Patents Assigned to Children's National Medical Center
  • Patent number: 11389686
    Abstract: Systems, apparatuses, and methods for performing robotically assisted physical therapy. The system, apparatus, and method can include a motion platform having three-degrees of freedom to achieve pitch motion, yaw motion, and roll motion; a plurality of motors connected to the motion platform to enable the pitch motion, the yaw motion, and/or the roll motion; at least one sensor configured to collect data relating to position and/or motion of the motion platform; and a motion controller configured to control the motion platform based on the collected data and/or external commands.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: July 19, 2022
    Assignee: CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Kevin Cleary, Sarah Evans, Reza Monfaredi, Hadi F. Talari, Catherine Coley
  • Publication number: 20220185909
    Abstract: Disclosed are Synovial Sarcoma X breakpoint 2 binding molecules and methods for their use in the detection and treatment of cancer.
    Type: Application
    Filed: December 16, 2021
    Publication date: June 16, 2022
    Applicants: CHILDREN'S NATIONAL MEDICAL CENTER, THE GEORGE WASHINGTON UNIVERSITY, UNIVERSITAT DES SAARLANDES
    Inventors: Eric YVON, Catherine BOLLARD, Stacey VAN PELT, Scott RASKIN, Gerhard HELD, Christine STURM, Michael PFREUNDSCHUH
  • Patent number: 11344463
    Abstract: A delayed cord-clamping surface is provided that includes a newborn platform having a recessed surface configured to receive a chemical warming mattress, where the chemical warming mattress includes a conformable surface, where the newborn platform includes a detachable platform support that is configured to position the newborn platform proximal to a surgical region of a C-section patient, where the newborn platform is configured to support a newborn baby while an umbilical cord remains connected between the newborn and the C-section patient for draining from a placenta, where the newborn platform is configured to fitably mount with a warming table when the newborn platform is in a detached state from the detachable platform support.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: May 31, 2022
    Assignee: Children's National Medical Center
    Inventors: Jules P. Sherman, Douglas F. Schwandt, Chris A. Rothe
  • Patent number: 11344180
    Abstract: The present disclosure relates to an apparatus and method for correcting rotational error during use of an oblique-viewing endoscope. Specifically, the present disclosure relates to a fast calibration process wherein a new approach is employed in estimating a center of rotation of a plane of an image. Moreover, the approach, allows for updating of a camera matrix during use.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: May 31, 2022
    Assignee: CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Raj Shekhar, Xinyang Liu
  • Publication number: 20220160767
    Abstract: The disclosure relates to methods of culturing and expanding CD4+ and/or CD8+ T cells in culture. In some embodiments, the methods include expanding, proliferating and storing lymphocytes in tissue culture by exposing the lymphocytes to a combination of cytokines and/or nucleic acids expressing cytokines or functional fragments or variants thereof. The disclosure further relates to methods of generating and manufacturing CD4+ and/or CD8+ T cells that are specific to one or a plurality of viral antigens.
    Type: Application
    Filed: November 30, 2021
    Publication date: May 26, 2022
    Applicant: CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Patrick HANLEY, Christopher LAZARSKI, Michael KELLER, Catherine BOLLARD
  • Publication number: 20220160929
    Abstract: The present disclosure relates to a biocompatible composition comprising a solution of low molecular weight polymer and high molecular weight polymer. The present disclosure also relates to biocompatible compositions comprising poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG), and additionally including a suspension of silica particles and/or a therapeutic agent. The present disclosure is also directed to biocompatible polymer fiber constructs formed from the disclosed compositions, methods of fabrication thereof, and uses of such constructs and compositions.
    Type: Application
    Filed: March 10, 2020
    Publication date: May 26, 2022
    Applicants: University of Maryland, College Park, Children's National Medical Center
    Inventors: John Daristotle, Shadden Zaki, Peter Kofinas, Anthony Sandler, Lung Lau, Leopoldo Torres
  • Patent number: 11337726
    Abstract: The present disclosure relates to devices used to access the pericardial space of the heart. In particular, the present disclosure describes an apparatus to enable an operator to access the pericardial space of the heart, and deliver cardiac therapies to the pericardial space, under direct visualization through a single, small incision.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: May 24, 2022
    Assignee: CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Justin Opfermann, Charles Berul, Bradley Clark, Axel Krieger, Rohan Kumthekar, Paige Mass, Austeja Staneviciute
  • Patent number: 11337612
    Abstract: Described herein is a system and method for determining characteristics of a wound. The system includes a first imaging sensor that obtains imaging information of a wound area and a second imaging sensor that obtains topology information of the wound area.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: May 24, 2022
    Assignee: CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Kyle Wu, Peng Cheng, Peter Kim, Ozgur Guler
  • Patent number: 11320441
    Abstract: The invention relates to isolation of adipocyte-derived exosomes from a biological sample, as well as methods, compositions and kits for detecting an obesity-related disorder, for detecting risk of having an obesity-related disorder, for screening or identifying a therapy for an obesity-related disorder, for screening or identifying a therapeutic agent for an obesity-related disorder, and for treating or preventing an obesity-related disorder.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: May 3, 2022
    Assignee: CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Robert J. Freishtat, Evan Nadler, Monica Hubal, Sarah Ferrante
  • Publication number: 20220117476
    Abstract: The present disclosure relates to non-invasive nerve identification using snapshot polarimetry. The present disclosure further relates to a system for nerve identification, the system comprising a camera including a sensor, and a filter having a linear polarizer array, an illumination system configured to illuminate a target area with polarized light illumination, the polarized light illumination having at least one predetermined polarization angle, the illumination system including one more light sources, and one or more polarizer filters, and a processor configured to process imaging data obtained from the camera, and output a birefringence map of the target area including indicia of a nerve structure.
    Type: Application
    Filed: January 31, 2020
    Publication date: April 21, 2022
    Applicant: CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Jaepyeong CHA, Bo NING
  • Publication number: 20220098278
    Abstract: The present invention relates to compositions and their use in methods of protecting and maintaining oligodendrocytes, and of treating demyelinating disorders
    Type: Application
    Filed: September 30, 2021
    Publication date: March 31, 2022
    Applicants: Oncolmmune, Inc., Children's National Medical Center
    Inventors: Yang Liu, Pan Zheng, Martin Devenport, Ning Li
  • Publication number: 20220090082
    Abstract: SARS-CoV-2 causes pandemic COVID19. Developing an effective treatment to directly target the virus could significantly impact viral burden in those most vulnerable to the devastating effects of this virus. The invention provides antisense oligonucleotides (AOs) to target the single stranded RNA genome of the SARS-CoV-2 viruses. The administration of AOs can significantly reduce the target viral RNAs.
    Type: Application
    Filed: September 10, 2021
    Publication date: March 24, 2022
    Applicant: CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Yi-Wen CHEN, Alexander E. LIU
  • Patent number: 11261233
    Abstract: This invention relates to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy. Specifically, the disclosure provides a CTLA-4 protein comprising a mutant extracellular domain of CTLA-4, wherein the CTLA-4 protein exhibits reduced binding to an anti-CTLA-4 antibody as compared to a wild-type extracellular domain of CTLA-4, wherein the anti-CTLA-4 antibody has anti-cancer immunotherapeutic activity.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: March 1, 2022
    Assignees: ONCOC4, INC., CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Yang Liu, Pan Zheng, Martin Devenport, Wei Wu, Xuexiang Du, Mingyue Liu, Fei Tang
  • Publication number: 20210380943
    Abstract: Safe, rapid, and efficient methods for producing antigen-specific T cells recognizing human papilloma virus (HPV antigens); HPV-specific T cells, and methods for treating HPV infections and HPV-related malignancies by adoptive transfer of HPV-specific T cells.
    Type: Application
    Filed: August 17, 2021
    Publication date: December 9, 2021
    Applicant: CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Catherine BOLLARD, Conrad CRUZ, Patrick HANLEY
  • Publication number: 20210371852
    Abstract: The present disclosure relates, at least in part, to a closed and semi-automated system for the isolation of naive T cells, their expansion, and/or final harvest. The disclosure also relates to using those isolated cells in a large batch format for compiling stocks of stimulated CD45A+ T cells and/or using the stimulated CD45A+ T cells for therapeutic purposes.
    Type: Application
    Filed: May 20, 2019
    Publication date: December 2, 2021
    Applicant: CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Catherine Mary Bollard, Conrad Russell Y. Cruz, Patrick Hanley
  • Patent number: 11135028
    Abstract: A method is provided for making an appendage of a soft surgical tool, including: receiving a set of mechanical constraints for a surgical procedure; calculating a set of articulation states based on the set of mechanical constraints; generating a plurality of print commands for printing an appendage configured to form the set of articulation states based on the calculation; and printing an appendage based on the plurality of print commands. Multiple printed appendages can be formed into an orienting assembly.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: October 5, 2021
    Assignee: CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Peter C. Kim, Justin D. Opfermann, Axel Krieger
  • Publication number: 20210282654
    Abstract: A visualization system, an apparatus, and a visualization method are provided. The visualization system includes a laparoscope, a camera operatively coupled to the laparoscope, a light source operatively coupled to an illumination port of the laparoscope, and processing circuitry. The light source is configured to output one or more light beams each at a predetermined frequency to illuminate a target area. The processing circuitry is configured to process imaging data from the laparoscope received by the camera to generate one or more images of the target area including at least one laser speckle contrast image. The laparoscope is configured to output the one or more light beams toward the target area at a distal end thereof and to collect reflected and/or scattered light from the target area via the distal end.
    Type: Application
    Filed: June 28, 2019
    Publication date: September 16, 2021
    Applicant: CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Jaepyeong CHA, Corey ZHENG, Lung Wai LAU
  • Patent number: 11116726
    Abstract: A liposomal drug formulation for treating a disease in a patient characterized by overexpression of HIF-1? and/or HIF-2? includes a plurality of liposomes in a pharmaceutically acceptable carrier. The liposomes encapsulate echinomycin and are made from a peglyated phospholipid, a neutral phosphoglyceride, and a sterol. The PEGylated liposomes may be used to treat proliferative diseases, leukemia, cancer, autoimmune diseases and graft-versus-host disease.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: September 14, 2021
    Assignee: CHILDRENS RESEARCH INSTITUTE, CHILDRENS NATIONAL MEDICAL CENTER
    Inventors: Yang Liu, Yin Wang, Yan Liu, Christopher Bailey, Pan Zheng
  • Publication number: 20210277355
    Abstract: Safe, rapid and efficient methods for producing virus-specific or other antigen-specific T-cells from cord blood and other samples containing naive immune cells.
    Type: Application
    Filed: May 26, 2021
    Publication date: September 9, 2021
    Applicant: CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Catherine BOLLARD, Conrad CRUZ, Patrick HANLEY
  • Publication number: 20210213066
    Abstract: The present disclosure provides for isolated and processed cell therapeutic compositions and Methods of using those compositions for the treatment of a patient undergoing a hematopoietic stem cell transplant (HSCT). In some embodiments, the disclosure provides for methods of making these cells by exposing the isolated T cell populations to one or more tumor antigens.
    Type: Application
    Filed: May 20, 2019
    Publication date: July 15, 2021
    Applicant: CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Catherine Mary Bollard, Conrad Russell Y. Cruz, Patrick Hanley