Patents Assigned to Clemson University
  • Patent number: 9957518
    Abstract: The present invention provides methods and compositions for regulation of gene expression in plants. In particular, the invention provides nucleic acids that can confer tissue specific and constitutive expression to operably linked polynucleotides of interest.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: May 1, 2018
    Assignee: Clemson University
    Inventors: Hong Luo, Ning Yuan
  • Patent number: 9944942
    Abstract: The present invention provides transgenic plants having increased tolerance to abiotic stress comprising a recombinant nucleic acid molecule, said recombinant nucleic acid molecule comprising a nucleotide sequence encoding miR319 operatively associated with a promoter, a nucleotide sequence that is antisense to a portion of consecutive nucleotides of a nucleotide sequence encoding PCF5, and/or a nucleotide sequence that encodes a portion of consecutive nucleotides of a nucleotide sequence encoding PCF5, which when expressed produces an antisense nucleotide sequence, wherein expression of the nucleotide sequence confers increased tolerance to abiotic stress. Also provided are methods and compositions for making said transgenic plants.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: April 17, 2018
    Assignee: CLEMSON UNIVERSITY
    Inventors: Hong Luo, Dayong Li, Man Zhou, Qian Hu
  • Patent number: 9920014
    Abstract: The present invention provides novel bisbenzimidazole compounds and methods of using the compounds as antibacterial agents.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: March 20, 2018
    Assignees: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES, CLEMSON UNIVERSITY
    Inventors: Nihar Ranjan, Dev P. Arya, Fenfei Leng
  • Patent number: 9890259
    Abstract: Illustrative embodiments of microdevices and methods of manufacturing such microdevices are disclosed. In at least one illustrative embodiment, one or more microdevices may be formed on a substrate, with each of the one or more microdevices comprising a body micromachined from a continuous film formed on the substrate, the continuous film having a controlled microstructure of cellulose nanocrystals (CNC).
    Type: Grant
    Filed: May 1, 2016
    Date of Patent: February 13, 2018
    Assignees: Auburn University, Clemson University
    Inventors: William Robert Ashurst, Virginia A. Davis, Christopher L. Kitchens
  • Patent number: 9868963
    Abstract: Disclosed are methods for forming ammonia and ammonium that can be utilized in certifiably organic farming productions according to most if not all known certification standards. Also disclosed are bioreactors that can be utilized in carrying out disclosed methods. Methods and systems utilize obligate anaerobic bacteria to breakdown organic protein substrates, i.e., compounds containing bound nitrogen, to provide nitrogen in an unbound plant available form, and particularly, ammonia and/or ammonium. Obligate anaerobic bacteria include high ammonia producing bacteria such as Peptostreptococcus anaerobius, Clostridium sticklandii, and Clostridium aminophilum.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: January 16, 2018
    Assignee: Clemson University
    Inventor: Brian Keith Ward
  • Patent number: 9827552
    Abstract: A solid phase for use in separation has been modified using an aqueous phase adsorption of a headgroup-modified lipid to generate analyte specific surfaces for use as a stationary phase in separations such as high performance liquid chromatography (HPLC) or solid phase extraction (SPE). The aliphatic moiety of the lipid adsorbs strongly to a hydrophobic solid surface, with the hydrophilic and active headgroups orienting themselves toward the more polar mobile phase, thus allowing for interactions with the desired solutes. The surface modification approach is generally applicable to a diversity of selective immobilization applications such as protein immobilization clinical diagnostics and preparative scale HPLC as demonstrated on capillary-channeled fibers, though the general methodology could be implemented on any hydrophobic solid support material.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: November 28, 2017
    Assignee: Clemson University
    Inventors: R. Kenneth Marcus, Kenneth A. Christensen
  • Patent number: 9795573
    Abstract: A multi-step stabilization method for connective tissue is described. Stabilized tissues can exhibit increased resistance to degradation due to enzyme activity, fatigue and storage. The multi-step method includes a first step during which the tissue can be incubated with a glycosaminoglycanase inhibitor such as a sulfated oligosaccharide, one example of which being neomycin, a second step during which the tissue can be incubated with a crosslink activator such as a carbodiimide crosslink activator and/or a crosslinking agent such as a heterobifunctional crosslinking agent and/or a phenolic compound such as a tannin, examples of which include tannic acid and pentagalloylglucose, and a third step during which the tissue can be incubated with a second crosslink activator that can be the same or different as the first crosslink activator.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: October 24, 2017
    Assignee: Clemson University
    Inventors: Naren Vyavahare, Hobey Tam
  • Patent number: 9778629
    Abstract: A system and method for modeling, controlling and analyzing electrical grids for use by control room operators and automatic control provides a multi-dimensional, multi-layer cellular computational network (CCN) comprising an information layer; a knowledge layer; a decision-making layer; and an action layer; wherein each said layer of said CCN represents one of a variable in an electric power system. Situational awareness/situational intelligence is provided therefrom so that the operators and grid control systems can make the correct decision and take informed actions under difficult circumstances to maintain a high degree of grid integrity and reliability by analyzing multiple variables within a volume of time and space to provide an understanding of their meaning and predict their states in the near future where these multiple variables can have different timescales.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: October 3, 2017
    Assignee: Clemson University
    Inventor: Ganesh Kumar Venayagamoorthy
  • Patent number: 9764515
    Abstract: Disclosed are systems, compositions, and methods for three-dimensional (3D) printing. An example system includes a plurality dispensers configured to deposit materials from their tips and a printing surface for receiving the materials. The system includes a position sensing detector configured to detect positions of the tips of the dispensers and the location and dimensions of the printing surface. The system includes a robotic positioning device configured to drive the dispensers. The system also includes a control unit configured to receive and map in a 3D space the positions of the tips of the dispensers and the position and dimensions of the printing surface. The control unit is further configured to control the robotic positioning device to drive the dispensers relative to the printing surface in the 3D space, and to independently deposit materials on the printing surface, or on material deposited on the printing surface.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: September 19, 2017
    Assignees: MUSC Foundation for Research Development, Izumi International, Inc., Clemson University
    Inventors: Michael J. Yost, Thomas Trusk, Ying Mei, Michael Chappell, Walter Boylan
  • Patent number: 9767943
    Abstract: Methods for forming a nanoparticle assembly are generally provided. The method can comprise applying a colloidal fluid to a surface of a magnetic media, wherein the colloidal fluid comprises magnetic nanoparticles, a surfactant, a trigger salt, and a carrier medium; and assembling the magnetic nanoparticles into a pattern through a magnetic force arising from the surface of the magnetic media.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: September 19, 2017
    Assignees: University of South Carolina, Clemson University
    Inventors: Thomas M. Crawford, Longfei Ye, Tanner G. Pearson, O. Thompson Mefford, Yves Cordeau
  • Patent number: 9751081
    Abstract: The present invention relates to self-regenerating antioxidant catalysts and methods of using the same.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: September 5, 2017
    Assignee: Clemson University
    Inventors: Andrew Gregory Tennyson, Yamin Htet, Anshuman Mangalum
  • Patent number: 9711928
    Abstract: Single heterogeneous crystals are described that contain multiple regimes, adjacent regimes varying from one another with regard to function. Also disclosed is a hydrothermal epitaxial growth process that can be utilized to form the single heterogeneous crystals. The single heterogeneous crystals can exhibit enhanced performance when used as a laser gain medium as compared to previously known single crystals and multi-crystal constructs. The heterogeneous single crystal can be utilized for thin disk lasers and can minimize the thermal distortion effects at high powers. The heterogeneous crystal can also serve as an embedded waveguide.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: July 18, 2017
    Assignee: Clemson University Research Foundation
    Inventors: Joseph Kolis, Colin McMillen
  • Patent number: 9693867
    Abstract: Total knee replacements for hinged knee implants include a tibial member, a femoral member, a hinge assembly having a laterally extending axle configured to hingedly attach the femoral member to the tibial member, and a lock mechanism in communication with the hinge assembly. The lock mechanism is configured to (i) lock the femoral member in alignment with the tibial member for a full extension or other defined stabile walking configuration to thereby allow an arthrodesis or stiff knee gait and (ii) unlock to allow the femoral and tibial members to pivot relative to each other for flexion or bending when not ambulating.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: July 4, 2017
    Assignees: Clemson University Research Foundation, University of South Carolina
    Inventors: Eric Montgomery Lucas, John David DesJardins, Kim John Chillag, Frank Richard Voss
  • Patent number: 9687775
    Abstract: A hydrogen permeation membrane is provided that can include a metal and a ceramic material mixed together. The metal can be Ni, Zr, Nb, Ta, Y, Pd, Fe, Cr, Co, V, or combinations thereof, and the ceramic material can have the formula: BaZr1-x-yYxTyO3-? where 0?x?0.5, 0?y?0.5, (x+y)>0; 0???0.5, and T is Sc, Ti, Nb, Ta, Mo, Mn, Fe, Co, Ni, Cu, Zn, Ga, In, Sn, or combinations thereof. A method of forming such a membrane is also provided. A method is also provided for extracting hydrogen from a feed stream.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: June 27, 2017
    Assignees: University of South Carolina, Clemson University Research Foundation
    Inventors: Fanglin Chen, Shumin Fang, Kyle S. Brinkman
  • Patent number: 9685097
    Abstract: Devices and methods for detecting an eating activity occurrence are provided. A device includes a sensor for monitoring movement of a portion of an arm of a subject, and a processor in communication with the sensor for collecting raw data associated with movement of the portion of the arm. The processor is configured to process the raw data and form processed data. The processed data includes a determination of whether an eating activity has occurred. A method includes sensing movement of a portion of an arm of a subject, and processing raw data associated with the movement of the portion of the arm of the subject to form processed data. The processed data includes a determination of whether an eating activity has occurred.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: June 20, 2017
    Assignee: Clemson University
    Inventors: Adam Hoover, Eric Muth, Yujie Dong, Jenna Scisco
  • Publication number: 20170164984
    Abstract: Rib hook devices, systems, and methods of assembling and using the devices and systems are disclosed. The rib hook device includes a body with a first end and a second end and a rod attachment member coupled to and extending away from the second end of the body. The rib hook system includes at least one rib hook device, a first rod for engaging the at least one rib hook device, and at least one fastener for securing the first rod to the at least one rib hook device. Methods for assembling and using the rib hook devices and systems are also disclosed.
    Type: Application
    Filed: December 9, 2016
    Publication date: June 15, 2017
    Applicants: MUSC Foundation for Research Development, Clemson University
    Inventors: Gregory J. WRIGHT, Hai YAO, Richard H. GROSS
  • Patent number: 9651629
    Abstract: A hardware-in-the-loop (HIL) electrical grid simulation system and method that combines a reactive divider with a variable frequency converter to better mimic and control expected and unexpected parameters in an electrical grid. The invention provides grid simulation in a manner to allow improved testing of variable power generators, such as wind turbines, and their operation once interconnected with an electrical grid in multiple countries. The system further comprises an improved variable fault reactance (reactive divider) capable of providing a variable fault reactance power output to control a voltage profile, therein creating an arbitrary recovery voltage. The system further comprises an improved isolation transformer designed to isolate zero-sequence current from either a primary or secondary winding in a transformer or pass the zero-sequence current from a primary to a secondary winding.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: May 16, 2017
    Assignee: Clemson University
    Inventors: John Curtiss Fox, Edward Randolph Collins, Nikolaos Rigas
  • Publication number: 20170117537
    Abstract: A silicon-based anode comprising silicon, a carbon coating that coats the surface of the silicon, a polyvinyl acid that binds to at least a portion of the silicon, and vinylene carbonate that seals the interface between the silicon and the polyvinyl acid. Because of its properties, polyvinyl acid binders offer improved anode stability, tunable properties, and many other attractive attributes for silicon-based anodes, which enable the anode to withstand silicon cycles of expansion and contraction during charging and discharging.
    Type: Application
    Filed: January 9, 2017
    Publication date: April 27, 2017
    Applicants: Clemson University, Georgia Tech Research Corporation
    Inventors: Gleb Nikolayevich YUSHIN, Igor LUZINOV, Bogdan ZDYRKO, Alexandre MAGASINSKI
  • Patent number: 9615815
    Abstract: Adaptors for ultrasound probes can have an adaptor body can have an open lower end that allows a distal end of the ultrasound probe to extend therethrough to contact skin of a patient. The adaptor can include a plurality of spaced apart resilient members held by the adaptor body that, in operation, are able to change in length such that the resilient members translate from a first longer length to a second shorter length when the probe applies compressive force to the target tissue.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: April 11, 2017
    Assignee: Clemson University Research Foundation
    Inventors: David Kwartowitz, Erika Trent, Fuad Mefleh, Vipul Pai Raikar, Delphine Dean
  • Patent number: 9560848
    Abstract: A method of deterring biofouling of a surface comprising attaching an adduct having formula (I) or noradrenalin to the surface. Formula (I) being defined as compounds that have the formula A-L-R wherein A is i) a C6 or C10 substituted aryl ring, or ii) a C1-C9 substituted or unsubstituted heteroaryl ring: L is a linking group, and R is a primary amino moiety comprising unit.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: February 7, 2017
    Assignee: Clemson University
    Inventors: Andrew S. Mount, Neeraj V. Gohad, Andrew Metters, Nihar M. Shah