Patents Assigned to CNRS
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Publication number: 20240426624Abstract: The method (P1) for detecting a boundary (L1, L2, L3) of a traffic lane (VC1, VC2) for a motor vehicle (1) involves: (E1) detecting the boundary by a vehicle environment detection means (3), the boundary being defined by a function, in particular a polynomial function, (E4) determining a plurality of first vectors (MXi) characterizing the boundary on the basis of map data and on the basis of data on the current position and orientation of the vehicle, (E6) determining a plurality of second vectors (Fj) characterizing the boundary, each second vector being determined by an orthogonal projection of a first vector onto said function, and (E8) calculating Mahalanobis distances between each first vector and each second vector.Type: ApplicationFiled: October 10, 2022Publication date: December 26, 2024Applicants: AMPERE S.A.S., CNRS, UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE (UTC)Inventors: Federico Camarda, Véronique Cherfaoui, Franck Davoine, Bruno Durand
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Publication number: 20240424297Abstract: A method for determining a profile of stimulation charge rate for at least one muscle or group of muscles of a subject using the ergometer equipped with a FES system, the profile of stimulation charge rate being specific to the ergometer user. Also, a method for stimulation intervals for at least one muscle or group of muscles of a subject using the ergometer equipped with a FES system. Further, an ergometer, preferably a cyclic ergometer such as an electric stimulation stationary bike, including a FES controller with instructions to operate the method.Type: ApplicationFiled: September 16, 2022Publication date: December 26, 2024Applicants: KURAGE, ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRSInventors: Lana POPOVIC MANESKI, Amine METANI
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Patent number: 12169286Abstract: A device for creating a patterned field on a diopter includes: an objective lens within whose image focal plane the surface of the diopter lies; a light injection element emitting a collimated light beam; and an optical assembly between the element and the objective lens by which the object plane of the objective lens is optically conjugate with the image plane of the element. The assembly is configured so a collimated light beam from the element is emitted towards the objective lens to be reflected towards the surface of the diopter with an angle of incidence?the critical angle of the diopter, an optical device for forming patterns is in the object plane of the element, so the pattern formed by the optical device for forming patterns in transmitted light on the light beam in the object plane of the element is on the surface of the diopter.Type: GrantFiled: May 13, 2020Date of Patent: December 17, 2024Assignees: UNIVERSITÉ GRENOBLE ALPES, CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE)Inventors: Alexei Grichine, Olivier Destaing
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Patent number: 12169761Abstract: Control system (1) for a state of a quantum harmonic oscillator, comprising: —a harmonic oscillator (3) in a Schrödinger's cat type state, —a stabilisation device (10) with a predetermined parity of a number of bosons of the state, which device is configured to use first and second frequency combs each comprising at least as many rays as a mean number of bosons in the state, and —a multiphonic dissipation device (20) which is suitable for removing at least one pair of bosons simultaneously from the oscillator, the dissipation device being activated only between two successive time peaks of the frequency combs over a time period greater than the inverse of the product of the mean number and the inverse of the characteristic time of the multiphonic dissipation, a time period separating two activation periods being less than a characteristic loss time of a boson.Type: GrantFiled: December 16, 2021Date of Patent: December 17, 2024Assignees: UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE DE LYONInventors: Théau Peronnin, Benjamin Huard, Sébastien Jezouin, Antoine Marquet
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Publication number: 20240409588Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.Type: ApplicationFiled: June 13, 2024Publication date: December 12, 2024Applicants: Institut National De La Sante Et De La Recherche Medicale (INSERM), Centre National De La Recherche Scientifique (CNRS), Ecole Normale Superieure De Lyon, Universite Claude Bernard Lyon 1Inventors: Théophile OHLMANN, Philippe MANGEOT, Emiliano RICCI
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Publication number: 20240409869Abstract: A fluidic system for producing extracellular vesicles from producer cells, including at least one container, a liquid medium contained by the container and producer cells, characterised in that it also includes microcarriers suspended in the liquid medium, the majority of producer cells being adherent to the surface of the microcarriers, and a liquid medium agitator, the agitator and the dimensions of the container being adapted to control a turbulent flow of the liquid medium in the container.Type: ApplicationFiled: August 19, 2024Publication date: December 12, 2024Applicants: UNIVERSITE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), GENETHONInventors: Florence GAZEAU, Amanda Karine Andriola SILVA, Otto-Wilhelm MERTEN, Claire WILHELM, Max PIFFOUX
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Patent number: 12162988Abstract: A process for preparing a polyaminoborane comprising reacting at least one monomer with an aminoborane, wherein the at least one monomer is selected from the group consisting of ammonia, a primary amine and a substituted or unsubstituted hydrazine; and wherein the aminoborane comprises a borane substituted by a secondary amino group; polyaminoboranes obtainable by said process; use of said polyaminoboranes for the preparation of a ceramic precursor or a ceramic, the production of boron nitride, or the storage and/or production of dihydrogen; ceramic precursors, ceramics, hydrogen cells or energy materials comprising said polyaminoboranes.Type: GrantFiled: July 13, 2021Date of Patent: December 10, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE DE RENNESInventors: Gilles Alcaraz, Carlos Antonio De Albuquerque Pinheiro, Claire Roiland
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Patent number: 12161514Abstract: A device for assisting surgery includes means for offsetting a rotation of a first type and a second type, a mechanism for transmitting a rotation of a third type, and a mechanism for transforming the rotation of a third type into a translation. An elastic element is connected at one end to the mechanism for transmitting the rotation of a third type. The mechanism for transmitting the rotation of a third type is connected to a rotary motor, the rotation of the motor in a first direction causing the lowering of a tool and an elongation of the elastic element, the rotation of the motor in a second direction causing the raising of the tool and a contraction of the elastic element, and, when the tool is lowered and the rotary motor is not exerting any torque, the elastic element returns to an initial shape causing the raising of the tool.Type: GrantFiled: September 22, 2020Date of Patent: December 10, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, CHU DE NANTESInventors: Damien Chablat, Guillaume Michel, Philippe Bordure
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Publication number: 20240391887Abstract: The present invention concerns a compound of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, wherein X, R1, R2, R3 are defined, a conjugate thereof and their uses as drug or research tools.Type: ApplicationFiled: August 24, 2022Publication date: November 28, 2024Applicants: Centre National de Recherche Scientifique (CNRS), Universite de Montpellier, Ecole Nationale Superieure de Chimie de Montpellier, MT ACTInventors: Krzysztof ROGOWSKI, Muriel AMBLARD-CAUSSIL, Siem VAN DER LAAN, Lubomir VEZENKOV, Guillaume MARCELLIN, Yoann LANNAY, Khaled HACHED
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Publication number: 20240391851Abstract: The present invention relates to a process for the non-oxidative conversion of saturated C1+ hydrocarbons into unsaturated C2+ hydrocarbons and hydrogen in the presence of an unsupported carbon-based catalyst having a carbon content of at least 90.0 wt % and a metal concentration which is less than 0.3 wt %; with wt % expressed based on the total weight of said carbon-based catalyst. The present invention also provides a process for producing a graphite derivative. Further provided are a graphite derivative, and uses thereof, and systems for carrying out the processes of the invention.Type: ApplicationFiled: October 26, 2022Publication date: November 28, 2024Applicants: TOTALENERGIES ONETECH, UNIVERSITÉ DE STRASBOURG-UNISTRA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRSInventors: Stijn VAN DAELE, Nikolai NESTERENKO, Jean-Pierre DATH, Miroslave KETTNER, Cuong PHAM-HUU, Jean-Mario NHUT, Zhenxin XU
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Patent number: 12153131Abstract: Method for ultrasonic characterization of a medium, including generating a series of incident ultrasonic waves, generating an experimental reflection matrix Rui(t) defined between the emission basis (i) as input and a reception basis (u) as output, and determining a focused reflection matrix RFoc(rin, rout, ?t) of the medium between an input virtual transducer (TVin) calculated based on a focusing as input to the experimental reflection matrix and an output virtual transducer (TVout) calculated based on a focusing as output from the experimental reflection matrix, the responses of the output virtual transducer (TVout) being obtained at a time instant that is shifted by an additional delay ?t relative to a time instant of the responses of the input virtual transducer (TVin).Type: GrantFiled: September 13, 2021Date of Patent: November 26, 2024Assignees: SUPERSONIC IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARISInventors: William Lambert, Alexandre Aubry, Mathias Fink, Thomas Frappart
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Patent number: 12146150Abstract: Described herein are compositions and methods for treating Friedreich's Ataxia (FA) using adeno-associated virus (AAV) to deliver therapeutics agents.Type: GrantFiled: September 13, 2022Date of Patent: November 19, 2024Assignees: VOYAGER THERAPEUTICS, INC., INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ DE STRASBOURGInventors: Dinah Wen-Yee Sah, Martin Goulet, Holger Patzke, Yanqun Shu, Jinzhao Hou, Hélène Puccio
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Patent number: 12144896Abstract: The treatment of cancer using platinum-based compounds includes certain drawbacks such as biocompatibility, loading efficacy, leakage of drugs during storage and in the bloodstream, more particularly due to the nature of the nanocarriers for platinum delivery. A nanosystem that allows improving platinum-based drug in vivo performance, kinetics and efficacy. In particular, nanoparticles useful as drug delivery system, these nanoparticles being formed from at least: (a) platinum-based drug, (b) poly-L-arginine, and (c) hyaluronic acid. Particularly, these nanoparticles have been tested in terms of entrapment efficiency and also carried out in vitro experiments in 2D cell culture (viability studies on B6KPC3, A549 and HT-29 cells) and 3D cell model (spheroids made of HTC-116) and in vivo experiments (by injecting intravenously to mice the nanoparticles or comparative oxaliplatin solution) to prove their efficiency.Type: GrantFiled: September 16, 2019Date of Patent: November 19, 2024Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS—, UNIVERSITE D'ANGERS, CENTRE HOSPITALIER UNIVERSITAIRE D'ANGERSInventors: Giovanna Lollo, Jean-Pierre Benoit, Marie Brachet-Botineau
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Publication number: 20240377341Abstract: The invention relates to a method for non-destructively testing a part by means of transmission radiography, which method comprises the following steps of acquiring N projections (P(n)) of the part, generating calculated N images (P(n)) of the part, estimating, by successive iterations, the vector p from an initial vector p=pini and the vector c from an initial vector c=cini and/or the parameter vector a from an initial vector ?=?ini, by minimising the sum of the squared differences between the projections (P(n)) and the images (P(n)), processing the projections (P(n)) and/or the images (P(n)), identifying defects in the part by comparing the processed projections (P(n)) and the processed images (P(n)).Type: ApplicationFiled: September 8, 2022Publication date: November 14, 2024Applicants: SAFRAN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE PARIS-SACLAYInventors: Cédric FRAGNAUD, Stéphane ROUX, Julian BETANCUR
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Patent number: 12138118Abstract: The invention concerns a multi-sensor brain detecting apparatus, the detecting apparatus being adapted to obtain two different physical values of a brain of a subject, the detecting apparatus comprising: a set of sensors comprising an ultrasound transducer adapted to produce ultrasound waves, a frame with a position with relation to the brain known with a stereotaxic precision, the frame being adapted to hold a sensor that can be positioned at a specific location by a user of the detecting apparatus without using a tool.Type: GrantFiled: October 21, 2021Date of Patent: November 12, 2024Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, SORBONNE UNIVERSITÉ, UNIVERSITÉ PARIS CITÉ, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARISInventors: Jean-Luc Gennisson, Mickaël Tanter, Thomas Deffieux, Mathieu Pernot
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Patent number: 12142394Abstract: The invention relates to an electrically insulating composite material (1) comprising a polyepoxide matrix (2) of cycloaliphatic type or of diglycidyl ether type in a content of less than 40% by mass, from 20 to 75% by mass of one or several micrometric and/or mesometric filler(s) (3), and from 0.1 to 20% by mass of at least one ionic liquid (4), the masses being expressed relative to the total mass of the electrically insulating composite material (1). The invention also relates to a method for manufacturing such an electrically insulating composite material (1), as well as its use for an electrically insulating support (9) in a metal-enclosed substation (5).Type: GrantFiled: December 27, 2019Date of Patent: November 12, 2024Assignees: SUPERGRID INSTITUTE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON 1, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE JEAN MONNET SAINT ETIENNE SAINTInventors: Thibaut Lefort, Damien Bachellerie, Sébastien Pruvost, Jannick Duchet, Sébastien Livi
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Patent number: 12140594Abstract: The present invention relates to a non invasive diagnostic method of pancreatic ductal adenocarcinoma (PDAC) in a subject said method comprising the step of measuring the level of ?ig-h3 protein in a blood sample wherein the serum level of ?ig-h3 is positively correlated with the risk of having a PDAC. By following studies on 2 distinct cohorts of 20 and 104 of PDAC patients, and on PDAC mouse model, the inventors show that ?ig-h3 can be directly detected in the blood sample and ?ig-h3 is expressed very early in tumorigenesis in pancreatic neoplastic lesions. The present invention also relates to antagonist of ?ig-h3 protein, for use in the treatment of PDAC. The inventors found that ?ig-h3 bind directly on CD8+ T cells by reducing their activation and cytotoxic properties. Furthermore, the use of neutralizing ?ig-h3 antibodies in PDAC mouse model, reduced tumor growth by enhancing CD8+ T cell anti-tumoral response.Type: GrantFiled: July 7, 2023Date of Patent: November 12, 2024Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE CLAUDÉBERNARD—LYON 1, CENTRE LEON BERARD, KIST (KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY)Inventors: Kim In-San, Philippe Bertolino, Ana Hennino
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Patent number: 12138111Abstract: Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method, which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.Type: GrantFiled: September 25, 2020Date of Patent: November 12, 2024Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITÉ PARIS CITÉ, SORBONNE UNIVERSITÉ, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARISInventors: Mathieu Pernot, Thomas Deffieux, Mickael Tanter, Clément Papadacci
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Patent number: 12128640Abstract: The disclosure provides a process for treatment of an article (1) made of a polymer composition; comprising the steps of providing an article (1) with a surface, the article being made of a polymer composition comprising one or more polyolefins; providing one or more texturing solvents (3, 5, 7, 9) selected from one or more vegetable oils, one or more terpenes, one or more alkanes and any combination thereof; wherein the one or more texturing solvents (3, 5, 7, 9) are further selected to have a boiling point which is above the crystallisation temperature Tc of the one or more polyolefins and to be devoid of a halogenated atom and/or an aromatic group; contacting the surface of the article (1) with the one or more texturing solvents (3, 5, 7, 9); and recovering an article with a textured surface with water contact angle following ISO 19403-6:2017 that is increased by comparison to the initial water contact angle.Type: GrantFiled: October 24, 2022Date of Patent: October 29, 2024Assignees: TOTALENERGIES ONETECH, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Olivier Lhost, Guillaume Espy, Jannick Duchet-Rumeau, Jean-François Gerard, Sébastien Livi
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Patent number: 12129907Abstract: The structure (10) comprises an elastically deformable body (12) defining at least one network of internal cavities (14), each internal cavity (14) having a closed contour in at least one section of the internal cavity (14). Each internal cavity (14) is able to be pressurized so as to make the elastically deformable body (12) pass from a rest configuration to at least one pressurized configuration. In each pressurized configuration, the elastically deformable body (12) has a macroscopic metric that is distinct from its macroscopic metric in the rest position. In each pressurized configuration, the radius of curvature of an outer surface of the elastically deformable body (12), considered regarding each internal cavity (14) adjacent to the outer surface, is greater than twice the size of the internal cavity (14) adjacent to the outer surface.Type: GrantFiled: July 22, 2019Date of Patent: October 29, 2024Assignees: PARIS SCIENCES ET LETTRES—QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, SORBONNE UNIVERSITÉ, UNIVERSITÉ DE PARISInventors: Emmanuel Siefert, Benoît Roman, José Bico, Etienne Reyssat