Abstract: The present invention is related to compositions and methods for enhanced synthesis of hydrocarbons, particularly, but not limited to, alkanes. The invention, in one embodiment, utilizes the co-expression of a hydrogen peroxide metabolizing enzyme in the presence of an aldehyde decarbonylase enzyme to relieve hydrogen peroxide inhibition of the aldehyde decarbonylase enzyme by hydrogen peroxide. In a preferred embodiment a catalase-aldehyde decarbonylase expression construct and fusion peptide is used. The present invention also relates to microorganisms engineered to express said enzymes and to produce hydrocarbon molecules.
Abstract: Vapor-liquid-solid growth of nanowires is tailored to achieve complex one-dimensional material geometries using phase diagrams determined for nanoscale materials. Segmented one-dimensional nanowires having constant composition display locally variable electronic band structures that are determined by the diameter of the nanowires. The unique electrical and optical properties of the segmented nanowires are exploited to form electronic and optoelectronic devices. Using gold-germanium as a model system, in situ transmission electron microscopy establishes, for nanometer-sized Au—Ge alloy drops at the tips of Ge nanowires (NWs), the parts of the phase diagram that determine their temperature-dependent equilibrium composition. The nanoscale phase diagram is then used to determine the exchange of material between the NW and the drop. The phase diagram for the nanoscale drop deviates significantly from that of the bulk alloy.
Type:
Grant
Filed:
June 18, 2012
Date of Patent:
November 18, 2014
Assignee:
Brookhaven Science Associates, LLC
Inventors:
Eli Anguelova Sutter, Peter Werner Sutter
Abstract: This disclosure relates to a polymer having the formula: wherein x is between 1 and about 100 an y is between about 99 and about 1, and x+Y=about 100. The disclosure also includes the use of the polymer in photovoltaic devices.
Type:
Grant
Filed:
February 6, 2014
Date of Patent:
November 18, 2014
Assignee:
Brookhaven Science Associates, LLC
Inventors:
Yang Qin, Robert B. Grubbs, Young Suk Park
Abstract: A method and apparatus for pulse pile-up rejection are disclosed. The apparatus comprises a delay value application constituent configured to receive a threshold-crossing time value, and provide an adjustable value according to a delay value and the threshold-crossing time value; and a comparison constituent configured to receive a peak-occurrence time value and the adjustable value, compare the peak-occurrence time value with the adjustable value, indicate pulse acceptance if the peak-occurrence time value is less than or equal to the adjustable value, and indicate pulse rejection if the peak-occurrence time value is greater than the adjustable value.
Abstract: Modified (iso)eugenol 4-O-methyltransferase enzymes having novel capacity for methylation of monolignols and reduction of lignin polymerization in plant cell wall are disclosed. Sequences encoding the modified enzymes are disclosed.
Abstract: The present invention relates to the design and use of an ion source with a rapid beam current controller for experimental and medicinal purposes. More particularly, the present invention relates to the design and use of a laser ion source with a magnetic field applied to confine a plasma flux caused by laser ablation.
Abstract: The bio-programmable crystallization of multi-component functional nanoparticle systems is Ascribed, as well as methods for such bio-programmable crystallization, and the products resultant from such methods. Specifically, the systems disclosed and taught herein are directed to improved strategies for the DNA-mediated self-assembly of multi-component functionalized nanoparticles into three-dimensional order surperlattices, wherein the functionalization of the nanoparticles with DNA is independent of either the composition of the material, or the shape of the nanoparticles.
Type:
Application
Filed:
April 12, 2012
Publication date:
October 16, 2014
Applicant:
BROOKHAVEN SCIENCE ASSOCIATES, LLC
Inventors:
Yugang Zhang, Fang Lu, Oleg Gang, Daniel Van Der Lelie
Abstract: This disclosure relates to a polymer having the formula: wherein x is between 1 and about 100 an y is between about 99 and about 1, and x+y=about 100. The disclosure also includes the use of the polymer in photovoltaic devices.
Type:
Application
Filed:
February 6, 2014
Publication date:
September 25, 2014
Applicant:
Brookhaven Science Associates, LLC
Inventors:
Yang Qin, Robert B. Grubbs, Young Suk Park
Abstract: A radiation detector device is provided that is capable of distinguishing between full charge collection (FCC) events and incomplete charge collection (ICC) events based upon a correlation value comparison algorithm that compares correlation values calculated for individually sensed radiation detection events with a calibrated FCC event correlation function. The calibrated FCC event correlation function serves as a reference curve utilized by a correlation value comparison algorithm to determine whether a sensed radiation detection event fits the profile of the FCC event correlation function within the noise tolerances of the radiation detector device. If the radiation detection event is determined to be an ICC event, then the spectrum for the ICC event is rejected and excluded from inclusion in the radiation detector device spectral analyses. The radiation detector device also can calculate a performance factor to determine the efficacy of distinguishing between FCC and ICC events.
Type:
Application
Filed:
June 29, 2012
Publication date:
August 21, 2014
Applicant:
BROOKHAVEN SCIENCE ASSOCIATES, LLC
Inventors:
Aleksey Bolotnikov, Gianluigi De Geronimo, Emerson Vernon, Ge Yang, Giuseppe Camarda, Yonggang Cui, Anwar Hossain, KiHyun Kim, Ralph B. James
Abstract: A method of forming and processing of graphene is disclosed based on exposure and selective intercalation of the partially graphene-covered metal substrate with atomic or molecular intercalation species such as oxygen (O2) and nitrogen oxide (NO2). The process of intercalation lifts the strong metal-carbon coupling and restores the characteristic Dirac behavior of isolated monolayer graphene. The interface of graphene with metals or metal-decorated substrates also provides for controlled chemical reactions based on novel functionality of the confined space between a metal surface and a graphene sheet.
Abstract: Methods and means are provided to increase the oil content of plants, particularly oleaginous plants by preventing feedback inhibition by 18:1-Coenzyme A or 18:1-Acyl Carrier Protein of the acetyl CoA-carboxylase enzyme in cells of these plants in various manners.
Abstract: Radiotracer vorozole compounds for in vivo and in vitro assaying, studying and imaging cytochrome P450 aromatase enzymes in humans, animals, and tissues and methods for making and using the same are provided. [N-radio-methyl] vorozole substantially separated from an N-3 radio-methyl isomer of vorozole is provided. Separation is accomplished through use of chromatography resins providing multiple mechanisms of selectivity.
Type:
Grant
Filed:
March 19, 2013
Date of Patent:
August 12, 2014
Assignee:
Brookhaven Science Associates, LLC
Inventors:
Sung Won Kim, Anat Biegon, Joanna S. Fowler
Abstract: Structures useful for forming contacts to materials having low charge carrier mobility are described. Methods for their formation and use are also described. These structures include interdigitated electrodes capable of making electrical contact to semiconducting materials having low electron and/or whole mobility. In particular, these structures are useful for organic semiconducting devices made with conducting polymers and small molecules. They are also useful for semiconducting devices made with nanocrystalline semiconductors.
Type:
Application
Filed:
April 27, 2012
Publication date:
August 7, 2014
Applicant:
BROOKHAVEN SCIENCE ASSOCIATES, LLC
Inventors:
Danvers E. Johnston, Jonathan E. Allen, Charles T. Black, Chang-Yong Nam
Abstract: A radiation detector system is disclosed that effectively solves the electron trapping problem by optimizing shielding of the individual virtual Frisch-grid detectors in an array configuration.
Type:
Application
Filed:
October 29, 2013
Publication date:
August 7, 2014
Applicant:
Brookhaven Science Associates, LLC
Inventors:
Aleksey Bolotnikov, Ralph B. James, Gianluigi De Geronimo, Emerson Vernon
Abstract: Radiotracer vorozole compounds for in vivo and in vitro assaying, studying and imaging cytochrome P450 aromatase enzymes in humans, animals, and tissues and methods for making and using the same are provided. [N-radio-methyl] vorozole substantially separated from an N-3 radio-methyl isomer of vorozole is provided. Separation is accomplished through use of chromatography resins providing multiple mechanisms of selectivity.
Type:
Grant
Filed:
February 11, 2010
Date of Patent:
August 5, 2014
Assignee:
Brookhaven Science Associates, LLC
Inventors:
Sung Won Kim, Anat Biegon, Joanna S. Fowler
Abstract: A nucleotide construct comprising a nucleotide sequence that forms a stem and a loop, wherein the loop comprises a nucleotide sequence that modulates expression of a target, wherein the stem comprises a nucleotide sequence that modulates expression of a target, and wherein the target modulated by the nucleotide sequence in the loop and the target modulated by the nucleotide sequence in the stem may be the same or different. Vectors, methods of regulating target expression, methods of providing a cell, and methods of treating conditions comprising the nucleotide sequence are also disclosed.
Abstract: A particle beam to treat malignant tissue is delivered to a patient by a gantry. The gantry includes a plurality of small magnets sequentially arranged along a beam tube to transfer the particle beam with strong focusing and a small dispersion function, whereby a beam size is very small, allowing for the small magnet size. Magnets arranged along the beam tube uses combined function magnets where the magnetic field is a combination of a bending dipole field with a focusing or defocusing quadrupole field. A triplet set of combined function magnets defines the beam size at the patient. A scanning system of magnets arranged along the beam tube after the bending system delivers the particle beam in a direction normal to the patient, to minimize healthy skin and tissue exposure to the particle beam.
Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
Type:
Application
Filed:
November 12, 2013
Publication date:
May 22, 2014
Applicants:
BAXTER INTERNATIONAL INC., Brookhaven Science Associates, LLC, Research Foundation of the State University of New York, BAXTER HEALTHCARE SA
Inventors:
Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
Abstract: A method of forming and processing of graphene is disclosed based on exposure and selective intercalation of the partially graphene-covered metal substrate with atomic or molecular intercalation species such as oxygen (O2) and nitrogen oxide (NO2). The process of intercalation lifts the strong metal-carbon coupling and restores the characteristic Dirac behavior of isolated monolayer graphene. The interface of graphene with metals or metal-decorated substrates also provides for controlled chemical reactions based on novel functionality of the confined space between a metal surface and a graphene sheet.
Type:
Grant
Filed:
May 10, 2012
Date of Patent:
May 20, 2014
Assignee:
Brookhaven Science Associates, LLC
Inventors:
Peter Werner Sutter, Eli Anguelova Sutter
Abstract: The invention relates to the use of peptides, proteins, and other oligomers to provide a means by which normally quenched nanoparticle fluorescence may be recovered upon detection of a target molecule. Further, the inventive technology provides a structure and method to carry out detection of target molecules without the need to label the target molecules before detection. In another aspect, a method for forming arbitrarily shaped two- and three-dimensional protein-mediated nanoparticle structures and the resulting structures are described. Proteins mediating structure formation may themselves be functionalized with a variety of useful moieties, including catalytic functional groups.
Type:
Grant
Filed:
June 2, 2009
Date of Patent:
May 20, 2014
Assignee:
Brookhaven Science Associates, LLC
Inventors:
Soo-Kwan Lee, Oleg Gang, Daniel van der Lelie