Publication number: 20160221977
Abstract: An antibacterial therapeutic wherein R1 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, alkoxyalkyl, substituted alkoxyalkyl, NH2, NHR, NR2, mono- or polyhydroxy-substituted alkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl and the like; and wherein, R2 is contemplated as a single substitution of a hydrogen at any position on the benzene ring where the substituted moiety is selected from the group consisting of alkyl, substituted alkyl, alkynyl, substituted alkyl, vinyl, nitro, halo (e.g., includes bromine, chlorine, fluorine and iodine), cyano, aryl, hetero aryl, alkoxy and Cn is carbon and n is a number of from 1 to 5. The invention further encompasses a method of making Structure A, a pharmaceutical preparation of Structure A and method of therapeutically treating a subject by administering Structure A, with particular reference to treating an infection.
Type:
Application
Filed:
August 26, 2014
Publication date:
August 4, 2016
Applicant:
Brown University
Inventors:
Jason K. Sello, Corey L. Compton