Patents Assigned to CNRS
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Patent number: 12385014Abstract: The invention relates to a method for producing a recombinant baculovirus comprising n exogenous genes in an insect cell, by means of homologous recombination of a replication-deficient baculovirus genome and n transfer vectors, each comprising one of the n exogenous genes, n being an integer at least equal to 2.Type: GrantFiled: August 4, 2017Date of Patent: August 12, 2025Assignees: CENTRE NATIONAL DEL LA RECHERCH SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMQIUEInventors: Martine Cerutti, Sylvie Juliant, Sylvie Thery
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Publication number: 20250251345Abstract: A method for fluorescence microscopic imaging of an object may be performed by means of a fluorescence microscopic imaging system with light sheet illumination. The method includes generating a line of light and scanning the line of light to generate a light sheet and further includes performing a wavefront analysis on an analysis field of the object. The method further includes applying spatial filtering of the fluorescence light, where the spatial filtering includes scanning a filtering element with respect to a fluorescence image of the line of light formed in a filtering plane of the filtering element. The scanning of the filtering element may be synchronized with the scanning of the line of light such as to obtain a superposition, at each instant, of the filtering element and the fluorescence image of the line of light.Type: ApplicationFiled: March 31, 2023Publication date: August 7, 2025Applicants: IMAGINE OPTIC, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMEIE INDUSTRIELLES DE LA VILLE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), SORBONNE UNIVERSITE, Paris Sciences et LettresInventors: Fabrice Harms, Xavier Levecq, Alexandra Fragaola
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Patent number: 12371402Abstract: The invention relates to compounds of formula (I) as follows: (I) wherein X1 and X2, identical or different, are NR5 or a sulfur atom, Y is a group (C1-C10)alkanediyl, Ar1 and Ar2, identical or different, are an aryl group optionally substituted by one or several groups selected from a halogen atom, a (C1-C6) alkyl, —OR1, —NR1R2 and —COOR3? with R1 and R2, independently of each other, are a hydrogen atom, a (C-1-C6) alkyl group or a —COR3 group, R3 and R4? independently of each other, are a hydrogen atom or a (C1-C6) alkyl group, and R5 is a hydrogen atom or a (C1-C6)alkyl group, or a pharmaceutically acceptable salt and/or solvate thereof, in particular for use in cancer treatment.Type: GrantFiled: November 28, 2019Date of Patent: July 29, 2025Assignees: CENTRE LEON BERARD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON 1, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE GRENOBLE ALPES, UNIVERSITE DE CAEN NORMANDIEInventors: Marc Billaud, Renaud Prudent, Martine Cordier-Bussat, Eric Fontaine, Patrick Dallemagne, Peggy Suzanne, Sylvain Rault
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Patent number: 12371471Abstract: The present invention relates to an engineered immune cell defective for Suv39h1. Preferably, said engineered immune cell further comprises a genetically engineered antigen receptor that specifically hinds a target antigen. The present invention also relates to a method for obtaining a genetically engineered immune cell comprising a step consisting in inhibiting the expression and/or activity of Suv39h1 in the immune cell; and further optionally comprising a step consisting in introducing in the said immune cell a genetically engineered antigen receptor that specifically binds to a target antigen. The invention also encompasses said engineered immune cell for their use in adoptive therapy, notably for the treatment of cancer.Type: GrantFiled: September 24, 2024Date of Patent: July 29, 2025Assignees: INSTITUT CURIE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Sebastian Amigorena, Eliane Piaggio, Christel Goudot, Luigia Pace, Genevieve Almouzni, Leticia Niborski
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Patent number: 12358316Abstract: The present application relates to an anti-counterfeiting object including a face with an optical identification marking which is readable by the eye and/or by a machine, and an authentication volume, the authentication volume extending from the face in the thickness (z) direction so as to be accessible from the face in order to be read by X-ray diffractometry (XRD). The authentication volume is a composite of a first material, referred to as the authentication material, and at least one second material, the authentication volume constituting a material volume of at least 5 mm3. The authentication material includes at least one amorphous phase, at least one crystalline phase and at least one complex metal phase. The second material is typically a polymer. The application may advantageously be implemented by 3D printing.Type: GrantFiled: July 15, 2020Date of Patent: July 15, 2025Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Samuel Kenzari, Vincent Fournee, Bénédicte Boy
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Publication number: 20250224313Abstract: An assembly for detecting volatile compounds in a gaseous fluid includes a detector for detecting vapours, equipped with a suction tube, and a vapour-sampling optimisation device. This vapour-sampling optimisation device has an end piece with a body having a through-passage extending along an axis in a suction direction and configured to accept the suction tube. The device also has a fluidic network with an inlet in fluidic communication with at least one outlet. When the gaseous fluid is injected into the end piece via the inlet of the fluidic network, the network forms a jet of gaseous fluid which is ejected from the end piece on either side of the suction direction. Each jet forms an angle of 10° to 90° in absolute value with the axis of the suction direction, so that the jet ejected from the end piece moves away from the suction axis.Type: ApplicationFiled: March 29, 2023Publication date: July 10, 2025Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CNRS DÉLÉGATION CENTRE LIMOUSIN POITOU-CHARENTES (DR8), UNIVERSITE DE TOURSInventors: Nicolas CLAVERIE, Pierrick BUVAT, Jérôme CASAS
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Patent number: 12351556Abstract: The present invention concerns novel pyridin-2(1H)one derivatives, their process of preparation and their use in therapeutics, in particular as agents for treating and/or preventing pain.Type: GrantFiled: October 2, 2020Date of Patent: July 8, 2025Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CENTRE HOSPITALIER UNIVERSITAIRE DE CLERMONT-FD, SIGMA CLERMONT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLERMONT AUVERGNEInventors: Radhouane Dallel, Alain Artola, Amélie Descheemaeker, Fabrice Anizon, Isabelle Thomas, Pascale Moreau, Alexia Visseq, Francis Giraud
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Patent number: 12343725Abstract: The present invention relates to a method for transferring material in a microfluidic or millifluidic device between a droplet of a first droplet train and a droplet of a second droplet train, as well as to the use of this method for the preparation of biological or chemical samples, the implementation of biological or chemical reactions, the screening of a molecule of synthetic or biological origin, or the screening or cultivation of microorganisms. The present invention also relates to a microfluidic or millifluidic device suitable for carrying out the method according to the invention.Type: GrantFiled: June 14, 2019Date of Patent: July 1, 2025Assignees: Centre National de la Recherche Scientifique (CNRS), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris, Paris Sciences et LettresInventors: Jean-Baptiste Dupin, Ankur Shubhlal Chaurasia, Jérôme Bibette, Nicolas Bremond, Jean Baudry, Wilfried Sire
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Publication number: 20250205393Abstract: The present disclosure relates to injectable or implantable compositions that are able to mimic different types of mineralized biological tissues and their uses in mineralized tissues repair and regeneration.Type: ApplicationFiled: March 23, 2022Publication date: June 26, 2025Applicants: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Nadine NASSIF, Miléna LAMA, Camila BUSSOLA TOVANI, Marc ROBIN
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Publication number: 20250208098Abstract: This disclosure relates to a method for characterising a target object in a medium. The method comprises: obtaining a reference matrix F(q) associated with the target object, measuring a reflection matrix R associated with the probed medium, and projecting the reflection matrix R onto the reference matrix F(q) to estimate a probability P(q) that the object is in a state q.Type: ApplicationFiled: December 19, 2024Publication date: June 26, 2025Applicants: SUPERSONIC IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, UNIVERSITÉ GUSTAVE EIFFELInventors: Arthur LE BER, Antton GOICOECHEA, William LAMBERT, Alexandre AUBRY, Xiaoping JIA, Arnaud TOURIN, Mathias FINK, Nicolas ETAIX, Stefan ROTTER, Lukas RACHBAUER
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Publication number: 20250207277Abstract: A catalytic material comprising at least one group VIB metal at least partly in sulfide form, at least one group IVB metal at least partly in sulfide form, and an electrically conductive support wherein said group VIB metal is chosen from molybdenum and/or tungsten, said group IVB metal is chosen from titanium, zirconium and/or hafnium.Type: ApplicationFiled: March 8, 2023Publication date: June 26, 2025Applicants: IFP ENERGIES NOUVELLES, ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD (LYON 1), GRENOBLE INP (INSTITUT POLYTECHNIQUE DE GRENOBLE), UNIVERSITE SAVOIE MONT BLANC, UNIVERSITE GRENOBLE ALPESInventors: Audrey BONDUELLE, Mona Marie OBADIA, Quentin CACCIUTTOLO, Stephan STEINMANN, Nawras ABIDI, Laetitia DUBAU, Eric SIBERT
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Patent number: 12338423Abstract: A method to provide a microfluidic flow comprising a central flow and at least one outer flow, such that the central flow includes a first material and the at least one outer flow comprises a second material. One of the first material and the second material has cells and the other of the first material and the second material has solid particles. The method involves injection of a first suspension including the first material through a central inlet with a flow rate Q2 and injection of a second suspension comprising the second material through a pair of side inlets with a flow rate Q2, whereby the ratio of the flow rate Q2 over the flow rate Q1 is at least 4. A device provides such microfluidic flow and a method is provided to alter biological cells.Type: GrantFiled: April 30, 2020Date of Patent: June 24, 2025Assignees: UNIVERSITEIT GENT, CNRS, ISEN YNCRÉA HAUTS-DE-FRANCE, UNIVERSITÉ DE LILLE, UNIVERSITÉ POLYTECHNIQUE HAUTS-DE-FRANCE, CENTRALE LILLE INSTITUTEInventors: Kevin Braeckmans, Ranhua Xiong, Majid Layachi, Anthony Treizebre, Francois Anquez, Quentin Thommen, Emmanuel Courtade
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Publication number: 20250195040Abstract: An ultrasound characterisation method of a medium comprising the steps of generating a series of incident ultrasound waves, measuring a canonical reflection matrix defined between the input emission base and an output reception base, determining a set of responses of the medium obtained from the canonical reflection matrix, at a plurality of frequencies and for several points in a region around a reference point, determination of a frequency correction law from the responses of the medium at the various points, the frequency correction law being adapted to the reference point and being determined at frequencies, determination of the corrected responses of the medium by applying the frequency correction law to the responses of the medium around the reference point and for the plurality of frequencies.Type: ApplicationFiled: December 13, 2024Publication date: June 19, 2025Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, SUPERSONIC IMAGINE, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, UNIVERSITE PARIS CITEInventors: Flavien BUREAU, Elsa GIRAUDAT, William LAMBERT, Nicolas ETAIX, Mathias FINK, Alexandre AUBRY, Arthur LE BER
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Patent number: 12329455Abstract: A full-field optical coherence tomography imaging method, FFOCT, using a system comprising an FFOCT device and a sample, the sample comprising a layer of interest to be imaged, the FFOCT device comprising an incoherent light source, an imager, a beam splitter defining a sample arm and a reference arm, the method comprising—generating sample light containing interest light originating from the layer of interest and reference light traveling from the reference arm, —acquiring an image from reference light and sample light combined in the beam splitter; wherein at least one of the sample arm and the reference arm comprises an optical curvature compensator that modifies a transverse variation distribution of an optical path length to match the transverse variation distributions of the optical path lengths travelled by the reference light and the interest light incident on the imager.Type: GrantFiled: December 18, 2020Date of Patent: June 17, 2025Assignees: Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De ParisInventors: Viacheslav Mazlin, Pedro Francisco Baracal De Mece, Albert Claude Boccara
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Patent number: 12325735Abstract: The present invention relates to regulatory T cell and uses thereof. By their immunosuppressive and anti-inflammatory activities, regulatory T cells play a central role in peripheral tolerance and thus critically prevent the development of autoimmune and inflammatory disorders. The inventors showed that Foxp3+CD4+ Tregs express high levels of LT?, which negatively regulates their immunosuppressive signature. They demonstrated that the adoptive transfer of LT??/? Tregs in mice protects from dextran sodium sulfate (DSS)-induced colitis and attenuates inflammatory bowel disease (IBD), multi-organ autoimmunity and the development of CAC. The inventors also showed that by mixed bone marrow chimeras that LT? expression specifically in hematopoietic cells negatively controls the immunosuppressive signature of Tregs. In particular, the present invention relates to regulatory T cell characterized in that it does not express or expresses reduced levels of lymphotoxin alpha.Type: GrantFiled: February 13, 2023Date of Patent: June 10, 2025Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE D'AIX-MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventor: Magali Irla
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Patent number: 12318315Abstract: Methods and systems are provided for decoding movement intentions using functional ultrasound (fUS) imaging of the brain. In one example, decoding movement intentions include determining a memory phase of a cognitive state of the brain, the memory phase between a gaze fixation phase and movement execution phase, and determining one or more movement intentions including one or more of intended effector (e.g., hand, eye) and intended direction (e.g., right, left) according to a machine learning algorithm trained to classify one or more movement intentions simultaneously.Type: GrantFiled: May 12, 2021Date of Patent: June 3, 2025Assignees: California Institute of Technology, INSERM (Institut National de la Santé et de la Recherche Médicale), CNRS-CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de ParisInventors: Sumner L Norman, David Maresca, Vasileios Christopoulos, Mikhail Shapiro, Richard A Andersen, Mickael Tanter, Charlie Demene
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Patent number: 12311372Abstract: A device positioning an object according to a given direction, including a frame, a holder for holding the object, the holder being movable relative to the frame according to the given direction, a main lever extending between a first point and a second point, said main lever being rotatably mounted to the frame via a first pivot link connecting the main lever and the frame at the first point of the main lever, the main lever being connected to the holder at a third point which is arranged between the first point and the second point, so that a displacement of the second point of the main lever relative to the frame according to the given direction causes displacement of the holder in said given direction.Type: GrantFiled: June 26, 2020Date of Patent: May 27, 2025Assignees: Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite, UNIVERSITÉ PARIS CITÉInventors: Gaël Radou, Thibault Vieille, Vincent Croquette
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Publication number: 20250152124Abstract: Method for estimating a movement of particles in a bone, including the following steps: obtaining data associated with ultrasonic waves emitted at a temporal frequency; obtaining ultrasonic wave phase velocities in the bone in various directions followed by the ultrasonic waves; obtaining videos showing the bone at a point, the videos issuing from ultrasonic waves; computing phase variations at the point between two images of the videos; and computing a particle movement at the point based on the temporal frequency, the data associated with the ultrasonic waves, the phase variations, and the phase velocities in the various directions.Type: ApplicationFiled: February 16, 2022Publication date: May 15, 2025Applicants: SORBONNE UNIVERSITÉ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), TECHNISCHE UNIVERSITEIT DELFTInventors: Guillaume RENAUD, Sébastien SALLES
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Patent number: 12297237Abstract: The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.Type: GrantFiled: April 8, 2024Date of Patent: May 13, 2025Assignees: Centre National de la Recherche Scientifique (CNRS), Université Paris-SaclayInventors: Aurélie Albertini, Yves Gaudin, Hélène Raux, Laura Belot, Jovan Nikolic
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Patent number: 12292372Abstract: The invention relates to a measuring device (10) for measuring physical characteristics of cells. The device (10) comprises: a microfluidic chip (20) provided with a flow channel (22) for allowing cells to flow through; a manipulator (24) configured to apply deformation force to a cell in a continuous flow; and a sensor (26) configured to sense a physical characteristic of the cell. The manipulator (24) and the sensor (26) are configured to define a width (W2) of the flow channel (22) as a gap formed between them. The manipulator (24) is configured to apply the deformation force to the cell by compressing the cell against the sensor (26).Type: GrantFiled: October 6, 2020Date of Patent: May 6, 2025Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), JUNIAInventors: Dominique Collard, Hiroyuki Fujita, Stanislav Karsten, Mehmet Cagatay Tarhan