Abstract: This invention relates to CTLA-4 protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy.
Type:
Application
Filed:
February 22, 2022
Publication date:
August 18, 2022
Applicants:
ONCOC4, INC., CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Yang LIU, Pan ZHENG, Martin DEVENPORT, Wei WU, Xuexiang DU, Mingyue LIU, Fei TANG
Abstract: This invention relates to CTLA-4 protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy.
Type:
Application
Filed:
February 22, 2022
Publication date:
August 18, 2022
Applicants:
ONCOC4, INC., CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Yang LIU, Pan ZHENG, Martin DEVENPORT, Wei WU, Xuexiang DU, Mingyue LIU, Fei TANG
Abstract: Systems, apparatuses, and methods for performing robotically assisted physical therapy. The system, apparatus, and method can include a motion platform having three-degrees of freedom to achieve pitch motion, yaw motion, and roll motion; a plurality of motors connected to the motion platform to enable the pitch motion, the yaw motion, and/or the roll motion; at least one sensor configured to collect data relating to position and/or motion of the motion platform; and a motion controller configured to control the motion platform based on the collected data and/or external commands.
Type:
Grant
Filed:
October 9, 2017
Date of Patent:
July 19, 2022
Assignee:
CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Kevin Cleary, Sarah Evans, Reza Monfaredi, Hadi F. Talari, Catherine Coley
Abstract: The present disclosure relates to an apparatus and method for correcting rotational error during use of an oblique-viewing endoscope. Specifically, the present disclosure relates to a fast calibration process wherein a new approach is employed in estimating a center of rotation of a plane of an image. Moreover, the approach, allows for updating of a camera matrix during use.
Abstract: A delayed cord-clamping surface is provided that includes a newborn platform having a recessed surface configured to receive a chemical warming mattress, where the chemical warming mattress includes a conformable surface, where the newborn platform includes a detachable platform support that is configured to position the newborn platform proximal to a surgical region of a C-section patient, where the newborn platform is configured to support a newborn baby while an umbilical cord remains connected between the newborn and the C-section patient for draining from a placenta, where the newborn platform is configured to fitably mount with a warming table when the newborn platform is in a detached state from the detachable platform support.
Type:
Grant
Filed:
February 25, 2019
Date of Patent:
May 31, 2022
Assignee:
Children's National Medical Center
Inventors:
Jules P. Sherman, Douglas F. Schwandt, Chris A. Rothe
Abstract: The present disclosure relates to a biocompatible composition comprising a solution of low molecular weight polymer and high molecular weight polymer. The present disclosure also relates to biocompatible compositions comprising poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG), and additionally including a suspension of silica particles and/or a therapeutic agent. The present disclosure is also directed to biocompatible polymer fiber constructs formed from the disclosed compositions, methods of fabrication thereof, and uses of such constructs and compositions.
Type:
Application
Filed:
March 10, 2020
Publication date:
May 26, 2022
Applicants:
University of Maryland, College Park, Children's National Medical Center
Inventors:
John Daristotle, Shadden Zaki, Peter Kofinas, Anthony Sandler, Lung Lau, Leopoldo Torres
Abstract: The disclosure relates to methods of culturing and expanding CD4+ and/or CD8+ T cells in culture. In some embodiments, the methods include expanding, proliferating and storing lymphocytes in tissue culture by exposing the lymphocytes to a combination of cytokines and/or nucleic acids expressing cytokines or functional fragments or variants thereof. The disclosure further relates to methods of generating and manufacturing CD4+ and/or CD8+ T cells that are specific to one or a plurality of viral antigens.
Type:
Application
Filed:
November 30, 2021
Publication date:
May 26, 2022
Applicant:
CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Patrick HANLEY, Christopher LAZARSKI, Michael KELLER, Catherine BOLLARD
Abstract: The present disclosure relates to devices used to access the pericardial space of the heart. In particular, the present disclosure describes an apparatus to enable an operator to access the pericardial space of the heart, and deliver cardiac therapies to the pericardial space, under direct visualization through a single, small incision.
Type:
Grant
Filed:
July 2, 2018
Date of Patent:
May 24, 2022
Assignee:
CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Justin Opfermann, Charles Berul, Bradley Clark, Axel Krieger, Rohan Kumthekar, Paige Mass, Austeja Staneviciute
Abstract: Described herein is a system and method for determining characteristics of a wound. The system includes a first imaging sensor that obtains imaging information of a wound area and a second imaging sensor that obtains topology information of the wound area.
Type:
Grant
Filed:
September 19, 2014
Date of Patent:
May 24, 2022
Assignee:
CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Kyle Wu, Peng Cheng, Peter Kim, Ozgur Guler
Abstract: The invention relates to isolation of adipocyte-derived exosomes from a biological sample, as well as methods, compositions and kits for detecting an obesity-related disorder, for detecting risk of having an obesity-related disorder, for screening or identifying a therapy for an obesity-related disorder, for screening or identifying a therapeutic agent for an obesity-related disorder, and for treating or preventing an obesity-related disorder.
Type:
Grant
Filed:
June 10, 2016
Date of Patent:
May 3, 2022
Assignee:
CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Robert J. Freishtat, Evan Nadler, Monica Hubal, Sarah Ferrante
Abstract: The present disclosure relates to non-invasive nerve identification using snapshot polarimetry. The present disclosure further relates to a system for nerve identification, the system comprising a camera including a sensor, and a filter having a linear polarizer array, an illumination system configured to illuminate a target area with polarized light illumination, the polarized light illumination having at least one predetermined polarization angle, the illumination system including one more light sources, and one or more polarizer filters, and a processor configured to process imaging data obtained from the camera, and output a birefringence map of the target area including indicia of a nerve structure.
Abstract: The present invention relates to compositions and their use in methods of protecting and maintaining oligodendrocytes, and of treating demyelinating disorders
Type:
Application
Filed:
September 30, 2021
Publication date:
March 31, 2022
Applicants:
Oncolmmune, Inc., Children's National Medical Center
Inventors:
Yang Liu, Pan Zheng, Martin Devenport, Ning Li
Abstract: SARS-CoV-2 causes pandemic COVID19. Developing an effective treatment to directly target the virus could significantly impact viral burden in those most vulnerable to the devastating effects of this virus. The invention provides antisense oligonucleotides (AOs) to target the single stranded RNA genome of the SARS-CoV-2 viruses. The administration of AOs can significantly reduce the target viral RNAs.
Abstract: This invention relates to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy. Specifically, the disclosure provides a CTLA-4 protein comprising a mutant extracellular domain of CTLA-4, wherein the CTLA-4 protein exhibits reduced binding to an anti-CTLA-4 antibody as compared to a wild-type extracellular domain of CTLA-4, wherein the anti-CTLA-4 antibody has anti-cancer immunotherapeutic activity.
Type:
Grant
Filed:
September 19, 2017
Date of Patent:
March 1, 2022
Assignees:
ONCOC4, INC., CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Yang Liu, Pan Zheng, Martin Devenport, Wei Wu, Xuexiang Du, Mingyue Liu, Fei Tang
Abstract: Safe, rapid, and efficient methods for producing antigen-specific T cells recognizing human papilloma virus (HPV antigens); HPV-specific T cells, and methods for treating HPV infections and HPV-related malignancies by adoptive transfer of HPV-specific T cells.
Type:
Application
Filed:
August 17, 2021
Publication date:
December 9, 2021
Applicant:
CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Catherine BOLLARD, Conrad CRUZ, Patrick HANLEY
Abstract: The present disclosure relates, at least in part, to a closed and semi-automated system for the isolation of naive T cells, their expansion, and/or final harvest. The disclosure also relates to using those isolated cells in a large batch format for compiling stocks of stimulated CD45A+ T cells and/or using the stimulated CD45A+ T cells for therapeutic purposes.
Type:
Application
Filed:
May 20, 2019
Publication date:
December 2, 2021
Applicant:
CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Catherine Mary Bollard, Conrad Russell Y. Cruz, Patrick Hanley
Abstract: A method is provided for making an appendage of a soft surgical tool, including: receiving a set of mechanical constraints for a surgical procedure; calculating a set of articulation states based on the set of mechanical constraints; generating a plurality of print commands for printing an appendage configured to form the set of articulation states based on the calculation; and printing an appendage based on the plurality of print commands. Multiple printed appendages can be formed into an orienting assembly.
Type:
Grant
Filed:
October 31, 2016
Date of Patent:
October 5, 2021
Assignee:
CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Peter C. Kim, Justin D. Opfermann, Axel Krieger
Abstract: A visualization system, an apparatus, and a visualization method are provided. The visualization system includes a laparoscope, a camera operatively coupled to the laparoscope, a light source operatively coupled to an illumination port of the laparoscope, and processing circuitry. The light source is configured to output one or more light beams each at a predetermined frequency to illuminate a target area. The processing circuitry is configured to process imaging data from the laparoscope received by the camera to generate one or more images of the target area including at least one laser speckle contrast image. The laparoscope is configured to output the one or more light beams toward the target area at a distal end thereof and to collect reflected and/or scattered light from the target area via the distal end.
Type:
Application
Filed:
June 28, 2019
Publication date:
September 16, 2021
Applicant:
CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Jaepyeong CHA, Corey ZHENG, Lung Wai LAU
Abstract: A liposomal drug formulation for treating a disease in a patient characterized by overexpression of HIF-1? and/or HIF-2? includes a plurality of liposomes in a pharmaceutically acceptable carrier. The liposomes encapsulate echinomycin and are made from a peglyated phospholipid, a neutral phosphoglyceride, and a sterol. The PEGylated liposomes may be used to treat proliferative diseases, leukemia, cancer, autoimmune diseases and graft-versus-host disease.
Type:
Grant
Filed:
November 9, 2016
Date of Patent:
September 14, 2021
Assignee:
CHILDRENS RESEARCH INSTITUTE, CHILDRENS NATIONAL MEDICAL CENTER
Inventors:
Yang Liu, Yin Wang, Yan Liu, Christopher Bailey, Pan Zheng