Patents Assigned to Brown University
  • Patent number: 12270676
    Abstract: According to some aspects, a wearable device for estimating a location of the device within a space is provided, the device comprising a plurality of cameras mounted to a structure, at least a portion of the structure being adapted to facilitate a user wearing the device, the plurality of cameras having substantially fixed positions and orientations on the structure relative to each other, and at least one processor configured to receive image data from the plurality of cameras, perform feature detection on the image data to obtain a first plurality of features from the image data, and determine an estimate of the location of the device in the space based, at least in part, on a location associated with a second plurality of features obtained from image data previously captured of the space that matches the first plurality of features.
    Type: Grant
    Filed: August 21, 2023
    Date of Patent: April 8, 2025
    Assignee: Brown University
    Inventor: Benjamin Kimia
  • Publication number: 20250014321
    Abstract: An electronic device and method for using neural language models for long-term action anticipation from videos is provided. The electronic device receives a video that includes one or more objects performing a physical task and generates, based on the video, a first set of tags that corresponds to a first sequence of actions associated with the physical task. The electronic device generates a first prompt for a neural language model based on the first set of tags and predicts, by application of the neural language model on the first prompt, a second set of tags that corresponds to a second sequence of actions associated with the physical task. The second sequence of actions succeeds the first sequence of actions. The electronic device controls a display device to display first prediction information based on the second set of tags.
    Type: Application
    Filed: December 14, 2023
    Publication date: January 9, 2025
    Applicants: Honda Motor Co., Ltd., Brown University
    Inventors: CE ZHANG, CHANGCHENG FU, SHIJIE WANG, QI ZHAO, CHEN SUN, NAKUL AGARWAL, KWONJOON LEE
  • Publication number: 20250014338
    Abstract: An electronic device and method for object-centric video representation for action prediction is provided. The electronic device extracts a first sequence of video segments from video content associated with a domain and detects a set of objects in the first sequence of video segments. The electronic device generates a set of embeddings based on the first sequence of video segments and the set of objects. The electronic device applies a PTE model on the set of embeddings. The electronic device predicts, based on the application, a set of object-action pairs associated with a second sequence of video segments of the video content. Each object-action pair includes an action to be executed using an object of the set of objects in a video segment of the second sequence of video segments. The second sequence of video segments succeeds the first sequence of video segments in a timeline of the video content.
    Type: Application
    Filed: December 14, 2023
    Publication date: January 9, 2025
    Applicants: Honda Motor Co., Ltd., Brown University
    Inventors: CE ZHANG, CHANGCHENG FU, SHIJIE WANG, NAKUL AGARWAL, KWONJOON LEE, CHIHO CHOI, CHEN SUN
  • Publication number: 20240361331
    Abstract: The present disclosure generally relates to systems and methods for analysis of peptide photodissociation for single-molecule protein sequencing. In one aspect, systems and methods are directed to allowing one to fragment a single protein molecule in aqueous solution so that its composition and sequence of amino acids can be measured by mass spectrometry. This may be useful for single-molecule protein sequencing technology.
    Type: Application
    Filed: August 18, 2022
    Publication date: October 31, 2024
    Applicant: Brown University
    Inventors: Derek M. Stein, Jacob Sage Vietorisz, Nicholas Drachman
  • Patent number: 12130892
    Abstract: A method includes receiving data, flagging outliers in the received data, each of the outliers representing extreme data values in the received data that stand out greatly from an overall pattern of data values at a given scale in the received data, storing the flagged outliers in an outlier file, removing the flagged outliers from the received data, curating the flagged data points with respect to various neighborhood kernel sizes, and further curating data points with small perturbations using contextual custom regression techniques as a second order refinement process.
    Type: Grant
    Filed: August 11, 2022
    Date of Patent: October 29, 2024
    Assignee: Brown University
    Inventor: Prasanta Pal
  • Patent number: 12076110
    Abstract: A method includes providing an ensemble of distributed sensors, delivering radio frequency (RF) power to each sensor by inductive near-field coupling by a magnetic field projected by an epidermal transmit (Tx) coil, in each individual sensor, detecting a sparse binary event in its immediate environment, reporting the detected sparse binary event to an external RF receiver hub asynchronously and with low latency, and minimizing error rates due to statistical data packet collisions in asynchronous telemetry by digitally encoding each sensor according to a particular address scheme where each address is one function from an infinite set of mathematically orthogonal functions, enabling a simultaneous detection from up to ten thousand points without interference at a common receiver.
    Type: Grant
    Filed: October 20, 2022
    Date of Patent: September 3, 2024
    Assignee: Brown University
    Inventors: Arto Nurmikko, Jihun Lee, Ah-Hyoung Lee, Farah Laiwalla
  • Patent number: 12074370
    Abstract: A multi-frequency wireless access device including a first waveguide having a pair of parallel metal plates with open sides and a slot in one of the metal plates, the slot permitting radiation to leak out, the leaked radiation illuminating a range of angles depending on frequency.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: August 27, 2024
    Assignees: Brown University, William Marsh Rice University
    Inventors: Daniel Mittleman, Edward Knightly
  • Patent number: 12060557
    Abstract: The invention provides enhancer RNAs (eRNAs) that are expressed specifically in glioma stem cells and whose expression correlates with decreased survival of patients with glioblastomas. The eRNAs are selected, for example, from eTMEM88b, eRTP5, or eNINJ1. The invention also provides an RNA therapy that targets glioma stem cell eRNAs using synthetic oligonucleotides that knock out the eRNA expression. The invention further provides viral vectors that deliver shRNA that inhibit the expression of the eRNA.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: August 13, 2024
    Assignees: Brown University, Rhode Island Hospital
    Inventors: Nikolaos Tapinos, Blessing Akobundu
  • Patent number: 12042303
    Abstract: A patient communication system comprises a hand-held data input subsystem and a display subsystem. The data input subsystem may be configured to sense, and wirelessly convey, information associated with 3-D movement of the data input subsystem, and actuation of a signaling element within the data input subsystem. The display subsystem may receive the information and to present a visual representation of the information in a graphical user interface (GUI). The display subsystem may adaptively interpret the information with respect to range of motion sensitivity and orientation of the data input subsystem, and movement of the data input subsystem with respect to its prior state. The system may map the conveyed information to the GUI, generate and display images on the GUI with which a patient may interact by manipulating the data input subsystem, and capture one or more selections executed by the patient through actuation of the signaling element.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: July 23, 2024
    Assignees: Brown University, University of Massachusetts, The United States Government as Represented By The Department of Veterans Affairs
    Inventors: Miriam Anna Rimm Goldberg, Leigh Hochberg
  • Patent number: 12016624
    Abstract: A thermal accelerant is delivered to a tissue site and localized to modulate the shape, extent or other characteristic of RF or microwave-induced hyperthermic tissue ablation. The accelerant may be provided via an image-guided hand piece or via a lumen added to a microwave antenna, and promotes faster heating, more complete ablation and/or a more extensive treatment region to reduce recurrence of treated cancers, overcoming natural limitations, variations in tissue response and drop-off or thermal loss away from the antenna. The accelerant is delivered as a viscous but heat sensitive fluid, and is fixed in place to provide regions of preferential absorption or heating. Shorter exposure times to heat the far field may allow survival of vulnerable tissue such as vessels, and multiple antennae may be used for effective treatment of irregular or large tumors.
    Type: Grant
    Filed: July 9, 2021
    Date of Patent: June 25, 2024
    Assignees: Rhode Island Hospital, Brown University
    Inventors: William Keun Chan Park, Damian E. Dupuy
  • Publication number: 20240203724
    Abstract: The present disclosure generally relates to mass spectrometers, including but not limited to mass spectrometers able to emit ions at determinable times. In some aspects, the time between when ions leave an ion source and the time the ions reach a detector may be determined at a relatively high time resolutions, which may be useful for certain applications such as sequencing of biopolymers. In addition, in some cases, a relatively high number of ions leaving an ion source may be determined at a detector, e.g., at least 50% or more of the ions that are produced. Other aspects are generally directed to systems and methods for using such mass spectrometers, techniques involving such mass spectrometers, or the like.
    Type: Application
    Filed: April 22, 2022
    Publication date: June 20, 2024
    Applicant: Brown University
    Inventors: Derek M. Stein, Nicholas Drachman, Benjamin Wiener
  • Patent number: 11977317
    Abstract: A photon source for generating entangled photons includes a pump laser, and 4-N, N-dimethylamino-4?-N?-methyl-stilbazolium-tosylate (DAST) crystals, the pump laser pumping the DAST crystals with pump photons to generate a stream of pairs of entangled photons, each pair comprising a signal photon and an idler photon.
    Type: Grant
    Filed: February 16, 2023
    Date of Patent: May 7, 2024
    Assignee: Brown University
    Inventors: Jimmy Xu, Petr Moroshkin, Akshay Nagar
  • Patent number: 11964995
    Abstract: The present disclosure relates to a composition that includes a perovskite having a stoichiometry comprising A1-xFAxSn1-yBy(I1-zXz)3, where A is a first cation, B is a second cation, X is a halide, and 0.5?x?0.9, 0.5?y?0.9, and 0?z?1. In some embodiments of the present disclosure, A may include at least one of cesium, guanidinium, and/or methylammonium. In some embodiments of the present disclosure, X may include at least one of bromide and/or chloride. In some embodiments of the present disclosure, z may be equal to zero.
    Type: Grant
    Filed: January 27, 2022
    Date of Patent: April 23, 2024
    Assignees: Alliance for Sustainable Energy, LLC, Brown University
    Inventors: Kai Zhu, Jinhui Tong, Yuanyuan Zhou, Nitin P. Padture, Jue Gong
  • Patent number: 11957899
    Abstract: A system for placement of biocompatible electrodes in an opening formed in a patient's body part, such as DBS electrodes inserted into a patient's skull during surgical procedures in the brain. The system includes a coupled catheter and annulus. The catheter includes a guide tube having at least three cooperating guide elements configured to releasably fit together and collectively form a continuous lumen through the catheter that is dimensioned to receive an electrode therein. The annulus is configured to be placed in the opening formed in the patient's body part, and to receive the catheter therethrough. A track mechanism is used to operably couple the catheter to the annulus.
    Type: Grant
    Filed: January 19, 2021
    Date of Patent: April 16, 2024
    Assignee: Brown University
    Inventors: Wael Asaad, Shane Lee, Owen Leary, Noah Trac, Zakir Tahiry, Rohan Rastogi
  • Patent number: 11930581
    Abstract: A modular laser-produced plasma X-ray system includes a liquid metal flow system enclosed within a low-pressure chamber, the flow system including a liquid metal, wherein in at least one location on the liquid metal forms a metal target directly illuminated by laser pulses, a circulation pump within the liquid metal flow system for circulating the liquid metal, a laser pulse emitter configured to transmit laser pulses into the chamber via a laser window, focusing optics, located between the emitter and the metal target, the focusing optics directing the laser pulses to strike the metal target at a target location to form X-ray pulses, and an X-ray window positioned within the chamber to enable the X-ray pulses to exit the chamber.
    Type: Grant
    Filed: April 28, 2022
    Date of Patent: March 12, 2024
    Assignees: Brown University, Research Instruments Corporation
    Inventors: Daniel John DeCiccio, Christoph Rose-Petruck
  • Patent number: 11879020
    Abstract: The present invention provides to compositions and methods useful in the treatment of neurological disorders including, but not limited to, Angelman syndrome, depression, traumatic brain injury, stroke, and Alzheimer's disease. CN2097, a rationally designed cyclic peptidomimetic drug that has been demonstrated to have effectiveness in preclinical models for the treatment of neurological disorders, is rapidly cleared and has a short half-life. The present invention provides a stable analog of CN2097.
    Type: Grant
    Filed: March 9, 2022
    Date of Patent: January 23, 2024
    Assignee: Brown University
    Inventor: John Marshall
  • Patent number: 11881579
    Abstract: An energy storage composition can be used as a new Na-ion battery cathode material. The energy storage composition with an alluaudite phase of AxTy(PO4)z, NaxTy(PO4)z, Na1.702Fe3(PO4)3 and Na0.872Fe3(PO4)3, is described including the hydrothermal synthesis, crystal structure, and electrochemical properties. After ball milling and carbon coating, the compositions described herein demonstrate a reversible capacity, such as about 140.7 mAh/g. In addition these compositions exhibit good cycling performance (93% of the initial capacity is retained after 50 cycles) and excellent rate capability. These alluaudite compounds represent a new cathode material for large-scale battery applications that are earth-abundant and sustainable.
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: January 23, 2024
    Assignee: Brown University
    Inventors: G. Tayhas R. Palmore, Dan Liu
  • Patent number: 11847841
    Abstract: A method includes, as a robot encounters an object, creating a probabilistic object model to identify, localize, and manipulate the object, the probabilistic object model using light fields to enable efficient inference for object detection and localization while incorporating information from every pixel observed from across multiple camera locations.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: December 19, 2023
    Assignee: Brown University
    Inventors: Stefanie Tellex, John Oberlin
  • Patent number: 11793814
    Abstract: Disclosed is a method for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one reverse transcriptase inhibitor (RTI).
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: October 24, 2023
    Assignee: Brown University
    Inventors: John M. Sedivy, Marco De Cecco
  • Patent number: 11787821
    Abstract: The present invention discloses new catalyst systems based on trivalent metal complexes of Formula I, which can facilitate the stereospecific ring-opening polymerization of (rac)-?-Butyrolactone (rac-BBL). Also provided is a process for the stereospecific synthesis of aliphatic polyesters using the catalysts of Formula I, including alcohols and polyols as chain-transfer agents to facilitate immortal ring-opening polymerization.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: October 17, 2023
    Assignee: Brown University
    Inventors: Jerome R. Robinson, Xiang Dong