Patents Assigned to Children's National Medical Center
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Publication number: 20250032755Abstract: A securement assembly for a medical catheter inserted into a human body, including an assembly body and a domed cap removably coupled to the assembly body, the domed cap having a first half and an opposing second half, the first half and the second half being coupled together to form a channel inside the domed cap terminating at an opening in the domed cap, the channel being configured to secure the medical catheter, and the assembly body securing an area of the human body surrounding the insertion site of the medical catheter.Type: ApplicationFiled: December 9, 2022Publication date: January 30, 2025Applicant: Children's National Medical CenterInventors: Anthony SANDLER, Reza MONFAREDI, Michele SARUWATARI
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Publication number: 20250025509Abstract: A method for improving neurobehavioral outcomes in neonates or infants undergoing cardiac bypass surgery by administering BM-MSCs, BM-MSC derived exosomes, or BM-MSC miRNA into CPB bypass circuit. Compositions comprising BM-MSCs or their products such as exosomes or miRNA are also aspects of the invention as is a kit suitable for performing the methods disclosed herein.Type: ApplicationFiled: September 29, 2023Publication date: January 23, 2025Applicant: CHILDREN'S NATIONAL MEDICAL CENTERInventor: Nobuyuki ISHIBASHI
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Patent number: 12168046Abstract: The present disclosure relates, at least in part, to mycobacterial polynucleotides and polypeptides, to fragments or variants thereof, to cells comprising the mycobacterial polynucleotides and polypeptides, to cells comprising the mycobacterial polynucleotides and polypeptides, that are engineered to expand T-cells ex vivo, and to methods of use thereof.Type: GrantFiled: April 26, 2019Date of Patent: December 17, 2024Assignee: Children's National Medical CenterInventors: Michael Keller, Catherine Bollard, Patrick Hanley, Conrad Russell Cruz, Haili Lang, Shabnum Patel
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Patent number: 12163132Abstract: SARS-CoV-2 causes pandemic COVID19. Developing an effective treatment to directly target the virus could significantly impact viral burden in those most vulnerable to the devastating effects of this virus. The invention provides antisense oligonucleotides (AOs) to target the single stranded RNA genome of the SARS-CoV-2 viruses. The administration of AOs can significantly reduce the target viral RNAs.Type: GrantFiled: September 10, 2021Date of Patent: December 10, 2024Assignee: CHILDREN'S NATIONAL MEDICAL CENTERInventors: Yi-Wen Chen, Alexander E. Liu
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Patent number: 12156708Abstract: The present disclosure provides a system and method for controlling an articulating member including a tool. The method includes determining a first confidence indicator based on a manual control mode for the articulating member, determining a second confidence indicator based on an autonomous control mode for the articulating member, generating an allocation function based on the first confidence indicator and the second confidence indicator, and generating a control command for the articulating member based on the allocation function.Type: GrantFiled: May 16, 2019Date of Patent: December 3, 2024Assignees: UNIVERSITY OF MARYLAND, COLLEGE PARK, THE JOHN HOPKINS UNIVERSITY, CHILDREN'S NATIONAL MEDICAL CENTERInventors: Hamed Saeidi, Axel Krieger, Simon Leonard, Justin Opfermann
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Patent number: 12150713Abstract: The present disclosure provides a system and method for controlling an articulating member including a tool. The system may include a dual camera system that captures near-infrared (NIR) images and point cloud images of a tissue or other substance that includes NIR markers. The system may generate a three-dimensional (3D) path based on identified positions of the NIR markers, may filter the generated path, and may generate a 3D trajectory for controlling the articulated arm of a robot having a tool to create an incision along the filtered path. In a shared control mode, an operator may generate manually control commands for the robot to guide the tool along such a path, while automated control commands are generated in parallel. One or more allocation functions may be calculated based on calculated manual and automated error models, and shared control signals may be generated based on the allocation functions.Type: GrantFiled: November 16, 2020Date of Patent: November 26, 2024Assignees: UNIVERSITY OF MARYLAND, COLLEGE PARK, THE JOHNS HOPKINS UNIVERSITY, CHILDREN'S NATIONAL MEDICAL CENTERInventors: Hamed Saeidi, Axel Krieger, Simon Leonard, Justin Opfermann, Michael Kam
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Publication number: 20240374189Abstract: A method for predicting a severity and appearance of renal obstruction, including receiving, via processing circuitry, a plurality of medical images corresponding to a kidney of a patient, identifying, the kidney in the plurality of medical images, selecting, at least one relevant image from the plurality of medical images based on a relationship to renal function, standardizing the at least one relevant image, determining, via a deep learning model at least one risk score based on the at least one relevant image, and determining, a final ultrasound-based risk score based on the at least one risk score, wherein the final ultrasound-based risk score is a determination of renal obstruction and/or a probability of renal obstruction.Type: ApplicationFiled: April 11, 2022Publication date: November 14, 2024Applicant: CHILDREN'S NATIONAL MEDICAL CENTERInventors: Marius George LINGURARU, Pooneh ROSHANITABRIZI, Hans G. POHL
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Publication number: 20240366081Abstract: A laryngoscope, including a blade having a flat top surface and a bottom surface extending from a base of the blade and a first vertical projection and a second vertical projection at the base of the blade extending from the bottom surface of the blade and a connector configured to couple to a handle of the laryngoscope and further configured to couple to the base of the blade via a first opening configured to receive the first vertical projection and a second opening configured to receive the second vertical projection, wherein the base of the blade and a first portion of the blade are transparent or translucent and a second portion of the blade is opaque, and the base of the blade further includes a cutout aligned with a channel in the connector between the first opening and the second opening when the blade is coupled to the connector.Type: ApplicationFiled: May 6, 2024Publication date: November 7, 2024Applicant: Children's National Medical CenterInventors: Louis Marmon, Marjorie Brennan, Niya Khanjar, Catherine Schilling, Dhatri Saamak, Joseph Lipari, Zain Shamsuddin
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Publication number: 20240342450Abstract: A solution blow spin device includes a syringe pump assembly, an airbrush adapter, and a handle base. The syringe pump assembly, airbrush adapter, and handle base are reversibly coupled to one another and configured to work in tandem to address wound dressing using a polymer solution and autologous skin cell suspension co-spray. The airbrush adapter includes multiple nozzles for deposition of multiple solutions sequentially or simultaneously in order to improve would dressing efficacy. The syringe pump assembly includes multiple syringes holding the multiple solutions, and the syringes can be emptied by individually addressable lead screws configured to translate blocks to depress syringe plungers when the lead screws are rotated via corresponding actuators.Type: ApplicationFiled: April 17, 2024Publication date: October 17, 2024Applicants: Children's National Medical Center, University of Maryland, College ParkInventors: Anthony Sandler, Reza Monfaredi, Tyler Salvador, Michele Saruwatari, Peter Kofinas
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Publication number: 20240316329Abstract: Aspects of the disclosure provide a connection protector and a securement system including the connection protector. For example, the connection protector can include a first cover portion and a second cover portion, a combination of which forms an internal compartment configured to enclose a connection point of a first conveying device and a second conveying device. A hinge can be coupled to first sides of the first and second cover portions, enabling the first and second cover portions to be in open or close position. Two openings can be formed on both ends of the first and second cover portions, allowing the first and second conveying devices to pass therethrough, respectively. A first tamper-proof locking assembly attached to second sides of the first and second cover portions, the first tamper-proof locking assembly configured to lock the first cover portion to the second cover portion.Type: ApplicationFiled: December 23, 2021Publication date: September 26, 2024Applicant: CHILDREN'S NATIONAL MEDICAL CENTERInventors: Lori IRVIN, Jules SHERMAN
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Publication number: 20240285215Abstract: A method for extracting a fetal electrocardiogram (ECG). comprising determining, via processing circuitry, a coherence between a maternal ECG and an abdominal ECG, attenuating, via the processing circuitry, the maternal ECG independent of the coherence, and extracting, via the processing circuitry, the fetal ECG from the abdominal ECG based on the coherence and the attenuated maternal ECG.Type: ApplicationFiled: October 14, 2022Publication date: August 29, 2024Applicant: CHILDREN'S NATIONAL MEDICAL CENTERInventors: Anita KRISHNAN, Rathinaswamy B. GOVINDAN, Pooneh ROSHANITABRIZI
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Publication number: 20240268752Abstract: A method for determining a burn percentage of a patient, including presenting, via processing circuitry, an image of at least one segment of a body, receiving, via the processing circuitry, a burn indication representing areas within the at least one segment of the body that have sustained a burn, determining, via the processing circuitry, a burned percentage of the at least one segment of the body based on the burn indication, determining, via the processing circuitry, a surface area of the at least one segment of the body based on an age of the patient and a weight of the patient, and determining, via the processing circuitry, the burn percentage of the patient based on the burned percentage of the at least one segment of the body and the surface area of the at least one segment of the body.Type: ApplicationFiled: June 9, 2022Publication date: August 15, 2024Applicant: CHILDREN'S NATIONAL MEDICAL CENTERInventor: Cindy COLSON
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Publication number: 20240238164Abstract: A gastrostomy tube for insertion through an abdomen and into a stomach, including a cylindrical outer tube including a first proximal opening and a first distal opening, a flange surrounding the first proximal opening of the outer tube, a detachable cylindrical inner tube including a second proximal opening and a second distal opening, and one or more spokes attached to a distal end of the gastrostomy tube, wherein the one or more spokes include an actuatable portion configured to rotate the one or more spokes between a retracted position and an expanded position, wherein the inner tube is insertable into the first proximal opening of the outer tube, wherein the one or more spokes are rotatable into the expanded position when the inner tube is inserted through the first distal opening of the outer tube, and wherein the one or more spokes are substantially perpendicular to the outer tube in the expanded position.Type: ApplicationFiled: May 24, 2022Publication date: July 18, 2024Applicant: CHILDREN'S NATIONAL MEDICAL CENTERInventors: Mihika AEDLA, Karun SHARMA, Siya ZHANG, Jason QIAN, Charlotte CHENG, Jocelyn HSU, Anson ZHOU, Katherine HU, Kevin SOMPEL
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Publication number: 20240216507Abstract: The invention pertains to a method for preventing or treating SARS-CoV-2 infection by administering SARS-CoV-2 specific T cells which recognize particular peptide epitopes in SARS-CoV-2 spike (S), nucleocapsid (N), membrane, and envelope proteins.Type: ApplicationFiled: March 22, 2021Publication date: July 4, 2024Applicant: CHILDREN'S NATIONAL MEDICAL CENTERInventors: Catherine BOLLARD, Michael KELLER, Chris LAZARSKI, Allistair ABRAHAM, Patrick HANLEY, Conrad Russell Y. CRUZ
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Publication number: 20240188657Abstract: The present disclosure relates to an isolation gown. In particular, the present disclosure relates to an isolation gown, comprising a garment body including opening running a length of the garment body and terminating at a neck opening, the garment body having a first side and a second side and being configured to permit a wearer to don the medical gown, sleeves extending distally from the garment body, and one or more restraining mechanisms configured to secure the garment body, the sleeves, or a combination thereof, to a body of the wearer, wherein the one or more restraining mechanisms including an actuatable portion utilizing friction to allow the neck opening of the garment body to be contracted to a size of a neck of the wearer, and expanded to be larger than a shoulder width of the wearer.Type: ApplicationFiled: March 30, 2022Publication date: June 13, 2024Applicant: CHILDREN'S NATIONAL MEDICAL CENTERInventors: Xiaoyan SONG, Jules SHERMAN, Rahul K. SHAH
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Patent number: 11999967Abstract: Safe, rapid and efficient methods for producing antigen-specific T cells recognizing human papilloma virus or HPV antigens.Type: GrantFiled: February 5, 2021Date of Patent: June 4, 2024Assignee: CHILDREN'S NATIONAL MEDICAL CENTERInventors: Catherine M. Bollard, Conrad Russell Cruz, Patrick J. Hanley, Michael Keller
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Patent number: 11986254Abstract: The disclosed apparatus comprises an intravascular sheath and dilator that can be placed over a guidewire after percutaneous vascular access. One or more electrodes are positioned axially at or near the distal end of the dilator, facilitating guidance of the sheath to the heart without fluoroscopy (i.e., by using electrical and/or magnetic guidance). The electrodes are in electrical conductance with leads via wires that extending proximally from the electrodes on or through the wall of the dilator or sheath.Type: GrantFiled: March 7, 2018Date of Patent: May 21, 2024Assignee: Children's National Medical CenterInventors: Jeffrey P. Moak, Henry Blicharz
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Patent number: 11986315Abstract: The present disclosure is related to a method and apparatus for determining THC usage of a person. The present disclosure describes acquiring a video sequence, of an eye of a patient, the video sequence being a plurality of video frames, determining a frequency spectrum from a pupillary data of the video sequence, and determining, based on the frequency spectrum, the physiological characteristic or drug of use of the patient. In an embodiment, at least one frequency can be probed based on which physiological characteristic is being explored. For example, the physiological characteristic can be ?#-tetrahydrocannabinol, and the at least one frequency probed can be selected to be specific to ?#-tetrahydrocannabinol.Type: GrantFiled: January 15, 2019Date of Patent: May 21, 2024Assignee: CHILDREN'S NATIONAL MEDICAL CENTERInventor: Julia C. Finkel
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Patent number: 11931465Abstract: Combination treatment with Prussian blue nanoparticles and at least one immunotherapeutic treatment. Stable, functionalized Prussian blue nanoparticles, including those with enhanced stability under alkaline conditions, and methods of cancer, neoplasm, and tumor treatment using them, including photothermal treatment and combination immunotherapeutic treatments.Type: GrantFiled: March 8, 2017Date of Patent: March 19, 2024Assignee: Children's National Medical CenterInventors: Rohan Fernandes, Raymond W. Sze, Conrad Russell Y. Cruz, Anthony D. Sandler, Catherine M. Bollard, Elizabeth E. Sweeney, Juliana Cano-Mejia, Rachel Burga, Matthieu F. Dumont
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Patent number: 11931171Abstract: The present disclosure is related to a method and apparatus for determining drug usage or a physiological characteristic of a patient. The present disclosure describes acquiring a video sequence, of an eye of a patient, the video sequence being a plurality of video frames, determining a frequency spectrum from a pupillary data of the video sequence, and determining, based on the frequency spectrum, the physiological characteristic or drug of use of the patient. In an embodiment, at least one frequency can be probed based on which physiological characteristic is being explored.Type: GrantFiled: January 15, 2019Date of Patent: March 19, 2024Assignee: CHILDREN'S NATIONAL MEDICAL CENTERInventor: Julia C. Finkel