromagnetically excitable particles in the adhesive composition. The substrates can be any metal material, any composite material, any hybrid material, or otherwise. The disclosed adhesive compositions allow for recyclability of parts at the end of their lifetime and repair/replacement of parts during their lifetime.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: October 16, 2018
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Mahmoodul Haq, Lawrence T. Drzal, Ermias G. Koricho
  • Patent number: 10102319
    Abstract: An iso-geometric analysis technique based on subdivision is presented for boundary integral equations associated with electromagnetics. Subdivision geometry processing has seen rapid growth in the computer graphics community. In terms of geometry processing, subdivision offers several advantages including adaptivity, refinement, smoothness, etc. As a result, these salient features are inherited by physics solvers providing unprecedented accuracy, convergence, low frequency stability, etc.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: October 16, 2018
    Assignee: Board of Trustees of Michigan State University
    Inventors: Jie Li, Shanker Balasubramaniam
  • Patent number: 10101301
    Abstract: A rotating magnetic field probe includes three (or more) windings that work in both transmit and receive mode, to form an eddy current detection transceiver. In a transmit mode, the windings are driven with a drive signal (e.g., an alternating current) having similar or the same magnitude at each winding, but differing in phase from one another. In a receive mode, the terminal voltages of the windings is measured and summed to determine the location of a defect.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: October 16, 2018
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Chaofeng Ye, Satish S. Udpa, Lalita Udpa
  • Publication number: 20180289288
    Abstract: A method and apparatus for monitoring arterial properties, including systolic and diastolic pressure levels, of a subject is provided, in which a hardware processor receives and analyzes ballistocardiogram (BCG) data of the subject. A non-transient computer readable medium, accessible by the hardware processor, contains instructions that, when executed by the hardware processor, identify features of the BCG waveform and determine the arterial properties therefrom. For example, a diastolic pressure level may be determined from a time interval between the ‘I’ and ‘J’ peaks of the waveform and a systolic pressure level determined from the amplitude difference between the ‘J’ and ‘K’ peaks of the waveform in combination with the ‘I-J’ time interval or amplitude difference. A physical mechanism for the BCG data is disclosed that enables other arterial properties of the subject to be determined from the BCG data alone or from the BCG data in combination with other measurements.
    Type: Application
    Filed: April 6, 2018
    Publication date: October 11, 2018
    Applicants: UNIVERSITY OF MARYLAND AT COLLEGE PARK, BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Chang-Sei KIM, Stephanie OBER, Jin-Oh HAHN, Ramakrishna Mukkamala, Omer T. INAN
  • Patent number: 10097000
    Abstract: The analysis tool employs a computer-implemented algorithm that uses homotopy-based approaches to map the solution from the exit point to the controlling unstable equilibrium point (UEP). The computational time is reduced significantly by using an approximate exit point rather than computing an accurate exit point as it is required in finding the controlling UEPs using traditional transient stability direct methods. In addition, this method eliminates the necessity of computing the minimum gradient point (MGP) which is a key element in using Newton methods. These properties provide an advantage to homotopy-based approaches over traditional iterative methods in terms of both speed of computation and reliability of finding solutions.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: October 9, 2018
    Assignee: Board of Trustees of Michigan State University
    Inventors: Joydeep Mitra, Mohammed Ben-Idris, Niannian Cai
  • Publication number: 20180267072
    Abstract: The superposition of Laguerre-Gaussian guided into and scattered by a particle in a rotated fluid allows the detection of the rotational of the fluid. The presented system allows for virtually real-time determination of vorticity characterization in a fluid. The system allows the direct measurements of fluid flow vorticity using a spatially shaped beam with a superposition of Laguerre-Gaussian modes that reports on the rotational Doppler shift from microparticles intersecting the beam focus.
    Type: Application
    Filed: February 10, 2017
    Publication date: September 20, 2018
    Applicant: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: MARCOS DANTUS, MANOOCHEHR M. KOOCHESFAHANI, SHAHRAM POUYA, ANTON G. RYABTSEV, ALIREZA SAFARIPOUR TABALVANDANI
  • Patent number: 10077278
    Abstract: The disclosure is directed to diboron compounds, related methods of making, and related intermediate boron and diboron compounds used to make the same. The diboron compounds can be used as reagents to prepare chemical intermediates that are used in pharmaceutical, agrochemical, and specialty electronics industries. The disclosed processes and compounds provide simplified synthetic paths that significantly reduce steps, improve scalability, and minimize costs for producing the diboron reagents.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: September 18, 2018
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Milton R. Smith, III, Robert E. Maleczka, Jr.
  • Publication number: 20180256045
    Abstract: Most automatic cuff blood pressure (BP) measurement devices are based on oscillometry. These devices estimate BP from the envelopes of the cuff pressure oscillations using fixed ratios. The values of the fixed ratios represent population averages, so the devices may be accurate only in subjects with normal BP levels. A patient-specific oscillometric BP measurement method was developed. The idea was to represent the cuff pressure oscillation envelopes with a physiologic model and then estimate the patient-specific parameters of the model, which includes BP levels, by optimally fitting it to the envelopes.
    Type: Application
    Filed: September 9, 2016
    Publication date: September 13, 2018
    Applicants: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY, UNIVERSITY OF MARYLAND
    Inventors: Jiankun LIU, Mohsen MOSLEHPOUR, Jin-Oh HAHN, Ramakrishna MUKKAMALA
  • Patent number: 10074867
    Abstract: Bioelectrochemical systems comprising a microbial fuel cell (MFC) or a microbial electrolysis cell (MEC) are provided. Either type of system is capable of fermenting insoluble or soluble biomass, with the MFC capable of using a consolidated bioprocessing (CBP) organism to also hydrolyze an insoluble biomass, and an electricigen to produce electricity. In contrast, the MEC relies on electricity input into the system, a fermentative organism and an electricigen to produce fermentative products such as ethanol and 1,3-propanediol from a polyol biomass (e.g., containing glycerol). Related methods are also provided.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: September 11, 2018
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Gemma Reguera, Allison M. Speers, Jenna M. Young, Bhushan Awate
  • Patent number: 10066207
    Abstract: The invention relates to a specialized subpopulation of natural killer cells that have enhanced effector functions and the potential to kill malignant tumor cells or infected cells when the natural killer cells are exposed to an antibody bound to the tumor cells or the infected cells.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: September 4, 2018
    Assignee: Board of Trustees of Michigan State University
    Inventors: Sungjin Kim, Jeannine Scott
  • Patent number: 10059955
    Abstract: The invention relates to isolated nucleic acids encoding a feruloyl-CoA:monolignol transferase and feruloyl-CoA:monolignol transferase enzymes. The isolated nucleic acids and/or the enzymes enable incorporation of monolignol ferulates into the lignin of plants, where such monolignol ferulates include, for example, p-coumaryl ferulate, coniferyl ferulate, and/or sinapyl ferulate. The invention also includes methods and plants that include nucleic acids encoding a feruloyl-CoA:monolignol transferase enzyme and/or feruloyl-CoA:monolignol transferase enzymes.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: August 28, 2018
    Assignees: Board of Trustees of Michigan State University, The University of British Columbia, Wisconsin Alumni Resarch Foundation
    Inventors: Curtis Wilkerson, John Ralph, Saunia Withers, Shawn D. Mansfield
  • Patent number: 10052070
    Abstract: A method is provided for determining a central aortic pressure waveform. The method includes: measuring two or more peripheral artery pressure waveforms; analyzing the signals so as to extract common features in the measured waveforms; and determining an absolute central aortic pressure waveform based on the common features.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: August 21, 2018
    Assignee: Board of Trustees of Michigan State University
    Inventors: Ramakrishna Mukkamala, Gokul Swamy, Qi Ling, Tongtong Li
  • Publication number: 20180233646
    Abstract: Thermoelectric materials based on tetrahedrite structures for thermoelectric devices and methods for producing thermoelectric materials and devices are disclosed.
    Type: Application
    Filed: December 18, 2015
    Publication date: August 16, 2018
    Applicants: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Donald T. MORELLI, Xu LU, Vidvuds OZOLINS
  • Patent number: 10047113
    Abstract: The invention relates to nucleic acids encoding a feruloyl-CoA:monolignol transferase and the feruloyl-CoA:monolignol transferase enzyme that enables incorporation of monolignol ferulates, for example, including p-coumaryl ferulate, coniferyl ferulate, and sinapyl ferulate, into the lignin of plants.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: August 14, 2018
    Assignees: Board of Trustees of Michigan State University, The University of British Columbia, Wisconsin Alumni Research Foundation
    Inventors: Curtis Wilkerson, John Ralph, Saunia Withers, Shawn D. Mansfield
  • Patent number: 10051663
    Abstract: A method and device for transmitting data between wireless devices includes: generating and transmitting, by a first device, a data cluster signal having a signal identifier, a completion marker, and at least one silence interval provided between the signal identifier and the completion marker; receiving, by a second device, the data cluster signal; identifying, by the second device, a signal type and a transmission completion of the signal received; and decoding, by the second device, the silence interval into the data based on the signal type and a duration of the silence interval.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: August 14, 2018
    Assignee: Board of Trustees of Michigan State University
    Inventors: Subir K. Biswas, Dezhi Feng, Faezeh Hajiaghajani Memar, Saptarshi Das
  • Patent number: 10045949
    Abstract: The present invention relates to the administration of compositions comprising polyethylene glycol, for improving the general gastrointestinal health of an animal increasing growth performance and treating osteopenia, osteoporosis and other bone disorders.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 14, 2018
    Assignees: MIDWAY PHARMACEUTICALS, INC, BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Rifat Pamukcu, Laura Rae McCabe