Patents Assigned to CNRS
-
Patent number: 11649264Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.Type: GrantFiled: February 12, 2021Date of Patent: May 16, 2023Assignees: Institut National De La Sante Et De La Recherche Medicale (INSERM), Centre National De La Recherche Scientifique (CNRS), Ecole Normale Superieure De Lyon, Universite De Claude Bernard Lyon 1Inventors: Théophile Ohlmann, Philippe Mangeot, Emiliano Ricci
-
Patent number: 11644422Abstract: A calibration standard for determining an intensity decay related to an evanescent field generated close to the interface between a sample to be tested and a substrate on which the sample is to be deposited, preparation and analysis methods and use thereof.Type: GrantFiled: September 12, 2019Date of Patent: May 9, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE PARIS, UNIVERSITE BAR-ILANInventors: Martin Oheim, Adi Salomon
-
Publication number: 20230136949Abstract: A method for growing a III-V material may include forming at least one layer on a stack including a crystalline layer made of III-V material, a first masking layer surmounting the germination layer, the first masking layer having at least one first opening; depositing a second masking layer covering an upper face of the sacrificial layer; forming at least one second opening in the second masking layer; removing the sacrificial layer selectively at the first masking layer and at the second masking layer; epitaxially growing a material made of the III-V material from the germination layer; forming al least one third opening in the second masking layer; and epitaxially growing at least one material made of the III-V material from the first epitaxial layer.Type: ApplicationFiled: November 2, 2022Publication date: May 4, 2023Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CNRSInventors: Matthew CHARLES, Yvon CORDIER
-
Patent number: 11634405Abstract: The present invention relates to the Compound of following formula (I): or a pharmaceutically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing such a compound and a method for preparing such a compound.Type: GrantFiled: April 26, 2019Date of Patent: April 25, 2023Assignees: UNIVERSITE PARIS-SACLAY PARC TECHNOLOGIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT GUSTAVE-ROUSSY, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)Inventors: Mouad Alami, Olivier Provot, Abdallah Hamze, Ilhem Khelifi, Timothée Naret, Sébastien Apcher, Romain Darrigrand
-
Patent number: 11635367Abstract: A contrast-amplifying carrier for observing a sample, includes a transparent substrate bearing at least one absorbent coating suitable for behaving as an antireflection coating when it is illuminated at normal incidence at an illumination wavelength ? through the substrate and when the face of the coating opposite the substrate is in contact with a medium referred to as a transparent ambient medium, the refractive index n3 of which is lower than that of the refractive index n0 of the substrate. The absorbent coating comprises: an absorbent sublayer referred to as the contrast sublayer, deposited on the surface of the transparent substrate; and an absorbent layer referred to as the sensitive layer, distinct from the contrast sublayer and comprising between 1 and 5 sheets of a graphene-type material. Methods for producing and for using such a contrast-amplifying carrier are also provided.Type: GrantFiled: December 16, 2016Date of Patent: April 25, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DU MANS, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Stéphane Campidelli, Renaud Cornut, Vincent Derycke, Dominique Ausserre, Manuel Ausserre
-
Patent number: 11634452Abstract: The invention relates to compounds of formula (I), their method of synthesis as well as their use to treat neurodegenerative disorders.Type: GrantFiled: December 11, 2017Date of Patent: April 25, 2023Assignees: ETHNODYNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Chérif Rabhi, Léon Cariel, Christian Da Costa Noble, Jamal Ouazzani, Guillaume Arcile, Géraldine Le Goff
-
Publication number: 20230121377Abstract: A method for preparing a nanoporous silica sol-gel matrix containing at least one amine reactant selected from hydroxylamine, methylhydroxylamine, tertbutylhydroxylamine, methoxyamine, tetraethylenepentamine, dicarboxylic acid dihydrazides, particularly adipic acid dihydrazide, and the salts thereof, said method including the following steps: a) synthesising a gel from tetramethoxysilane or from a mixture of tetramethoxysilane and another organosilicon precursor selected from among phenyltrimethoxysilane, phenyltriethoxysilane, a fluoroalkyltrimethoxysilane, a fluoroalkyltriethoxysilane, a chloroalkylmethoxysilane, a chloroalkylethoxysilane, an alkyltrimethoxysilane, an alkyltriethoxysilane, an aminopropyltriethoxysilane and the mixtures thereof, the synthesis being performed in an aqueous medium at a temperature ranging from 10 to 70° C.Type: ApplicationFiled: December 16, 2022Publication date: April 20, 2023Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -Inventors: Thu-Hoa TRAN-THI, Ana BORTA, Mickael GINEYS, Marie-Pierre SOM, Frédéric HAMMEL
-
Patent number: 11629192Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of diseases mediated by the NRP-1/OBR complex signaling pathway. In particular, the present invention relates to a method for treating a disease selected from the group consisting of cancers, obesity and obesity related diseases, anorexia, autoimmune diseases and infectious diseases in a subject in need thereof comprising administering the subject with a therapeutically effective amount of an antagonist of the NRP-1/OBR signaling pathway.Type: GrantFiled: September 4, 2018Date of Patent: April 18, 2023Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITÉ PARIS CITÉ, FONDATION IMAGINE, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE GRENOBLE ALPES, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE DE BOURGOGNEInventors: Zakia Belaid-Choucair, Olivier Hermine, Carmen Garrido-Fleury, Claude Cochet, Odile Filhol-Cochet, Renaud Seigneuric
-
Patent number: 11622978Abstract: The present invention relates to an engineered immune cell defective for Suv39h1. Preferably, said engineered immune cell further comprises a genetically engineered antigen receptor that specifically binds a target antigen. The present invention also relates to a method for obtaining a genetically engineered immune cell comprising a step consisting in inhibiting the expression and/or activity of Suv39h1 in the immune cell; and further optionally comprising a step consisting in introducing in the said immune cell a genetically engineered antigen receptor that specifically binds to a target antigen. The invention also encompasses said engineered immune cell for their use in adoptive therapy, notably for the treatment of cancer.Type: GrantFiled: January 20, 2020Date of Patent: April 11, 2023Assignees: INSTITUT CURIE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Sebastian Amigorena, Eliane Piaggio, Christel Goudot, Luigia Pace, Genevieve Almouzni, Leticia Niborski
-
Patent number: 11618884Abstract: The present invention relates to regulatory T cell and uses thereof. By their immunosuppressive and anti-inflammatory activities, regulatory T cells play a central role in peripheral tolerance and thus critically prevent the development of autoimmune and inflammatory disorders. The inventors showed that Foxp3+CD4+ Tregs express high levels of LT?, which negatively regulates their immunosuppressive signature. They demonstrated that the adoptive transfer of LT??/? Tregs in mice protects from dextran sodium sulfate (DSS)-induced colitis and attenuates inflammatory bowel disease (IBD), multi-organ autoimmunity and the development of CAC. The inventors also showed that by mixed bone marrow chimeras that LT? expression specifically in hematopoietic cells negatively controls the immunosuppressive signature of Tregs. In particular, the present invention relates to regulatory T cell characterized in that it does not express or expresses reduced levels of lymphotoxin alpha.Type: GrantFiled: November 13, 2018Date of Patent: April 4, 2023Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE D'AIX MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventor: Magali Irla
-
Patent number: 11618829Abstract: The present invention concerns a solid nanocomposite material consisting of a polymer-matrix in which are dispersed alkali metal, hydronium or ammonium salts of polyanionic components, wherein the polymer-matrix comprises at least a linear or branched polymer or copolymer containing one or several poly(ethylene oxide) (PEO) chains, said polymer or copolymer being optionally crosslinked and each PEO chain having at least 4 ethylene oxide monomer units. The present invention relates also to a photonic, e.g. optoelectronic, device comprising such a nanocomposite material. Such material and device can be used as phosphorescence emitter, for crop growth lighting or for generating singlet oxygen.Type: GrantFiled: October 30, 2018Date of Patent: April 4, 2023Assignees: Universite de Rennes 1, Centre National de la Recherche Scientifique (CNRS), Universidade de Franca—UNIFRANInventors: Yann Molard, Maria De Los Angeles Amela-Cortes, Malo Robin, Stephane Cordier, Eduardo Ferreira Molina
-
Patent number: 11614460Abstract: An electronic device for measuring a speed of flow of a fluid that includes at least two electroacoustic transducers adapted for emitting and/or receiving acoustic signals through the flow of the fluid, the electronic device being adapted for determining a measurement of the speed of flow of the fluid from the characteristics of an acoustic signal emitted and one or more acoustic signals received, these received acoustic signals corresponding to reflections of the emitted acoustic signal.Type: GrantFiled: April 19, 2019Date of Patent: March 28, 2023Assignees: UNIVERSITE DU MANS, ASSOC TRANSFERTS TECHNOLOGIES MANS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Jacques Emery, Mohammed Tabellout, Charfeddine Mechri
-
Patent number: 11612743Abstract: The present invention relates to methods and devices to consolidate memory and/or cognitive functions by monitoring brain rhythms and delivering a stimulus at an appropriate stage of sleep cycle.Type: GrantFiled: January 24, 2020Date of Patent: March 28, 2023Assignees: ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE, APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA ECHERCHE MEDICALE), SORBONNE UNIVERSITEInventors: Michel Le Van Quyen, Stéphane Charpier, Séverine Mahon
-
Patent number: 11613513Abstract: The present invention relates to a compound of the following formula (I). The invention also relates to uses thereof as a chromophore as such or for building pigments displaying special optical effects, including metal-like reflection.Type: GrantFiled: December 28, 2017Date of Patent: March 28, 2023Assignees: Centre National de la Recherche Scientifique (CNRS), Université Paris CitéInventors: Philippe Laine, Laurélie Poulard, Grégory Dupeyre
-
Patent number: 11608509Abstract: The present invention relates to pseudotyped retrovirus-like particles or retroviral vectors comprising both engineered envelope glycoproteins derived from a virus of the Paramyxoviridae family fused to a cell targeting domain and fused to a functional domain. The present invention also relates to the use of said pseudotyped retrovirus-like particles or retroviral vectors to selectively modulate the activity of specific subsets of cells, in particular of specific immune cells. These pseudotyped retrovirus-like particles or retroviral vectors are particularly useful for gene therapy, immune therapy and/or vaccination.Type: GrantFiled: April 20, 2017Date of Patent: March 21, 2023Assignees: Ecole Normale Superieure de Lyon, Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1, Institut National de la Sante et de la Recherche Medicale (INSERM)Inventors: Caroline Costa Fejoz, Els Verhoeyen, François-Loïc Cosset, Ruben Bender, Christian Buchholz, Qi Zhou
-
Patent number: 11610647Abstract: The invention relates to a method for generating a unique identifier of a subject from a genotyped DNA sample from said subject, the method comprising the steps of: obtaining a number N?2 of genomic positions of interest, said obtained genomic positions being such that, in a population of M subjects, these genomic positions exhibit a polymorphism of at least one nucleotide having an allelic frequency of between 25% and 35%, for the minority allele; combining in pairs the obtained genomic positions by means of logical functions so as to obtain a binary code bc.Type: GrantFiled: October 18, 2018Date of Patent: March 21, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PAUL SABATIER TOULOUSE IIIInventors: Denis Pierron, Thierry Letellier, Margit Heiske, Veronica Pereda
-
Patent number: 11609124Abstract: A method for determining wavefront shapes of N angular channels CL of different propagation directions PL, said propagation directions PL being determined by a mean propagation direction vector , from a single signal image acquisition I(x,y) of a multi-angular signal light beam containing said angular channels, each angular channel Ci being separated from other angular channels Cj by an angular separation ??ij defined by ??ij=arccos, where “·” stands for the inner product between and .Type: GrantFiled: September 28, 2021Date of Patent: March 21, 2023Assignees: UNIVERSITE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), SORBONNE UNIVERSITEInventors: Marc Guillon, Gilles Tessier, Tengfei Wu, Pascal Berto
-
Patent number: 11608315Abstract: The invention relates to a process for preparing methyl mercaptan from a mixture of carbon oxide, hydrogen sulfide and hydrogen, in the presence of a catalyst based on molybdenum and potassium supported on zirconia, said catalyst not comprising any promoter.Type: GrantFiled: December 20, 2018Date of Patent: March 21, 2023Assignees: Arkema France, Universite Lille 1-Sciences et Technologies, Centre National de la Recherche Scientifique (CNRS)Inventors: Georges Frémy, Hélori Salembier, Carole Lamonier, Pascal Blanchard
-
Publication number: 20230066255Abstract: A medical analysis device with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarised opening. This device further comprises a classifier (6) comprising a convolutional neural network receiving the pulse data sets as input and is provided with at least one convolutional layer, which convolutional layer has a depth greater than or equal to 3, and at least two fully connected layers, in addition to an output layer rendering a cell classification from which a pulse data set is derived.Type: ApplicationFiled: January 15, 2021Publication date: March 2, 2023Applicants: HORIBA ABX SAS, UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Pierre TARACONAT, Damien ISEBE, Simon MENDEZ, Franck NICOUD
-
Publication number: 20230054300Abstract: The present application relates to a double-stranded DNA molecule comprising a first double-stranded DNA molecule (1) connected to a second double-stranded DNA molecule (2) by at least one covalent bond which is not a phosphodiester, phosphorothioate, phosphoramidate or phosphorodiamidate bond, preferably by a tether, said tether preferably being a double-stranded DNA molecule.Type: ApplicationFiled: December 21, 2018Publication date: February 23, 2023Applicants: PARIS SCIENCES ET LETTRES - QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE, UNIVERSITÉ DE PARISInventors: Térence STRICK, Charlie GOSSE, Dorota KOSTRZ, Jinglong WANG, Marc NADAL