Patents Assigned to CNRS
  • Patent number: 12036237
    Abstract: The present invention relates to a novel pharmaceutical use of bromide, i.e. the treatment of autism spectral disorder (ASD).
    Type: Grant
    Filed: April 20, 2023
    Date of Patent: July 16, 2024
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, CNRS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG
    Inventors: Sébastien Roux, Thierry Plouvier, Julie Le Merrer, Jérôme Becker
  • Publication number: 20240228546
    Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.
    Type: Application
    Filed: April 3, 2023
    Publication date: July 11, 2024
    Applicants: Institut National De La Sante Et De La Recherche Medicale (INSERM), Centre National De La Recherche Scientifique (CNRS), Ecole Normale Superieure De Lyon, Universite Claude Bernard Lyon 1
    Inventors: Théophile OHLMANN, Philippe MANGEOT, Emiliano RICCI
  • Publication number: 20240228556
    Abstract: The present invention relates to the use of a sequence chosen among Seq ID No 3, Seq ID No 1, Seq ID No 2, Seq ID No 4, Seq ID No 5, Seq ID No 6, Seq ID No 7, Seq ID No 8, and functional variants thereof, as an odorant binding protein (OBP).
    Type: Application
    Filed: February 23, 2022
    Publication date: July 11, 2024
    Applicants: SPECIALITES PET FOOD, Institut national de recherche pour l’agriculture, l’alimentation et l’environnement, UNIVERSITE DE BOURGOGNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL SUPERIEUR DES SCIENCES AGRONOMIQUES, DE L'ALIMENTATION ET DE L'ENVIRONNEMENT
    Inventors: Margot GLAZ, Fabrice NEIERS, Loïc BRIAND, Emilie LECLERC, Marion GUILLOUX
  • Publication number: 20240224889
    Abstract: The present disclosure relates to the use of mesoporous solids to control relative humidity in enclosed spaces while greatly reducing energy expenditure. The mesoporous solids are particularly suitable for controlling relative humidity in greenhouses.
    Type: Application
    Filed: May 4, 2022
    Publication date: July 11, 2024
    Applicants: UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Melaz TAYAKOUT-FAYOLLE, Elsa JOLIMAITRE
  • Patent number: 12030915
    Abstract: The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.
    Type: Grant
    Filed: September 25, 2023
    Date of Patent: July 9, 2024
    Assignees: Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay
    Inventors: Aurélie Albertini, Yves Gaudin, Hélène Raux, Laura Belot, Jovan Nikolic
  • Patent number: 12030333
    Abstract: The present invention particularly relates to a method for physical vacuum deposition of a coating (R) comprising at least one material (M) on at least a portion of a front face (10) of a support (1), said at least one material (M) originating from an evaporation source or an atomisation source (2), wherein: —use is made of a support (1), at least a portion of the front face (10) of which is smooth, that is to say, does not have any roughness and/or reliefs and/or recesses; —said vacuum deposition is carried out while varying the thickness distribution of the material (M) on said front face (10), that is, while progressively varying the thickness deposited, from a central region (11) in the direction of at least one lateral region (12) contiguous to the central region (11), without modifying the position of the evaporation source or atomisation source (2) of the material particles (M).
    Type: Grant
    Filed: November 28, 2019
    Date of Patent: July 9, 2024
    Assignees: OBERTHUR FIDUCIAIRE SAS, Centre National de la Recherche Scientifique (CNRS), ECOLE CENTRALE DE MARSEILLE, Universite D'Aix-Marseille
    Inventors: Julien Lumeau, Fabien Lemarchand, Antonin Moreau, Thomas Begou, Julien Gillot, Xavier Borde
  • Publication number: 20240218588
    Abstract: The invention relates to a method for coating a textile material, said method comprising the following steps: a) at least one cycle of impregnating the textile material with a sol-gel adhesion formulation, said sol-gel adhesion formulation being free of polycarboxylic acid; b) at least one cycle of drying the impregnated textile material obtained in step a); c) at least one cycle of impregnating the dried textile material obtained in step b) with an omniphobic or hydrophobic sol-gel formulation comprising sulphamic acid, said omniphobic or hydrophobic sol-gel formulation being different from the sol-gel adhesion formulation; d) at least one cycle of drying the impregnated textile material obtained in step c).
    Type: Application
    Filed: April 21, 2022
    Publication date: July 4, 2024
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -
    Inventors: Wanxian WANG, Thu-Hoa TRAN-THI, Guillaume LE CHEVALLIER, Justine AGAUD
  • Publication number: 20240216525
    Abstract: Enzyme-triggered self-reacting arm compounds and chemical intermediates used for preparing such compounds and uses thereof, specifically in prodrug design and conjugation technologies. A Ligand-Drug-Conjugate (LDC) includes such enzyme-triggered self-reacting arms.
    Type: Application
    Filed: March 30, 2022
    Publication date: July 4, 2024
    Applicants: MABLINK BIOSCIENCE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Warren VIRICEL, Benoît JOSEPH, Guy FOURNET
  • Patent number: 12005523
    Abstract: The invention relates to a process for nanostructuring the surface of a solid material in order to form a regular pattern of nanostructures on said surface, comprising: irradiating the surface by a plurality of pulse trains (20) of a femtosecond laser beam: each pulse train (20) comprises at least two pulses (21, 22), each pulse has a peak fluence, and a sum of the peak fluences of the pulses of a pulse train is between 10% and 70% of a threshold fluence corresponding to a material ablation threshold for one pulse for said material, two consecutive pulses of a pulse train are separated by a peak-to-peak duration ?T between 500 fs and 150 ps, two consecutive pulse trains are separated by a duration greater than 10 ?T, obtaining a regular pattern of nanostructures on said portion of surface, having a spatial periodicity lower than 130 nm.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: June 11, 2024
    Assignees: Universite Jean Monnet Saint Etienne, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Florent Pigeon, Anthony Abou Saleh, Jean-Philippe Colombier-Cinquantin, Florence Garrelie
  • Publication number: 20240181727
    Abstract: A method of manufacturing a composite material including at least one ply integrating at least one electronic element situated at the surface of the ply. Also, materials obtained thereof and devices including such materials. The method includes: a) preparing or providing a first substrate having at least one layer; b) applying at least one electronic element onto a face of the first substrate; c) at least partially impregnating the so-obtained product within an impregnation material to form a matrix incorporating the at least one electronic element and the first substrate; d) preparing or providing an impregnable second substrate, the second substrate being placed on top of the impregnated at least one electronic element so that the at least one electronic element is interposed between the first substrate and the second substrate; e) removing the first substrate from the impregnated product obtained; and f) recovering the composite material.
    Type: Application
    Filed: March 31, 2022
    Publication date: June 6, 2024
    Applicants: UNIVERSITE DE RENNES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, NANTES UNIVERSITÉ, CENTRALESUPELEC, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE RENNES
    Inventors: Maxime HARNOIS, Gaëtan HERRY, France LE BIHAN, Jean-Charles FUSTEC
  • Publication number: 20240181075
    Abstract: The present invention relates to an antibody-drug conjugate comprising a monoclonal antibody or an antigen-binding fragment thereof wherein the monoclonal antibody or the antigen-binding fragment thereof binds to Nectin-4 and wherein the drug is an amatoxin, particularly ?-amanitin.
    Type: Application
    Filed: March 31, 2022
    Publication date: June 6, 2024
    Applicants: EMERGENCE THERAPEUTICS AG, UNIVERSITE D’AIX-MARSEILLE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), INSTITUT JEAN PAOLI & IRENE CALMETTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE – CNRS
    Inventors: Jack ELANDS, Florence LHOSPPICE, Xavier PRÉVILLE, Daniel OLIVE, Marc LOPEZ
  • Patent number: 12000833
    Abstract: PI3K signalling is the most increased pathway in human cancers. The four isoforms of PI3K are thought to be activated by different redundant mechanisms leading to a common downstream signalling. However, the mutational pattern of PI3K pathway or its level of expression is not sufficient to predict the sensitivity to PI3K inhibitors. By identifying for the first time a phosphopeptide that predict the sensitivity to p110? and/or p110? inhibitors, the inventors provide insight in how to handle heterogeneity of PI3K expression patterns in tumoral samples for the choice of available PI3K-targetting drugs. Accordingly, the present relates to a phosphopeptide characterized by the amino acid sequence as set forth in SEQ ID NO:1 (PGTPSDHQSQEASQFER) wherein the threonine residue at position 3 is phosphorylated.
    Type: Grant
    Filed: November 22, 2018
    Date of Patent: June 4, 2024
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Julie Guillermet-Guibert, Thibaut Douche, Emmanuelle Mouton-Barbosa, Odile Schiltz, Marie-Pierre Bousquet, Célia Cintas
  • Publication number: 20240173424
    Abstract: The present invention relates to an antibody -drug conjugate comprising a monoclonal antibody or an antigen-binding fragment thereof wherein the monoclonal antibody or the antigen-binding fragment thereof binds to Nectin-4 and wherein the drug is a topoisomerase I inhibitor, particularly exatecan.
    Type: Application
    Filed: March 31, 2022
    Publication date: May 30, 2024
    Applicants: EMERGENCE THERAPEUTICS AG, UNIVERSITE D’AIX-MARSEILLE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), INSTITUT JEAN PAOLI & IRENE CALMETTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE – CNRS
    Inventors: Jack ELANDS, Florence LHOSPPICE, Xavier PRÉVILLE, Daniel OLIVE, Marc LOPEZ
  • Publication number: 20240178792
    Abstract: A lifetime optimization method for a two-sided photovoltaic module, which includes at least one multi-junction stack, where the stack's first junction layer is on the module's first side, which is exposed to the sun at the beginning of the module's life in the module's base position, and the stack's last junction layer is arranged under the module's second side, which receives diffused and reflected light and light passed through the stack. The method includes measuring the full module's output power (PFM); calculating an estimated output power for the last junction layer (PLL) as a function of the first irradiance in the module's turned over position, where the second side becomes its upper side; comparing the estimated PLL with the PFM when the first side is the upper side and recommending turning over the module when the base position's PFM becomes less than the turned over position's estimated PLL.
    Type: Application
    Filed: July 6, 2022
    Publication date: May 30, 2024
    Applicants: ELECTRICITE DE FRANCE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, ECOLE POLYTECHNIQUE, TOTALENERGIES ONETECH, INSTITUT PHOTOVOLTAIQUE D'ILE DE FRANCE (IPVF)
    Inventors: Jean-Baptiste PUEL, Arthur JULIEN
  • Publication number: 20240162460
    Abstract: A method may activate a fuel cell including a plurality of electrochemical cells in a stack, the fuel cell being intended to operate, during at least one nominal operating phase, as an electric generator. Such a method may include, during an activation phase by electrolysis, prior to the at least one nominal operating phase: electrically supplying the fuel cell by an external electric generator, the electric supply being configured to apply an activation voltage greater than the voltage of the cell in an open circuit (OCV); fluid supplying a humid gas fluid at a first electrode and/or a second electrodes. The humid gas may have a relative humidity (RH) such that 40%?RH<100%. The fuel cell may operate in electrolysis during the activation phase called by electrolysis.
    Type: Application
    Filed: November 9, 2023
    Publication date: May 16, 2024
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, INSTITUT POLYTECHNIQUE DE GRENOBLE, UNIVERSITE SAVOIE MONT BLANC, CNRS, UNIVERSITE GRENOBLE ALPES
    Inventors: Eric PINTON, Yann BULTEL, Timothée DRUGEOT, Fabrice MICOUD
  • Publication number: 20240148778
    Abstract: A composition of yeast polysaccharides including ?(1,6)-glucans, preferably also mannans and ?-glucans. The yeast polysaccharides are extracted from yeast cell wall fragments. Typically, the ?-glucans are ?(1,6)-glucans. Also, a method for obtaining such a composition, including at least one step of fractionating a composition of yeast cell walls and extracting an insoluble fraction, and at least one step of extracting a soluble fraction from the insoluble fraction obtained in step a). Further, a composition with a human or veterinary therapeutic objective, for the treatment of gastrointestinal pathologies associated with pathogenic microorganisms, as well as to its non-therapeutic use for improving intestinal comfort.
    Type: Application
    Filed: March 15, 2022
    Publication date: May 9, 2024
    Applicants: LESAFFRE ET COMPAGNIE, UNIVERSITÉ CLERMONT AUVERGNE, UNIVERSITE DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS
    Inventors: Nathalie BALLET, Pascal VANDEKERCKOVE, Yann GUERARDEL, Shin-Yi YU, Adeline SIVIGNON, Nicolas BARNICH
  • Publication number: 20240145106
    Abstract: Method for estimating an axial power imbalance in a nuclear reactor, comprising the following steps: obtaining a reactor power setpoint, for each variable of a plurality of variables of the reactor, determining a sequence of the variable, the sequence representing estimated future variations of the variable, determining a sequence of the axial power imbalance, by taking into account the sequences of the plurality of variables of the reactor, the determination of the sequence of the axial power imbalance using a machine learning module that is trained beforehand on historic reactor data.
    Type: Application
    Filed: October 31, 2023
    Publication date: May 2, 2024
    Applicants: Electricite de France, Centre National de la Recherche Scientifique (CNRS), Ecole Centrale De Nantes
    Inventors: Madina Traore, Giorgio Simonini, Yannig Goude, Mathieu Lagrange, Alexandre Girard, Jérôme Idier
  • Publication number: 20240132547
    Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.
    Type: Application
    Filed: April 2, 2023
    Publication date: April 25, 2024
    Applicants: Institut National De La Sante Et De La Recherche Medicale (INSERM), Centre National De La Recherche Scientifique (CNRS), Ecole Normale Superieure De Lyon, Universite Claude Bernard Lyon 1
    Inventors: Théophile OHLMANN, Philippe MANGEOT, Emiliano RICCI
  • Publication number: 20240132555
    Abstract: The present invention relates to the use of a sequence chosen among Seq ID No 3, Seq ID No 1, Seq ID No 2, Seq ID No 4, Seq ID No 5, Seq ID No 6, Seq ID No 7, Seq ID No 8, and functional variants thereof, as an odorant binding protein (OBP).
    Type: Application
    Filed: February 23, 2022
    Publication date: April 25, 2024
    Applicants: SPECIALITES PET FOOD, Institut national de recherche pour l’agriculture, l’alimentation et l’environnement, UNIVERSITE DE BOURGOGNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL SUPERIEUR DES SCIENCES AGRONOMIQUES, DE L'ALIMENTATION ET DE L'ENVIRONNEMENT
    Inventors: Margot GLAZ, Fabrice NEIERS, Loïc BRIAND, Emilie LECLERC, Marion GUILLOUX
  • Publication number: 20240116923
    Abstract: The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug for inhibiting ferroptosis.
    Type: Application
    Filed: January 25, 2022
    Publication date: April 11, 2024
    Applicants: Seabelife, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite, Institut National de la Santé et de la Recherche Médicale (INSERM), Université Claude Bernard Lyon 1, Universite de Rennes 1
    Inventors: Stéphane BACH, Arnaud COMTE, Claire DELEHOUZE, Marie-Thérèse DIMANCHE-BOITREL, Peter GOEKJIAN