Patents Assigned to Brown University
  • Patent number: 12780805
    Abstract: Provided herein are nitrophenyl-acrylamide compounds, their preparation, and uses thereof.
    Type: Grant
    Filed: April 15, 2022
    Date of Patent: November 3, 2026
    Assignees: Brown University, Rhode Island Hospital
    Inventors: Nikolaos Tapinos, John Zepecki, David Karambizi
  • Patent number: 12772480
    Abstract: III-nitride-based hot electron transistors (HETs) offer significant promise as high-speed, high-power devices, but their performance has been limited to below that of competing technologies. A HET with collector current density>440 kA/cm2 and common-emitter current gain>75 is disclosed. Polarization engineering of the emitter stack was used to allow for high-current collimated electron injection from the emitter with relatively low turn-on voltage. The use of only polarization charge in the undoped 10 nm-thick base allowed for high gain, through minimization of scattering, with atomic layer etching contact fabrication used to lower base access resistance.
    Type: Grant
    Filed: August 2, 2023
    Date of Patent: October 20, 2026
    Assignees: Massachusetts Institute of Technology, Brown University
    Inventors: Jeffrey William Daulton, Alexander Zaslavsky
  • Publication number: 20260312076
    Abstract: The present disclosure relates to high-temperature proton exchange membrane fuel cells (HT-PEMFCs) having phosphoric acid as a proton conductor comprising an anode, a cathode, and a proton exchange membrane (PEM) disposed between the anode and the cathode; and at least one catalyst layer disposed on the proton exchange membrane (PEM). The at least one catalyst layer comprises multi-metallic Cu—Pt—Au alloy catalyst nanoparticles comprising from about 5 to about 30 at % gold (Au), from about 5 to about 50 at % copper (Cu), and from about 30 to about 90 at % platinum (Pt).
    Type: Application
    Filed: April 4, 2025
    Publication date: October 8, 2026
    Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., Toyota Jidosha Kabushiki Kaisha, Brown University
    Inventors: Honghong Lin, Shouheng Sun, Yuliang Chen, Siwen Wang, Chen Ling, Gaohua Zhu
  • Patent number: 12746363
    Abstract: Systems tune, control, or remediate the intrinsic Circadian clock. A light controller sets spectral distribution, intensity of a bioactive spectral band to shift or entrain circadian response to enhance performance and/or synchronize with local or expected conditions. The systems enhance performance under conditions that might be changing, disrupted, or otherwise present an irregular phase or unnatural change in the subject's circadian status, for example, due to geographically discontinuous activity or spectrally deficient workplace illumination, or due to divergent individual sleep/wake behaviors of subjects in a structured group activity. An illumination recipe that compensates for the deficiency of lighting or of participant sleep or behavior patterns, or age- or disease-related changes, to evoke, shift, or align circadian response and improve behaviors such as classroom alertness, relaxation, excitability, attention, or focus.
    Type: Grant
    Filed: January 13, 2023
    Date of Patent: September 29, 2026
    Assignees: BROWN UNIVERSITY, EMMA PENDLETON BRADLEY HOSPITAL
    Inventors: Eliza Van Reen, Gustavo E. Fernandes, Jingming Xu, Mary A. Carskadon
  • Patent number: 12743884
    Abstract: A method for forming versatile action models for video understanding may gather data from a video. The data may comprise textual video representations and other task specific language inputs. The method may use a pre-trained large language model (LLM) next token prediction for action anticipation based on the data from the video.
    Type: Grant
    Filed: March 22, 2024
    Date of Patent: September 22, 2026
    Assignees: Honda Motor Co., Ltd., Brown University
    Inventors: Shijie Wang, Qi Zhao, Minh Quan Do, Nakul Agarwal, Kwonjoon Lee, Chen Sun
  • Patent number: 12738044
    Abstract: An electronic device and method for using neural language models for long-term action anticipation from videos is provided. The electronic device receives a video that includes one or more objects performing a physical task and generates, based on the video, a first set of tags that corresponds to a first sequence of actions associated with the physical task. The electronic device generates a first prompt for a neural language model based on the first set of tags and predicts, by application of the neural language model on the first prompt, a second set of tags that corresponds to a second sequence of actions associated with the physical task. The second sequence of actions succeeds the first sequence of actions. The electronic device controls a display device to display first prediction information based on the second set of tags.
    Type: Grant
    Filed: December 14, 2023
    Date of Patent: September 15, 2026
    Assignees: Honda Motor Co., Ltd., Brown University
    Inventors: Ce Zhang, Changcheng Fu, Shijie Wang, Qi Zhao, Chen Sun, Nakul Agarwal, Kwonjoon Lee
  • Patent number: 12732351
    Abstract: Methods and systems for performing secure quantum key distribution (QKD) over noisy channels are disclosed. A first computing device generates a challenge set using a secret seed, applies the challenges to its CRP, and receives an ordered set n responses, where n has the same number of bits as the key. It then sends only those responses in positions that correspond to 1s in the key to the second computing device. Those responses are sent under a QKD protocol such as BB84. The second computing device generates the same challenges and recovers the same responses with a mirror CRP mechanism. It also receives the subset of responses from the first computing device. Generated responses that match received responses correspond to 1s in the key, and 0s are assigned to all other positions.
    Type: Grant
    Filed: October 6, 2024
    Date of Patent: September 8, 2026
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY, BROWN UNIVERSITY
    Inventors: Bertrand F. Cambou, Jeffrey Hoffstein, Dina Ghanaimiandoab, Brit Riggs, Ian Burke, Julie B. Heynssens
  • Patent number: 12714991
    Abstract: This invention relates to an aqueous composition comprising, (a) an ion-exchange resin (IXR) comprising microporous beads having a particle size ranging from about 200 um to about 1000 um; (b) a water soluble surfactant having a molecular weight ranging from about 7,500 to about 15,000 Da; and (c) a buffer component; wherein the pH of the aqueous composition ranges from about 5 to about 8, and a process for isolating chemical contaminants using the aqueous composition.
    Type: Grant
    Filed: April 6, 2021
    Date of Patent: August 25, 2026
    Assignee: Brown University
    Inventors: Kurt Pennell, Chen Liu
  • Patent number: 12714386
    Abstract: Audio signals, collected with equipment commonly available to individuals (e.g., a mobile device), can be used to analyze a patient's breathing. An audio signal associated with the patient's breathing for a time period can be detected with the mobile device and used to approximate the patient's respiratory flow for the time period. For example, the audio signal can be analyzed by determining a representation of an audio frequency of the audio signal, splitting the audio frequency of the audio signal into distinct time steps, determining points comprising a weighted mean frequency at each time step, applying a frequency-to-flow rate linear transformation at each time step to approximate the respiratory flow versus time, and plotting a graphical representation of the respiratory flow versus time. The respiratory flow for the time period can be tagged with a factor related to the patient and saved in a database for future analysis.
    Type: Grant
    Filed: January 20, 2023
    Date of Patent: August 25, 2026
    Assignee: BROWN UNIVERSITY
    Inventors: Christopher M. Dodson, Rashid Zia, Christopher Rose
  • Patent number: 12713686
    Abstract: Described herein are devices that relate to sensor, data, and interactive interfaces between micro or nano electronics and biofilms, which optionally include an added extracellular matrix. Biofilms in the interfaces can include adherent cells or microorganisms, for example, fungi, bacteria, and the biofilms may include viruses. Computational capability, circuitry, and methods are provided for interactive measurements/processing between the electronics and biofilms.
    Type: Grant
    Filed: April 13, 2023
    Date of Patent: August 18, 2026
    Assignees: Brown University, Trustees of Boston University
    Inventors: Jacob K. Rosenstein, Kangping Hu, Joseph W. Larkin
  • Patent number: 12702478
    Abstract: A thermal accelerant can be used as a drug delivery vehicle to deliver one or more drugs to a target site. For example, in some embodiments, a carrier such as albumin or human serum albumin (HSA) can be impregnated with, or covalently attached to, an anti-tumor agent and delivered to a location proximate to a tumor of a patient. The carrier can be exposed to an energy source that structurally alters the carrier and releases the agent therefrom. The sources of energy can include one or more of microwave, radiofrequency, electrical pulse (electroporation) or sonar (HIFU or histotripsy). In some embodiments, the anti-tumor agent can be delayed release such that a portion of the agent is released from the carrier over an extended period of time. The incorporation of an anti-tumor agent in a thermal accelerant provides a thermal ablation-drug delivery combination therapy (e.g., a thermally-activated combination therapy).
    Type: Grant
    Filed: May 23, 2022
    Date of Patent: August 11, 2026
    Assignees: Rhode Island Hospital, Brown University
    Inventors: William Keun Chan Park, Damian E. Dupuy
  • Patent number: 12699079
    Abstract: A system includes an array of chemical, pressure, and temperature sensors, and a temporal airflow modulator configured to provide sniffed vapors in a temporally-modulated sequence through a plurality of different air paths across multiple sensor locations.
    Type: Grant
    Filed: October 20, 2023
    Date of Patent: August 4, 2026
    Assignee: Brown University
    Inventors: Jacob K. Rosenstein, Christopher Rose
  • Patent number: 12691097
    Abstract: Described are compositions and methods for treating polyoma viruses such as JCPyV.
    Type: Grant
    Filed: July 20, 2023
    Date of Patent: July 28, 2026
    Assignee: BROWN UNIVERSITY
    Inventors: Walter J. Atwood, Jacob S. Kaiserman
  • Patent number: 12691183
    Abstract: A method of making and using nanoparticles that target bacterial biofilm are provided.
    Type: Grant
    Filed: February 28, 2023
    Date of Patent: July 28, 2026
    Assignee: Brown University
    Inventors: Anita Shukla, Yingying Wang
  • Patent number: 12662434
    Abstract: Aspects of the invention are associated with the discovery of processes for converting methane (CH4), present in a methane-containing feed that may be obtained from a variety of sources such as natural gas, to higher hydrocarbons (e.g., C2+ hydrocarbons) such as C2 hydrocarbons (e.g., ethane, ethylene, and acetylene) and aromatic hydrocarbons (e.g., benzene, one or more C1- or C2-substituted benzenes, and/or one or more fused ring aromatic hydrocarbons). Representative processes involve direct, non-oxidative methane conversion (NOMC), such that the need for an oxidant to form CO as an intermediate may advantageously be avoided. This reduces overall complexity and the tendency to promote unwanted side reactions that reduce hydrocarbon yields and lead to CO2 production.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: June 23, 2026
    Assignees: Brown University, SK Innovation Co., Ltd.
    Inventors: Andrew Peterson, Franklin Goldsmith, Jongyoon Bae, Dongmin Yun, Juhwan Im, Dokyoung Kim
  • Patent number: 12663435
    Abstract: A method for scanning near-field optical microscopy comprises illuminating an apertureless atomic force microscopy (AFM) probe with electromagnetic energy having a frequency in the Terahertz range, where the sample under observation includes a dielectric layer having a thickness greater than the radius of the tip of the AFM probe. A system for scanning near-field optical microscopy comprises a collimated light source for emitting collimated light, a photoconductive antenna for converting collimated light into electromagnetic energy having a frequency in the Terahertz range, an AFM probe, a sample comprising a dielectric layer, the dielectric layer having a thickness greater than the radius of the probe tip; and a detector configured to detect energy that has interacted with the sample.
    Type: Grant
    Filed: January 4, 2024
    Date of Patent: June 23, 2026
    Assignee: Brown University
    Inventors: Daniel Mittleman, Angela Pizzuto
  • Patent number: 12651384
    Abstract: A method of representing a space of handwriting stroke styles includes representing writer-, character- and writer-character-level style variations within a recurrent neural network (RNN) model using decoupled style descriptors (DSD) that model the style variations such that character style variations depend on writer style.
    Type: Grant
    Filed: August 23, 2021
    Date of Patent: June 9, 2026
    Assignee: Brown University
    Inventors: Atsunobu Kotani, Stefanie Tellex, James Tompkin
  • Patent number: 12649792
    Abstract: Described herein are bispecific antibodies simultaneously targeting both CHI3L1 and the immune checkpoint molecule PD-1. These antibodies manifest enhanced synergistic cytotoxic effects compared to the effects of individual CHI3L1 and PD-1 antibodies, alone or in combination. Methods of treating a cancer by administering the bispecific antibodies described herein are also provided.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: June 9, 2026
    Assignee: Brown University
    Inventors: Jack A. Elias, Chun Geun Lee, Suchitra Kamle
  • Patent number: 12644859
    Abstract: A complementary metal-oxide-semiconductor sensor array includes an active sensing area of pixels arranged in an array with a pitch, each pixel including an exposed surface electrode alongside switches and logic gates, and non-overlapping clocks configured to rapidly charge and discharge the exposed surface electrode, wherein control signals steer a switched output current between shared column outputs.
    Type: Grant
    Filed: October 8, 2021
    Date of Patent: June 2, 2026
    Assignee: Brown University
    Inventors: Jacob K. Rosenstein, Kangping Hu
  • Patent number: 12627484
    Abstract: Methods for the encoding an encryption key for secure storage are disclosed. The methods rely on the use of unclonable, one-way functions, such as images of biological objects that may be measured according to challenges to result in responses. A biometric print of a biological object is measured with a set of n challenges resulting in n responses. The responses are an ordered sequence, with each response having a fixed position in the sequence. A key is generated of bit length n. A subset of m responses in the full set of n responses is selected, where the selected responses correspond to positions of is in the key. The response subset is stored. The key is then used, and deleted. A party wishing to re-generate the key generates the same set of challenges, measures the same biological object with the challenges a second time, and generates a second set of n responses.
    Type: Grant
    Filed: April 17, 2024
    Date of Patent: May 12, 2026
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY, BROWN UNIVERSITY
    Inventors: Bertrand F Cambou, Jeffrey Hoffstein