Abstract: The invention provides novel antibacterial diamide compounds, pharmaceutical compositions comprising the compounds and methods for treating or preventing an infection in a subject using the compounds.

Abstract: It is demonstrated herein that inhibitors of immune checkpoints and CHI3L1 are synergistic. Accordingly, described herein are methods and compositions relating to combinatorial therapies for cancer, e.g., comprising an inhibitor of CHI3L1; and an inhibitor of an immune checkpoint protein. In some embodiments, the CHI3L1 inhibitor can be an antibody or antibody reagent as described herein.

Abstract: A robot includes a gripping member configured to move and pick up the object, a camera affixed to the gripping member such that movement of the gripping member causes movement of the camera, the camera configured to measure and store data related to intensity of light and direction of light rays within the environment, an image processing module configured to process the data to generate a probabilistic model defining a location of the object within the environment, and an operation module configured to move the gripping member to the location and pick up the object.

Abstract: Described herein are methods and compositions relating to anti-Chi3L1 antibodies, antibody reagents, and antigen-binding fragments thereof which display superior properties, e.g., high sensitivity, high specificity, high binding affinity, neutralization activity ex vivo and in vivo (e.g., blocks Chi3L1-induced MAPK and AKT signaling). Methods of treatment, e.g., of treating cancer, obesity, and/or asthma by administering the compounds described herein are also provided.

Abstract: Compositions for stabilizing and delivering proteins and/or other bioactive agents are disclosed. The bioactive agents are embedded or encapsulated in a crystalline matrix. Typically the bioactive agents are in the form of micro- or nanoparticles. The crystalline matrix confers enhanced stability to the agents embedded therein relative to other microparticulate or nanoparticulate bioactive agents. The carriers are especially useful for stabilizing bioactive macromolecules, such as proteins.

Abstract: Methods' and compositions for making coated substrates using a co-solvent method are disclosed. Embodiments of the present disclosure relate in general to methods and compositions for making thin films of organometallic halides. According to one aspect, organometallic halides are deposited from solution on the surface of a substrate at temperatures between about 10 C and 50 C. According to one aspect, organometallic halides are deposited from solution on the surface of a substrate at room temperature.

Abstract: A system passively cools, regulates humidity and/or rectifies diffusive transport of water vapor in an interior area within a structure. The system includes a membrane assembly covering a portion of the structure, wherein the membrane has an interior side facing the interior area and an exterior side. The membrane assembly defines a plurality of pores. When cooling, a supply of fluid is provided to the membrane assembly so that capillary action of the pores redistributes the fluid to create evaporation and, in turn, the desired heat flow. The membrane assembly can include an architectural membrane coated with a porous matrix coating to form the pores. A pump can provide the fluid to the interior side of the membrane assembly. Preferably, the architectural membrane is woven PTFE-coated fiberglass and the porous matrix coating is titanium dioxide, zeolites and/or silica gel.

Abstract: An energy storage composition can be used as a new Na-ion battery cathode material. The energy storage composition with an alluaudite phase of AxTy(PO4)z, NaxTy(PO4)z, Na1.702Fe3(PO4)3 and Na0.872Fe3(PO4)3, is described including the hydrothermal synthesis, crystal structure, and electrochemical properties. After ball milling and carbon coating, the compositions described herein demonstrate a reversible capacity, such as about 140.7 mAh/g. In addition these compositions exhibit good cycling performance (93% of the initial capacity is retained after 50 cycles) and excellent rate capability. These alluaudite compounds represent a new cathode material for large-scale battery applications that are earth-abundant and sustainable.

Abstract: The invention relates to methods and kits for labeling and manipulating a cellular circuit. The methods includes transfecting a first-order cell in the cellular circuit with a nucleic acid molecule encoding a tethered ligand, and a second-order cell in the cellular circuit with a nucleic acid molecule encoding a receptor and an effector fusion polypeptide, a nucleic acid molecule encoding a receptor interactor and protease fusion polypeptide, and a nucleic acid molecule encoding a reporter/modifier gene.

Abstract: A system includes a robot having a module that includes a function for mapping natural language commands of varying complexities to reward functions at different levels of abstraction within a hierarchical planning framework, the function including using a deep neural network language model that learns how to map the natural language commands to reward functions at an appropriate level of the hierarchical planning framework.

Abstract: The present invention provides, in certain aspects, novel syringolin analogues, In certain embodiments, the compounds of the invention are proteasome inhibitors, In other embodiments, the compounds treat or prevent a cancer such as, but not limited to, leukemia in a subject.

Abstract: A method obtains the shape of a target by projecting and recording images of dual frequency fringe patterns. Locations in each projector image plane are encoded into the patterns and projected onto die target while images are recorded. The resulting images show the patterns superimposed onto the target. The images are decoded to recover relative phase values for the patterns primary and dual frequencies. The relative phases are unwrapped into absolute phases and converted back to projector image plane locations. The relation between camera pixels and decoded projector locations is saved as a correspondence image representing the measured shape of the target. Correspondence images with a geometric triangulation method create a 3D model of the target. Dual frequency hinge patterns have a low frequency embedded into a high frequency sinusoidal, both frequencies are recovered in closed form by the decoding method, thus, enabling direct phase unwrapping.

Abstract: Systems, methods, and computer-readable storage devices storing instructions for homomorphic encryption via finite ring isomorphisms are provided. An example method includes selecting a polynomial f(x) of exact degree n with small coefficients in a ring Fq[x] and selecting a polynomial h(y) of exact degree n in a ring Fq[y]. The method includes constructing an isomorphism from the ring Fq[x]/(f(x)) to the ring Fq[y]/(h(y)) and constructing an inverse isomorphism from the ring Fq[y]/(h(y)) to the ring Fq[x]/(f(x)). The method includes encrypting a message using said isomorphism from the ring Fq[x]/(f(x)) to the ring Fq[y]/(h(y)) and transmitting the encrypted message to a remote computer. The method also includes receiving one or more encrypted response messages from the remote computer based at least in part on the transmitted message and decrypting the one or more encrypted response messages.

Abstract: Methods, compositions, devices and kits having a novel chromatographic material are provided herein for separating and identifying organic molecules and compounds, for example molecules and compounds containing electron rich functional groups such as carbon-carbon double bonds. The methods, compositions, and kits include a metal-thiolate chromatographic medium (MTCM) with a sulfur-containing functional group or a metal-selenolate chromatographic medium (MSCM) comprising a selenium-containing functional group covalently attached to a support medium, such that the sulfur-containing functional group or selenium-containing functional group is bound to at least one metal atom. The MTCM and/or MSCM has affinity and specificity to compounds having one or more carbon-carbon double bonds, and performs a highly efficient and rapid separation of samples yielding non-overlapping peaks of purified materials compared to traditional media.

Abstract: A system and method of estimating the body shape of an individual from input data such as images or range maps. The body may appear in one or more poses captured at different times and a consistent body shape is computed for all poses. The body may appearin minimal tight-fitting clothing or in normal clothing wherein the described method produces an estimate of the body shape under the clothing. Clothed or bare regions of the body are detected via image classification and the fitting method is adapted to treat each region differently. Body shapes are represented parametrically and are matched to other bodies based on shape similarity and other features. Standard measurements are extracted using parametric or non-parametric functions of body shape. The system components support many applications in body scanning, advertising, social networking, collaborative filtering and Internet clothing shopping.

Abstract: A system generates a clothing deformation model which models one or more of a pose-dependent clothing shape variation which is induced by underlying body pose parameters, a pose-independent clothing shape variation which is induced by clothing size and underlying body shape parameters and a clothing shape variation including a combination of the pose-dependent clothing shape variation and/or the pose-independent clothing shape variation. The system generates, for an input human body, a custom-shaped garment associated with a clothing type by mapping, via the clothing deformation model, body shape parameters of the input human body to clothing shape parameters of the clothing type and dresses the input human body with the custom-shaped garment.

Abstract: The present invention is directed to methods for inhibiting growth of bacteria and to nanometer scale surfaces having antibacterial properties.

Abstract: A musical instrument for electronically producing music from audio segments. The musical instrument comprises: an apparatus having a first surface; a plurality of selectable elements disposed in a substantially circular geometry on the first surface; and at least one memory storing the plurality of audio segments, each of the plurality of audio segments being associated with a respective selectable element in the plurality of selectable elements, wherein, in response to detecting selection of a subset of the plurality of selectable elements, the system is configured to generate music using audio segments in the plurality of audio segments that are associated with the selected subset of the plurality of selectable elements.

Abstract: Several methods for prediction and detection of neurological events are proposed based on spatiotemporal patterns in recorded neural signals. The methods are illustrated with examples from neural data recorded from human and non-human primates.

Abstract: The invention is a computer implemented method, device, system, or article for reconstructing a surface of an object. In particular, the invention comprises estimating a non-convex hull signed distance function parameters from a data set of an object and evaluating the non-convex hull signed distance function on vertices of a volumetric mesh. The invention further comprises approximating the zero level set of the non-convex hull signed distance function by a polygonal mesh using an isosurface algorithm to provide surface reconstruction of an object.