Patents Assigned to CNRS
  • Patent number: 12385014
    Abstract: The invention relates to a method for producing a recombinant baculovirus comprising n exogenous genes in an insect cell, by means of homologous recombination of a replication-deficient baculovirus genome and n transfer vectors, each comprising one of the n exogenous genes, n being an integer at least equal to 2.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: August 12, 2025
    Assignees: CENTRE NATIONAL DEL LA RECHERCH SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMQIUE
    Inventors: Martine Cerutti, Sylvie Juliant, Sylvie Thery
  • Publication number: 20250251345
    Abstract: A method for fluorescence microscopic imaging of an object may be performed by means of a fluorescence microscopic imaging system with light sheet illumination. The method includes generating a line of light and scanning the line of light to generate a light sheet and further includes performing a wavefront analysis on an analysis field of the object. The method further includes applying spatial filtering of the fluorescence light, where the spatial filtering includes scanning a filtering element with respect to a fluorescence image of the line of light formed in a filtering plane of the filtering element. The scanning of the filtering element may be synchronized with the scanning of the line of light such as to obtain a superposition, at each instant, of the filtering element and the fluorescence image of the line of light.
    Type: Application
    Filed: March 31, 2023
    Publication date: August 7, 2025
    Applicants: IMAGINE OPTIC, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMEIE INDUSTRIELLES DE LA VILLE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), SORBONNE UNIVERSITE, Paris Sciences et Lettres
    Inventors: Fabrice Harms, Xavier Levecq, Alexandra Fragaola
  • Patent number: 12371402
    Abstract: The invention relates to compounds of formula (I) as follows: (I) wherein X1 and X2, identical or different, are NR5 or a sulfur atom, Y is a group (C1-C10)alkanediyl, Ar1 and Ar2, identical or different, are an aryl group optionally substituted by one or several groups selected from a halogen atom, a (C1-C6) alkyl, —OR1, —NR1R2 and —COOR3? with R1 and R2, independently of each other, are a hydrogen atom, a (C-1-C6) alkyl group or a —COR3 group, R3 and R4? independently of each other, are a hydrogen atom or a (C1-C6) alkyl group, and R5 is a hydrogen atom or a (C1-C6)alkyl group, or a pharmaceutically acceptable salt and/or solvate thereof, in particular for use in cancer treatment.
    Type: Grant
    Filed: November 28, 2019
    Date of Patent: July 29, 2025
    Assignees: CENTRE LEON BERARD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON 1, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE GRENOBLE ALPES, UNIVERSITE DE CAEN NORMANDIE
    Inventors: Marc Billaud, Renaud Prudent, Martine Cordier-Bussat, Eric Fontaine, Patrick Dallemagne, Peggy Suzanne, Sylvain Rault
  • Patent number: 12371471
    Abstract: The present invention relates to an engineered immune cell defective for Suv39h1. Preferably, said engineered immune cell further comprises a genetically engineered antigen receptor that specifically hinds a target antigen. The present invention also relates to a method for obtaining a genetically engineered immune cell comprising a step consisting in inhibiting the expression and/or activity of Suv39h1 in the immune cell; and further optionally comprising a step consisting in introducing in the said immune cell a genetically engineered antigen receptor that specifically binds to a target antigen. The invention also encompasses said engineered immune cell for their use in adoptive therapy, notably for the treatment of cancer.
    Type: Grant
    Filed: September 24, 2024
    Date of Patent: July 29, 2025
    Assignees: INSTITUT CURIE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Sebastian Amigorena, Eliane Piaggio, Christel Goudot, Luigia Pace, Genevieve Almouzni, Leticia Niborski
  • Patent number: 12358316
    Abstract: The present application relates to an anti-counterfeiting object including a face with an optical identification marking which is readable by the eye and/or by a machine, and an authentication volume, the authentication volume extending from the face in the thickness (z) direction so as to be accessible from the face in order to be read by X-ray diffractometry (XRD). The authentication volume is a composite of a first material, referred to as the authentication material, and at least one second material, the authentication volume constituting a material volume of at least 5 mm3. The authentication material includes at least one amorphous phase, at least one crystalline phase and at least one complex metal phase. The second material is typically a polymer. The application may advantageously be implemented by 3D printing.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: July 15, 2025
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Samuel Kenzari, Vincent Fournee, Bénédicte Boy
  • Publication number: 20250224313
    Abstract: An assembly for detecting volatile compounds in a gaseous fluid includes a detector for detecting vapours, equipped with a suction tube, and a vapour-sampling optimisation device. This vapour-sampling optimisation device has an end piece with a body having a through-passage extending along an axis in a suction direction and configured to accept the suction tube. The device also has a fluidic network with an inlet in fluidic communication with at least one outlet. When the gaseous fluid is injected into the end piece via the inlet of the fluidic network, the network forms a jet of gaseous fluid which is ejected from the end piece on either side of the suction direction. Each jet forms an angle of 10° to 90° in absolute value with the axis of the suction direction, so that the jet ejected from the end piece moves away from the suction axis.
    Type: Application
    Filed: March 29, 2023
    Publication date: July 10, 2025
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CNRS DÉLÉGATION CENTRE LIMOUSIN POITOU-CHARENTES (DR8), UNIVERSITE DE TOURS
    Inventors: Nicolas CLAVERIE, Pierrick BUVAT, Jérôme CASAS
  • Patent number: 12351556
    Abstract: The present invention concerns novel pyridin-2(1H)one derivatives, their process of preparation and their use in therapeutics, in particular as agents for treating and/or preventing pain.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: July 8, 2025
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CENTRE HOSPITALIER UNIVERSITAIRE DE CLERMONT-FD, SIGMA CLERMONT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLERMONT AUVERGNE
    Inventors: Radhouane Dallel, Alain Artola, Amélie Descheemaeker, Fabrice Anizon, Isabelle Thomas, Pascale Moreau, Alexia Visseq, Francis Giraud
  • Patent number: 12343725
    Abstract: The present invention relates to a method for transferring material in a microfluidic or millifluidic device between a droplet of a first droplet train and a droplet of a second droplet train, as well as to the use of this method for the preparation of biological or chemical samples, the implementation of biological or chemical reactions, the screening of a molecule of synthetic or biological origin, or the screening or cultivation of microorganisms. The present invention also relates to a microfluidic or millifluidic device suitable for carrying out the method according to the invention.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: July 1, 2025
    Assignees: Centre National de la Recherche Scientifique (CNRS), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris, Paris Sciences et Lettres
    Inventors: Jean-Baptiste Dupin, Ankur Shubhlal Chaurasia, Jérôme Bibette, Nicolas Bremond, Jean Baudry, Wilfried Sire
  • Publication number: 20250205393
    Abstract: The present disclosure relates to injectable or implantable compositions that are able to mimic different types of mineralized biological tissues and their uses in mineralized tissues repair and regeneration.
    Type: Application
    Filed: March 23, 2022
    Publication date: June 26, 2025
    Applicants: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Nadine NASSIF, Miléna LAMA, Camila BUSSOLA TOVANI, Marc ROBIN
  • Publication number: 20250208098
    Abstract: This disclosure relates to a method for characterising a target object in a medium. The method comprises: obtaining a reference matrix F(q) associated with the target object, measuring a reflection matrix R associated with the probed medium, and projecting the reflection matrix R onto the reference matrix F(q) to estimate a probability P(q) that the object is in a state q.
    Type: Application
    Filed: December 19, 2024
    Publication date: June 26, 2025
    Applicants: SUPERSONIC IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, UNIVERSITÉ GUSTAVE EIFFEL
    Inventors: Arthur LE BER, Antton GOICOECHEA, William LAMBERT, Alexandre AUBRY, Xiaoping JIA, Arnaud TOURIN, Mathias FINK, Nicolas ETAIX, Stefan ROTTER, Lukas RACHBAUER
  • Publication number: 20250207277
    Abstract: A catalytic material comprising at least one group VIB metal at least partly in sulfide form, at least one group IVB metal at least partly in sulfide form, and an electrically conductive support wherein said group VIB metal is chosen from molybdenum and/or tungsten, said group IVB metal is chosen from titanium, zirconium and/or hafnium.
    Type: Application
    Filed: March 8, 2023
    Publication date: June 26, 2025
    Applicants: IFP ENERGIES NOUVELLES, ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD (LYON 1), GRENOBLE INP (INSTITUT POLYTECHNIQUE DE GRENOBLE), UNIVERSITE SAVOIE MONT BLANC, UNIVERSITE GRENOBLE ALPES
    Inventors: Audrey BONDUELLE, Mona Marie OBADIA, Quentin CACCIUTTOLO, Stephan STEINMANN, Nawras ABIDI, Laetitia DUBAU, Eric SIBERT
  • Patent number: 12338423
    Abstract: A method to provide a microfluidic flow comprising a central flow and at least one outer flow, such that the central flow includes a first material and the at least one outer flow comprises a second material. One of the first material and the second material has cells and the other of the first material and the second material has solid particles. The method involves injection of a first suspension including the first material through a central inlet with a flow rate Q2 and injection of a second suspension comprising the second material through a pair of side inlets with a flow rate Q2, whereby the ratio of the flow rate Q2 over the flow rate Q1 is at least 4. A device provides such microfluidic flow and a method is provided to alter biological cells.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: June 24, 2025
    Assignees: UNIVERSITEIT GENT, CNRS, ISEN YNCRÉA HAUTS-DE-FRANCE, UNIVERSITÉ DE LILLE, UNIVERSITÉ POLYTECHNIQUE HAUTS-DE-FRANCE, CENTRALE LILLE INSTITUTE
    Inventors: Kevin Braeckmans, Ranhua Xiong, Majid Layachi, Anthony Treizebre, Francois Anquez, Quentin Thommen, Emmanuel Courtade
  • Publication number: 20250195040
    Abstract: An ultrasound characterisation method of a medium comprising the steps of generating a series of incident ultrasound waves, measuring a canonical reflection matrix defined between the input emission base and an output reception base, determining a set of responses of the medium obtained from the canonical reflection matrix, at a plurality of frequencies and for several points in a region around a reference point, determination of a frequency correction law from the responses of the medium at the various points, the frequency correction law being adapted to the reference point and being determined at frequencies, determination of the corrected responses of the medium by applying the frequency correction law to the responses of the medium around the reference point and for the plurality of frequencies.
    Type: Application
    Filed: December 13, 2024
    Publication date: June 19, 2025
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, SUPERSONIC IMAGINE, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, UNIVERSITE PARIS CITE
    Inventors: Flavien BUREAU, Elsa GIRAUDAT, William LAMBERT, Nicolas ETAIX, Mathias FINK, Alexandre AUBRY, Arthur LE BER
  • Patent number: 12329455
    Abstract: A full-field optical coherence tomography imaging method, FFOCT, using a system comprising an FFOCT device and a sample, the sample comprising a layer of interest to be imaged, the FFOCT device comprising an incoherent light source, an imager, a beam splitter defining a sample arm and a reference arm, the method comprising—generating sample light containing interest light originating from the layer of interest and reference light traveling from the reference arm, —acquiring an image from reference light and sample light combined in the beam splitter; wherein at least one of the sample arm and the reference arm comprises an optical curvature compensator that modifies a transverse variation distribution of an optical path length to match the transverse variation distributions of the optical path lengths travelled by the reference light and the interest light incident on the imager.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: June 17, 2025
    Assignees: Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris
    Inventors: Viacheslav Mazlin, Pedro Francisco Baracal De Mece, Albert Claude Boccara
  • Patent number: 12325735
    Abstract: The present invention relates to regulatory T cell and uses thereof. By their immunosuppressive and anti-inflammatory activities, regulatory T cells play a central role in peripheral tolerance and thus critically prevent the development of autoimmune and inflammatory disorders. The inventors showed that Foxp3+CD4+ Tregs express high levels of LT?, which negatively regulates their immunosuppressive signature. They demonstrated that the adoptive transfer of LT??/? Tregs in mice protects from dextran sodium sulfate (DSS)-induced colitis and attenuates inflammatory bowel disease (IBD), multi-organ autoimmunity and the development of CAC. The inventors also showed that by mixed bone marrow chimeras that LT? expression specifically in hematopoietic cells negatively controls the immunosuppressive signature of Tregs. In particular, the present invention relates to regulatory T cell characterized in that it does not express or expresses reduced levels of lymphotoxin alpha.
    Type: Grant
    Filed: February 13, 2023
    Date of Patent: June 10, 2025
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE D'AIX-MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventor: Magali Irla
  • Patent number: 12318315
    Abstract: Methods and systems are provided for decoding movement intentions using functional ultrasound (fUS) imaging of the brain. In one example, decoding movement intentions include determining a memory phase of a cognitive state of the brain, the memory phase between a gaze fixation phase and movement execution phase, and determining one or more movement intentions including one or more of intended effector (e.g., hand, eye) and intended direction (e.g., right, left) according to a machine learning algorithm trained to classify one or more movement intentions simultaneously.
    Type: Grant
    Filed: May 12, 2021
    Date of Patent: June 3, 2025
    Assignees: California Institute of Technology, INSERM (Institut National de la Santé et de la Recherche Médicale), CNRS-CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris
    Inventors: Sumner L Norman, David Maresca, Vasileios Christopoulos, Mikhail Shapiro, Richard A Andersen, Mickael Tanter, Charlie Demene
  • Patent number: 12311372
    Abstract: A device positioning an object according to a given direction, including a frame, a holder for holding the object, the holder being movable relative to the frame according to the given direction, a main lever extending between a first point and a second point, said main lever being rotatably mounted to the frame via a first pivot link connecting the main lever and the frame at the first point of the main lever, the main lever being connected to the holder at a third point which is arranged between the first point and the second point, so that a displacement of the second point of the main lever relative to the frame according to the given direction causes displacement of the holder in said given direction.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: May 27, 2025
    Assignees: Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite, UNIVERSITÉ PARIS CITÉ
    Inventors: Gaël Radou, Thibault Vieille, Vincent Croquette
  • Publication number: 20250152124
    Abstract: Method for estimating a movement of particles in a bone, including the following steps: obtaining data associated with ultrasonic waves emitted at a temporal frequency; obtaining ultrasonic wave phase velocities in the bone in various directions followed by the ultrasonic waves; obtaining videos showing the bone at a point, the videos issuing from ultrasonic waves; computing phase variations at the point between two images of the videos; and computing a particle movement at the point based on the temporal frequency, the data associated with the ultrasonic waves, the phase variations, and the phase velocities in the various directions.
    Type: Application
    Filed: February 16, 2022
    Publication date: May 15, 2025
    Applicants: SORBONNE UNIVERSITÉ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), TECHNISCHE UNIVERSITEIT DELFT
    Inventors: Guillaume RENAUD, Sébastien SALLES
  • Patent number: 12297237
    Abstract: The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.
    Type: Grant
    Filed: April 8, 2024
    Date of Patent: May 13, 2025
    Assignees: Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay
    Inventors: Aurélie Albertini, Yves Gaudin, Hélène Raux, Laura Belot, Jovan Nikolic
  • Patent number: 12292372
    Abstract: The invention relates to a measuring device (10) for measuring physical characteristics of cells. The device (10) comprises: a microfluidic chip (20) provided with a flow channel (22) for allowing cells to flow through; a manipulator (24) configured to apply deformation force to a cell in a continuous flow; and a sensor (26) configured to sense a physical characteristic of the cell. The manipulator (24) and the sensor (26) are configured to define a width (W2) of the flow channel (22) as a gap formed between them. The manipulator (24) is configured to apply the deformation force to the cell by compressing the cell against the sensor (26).
    Type: Grant
    Filed: October 6, 2020
    Date of Patent: May 6, 2025
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), JUNIA
    Inventors: Dominique Collard, Hiroyuki Fujita, Stanislav Karsten, Mehmet Cagatay Tarhan