Patents Assigned to CNRS
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Patent number: 12227767Abstract: The present invention is in the field of oncology, and more particularly of cancer stem cells. It relates to a method for producing cancer stem cells based on overexpression of ?133p53? isoform, ?133p53? isoform, or both ?133p53? and ?133p53? isoforms; a method for predicting the risk that treatment with a chemotherapeutic anti-cancer agent induces cancer stem cells in a subject suffering from cancer from a cancer sample of said subject, based on detection of an increase in ?133p53? isoform, ?133p53? isoform, or both ?133p53? and ?133p53? isoforms following chemotherapeutic anti-cancer treatment; to therapeutic uses of a combination of chemotherapeutic anti-cancer agent and an agent reducing ?133p53? isoform, ?133p53? isoform, or both ?133p53? and ?133p53? isoforms expression; and also to screening methods for anti-cancer stem cells agents.Type: GrantFiled: February 3, 2021Date of Patent: February 18, 2025Assignees: Centre National de la Recherche Scientifique (CNRS), Universite de MontpellierInventors: Pierre Roux, Nikola Arsic, Gilles Gadea, Philippe Fort, Fanny Tomas, Véronique Gire
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Publication number: 20250051403Abstract: The present invention relates to antimicrobial peptides, variants and chemical analogues thereof; in particular, a peptide of 20 amino acids, named Michelicin, having the sequence RVCVRICRNGRCYRRCWNT, derived from a longer precursor with a BRICHOS domain from the marine worm Capitella. The peptide has several cysteines which form disulfide bridges and provide stability in salt conditions. Several derivatives and analogues were produced. The peptide and the derivatives show antimicrobial activity against a wide range of bacteria. The application also concerns nucleic acid sequences encoding these, pharmaceutical composition and to their use as a drug, preservative and disinfectant.Type: ApplicationFiled: December 16, 2022Publication date: February 13, 2025Applicants: UNIVERSITE DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE D'AIX MARSEILLE, SORBONNE UNIVERSITE, ECOLE CENTRALE DE MARSEILLEInventors: Aurélie TASIEMSKI, Céline WICHLACZ, Marc MARESCA, Stéphane CANAAN, Jean-François CAVALIER, Kamel MABROUK, Stéphane HOURDEZ
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Publication number: 20250055418Abstract: A process for maximum power point tracking of a photovoltaic module, which includes monitoring the module's degradation by: for a periodicity n1?t0 with n1>1 constant or variable, steps of measuring parameters I and V of the module for points offset in voltage voltage VMPP+? and VMPP?? over the curve I(V) relative to the maximum power point MPP, calculating the slope dI/dV+ at the point VMPP+? and the slope dI/dV? at the point and VMPP?? and recording of the data with the MPP; for a periodicity n2?t0 with n2?n1 of > of steps of measuring values I and V by sweeping the curve I(V) and calculating and storing the module's parameters and values; one or several steps of calculating, tracing and displaying of (p/2) curves of data pairs based on p measured and calculated parameters; and one or more steps of detecting degradation from the measured and calculated parameters.Type: ApplicationFiled: December 16, 2022Publication date: February 13, 2025Applicants: ELECTRICITE DE FRANCE, INSTITUT PHOTOVOLTAIQUE D'ILE DE FRANCE (IPVF), TOTALENERGIES ONETECH, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, ECOLE POLYTECHNIQUEInventors: Jean-Baptiste PUEL, Arthur JULIEN, Jean-François GUILLEMOLES
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Patent number: 12220743Abstract: Equipment for selectively depositing, by shockwave-induced spraying, at least one particle on a deposition surface of a receiver substrate. The equipment including at least one laser source that emits a laser beam, a substrate carrier to which the substrate is fastened, a shockwave-generating layer having a first surface oriented toward the laser beam and a second surface oriented toward the deposition surface of the substrate, an optical system for directing and focusing the laser beam toward a focal region of the first surface. The second surface including a plurality of cavities, each cavity housing at least one particle. The laser beam generates a plasma in the focal region on the first surface and a shockwave that propagates within the generating layer from the first surface to the second surface in order to spray at least one particle in the direction of the deposition surface of the substrate.Type: GrantFiled: October 27, 2020Date of Patent: February 11, 2025Assignees: UNIVERSITE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, ECOLE NATIONALE SUPERIEURE D'ARTS ET METIERS, INSTITUT POLYTECHNIQUE DE BORDEAUXInventor: Robin Kromer
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Publication number: 20250040942Abstract: A medical device for penetrating an anatomic structure, e.g., a bone structure, including a processing unit programmed to execute one or more statistical algorithms, e.g., Bayesian-based perforation detection algorithms, with electrical conductivity measured during penetration of an anatomic structure as an input to detect a breach condition, e.g., a spinal canal perforation, based on the measured electrical conductivity. The medical device may include a drill bit having sensing capabilities coupled to the distal end of a robot arm via a power drill unit mounted on the robot arm. The power drill unit may cease transmission of rotary motion to the drill bit upon detection of the breach condition.Type: ApplicationFiled: July 25, 2024Publication date: February 6, 2025Applicants: SpineGuard, Sorbonne Universite, Centre National De La Recherche Scientifique-CNRS, INSERM (Institut National de la Sante et de la Recherche Medicale)Inventors: Lilyan LEBLANC, Brahim TAMADAZTE, Thibault CHANDANSON, Elie SAGHBINY
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Patent number: 12213486Abstract: A process for preparing a biocidal, bactericidal and/or bacteriostatic material including the preparation of a polymer precursor solution that has (a) at least one monomer A having a porphyrin group and at least one radical polymerizable function, (b) at least one radical polymerizable monomer B, a photoinitiator, and (c) at least one of the monomers chosen from a monomer C having a quaternary amine and a radical polymerizable function; and/or a monomer D having copper and a radical polymerizable function. Also, the material obtainable by the process and its uses.Type: GrantFiled: December 19, 2019Date of Patent: February 4, 2025Assignees: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (CEA), CONSERVATOIRE NATIONAL DES ARTS ET METIERS (CNAM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Thomas Berthelot, Céline Goulard-Huet, Fanny Hauquier
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Publication number: 20250034194Abstract: The present disclosure relates to lipid anionic oligosaccharides and to the uses thereof in medicine, especially in the treatment of the pathologies associated with abnormal hyperphosphorylation of tau protein, such as Alzheimer's disease.Type: ApplicationFiled: November 29, 2022Publication date: January 30, 2025Applicants: UNIVERSITE DE PICARDIE JULES VERNE, UNIVERSITE PARIS EST CRETEIL VAL DE MARNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Anne WADOUACHI, Dulce PAPY GARCIA, Gwladys POURCEAU, Sandrine CHANTEPIE
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Publication number: 20250034208Abstract: The present invention relates to novel peptides having the same motif LRIRX1TYX2, where X1 is selected from amino acids A or F; and X2 is selected from amino acids G or K. The present invention also relates to their use in the treatment of skin changes of various origins, to pharmaceutical and cosmetic compositions comprising them, and to a cosmetic method. More particularly, the treatment of said changes consists in reinforcing the dermal-epidermal junction, cell-matrix and/or cell-cell adhesion and cell migration in the epidermis, and in promoting the repair of the skin surface.Type: ApplicationFiled: September 20, 2022Publication date: January 30, 2025Applicants: LABORATOIRES D'ANJOU, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITÉ CLAUDE BERNARD LYON 1Inventor: Patricia ROUSSELLE
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Patent number: 12210076Abstract: The invention relates to a material for use as a pad in high field and/or very high field magnetic resonance imaging instrument, comprising at least one polar solvent having a melting point of 14° C. to 50° C., a dispersant and a dielectric charge. The invention relates also to a pad used in field of high field and/or very high field magnetic resonance imaging made of at least such a material.Type: GrantFiled: March 27, 2019Date of Patent: January 28, 2025Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, ECOLE CENTRALE DE MARSEILLE, UNIVERSITE D'AIX-MARSEILLE (AMU)Inventors: Abdeddaim Redha, Anne-Lise Adenot-Engelvin, Marc Dubois, Stefan Enoch, Nicolas Mallejac, Zo Raolison, Pierre Sabouroux, Alexandre Vignaud
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Patent number: 12202860Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.Type: GrantFiled: April 3, 2023Date of Patent: January 21, 2025Assignees: Institut National De La Sante Et De La Recherche Medicale (INSERM), Centre National De La Recherche Scientifique (CNRS), Ecole Normale Superieure De Lyon, Universite Claude Bernard Lyon 1Inventors: Théophile Ohlmann, Philippe Mangeot, Emiliano Ricci
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Publication number: 20250019748Abstract: The invention relates to a method for attaching nucleic acids to a platinum electrode, comprising the following steps: —a step (S1) of attaching an ethylenediamine molecule to the electrode, step (S1) comprising electro-oxidation of a primary amine from the ethylenediamine molecule by cyclic voltammetry, —a step (S2) of attaching a sulfo SMCC molecule of 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester to the ethylenediamine molecule, —a step (S3) of attaching a nucleic acid to the sulfo SMCC molecule, the nucleic acid having been modified beforehand to comprise a thiol function, the electrode being in contact with an aqueous solution, i.e. with a solution in which the solvent is water, during steps (S1), (S2) and (S3).Type: ApplicationFiled: November 30, 2022Publication date: January 16, 2025Applicants: UNIVERSITE PARIS-SACLAY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Jean GAMBY, Jeremy LE GALL, Djamila KECHKECHE, Claire POUJOULY
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Patent number: 12195437Abstract: The invention relates to compound of formula (I): in particular flavonoid derivatives (quercetin and catechin derivatives), for use in the prevention and/or the treatment of a disease or disorder involving both carbonyl and oxidative stresses.Type: GrantFiled: July 12, 2019Date of Patent: January 14, 2025Assignees: Centre National de la Recherche Scientifique (CNRS), Universite De Montpellier, Ecole Nationale Superieure de Chimie, Institut National de la Sante et de la Recherche Medicale (INSERM)Inventors: Céline Crauste, Espérance Moine, Philippe Brabet, Thierry Durand, Joseph Vercauteren
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Patent number: 12193864Abstract: The invention relates to a method for determining at least one property of an object, the method comprising a step of: a) obtaining first data relative to the object by an ultrasound imaging technique imaging the object at a frame rate superior to 300 Hz, characterized in that the method further comprises a step of: b) obtaining second data relative to the object by imaging the object with at least one of a X-ray and a ?-ray, and c) determining the at least one property of the object based on the first data and the second data.Type: GrantFiled: June 7, 2023Date of Patent: January 14, 2025Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, SORBONNE UNIVERSITE, UNIVERSITÉ PARIS CITÉ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, ASSISTANCE PUBLIQUE—HOPITAUX DE PARISInventors: Jean Provost, Anikitos Garofalakis, Mathieu Pernot, Mickaël Tanter, Bertrand Tavitian, Thomas Viel
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Patent number: 12188052Abstract: Method for preparing, in an insect cell, a recombinant baculovirus comprising one or more transgene(s) each encoding a protein maturation enzyme and n transgenes each encoding a polypeptide of interest, by homologous recombination between a replication deficient baculovirus genome which comprises one or more transgene(s) each encoding a protein maturation enzyme and n transfer vectors each comprising one of the n transgenes each encoding a polypeptide of interest, n being an integer at least equal to 2.Type: GrantFiled: October 25, 2018Date of Patent: January 7, 2025Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUEInventors: Martine Cerutti, Sylvie Juliant, Coralie Bernon
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Publication number: 20250006915Abstract: A process for preparing a compound of formula (NaOH)x[Fe(OH)2]yFeS, may include: (a) mixing iron and sodium sulfide in equimolar amounts, in an NaOH aqueous solution; (b) heating the obtained mixture up to a temperature in a range of from 110 to 210° C. for a duration in a range of from 1 hour to 1 week; and (c) recovering the active material by filtering and drying in a neutral atmosphere.Type: ApplicationFiled: September 21, 2022Publication date: January 2, 2025Applicants: AMPERE S.A.S., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Ecole Nationale Supérieure de Chimie de ParisInventors: Philippe BARBOUX, Mohamed CHAKIR, Domitille GIAUME, Ine HAUGLAND-GOSLING, Caroline MIR
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Publication number: 20250003980Abstract: Identification of at least one microorganism present in a sample based on the detection of peptides issued from the cleavage of ribosomal proteins of said microorganism, comprising lysis of microorganism(s) and cleavage of the proteins, obtaining a mixture of peptides, decomplexing the peptide mixture using a liquid separation device coupled with a mass spectrometer, nebulizing the liquid to produce an ion current, receiving the ion current from the ion source, executing on the ion current a series of filtering steps for detecting a transition, receiving data on the transitions, assigning the transitions associated with peptides into two or more contiguous groups, monitoring, and optionally generating a chromatogram or electropherogram, wherein the microorganism is identified according to the detection of said peptide(s).Type: ApplicationFiled: July 15, 2022Publication date: January 2, 2025Applicants: Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Ecole Normale Superieure de Lyon, Hospices Civils de LyonInventors: Jérôme LEMOINE, Maud GREGSON, Julie GIL, Romain CARRIERE, François VANDENESCH
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Publication number: 20250000428Abstract: A computer-implemented method for assisting a general anesthesia or a sedation of a subject, having receiving an electroencephalogram EEG signal of a subject, processing the EEG signal including ?-bands for defining for each instant of a plurality of instants, a part of the signal has in a time window having the instant, the part of the signal being related to the instant, determining for each instant, a distribution of a power of the part of the signal as a function of the frequency, determining for each instant a maximum power frequency as a frequency of maximum power in the distribution, the maximum power frequency being related to the instant, detecting a reference instant, so that the maximum power frequency as a function of time takes higher values before the reference instant than after, detecting in a time frame following the reference instant, an alpha instant corresponding to a first occurrence of a suppression of an ?-band, estimating a first parameter as the duration between the reference instType: ApplicationFiled: July 26, 2022Publication date: January 2, 2025Applicants: PARIS SCIENCES ET LETTRES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, NATIONAL INSTITUTE OF HEALTH AND MEDICAL RESEARCH, ASSISTANCE PUBLIQUE HÔPITAUX DE PARISInventors: David HOLCMAN, Matteo DORA, Christophe SUN
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Patent number: 12179187Abstract: Nanoparticles that can be used as hydrosilylation and dehydrogenative silylation catalysts. The nanoparticles have at least one transition metal with an oxidation state of 0, chosen from the metals of columns 8, 9 and 10 of the periodic table, and at least one carbonyl ligand, preferably a silicide.Type: GrantFiled: March 20, 2023Date of Patent: December 31, 2024Assignees: ELKEM SILICONES FRANCE SAS, UNIVERSITE CLAUDE BERNARD LYON I, CPE LYON FORMATION CONTINUE ET RECHERCHE—CPE LYON CFR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRSInventors: Valérie Meille, Chlóe Thieuleux, Laurent Veyre, Iurii Suleimanov, Thomas Galeandro-Diamant, Magali Bousquie
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Patent number: 12178790Abstract: Aspidin BB derivatives, compositions containing them, and methods of making and using them.Type: GrantFiled: August 5, 2021Date of Patent: December 31, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Jonathan Sorres, Véronique Eparvier
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Patent number: 12181415Abstract: A method for identifying a microorganism to be identified, which includes the following steps: obtaining an Excitation-Emission EEM of the microorganism to be identified, analysing the main components of the EEM matrix using at least one reference EEMr matrix, projecting the result of the analysis onto a plane defined by two main components, and identifying the microorganism to be identified.Type: GrantFiled: November 27, 2020Date of Patent: December 31, 2024Assignees: UNIVERSITE DU MANS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS-, CENTRE HOSPITALIER UNIVERSITAIRE D'ANGERS, UNIVERSITE D'ANGERSInventors: Jean-François Bardeau, Jean-Philippe Bouchara