Abstract: The present invention provides compositions and methods of treating hyperphenylalaninemia (e.g., phenylketonuria) in a subject in need thereof comprising administering to the subject an effective amount of a phenylalanine dehydrogenase (PheDH) polypeptide. The present invention also provides pharmaceutical formulations comprising PheDH for lowering the phenylalanine concentration in the subject (e.g., in the intestines and/or blood).

Abstract: The purpose of the “Dissolvable on-command Implant” is to act as a pressure equalizer tube in the eardrum, which has the unique characteristic that the tube can be dissolved with a specially formulated drop solution on-command. This tube can have various shapes and sizes, although the tube is usually a cylindrical tube with a hollow center, which maintains a ventilatory port for the middle ear space. With this design, the ear tube promotes drainage of middle ear fluid, lets air enter the middle ear, and allows for instillation of antibiotic drops.

Abstract: The present invention relates to a CD24 protein for treating immune-related adverse events (irAEs) associated with cancer immunotherapy. Provided herein is a method of treating, mitigating, minimizing, or preventing immunerelated adverse events (irAEs) associated with a cancer immunotherapy by administering a CD24 protein to a subject in need thereof. The irAE may be diarrhea or another gastrointestinal disorder, pure red cell aplasia, microcytic anemia, lupus, autoimmune nephritism, autoimmune hepatitis, pneumonitis, myocarditis, pericarditis, endocrinopathy, Addison's disease, hypogonadism, Sjogren's syndrome, or type I diabetes. The CCD24 protein may comprise a mature human CD24 or a variant thereof.

Abstract: The present disclosure relates to a tracking system for augmented reality in a clinical setting. Specifically, the present disclosure relates to an approach for combining hardware-based tracking and computer vision-based tracking in order to accurately overlay a projected image onto a video image.

Abstract: The present invention relates to compositions and their use in methods of protecting and maintaining oligodendrocytes, and of treating demyelinating disorders

Abstract: The present disclosure relates to an apparatus and method for intubation. The present disclosure relates to an image-guided laryngoscope comprising a housing having a translational assembly, a primary blade coupled to a distal end of the housing and having a channel, a camera assembly having an image capture device, a display holder coupled to a proximal end of the housing and configured to hold a display, and an endotracheal tube configured to translate within the channel of the primary blade.

Abstract: Described herein are an apparatus and methods for automating subtasks in surgery and interventional medical procedures. The apparatus consists of a robotic positioning platform, an operating system with automation programs, and end-effector tools to carry out a task under supervised autonomy. The operating system executes an automation program, based on one or a fusion of two or more imaging modalities, guides real-time tracking of mobile and deformable targets in unstructured environment while the end-effector tools execute surgical interventional subtasks that require precision, accuracy, maneuverability and repetition. The apparatus and methods make these medical procedures more efficient and effective allowing a wider access and more standardized outcomes and improved safety.

Abstract: The disclosure relates to compositions comprising a nucleic acid sequence having two domains: a cell targeting domain and a microRNA domain, wherein the cell targeting domain comprises an aptamer sequence that targets cancer cells and the microRNA domain comprises a microRNA sequence that binds to an endogenous mRNA sequence within a cancer cell and disrupts normal function of the cell.

Abstract: Combination treatment with Prussian blue nanoparticles and at least one immunotherapeutic treatment. Stable, functionalized Prussian blue nanoparticles, including those with enhanced stability under alkaline conditions, and methods of cancer, neoplasm, and tumor treatment using them, including photothermal treatment and combination immunotherapeutic treatments.

Abstract: The present disclosure relates to devices used to access the pericardial space of the heart. In particular, the present disclosure describes an apparatus to enable an operator to access the pericardial space of the heart, and deliver cardiac therapies to the pericardial space, under direct visualization through a single, small incision.

Abstract: The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perfluorinated membrane that comprises an ionomer in contact with an alkali buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care bio sensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.

Abstract: The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflurinated membrane that comprises an ionomer in contact with an alkali buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care bio sensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.

Abstract: Methods for treating learning disabilities associated with fetal alcohol syndrome and other neurological disorders by administering SK channel blockers, antagonists, inhibitors or modifiers like tamapin.

Abstract: Described herein is an apparatus and method for generating a pain score for a patient. The method includes the steps of generating a PLR response signature for each drug of a plurality of drugs and further initiating a light stimulus to the patient, and measuring a corresponding PLR response. The method includes initiating a neuro-stimulus to the patient, the neuro-stimulus being initiated over a set of frequencies, each frequency being associated with a unique intensity, and stimulating a unique nerve fiber type of the patient, and measuring a PRD response of the patient for the initiated neuro-stimulus. Further, the method includes determining, for each nerve fiber type, a threshold response based on the measured PRD, determining a weight for each threshold response based on the PLR response, and combining the determined weight for each threshold response to obtain a pain score for the patient.

Abstract: Systems, apparatuses, and methods for performing robotically assisted physical therapy. The system, apparatus, and method can include a motion platform having three-degrees of freedom to achieve pitch motion, yaw motion, and roll motion; a plurality of motors connected to the motion platform to enable the pitch motion, the yaw motion, and/or the roll motion; at least one sensor configured to collect data relating to position and/or motion of the motion platform; and a motion controller configured to control the motion platform based on the collected data and/or external commands.

Abstract: Systems, apparatuses, and methods for diagnosing ureteropelvic junction obstruction. A set of biomarkers may be extracted from each of one or more time-activity curves associated with diuresis renography and/or functional magnetic resonance urography of one or more kidneys of a patient. One or more calculations can be performed based on the set of biomarkers to identify uretero-pelvic junction obstruction and a classification of severity or criticality thereof.

Abstract: A method for determining a likelihood of appendicitis in a subject is disclosed. The method comprises the steps of (a) determining the relative abundance of microorganisms corresponding to one or more operational taxonomic units (OTUs) in a test biological sample obtained from the subject; (b) comparing the relative abundance of the microorganisms in each of the one or more OTUs to a corresponding reference value assigned to each of the one or more OTUs, and (c) determining a likelihood of appendicitis in the subject based on the result in step (b), wherein a significant increase in relative abundance of the microorganisms in the one or more OTUs indicates a high risk of appendicitis in the subject. Also disclosed is a kit for determining a likelihood of appendicitis in a subject.

Abstract: Image segmentation of a structure of complex shape proceeds by acquiring by circuitry, a plurality of training images of the structure. A shape model of the structure is formed by fusing the plurality of training images. The shape model is partitioned by circuitry into a predetermined number of portions, an appearance and shape of each portion being determined by a classifier.

Abstract: Described is a method for segmenting an anatomical part, including identifying a landmark on a contour/surface of a 2D/3D model of the anatomical part in an ultrasound image, assigning a weight to the landmark, identifying different appearance patterns of a region around the landmark based on a previously stored training set; and applying a filter to the different appearance patterns of the region around the landmark in order to identify contours of the anatomical part.

Abstract: A device for generating composite images of dynamically changing surgical anatomy includes circuitry configured to receive, from an endoscopic imaging device, endoscopic image data. The circuitry is configured to receive, from a tomographic imaging device, intra-operative tomographic image data. The circuitry is configured to receive, from a tracking device, spatial tracking data corresponding to the endoscopic imaging device and the tomographic imaging device. The circuitry is configured to generate real-time dynamically changing composite image data by overlaying, based on the spatial tracking data, the intra-operative tomographic image data on the endoscopic image data. The circuitry is configured to output the composite image data to a display.