Abstract: According to some aspects, a wearable device for estimating a location of the device within a space is provided, the device comprising a plurality of cameras mounted to a structure, at least a portion of the structure being adapted to facilitate a user wearing the device, the plurality of cameras having substantially fixed positions and orientations on the structure relative to each other, and at least one processor configured to receive image data from the plurality of cameras, perform feature detection on the image data to obtain a first plurality of features from the image data, and determine an estimate of the location of the device in the space based, at least in part, on a location associated with a second plurality of features obtained from image data previously captured of the space that matches the first plurality of features.

Abstract: Disclosed is a method for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one reverse transcriptase inhibitor (RTI).

Abstract: The present invention provides to compositions and methods useful in the treatment of neurological disorders including, but not limited to, Angelman syndrome, depression, traumatic brain injury, stroke, and Alzheimer's disease. CN2097, a rationally designed cyclic peptidomimetic drug that has been demonstrated to have effectiveness in preclinical models for the treatment of neurological disorders, is rapidly cleared and has a short half-life. The present invention provides a stable analog of CN2097.

Abstract: This dual-compartment liver co-culture system exposes target microtissue to metabolites, allowing for evaluating toxicity using a standard multi-well plate for high throughput analysis. Discovery scientists can rapidly select lead compounds with desirable metabolic profiles, while safety scientists can determine the safety of drugs, pesticides, and environmental chemicals. This platform is allometrically scalable, so it can mimic the natural size differences between healthy organs and, with the liver, produce sufficient quantities of metabolites. The device is simple to use and designed for immediate in vitro pathology assessment using confocal microscopy, transcriptomics, and proteomics.

Abstract: A magnetic gradiometer can be used in systems or methods for nondestructive testing, even when the material being tested is weakly magnetic. The magnetic gradiometer can include a printed circuit board (PCB) comprising a first end and a second end separated by a base length; an excitation coil encircling at least a portion of the PCB and configured to deliver an alternating current (AC) to generate an excitation magnetic field; and a differential sensor. The differential sensor can include a reference magnetic tunneling junction in magnetic vortex state (vortex MTJ) sensor array at the first end to generate a voltage based on the excitation magnetic field; and a signal vortex MTJ sensor array at the second end to generate another voltage based on the excitation magnetic field due to a composition of the measurement target. The second end of the PCB can be oriented towards the measurement target.

Abstract: A motion planner of a computer system of a primary agent, e.g., an autonomous vehicle, uses reconfigurable collision detection architecture hardware to perform a collision assessment on a planning graph for the primary agent prior to execution of a motion plan. For edges on the planning graph, which represent transitions in states of the primary agent, the system sets a probability of collision with another agent, e.g., a dynamic object, in the environment based at least in part on the collision assessment. Depending on whether the goal of the primary agent is to avoid or collide with a particular dynamic object in the environment, the system then performs an optimization to identify a path in the resulting planning graph with either a relatively low or relatively high potential of a collision with the particular dynamic object. The system then causes the actuator system of the primary agent to implement a motion plan with the applicable identified path based at least in part on the optimization.

Abstract: The invention provides a lipid bilayer mimicking the lipid composition of the placenta. The lipid composition provides an in vitro placenta model using the lipid composition of the placental cell membrane.

Abstract: An electronic device and method for object-centric video representation for action prediction is provided. The electronic device extracts a first sequence of video segments from video content associated with a domain and detects a set of objects in the first sequence of video segments. The electronic device generates a set of embeddings based on the first sequence of video segments and the set of objects. The electronic device applies a PTE model on the set of embeddings. The electronic device predicts, based on the application, a set of object-action pairs associated with a second sequence of video segments of the video content. Each object-action pair includes an action to be executed using an object of the set of objects in a video segment of the second sequence of video segments. The second sequence of video segments succeeds the first sequence of video segments in a timeline of the video content.

Abstract: An electronic device and method for using neural language models for long-term action anticipation from videos is provided. The electronic device receives a video that includes one or more objects performing a physical task and generates, based on the video, a first set of tags that corresponds to a first sequence of actions associated with the physical task. The electronic device generates a first prompt for a neural language model based on the first set of tags and predicts, by application of the neural language model on the first prompt, a second set of tags that corresponds to a second sequence of actions associated with the physical task. The second sequence of actions succeeds the first sequence of actions. The electronic device controls a display device to display first prediction information based on the second set of tags.

Abstract: The present invention is directed to methods for inhibiting growth of bacteria and to nanometer scale surfaces having antibacterial properties.

Abstract: A method includes converting ˜9 nm soft-magnet Al—CoPt into a hard-magnet L10-CoPt, acid etching the hard-magnet L10-CoPt, and annealing the acid etched hard-magnet L10-CoPt to generate a L10-CoPt/Pt catalyst.

Abstract: The present disclosure generally relates to systems and methods for analysis of peptide photodissociation for single-molecule protein sequencing. In one aspect, systems and methods are directed to allowing one to fragment a single protein molecule in aqueous solution so that its composition and sequence of amino acids can be measured by mass spectrometry. This may be useful for single-molecule protein sequencing technology.

Abstract: A method includes receiving data, flagging outliers in the received data, each of the outliers representing extreme data values in the received data that stand out greatly from an overall pattern of data values at a given scale in the received data, storing the flagged outliers in an outlier file, removing the flagged outliers from the received data, curating the flagged data points with respect to various neighborhood kernel sizes, and further curating data points with small perturbations using contextual custom regression techniques as a second order refinement process.

Abstract: Described herein is are compositions and methods for treating an articulating joint disorders, comprising systemically administering to a subject a nucleoside reverse transcriptase inhibitor (NRTI).

Abstract: A method includes providing an ensemble of distributed sensors, delivering radio frequency (RF) power to each sensor by inductive near-field coupling by a magnetic field projected by an epidermal transmit (Tx) coil, in each individual sensor, detecting a sparse binary event in its immediate environment, reporting the detected sparse binary event to an external RF receiver hub asynchronously and with low latency, and minimizing error rates due to statistical data packet collisions in asynchronous telemetry by digitally encoding each sensor according to a particular address scheme where each address is one function from an infinite set of mathematically orthogonal functions, enabling a simultaneous detection from up to ten thousand points without interference at a common receiver.

Abstract: The invention provides a highly versatile system to promote vascularization in ischemic tissue. The system is composed of a fully defined, customizable hydrogel loaded with a potent cocktail of proangiogenic growth factors. The hydrogel's mechanical, degradation, and factor release behavior can be tailored to the specifications of any given target tissue or ischemic disease state. The growth factor cocktail can be optimized for maximal vessel density or size to meet the perfusion specifications required by the tissue. The embodiments of the disclosure concern methods and compositions of the system, with examples of preparation for both injectable and implantable delivery modes.

Abstract: A multi-frequency wireless access device including a first waveguide having a pair of parallel metal plates with open sides and a slot in one of the metal plates, the slot permitting radiation to leak out, the leaked radiation illuminating a range of angles depending on frequency.

Abstract: The invention provides enhancer RNAs (eRNAs) that are expressed specifically in glioma stem cells and whose expression correlates with decreased survival of patients with glioblastomas. The eRNAs are selected, for example, from eTMEM88b, eRTP5, or eNINJ1. The invention also provides an RNA therapy that targets glioma stem cell eRNAs using synthetic oligonucleotides that knock out the eRNA expression. The invention further provides viral vectors that deliver shRNA that inhibit the expression of the eRNA.

Abstract: A patient communication system comprises a hand-held data input subsystem and a display subsystem. The data input subsystem may be configured to sense, and wirelessly convey, information associated with 3-D movement of the data input subsystem, and actuation of a signaling element within the data input subsystem. The display subsystem may receive the information and to present a visual representation of the information in a graphical user interface (GUI). The display subsystem may adaptively interpret the information with respect to range of motion sensitivity and orientation of the data input subsystem, and movement of the data input subsystem with respect to its prior state. The system may map the conveyed information to the GUI, generate and display images on the GUI with which a patient may interact by manipulating the data input subsystem, and capture one or more selections executed by the patient through actuation of the signaling element.

Abstract: An ultra high-resolution near infrared brain imager system includes a modular cap housing closely spaced multiple vertical-cavity surface-emitting laser-single-photon avalanche photodiode array (VCSEL-SPAD) modules, each one of the VCSEL-SPAD modules including a linear VCSEL array and a SPAD detector.