Patents Assigned to Cepheid
  • METHOD FOR FABRICATING A REACTION VESSEL
    Publication number: 20140093430
    Abstract: A reaction vessel having a reaction chamber for holding a sample is fabricated by producing a housing having a rigid frame defining the minor walls of the chamber. The housing also defines a port for introducing fluid into the chamber. At least one sheet or film is attached to the rigid frame to form at least one major wall of the chamber. In preferred embodiments, two sheets or films are attached to opposite sides of the rigid frame to form two opposing major walls of the chamber, the major walls being connected to each other by the minor walls.
    Type: Application
    Filed: October 1, 2012
    Publication date: April 3, 2014
    Applicant: Cepheid
    Inventor: Cepheid
  • HONEYCOMB TUBE
    Publication number: 20140087958
    Abstract: A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate. The well chamber is in fluidic communication between the pre-amplification chamber and the fluidic outlet.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 27, 2014
    Applicant: CEPHEID
    Inventors: YUH-MIN CHIANG, DOUG DORITY, DUSTIN DICKENS, JENNIFER GLASS, REUEL VAN ATTA
  • Fluid processing and control
    Patent number: 8673238
    Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: March 18, 2014
    Assignee: Cepheid
    Inventors: Douglas Dority, Ronald Chang
  • DNA recombination junction detection
    Patent number: 8652784
    Abstract: The present invention provides methods, compositions and kits for detecting the presence or absence of an integrated insertion polynucleotide.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: February 18, 2014
    Assignee: Cepheid
    Inventors: Jian Ping Zhang, Ernest Jay Friedlander, Robert Ruhfel, David Douglas Swenson, Alan Thomas Wortman
  • METHOD AND APPARATUS FOR STORING AND DISPENSING REAGENT BEADS
    Publication number: 20140030817
    Abstract: Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In one embodiment, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge.
    Type: Application
    Filed: March 25, 2013
    Publication date: January 30, 2014
    Applicant: Cepheid
    Inventor: Cepheid
  • REMOTE MONITORING OF MEDICAL DEVICES
    Publication number: 20140025809
    Abstract: A remote monitoring system for medical data collection can include a data-flagging process embeds authorization and settings information into a file containing the test results. Such data flagging can occur at a medical device or testing site, and may be based in policy settings received from a remote system. A file containing the test results can also include data category information that can be used to protect sensitive information by preventing such information from being communicated to the wrong server.
    Type: Application
    Filed: March 14, 2013
    Publication date: January 23, 2014
    Applicant: CEPHEID
    Inventor: Jan Steuperaert
  • FLUID PROCESSING AND CONTROL
    Publication number: 20140004621
    Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.
    Type: Application
    Filed: April 1, 2013
    Publication date: January 2, 2014
    Applicant: Cepheid
    Inventors: DOUGLAS DORITY, Ronald Chang
  • Method for separating an analyte from a sample
    Patent number: 8592157
    Abstract: An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: November 26, 2013
    Assignee: Cepheid
    Inventors: Kurt E. Petersen, William A. McMillan, Lee A. Christel, Ronald Chang, Farzad Pourahmadi, Jesus Ching, Gregory T. A. Kovacs, M. Allen Northrup
  • Device for extracting nucleic acid from a sample
    Patent number: 8580559
    Abstract: The present invention provides a cartridge for analyzing a fluid sample. The cartridge provides for the efficient separation of cells or viruses in the sample from the remaining sample fluid, lysis of the cells or viruses to release the analyte (e.g., nucleic acid) therefrom, and optionally chemical reaction and/or detection of the analyte. The cartridge is useful in a variety of diagnostic, life science research, environmental, or forensic applications for determining the presence or absence of one or more analytes in a sample.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: November 12, 2013
    Assignee: Cepheid
    Inventors: Kurt E. Petersen, Michael T. Taylor, Farzad Pourahmadi, William A. McMillan, Ronald Chang, Stanley H. Sakai, Jesus Ching, Douglas B. Dority, Phillip Belgrader, M. Allen Northrup
  • Polar dyes
    Patent number: 8546590
    Abstract: The present invention relates to novel polar fluorescent and quenchers dyes, and minor groove binder with enhanced polarity. The present invention further relates to methods of preparing oligonucleotide probes labeled with polar arsonate dyes under the condition of automated synthesis and method of using such probes.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: October 1, 2013
    Assignee: Cepheid
    Inventor: Alexander A. Gall
  • COMPOSITION, APPARATUS, AND METHOD FOR SEPARATING AN ANALYTE FROM A SAMPLE
    Publication number: 20130236907
    Abstract: An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.
    Type: Application
    Filed: April 12, 2013
    Publication date: September 12, 2013
    Applicant: CEPHEID
    Inventors: Kurt E. PETERSEN, William A. McMillan, Lee A. Christel, Ronald Chang, Farzad Pourahmadi, Jesus Ching, Gregory T.A. Kovacs, M. Allen Northrup
  • COMPOSITION, APPARATUS, AND METHOD FOR SEPARATING AN ANALYTE FROM A SAMPLE
    Publication number: 20130220931
    Abstract: An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.
    Type: Application
    Filed: April 12, 2013
    Publication date: August 29, 2013
    Applicant: CEPHEID
    Inventor: CEPHEID
  • Fluid processing and control
    Patent number: 8431413
    Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: April 30, 2013
    Assignee: Cepheid
    Inventors: Douglas B. Dority, Ronald Chang
  • METHODS OF DETECTING SEPSIS
    Publication number: 20130084343
    Abstract: Methods of sepsis in a sample from a patient are provided. Methods of detecting changes in expression of one or more RNAs associated with sepsis are also provided. Compositions and kits are also provided.
    Type: Application
    Filed: September 14, 2012
    Publication date: April 4, 2013
    Applicant: CEPHEID
    Inventors: David Vilanova, Olivier Delfour
  • REAGENT RESERVOIR SYSTEM FOR ANALYTICAL INSTRUMENTS
    Publication number: 20130084631
    Abstract: The invention provides a reagent reservoir system and disposable reaction cassettes using the same. In one aspect, such system comprises a chamber in which dried reagent, particularly lyophilized reagent, is constrained to remain in a defined region of the chamber by a retaining member that obstructs passage of such reagents to other regions of the chamber where they may escape hydration or activation.
    Type: Application
    Filed: April 27, 2012
    Publication date: April 4, 2013
    Applicant: Cepheid
    Inventors: Reuel Van Atta, Dias Lourenco Francisco
  • Apparatus for storing and dispensing reagent beads
    Patent number: 8409530
    Abstract: Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In some embodiments, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: April 2, 2013
    Assignee: Cepheid
    Inventors: Ronald Chang, Douglas B. Dority, Steve Montgomery
  • Method and apparatus for storing and dispensing reagent beads
    Patent number: 8409531
    Abstract: Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In some embodiments, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: April 2, 2013
    Assignee: Cepheid
    Inventors: Ronald Chang, Douglas B. Dority, Steve Montgomery
  • DNA RECOMBINATION JUNCTION DETECTION
    Publication number: 20130065774
    Abstract: The present invention provides methods, compositions and kits for detecting the presence or absence of an integrated insertion polynucleotide.
    Type: Application
    Filed: April 25, 2012
    Publication date: March 14, 2013
    Applicant: Cepheid
    Inventors: Jian Ping Zhang, Ernest Jay Friedlander, Robert Ruhfel, David Douglas Swenson, Alan Thomas Wortman
  • Analysis system
    Patent number: D684270
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: June 11, 2013
    Assignee: CEPHEID
    Inventors: Ron Chang, Steven M. Montgomery, Gregory E. Mote
  • Analysis system
    Patent number: D690023
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: September 17, 2013
    Assignee: Cepheid
    Inventors: Ron Chang, Steven M. Montgomery, Gregory E. Mote