Abstract: Safe, rapid and efficient methods for producing virus-specific or other antigen-specific T-cells from cord blood and other samples containing naive immune cells.
Type:
Application
Filed:
May 26, 2021
Publication date:
September 9, 2021
Applicant:
CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Catherine BOLLARD, Conrad CRUZ, Patrick HANLEY
Abstract: The present disclosure provides for isolated and processed cell therapeutic compositions and Methods of using those compositions for the treatment of a patient undergoing a hematopoietic stem cell transplant (HSCT). In some embodiments, the disclosure provides for methods of making these cells by exposing the isolated T cell populations to one or more tumor antigens.
Type:
Application
Filed:
May 20, 2019
Publication date:
July 15, 2021
Applicant:
CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Catherine Mary Bollard, Conrad Russell Y. Cruz, Patrick Hanley
Abstract: Provided herein are anti-CD24 antibodies that selectively bind human CD24 expressed in cancer cells, but not human CD24 expressed in non-cancerous cells, and the use of such antibodies in cancer therapy.
Type:
Application
Filed:
May 13, 2019
Publication date:
July 15, 2021
Applicants:
ONCOIMMUNE, INC, CHILDREN'S RESEARCH INSTITUTE, CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Yang Liu, Pan Zheng, Rhonda Flores, Hung-Yen Chou, Zhihong Xue, Peiying Ye, Martin Devenport
Abstract: The present disclosure provides a system and method for controlling an articulating member including a tool. The method includes determining a first confidence indicator based on a manual control mode for the articulating member, determining a second confidence indicator based on an autonomous control mode for the articulating member, generating an allocation function based on the first confidence indicator and the second confidence indicator, and generating a control command for the articulating member based on the allocation function.
Type:
Application
Filed:
May 16, 2019
Publication date:
July 8, 2021
Applicants:
University of Maryland, College Park, The Johns Hopkins University, Children's National Medical Center
Inventors:
Hamed Saeidi, Axel Krieger, Simon Leonard, Justin Opfermann
Abstract: The present disclosure relates to compositions comprising an antisense RNA sequence comprising a region of complementarity that is substantially complementary to an miRNA. Pharmaceutical compositions comprising the antisense RNA molecule, optionally further comprising an anti-inflammatory corticosteroid are also disclosed. Methods of treating or preventing inflammation, a steroid side effect, or a muscle disease using the one or the pharmaceutical compositions are also disclosed.
Abstract: Image segmentation of a structure of complex shape proceeds by acquiring by circuitry, a plurality of training images of the structure. A shape model of the structure is formed by fusing the plurality of training images. The shape model is partitioned by circuitry into a predetermined number of portions, an appearance and shape of each portion being determined by a classifier.
Type:
Grant
Filed:
December 11, 2017
Date of Patent:
June 22, 2021
Assignee:
CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Marius George Linguraru, Robert A. Avery, Awais Mansoor
Abstract: The present disclosure relates to an apparatus and method for correcting rotational error during use of an oblique-viewing endoscope. Specifically, the present disclosure relates to a fast calibration process wherein a new approach is employed in estimating a center of rotation of a plane of an image. Moreover, the approach, allows for updating of a camera matrix during use.
Abstract: The invention relates to a digital droplet polymerase chain reaction method that simultaneously detects and can quantify relative levels of multiple tumor associated antigens associated with relapse of a cancer after prior treatment. It does not require invasive bone marrow sampling or biopsy and permits rational targeting based on the types of TAAs expressed by relapsing cancer cells.
Type:
Application
Filed:
December 23, 2020
Publication date:
April 15, 2021
Applicant:
CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Kirsten WILLIAMS, Melanie GRANT, Javad NAZARIAN, Maja STANOJEVIC
Abstract: Heptamethine cyanines for use as fluorescent markers of the biliary and renal systems are disclosed. Certain heptamethine cyanines exhibit renal system specificity, while others exhibit biliary system specificity. The compounds may be used for diagnostic purposes and/or for visualization of renal or biliary systems during surgery.
Type:
Application
Filed:
February 14, 2019
Publication date:
April 8, 2021
Applicants:
CHILDREN'S NATIONAL MEDICAL CENTER, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC
Inventors:
Martin John SCHNERMANN, Peter C.W. KIM, Jaepyeong CHA, Roger Rauhauser NANI
Abstract: The present disclosure provides a system and method for controlling an articulating member including a tool. The system may include a dual camera system that captures near-infrared (NIR) images and point cloud images of a tissue or other substance that includes NIR markers. The system may generate a three-dimensional (3D) path based on identified positions of the NIR markers, may filter the generated path, and may generate a 3D trajectory for controlling the articulated arm of a robot having a tool to create an incision along the filtered path. In a shared control mode, an operator may generate manually control commands for the robot to guide the tool along such a path, while automated control commands are generated in parallel. One or more allocation functions may be calculated based on calculated manual and automated error models, and shared control signals may be generated based on the allocation functions.
Type:
Application
Filed:
November 16, 2020
Publication date:
March 18, 2021
Applicants:
University of Maryland, College Park, The Johns Hopkins University, Children's National Medical Center
Inventors:
Hamed Saeidi, Axel Krieger, Simon Leonard, Justin Opfermann, Michael Kam
Abstract: The present disclosure is a device and method associated with the delivery of medical devices in the pericardial space using a minimally invasive approach with direct visualization. More specifically, the device can be used to deliver permanent pacing, defibrillation and cardiac resynchronization leads, as well as leadless pacemakers for cardiac rhythm management to the epicardial surface of the heart. A subxiphoid procedure is proposed as a minimally invasive alternative to thoracotomy, while the delivery tool incorporates a camera for direct visualization of the procedure. The tool also incorporates a steerable catheter to provide selective control of the placement and orientation of the medical device in the pericardial space.
Type:
Grant
Filed:
February 18, 2015
Date of Patent:
February 23, 2021
Assignee:
CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Charles Berul, Justin Opfermann, Axel Krieger, Peter Kim, Tanya Davis, Bradley Clark
Abstract: The present invention relates to compositions of anti-CTLA-4 antibodies that bind to the human CTLA4 molecule and their use in cancer immunotherapy and for the reduction of autoimmune side effects compared to other immunotherapeutic agents.
Type:
Application
Filed:
January 29, 2019
Publication date:
February 18, 2021
Applicants:
Oncolmmune, Inc., Children's Research Institute, Children's National Medical Center
Inventors:
Yang Liu, Pan Zheng, Fei Tang, Mingyue Liu, Martin Devenport, Xuexiang Du, Yan Zhang
Abstract: The present disclosure is related to a method and apparatus for determining drug usage or a physiological characteristic of a patient. The present disclosure describes acquiring a video sequence, of an eye of a patient, the video sequence being a plurality of video frames, determining a frequency spectrum from a pupillary data of the video sequence, and determining, based on the frequency spectrum, the physiological characteristic or drug of use of the patient. In an embodiment, at least one frequency can be probed based on which physiological characteristic is being explored.
Abstract: The present disclosure is related to a method and apparatus for determining THC usage of a person. The present disclosure describes acquiring a video sequence, of an eye of a patient, the video sequence being a plurality of video frames, determining a frequency spectrum from a pupillary data of the video sequence, and determining, based on the frequency spectrum, the physiological characteristic or drug of use of the patient. In an embodiment, at least one frequency can be probed based on which physiological characteristic is being explored. For example, the physiological characteristic can be ?#-tetrahydrocannabinol, and the at least one frequency probed can be selected to be specific to ?#-tetrahydrocannabinol.
Abstract: A method of preventing the development of GvHD or reducing the severity of GvHD in a mammalian subject receiving an allogeneic hematopoietic stem cell (HSC) transplant includes administering to the subject a pharmaceutical composition comprising an active agent that inhibits the biological activity or expression of hypoxia-inducible factor-1a (HIF-1a) or hypoxia-inducible factor-2a (HIF-2a), wherein the active agent is administered in an amount effective for preventing or reducing the severity GvHD in the subject.
Type:
Grant
Filed:
August 18, 2016
Date of Patent:
January 26, 2021
Assignee:
Children's Research Institute, Children's National Medical Center
Abstract: A method for generating a electro spun fiber medical implant including determining dimensions of a portion of anatomy of a patient corresponding to the electro spun fiber medical implant via medical imaging, generating a model of the portion of the anatomy based on the dimensions, the model including one or more solid areas and one or more void areas encompassed within the one or more solid areas, inverting the model to generate a mandrel model, the mandrel model generated based on the one or more void areas, generating the mandrel based on the mandrel model, the mandrel including at least one electrically conductive material therein, and applying an electro-spinning process to the mandrel to generate the electro spun fiber medical implant which circumscribes the mandrel, wherein the mandrel is removable from within the electro spun fiber medical implant after a disassembly process.
Type:
Grant
Filed:
August 26, 2016
Date of Patent:
January 19, 2021
Assignees:
CHILDREN'S NATIONAL MEDICAL CENTER, RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, NANOFIBER SOLUTIONS LLC
Inventors:
Axel Krieger, Narutoshi Hibino, Jed Johnson, Justin Opfermann, Carolyn Cochenour Dorgan, Christopher K. Breuer
Abstract: The present disclosure is related to a device for gripping catheters that are used in interventional cardiac procedures without causing internal catheter damage. The present disclosure will allow the operator to maintain improved stability and maneuverability compared with current approaches, including, primarily, digital manipulation, which can lead to fatigue, instability and inappropriate catheter movement. Specifically in the pediatric population where small movements can lead to severe and permanent complications, the present disclosure has the potential to increase the safety profile of already high-risk interventional catheterization and electrophysiology procedures.
Type:
Application
Filed:
June 4, 2020
Publication date:
January 7, 2021
Applicant:
CHILDREN'S NATIONAL MEDICAL CENTER
Inventors:
Charles BERUL, Bradley CLARK, Morgan LOFTIS, Justin OPFERMANN, Paige MASS