Patents Assigned to Brown University
  • Patent number: 11904000
    Abstract: The present invention provides compositions and methods to enhance cutaneous wound healing in subjects afflicted with, or at risk for, a pulmonary infection and/or a pulmonary injury. More specifically, the embodiments of the present invention relate to using fibrin carrier as a vehicle to topically deliver one or more chemokine onto a cutaneous wound so as to accelerate wound healing.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: February 20, 2024
    Assignee: BROWN UNIVERSITY
    Inventors: Amanda M. Jamieson, Meredith Crane, Yun Xu
  • Patent number: 11897140
    Abstract: A system and method of operating a mobile robot to perform tasks includes representing a task in an Object-Oriented Partially Observable Markov Decision Process model having at least one belief pertaining to a state and at least one observation space within an environment, wherein the state is represented in terms of classes and objects and each object has at least one attribute and a semantic label. The method further includes receiving a language command identifying a target object and a location corresponding to the target object, updating the belief associated with the target object based on the language command, driving the mobile robot to the observation space identified in the updated belief, searching the updated observation space for each instance of the target object, and providing notification upon completing the task. In an embodiment, the task is a multi-object search task.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: February 13, 2024
    Assignee: BROWN UNIVERSITY
    Inventors: Arthur Richard Wandzel, Stefanie Tellex
  • Patent number: 11881579
    Abstract: An energy storage composition can be used as a new Na-ion battery cathode material. The energy storage composition with an alluaudite phase of AxTy(PO4)z, NaxTy(PO4)z, Na1.702Fe3(PO4)3 and Na0.872Fe3(PO4)3, is described including the hydrothermal synthesis, crystal structure, and electrochemical properties. After ball milling and carbon coating, the compositions described herein demonstrate a reversible capacity, such as about 140.7 mAh/g. In addition these compositions exhibit good cycling performance (93% of the initial capacity is retained after 50 cycles) and excellent rate capability. These alluaudite compounds represent a new cathode material for large-scale battery applications that are earth-abundant and sustainable.
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: January 23, 2024
    Assignee: Brown University
    Inventors: G. Tayhas R. Palmore, Dan Liu
  • Patent number: 11879020
    Abstract: The present invention provides to compositions and methods useful in the treatment of neurological disorders including, but not limited to, Angelman syndrome, depression, traumatic brain injury, stroke, and Alzheimer's disease. CN2097, a rationally designed cyclic peptidomimetic drug that has been demonstrated to have effectiveness in preclinical models for the treatment of neurological disorders, is rapidly cleared and has a short half-life. The present invention provides a stable analog of CN2097.
    Type: Grant
    Filed: March 9, 2022
    Date of Patent: January 23, 2024
    Assignee: Brown University
    Inventor: John Marshall
  • Patent number: 11847841
    Abstract: A method includes, as a robot encounters an object, creating a probabilistic object model to identify, localize, and manipulate the object, the probabilistic object model using light fields to enable efficient inference for object detection and localization while incorporating information from every pixel observed from across multiple camera locations.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: December 19, 2023
    Assignee: Brown University
    Inventors: Stefanie Tellex, John Oberlin
  • Patent number: 11828742
    Abstract: A system includes an array of chemical, pressure, and temperature sensors, and a temporal airflow modulator configured to provide sniffed vapors in a temporally-modulated sequence through a plurality of different air paths across multiple sensor locations.
    Type: Grant
    Filed: February 17, 2023
    Date of Patent: November 28, 2023
    Assignee: BROWN UNIVERSITY
    Inventors: Jacob K. Rosenstein, Christopher Rose
  • Patent number: 11793814
    Abstract: Disclosed is a method for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one reverse transcriptase inhibitor (RTI).
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: October 24, 2023
    Assignee: Brown University
    Inventors: John M. Sedivy, Marco De Cecco
  • Patent number: 11787821
    Abstract: The present invention discloses new catalyst systems based on trivalent metal complexes of Formula I, which can facilitate the stereospecific ring-opening polymerization of (rac)-?-Butyrolactone (rac-BBL). Also provided is a process for the stereospecific synthesis of aliphatic polyesters using the catalysts of Formula I, including alcohols and polyols as chain-transfer agents to facilitate immortal ring-opening polymerization.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: October 17, 2023
    Assignee: Brown University
    Inventors: Jerome R. Robinson, Xiang Dong
  • Patent number: 11790280
    Abstract: The invention provides methods for computing with chemicals by encoding digital data into a plurality of chemicals to obtain a dataset; translating the dataset into a chemical form; reading the data set; querying the dataset by performing an operation to obtain a perceptron; and analyzing the perceptron for identifying chemical structure and/or concentration of at least one of the chemicals, thereby developing a chemical computational language. The invention demonstrates a workflow for representing abstract data in synthetic metabolomes. Also presented are several demonstrations of kilobyte-scale image data sets stored in synthetic metabolomes, recovered at >99% accuracy.
    Type: Grant
    Filed: July 19, 2021
    Date of Patent: October 17, 2023
    Assignee: BROWN UNIVERSITY
    Inventors: Brenda Rubenstein, Jacob Karl Rosenstein, Christopher Arcadia, Shui Ling Chen, Amanda Doris Dombroski, Joseph D. Geiser, Eamonn Kennedy, Eunsuk Kim, Kady M. Oakley, Sherief Reda, Christopher Rose, Jason Kelby Sello, Hokchhay Tann, Peter Weber
  • Patent number: 11772061
    Abstract: Compositions and methods are provided for making hyper compliant polymer particles by inverse emulsification and having a predetermined mechanical compliance and a predetermined size with a monodisperse diameter. Compositions and methods are provided for use of hyper compliant polymer particles in drug delivery, assay, particle image velocimetry, ceramics, cosmetics, deconvolution, electronic paper, insulation, personal care, standards, retroreflective paint and paint applications, thickening agents, regenerative medicine, device calibration, micro-carriers and force indicators.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: October 3, 2023
    Assignee: Brown University
    Inventors: Eric M. Darling, Nicholas R. Labriola, Edith Mathiowitz
  • Publication number: 20230298878
    Abstract: The present disclosure generally relates in certain embodiments to the creation of ionized molecules, e.g., for detection in a mass spectrometer, or for other uses such as lithography, sputtering machines, propulsion etc. Some embodiments include an ion source comprising a capillary tip that may allow for direct ion evaporation of samples with an applied electric field. In some cases, the tip may have an opening with a cross-section less than 100 nm. In addition, certain aspects are directed to using a capillary tip that allow for detection of samples (e.g. amino acids), and in some cases allows for sequencing. For instance, some embodiments are directed to allowing single ions and ionic clusters to be evaporated at a high rate directly from aqueous samples in a mass spectrometer. Other aspects are directed to methods for making or using such ionized molecules, methods for making or using devices to create such ionized molecules, or the like.
    Type: Application
    Filed: April 23, 2021
    Publication date: September 21, 2023
    Applicant: Brown University
    Inventors: Derek M. Stein, Mathilde Lepoitevin, Nicholas Drachman
  • Patent number: 11747029
    Abstract: A system passively cools, regulates humidity and/or rectifies diffusive transport of water vapor in an interior area within a structure. The system includes a membrane assembly covering a portion of the structure, wherein the membrane has an interior side facing the interior area and an exterior side. The membrane assembly defines a plurality of pores. When cooling, a supply of fluid is provided to the membrane assembly so that capillary action of the pores redistributes the fluid to create evaporation and, in turn, the desired heat flow. The membrane assembly can include an architectural membrane coated with a porous matrix coating to form the pores. A pump can provide the fluid to the interior side of the membrane assembly. Preferably, the architectural membrane is woven PTFE-coated fiberglass and the porous matrix coating is titanium dioxide, zeolites and/or silica gel.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: September 5, 2023
    Assignee: Brown University
    Inventor: Derek Martin Stein
  • Patent number: 11717528
    Abstract: Described herein are methods of treating fibrosis and fibrotic diseases with certain aminoglycosides, e.g., kasugamycin derivatives thereof.
    Type: Grant
    Filed: January 7, 2022
    Date of Patent: August 8, 2023
    Assignee: BROWN UNIVERSITY
    Inventors: Jack A. Elias, Chun Geun Lee, Chang-Min Lee
  • Patent number: 11708641
    Abstract: An electrochemical method includes performing anodic halogenation of Cu foils, performing subsequent oxide-formation in a KHCO3 electrolyte, and performing an electroreduction in neutral KHCO3 to generate a copper catalyst.
    Type: Grant
    Filed: August 3, 2021
    Date of Patent: July 25, 2023
    Assignee: Brown University
    Inventors: G. Tayhas R. Palmore, Taehee Kim
  • Patent number: 11705639
    Abstract: An isolator based on a waveguide-based artificial dielectric medium is scalable to a range of desired terahertz frequencies, has non-reciprocal transmission and provides low insertion loss and high isolation at various tunable terahertz frequencies, far exceeding the performance of other terahertz isolators, and rivaling that of commercial optical isolators based on the Faraday effect. This approach offers a promising new route for polarization control of free-space terahertz beams in various instrumentation applications. Artificial dielectrics are man-made media that mimic properties of naturally occurring dielectric media, or even manifest properties that cannot generally occur in nature. A simple and effective strategy implements a polarizing-beam-splitter and a quarter wave plate to form a highly effective isolator. Performance of the device is believed to exceed that of any other experimentally demonstrated method for isolation of back-reflections for terahertz beams.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: July 18, 2023
    Assignee: Brown University
    Inventors: Rajind Mendis, Masaya Nagai, Daniel M. Mittleman
  • Patent number: 11684781
    Abstract: A system includes intracranial electrodes embedded into a cranium, a deep brain stimulation system embedded into the cranium, a brain implantable device embedded into the cranium, and a pulse generator, the deep brain stimulation system and the brain implantable device linked to the intracranial electrodes and to the pulse generator.
    Type: Grant
    Filed: September 9, 2021
    Date of Patent: June 27, 2023
    Assignees: Brown University, Rhode Island Hospital
    Inventors: Wael Farouk Asaad, Shane Lee, Peter Maxwell Lauro
  • Patent number: 11674142
    Abstract: Described herein are methods and compositions for the prevention or treatment of obesity and obesity-related disorders. The methods and compositions are based, inter alia, on the observations that OPN3 is the most highly expressed opsin in the hypothalamus, a key site for the regulation of energy homeostasis. Indeed, OPN3 expression was highest in regions associated with energy homeostasis, namely the paraventricular nucleus and arcuate nucleus of the hypothalamus. OPN3 was shown to interact and form a complex with MC3R and MC4R, and to modulate MC3R- and MC4R-mediated signaling in the hypothalamus. Accordingly, the methods involve the regulation of melanocortin receptors by downregulating opsin 3 (OPN3) protein expression, OPN3 gene expression, and/or OPN3 activation in the hypothalamus.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: June 13, 2023
    Assignee: Brown University
    Inventor: Elena Oancea
  • Patent number: 11667726
    Abstract: It is demonstrated herein that inhibitors of immune checkpoints and CHI3L1 are synergistic. Accordingly, described herein are methods and compositions relating to combinatorial therapies for cancer, e.g., comprising an inhibitor of CHI3L1; and an inhibitor of an immune checkpoint protein. In some embodiments, the CHI3L1 inhibitor can be an antibody or antibody reagent as described herein.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: June 6, 2023
    Assignee: Brown University
    Inventors: Jack A. Elias, Chun Geun Lee, Chuan Hua He, Bing Ma, Suchitra Kamle, Chang-Min Lee
  • Patent number: 11667725
    Abstract: Described herein are methods and compositions relating to anti-Chi3L1 antibodies, antibody reagents, and antigen-binding fragments thereof which display superior properties, e.g., high sensitivity, high specificity, high binding affinity, neutralization activity ex vivo and in vivo (e.g., blocks Chi3L1-induced MAPK and AKT signaling). Methods of treatment, e.g., of treating cancer, obesity, and/or asthma by administering the compounds described herein are also provided.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: June 6, 2023
    Assignee: Brown University
    Inventors: Jack A. Elias, Chun Geun Lee, Chuan Hua He, Bing Ma, Suchitra Kamle, Chang-Min Lee
  • Patent number: 11636346
    Abstract: A method includes providing a computer system, the computer system including at least a processor and a memory, the memory including at least an operating system, executing a process in the memory, the process including providing a recurrent circuit model, and converting the recurrent circuit model into a recurrent neural network that can be fit with gradient descent.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: April 25, 2023
    Assignee: Brown University
    Inventors: Drew Linsley, Junkyung Kim, Thomas Serre, Alekh Karkada Ashok, Lakshmi Narasimhan Govindarajan, Rex Gerry Liu