Patents Assigned to CNRS
  • Patent number: 12292372
    Abstract: The invention relates to a measuring device (10) for measuring physical characteristics of cells. The device (10) comprises: a microfluidic chip (20) provided with a flow channel (22) for allowing cells to flow through; a manipulator (24) configured to apply deformation force to a cell in a continuous flow; and a sensor (26) configured to sense a physical characteristic of the cell. The manipulator (24) and the sensor (26) are configured to define a width (W2) of the flow channel (22) as a gap formed between them. The manipulator (24) is configured to apply the deformation force to the cell by compressing the cell against the sensor (26).
    Type: Grant
    Filed: October 6, 2020
    Date of Patent: May 6, 2025
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), JUNIA
    Inventors: Dominique Collard, Hiroyuki Fujita, Stanislav Karsten, Mehmet Cagatay Tarhan
  • Patent number: 12291552
    Abstract: The present invention relates to a chimeric protein comprising at least one human amyloid P component and at least one fragment of an Fc region of a human antibody, the human amyloid P component and the fragment of an Fc region with which it is associated being bound to each other by means of a hinge region.
    Type: Grant
    Filed: April 26, 2022
    Date of Patent: May 6, 2025
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉDE LIMOGES
    Inventors: Christophe De Romeuf, Christophe Sirac, Jean-Claude Brouet
  • Patent number: 12291551
    Abstract: The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.
    Type: Grant
    Filed: April 8, 2024
    Date of Patent: May 6, 2025
    Assignees: Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay
    Inventors: Aurélie Albertini, Yves Gaudin, Hélène Raux, Laura Belot, Jovan Nikolic
  • Patent number: 12287453
    Abstract: An optical device suitable for transmitting/reflecting electromagnetic radiation in a wavelength range of the electromagnetic spectrum. The device comprises at least a first coating layer made of a first material, a substrate made of a material different from the first material, and surface texturing forming cavities in the device. A lower layer, disposed directly below the first coating layer, is either a second coating layer made of a material different from the first material or the substrate itself. The lower layer has a predetermined thickness. The optical device has cavities that extend through the first coating layer and are sunk into the lower layer through at least part of its thickness. This structure enhances the optical properties of the device for specific applications in electromagnetic radiation transmission or reflection.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: April 29, 2025
    Assignees: Hydromecanique et Frottement, Manutech-USD, Université Jean Monnet Saint-Etienne, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Thomas Kämpfe, Laurent Dubost, Xxx Sedao
  • Patent number: 12285433
    Abstract: The present invention relates to diltiazem for use as an agent for activating the expression of at least one gene encoding a type III interferon, in the prevention and/or treatment of infections by at least one pathogenic microorganism of the epithelia of the respiratory and/or intestinal tracts.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: April 29, 2025
    Assignees: UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE DE LYON, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE LAVAL
    Inventors: Manuel Rosa-Calatrava, Olivier Terrier, Claire Nicolas De Lamballerie, Guy Boivin, Mario Andres Pizzorno
  • Patent number: 12286497
    Abstract: Process of grafting of a polyethylene-containing material to produce a modified polyethylene composition comprising providing a twin screw extruder with one or more thermal regulation devices; a polyethylene-containing material and a grafting agent and extruding the polyethylene-containing material and the grafting agent to obtain a modified polyethylene composition; the step of extruding comprises a thermal treatment of the polyethylene-containing material by self-heating of the material at a maximum barrel temperature Ts ranging from 315° C. to 410° C. in one or more hot zones of the extruder.
    Type: Grant
    Filed: March 2, 2023
    Date of Patent: April 29, 2025
    Assignees: TOTALENERGIES ONETECH, UNIVERSITÉ CLAUDE BERNARD LYON 1 (UCBL), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ JEAN MONNET SAINT-ETIENNE, INSTITUT NATIONAL DES SCIENCES APPLIQUÉES DE LYON (INSA LYON)
    Inventors: Olivier Lhost, Pascal Navez, Yves Trolez, Philippe Cassagnau, Mohammad Abou-Taha, Karim Delage, Emmanuel Beyou
  • Publication number: 20250128943
    Abstract: The present invention relates to a process and a system for the production of hydrogen and carbon by catalytic non-oxidative decomposition of hydrocarbons, such as saturated C1+ hydrocarbons, such as methane, in the presence of a fresh or a spent catalyst composition comprising at least one carbon catalyst. The process of the invention is characterised in that the fresh or spent catalyst composition is heated by means of induction heating to a temperature comprised between 500° C. and 1100° C. The catalyst compositions as applied in accordance with the invention comprise, and preferably consist of, (I) a first component, wherein said first component is selected from one or more non-porous carbon catalysts and/or one or more porous carbon catalysts; and (II) optionally, a second component, wherein said second component consists of a non-carbon material, and preferably is a ceramic or zeolitic support material.
    Type: Application
    Filed: October 26, 2022
    Publication date: April 24, 2025
    Applicants: TOTALENERGIES ONETECH, UNIVERSITÉ DE STRASBOURG-UNISTRA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
    Inventors: Loïc FRANCKE, Christophe BENQUET, Jean-Pierre DATH, Lai TRUONG PHUOC, Cuong PHAM-HUU, Jean-mario NHUT
  • Patent number: 12275942
    Abstract: Disclosed is a method for producing, in one step, “made to measure” double-stranded DNA vectors from molecular bricks including sequences of interest in the presence of a one and only type IIs restriction enzyme.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: April 15, 2025
    Assignees: Universite de Lille, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Geoffroy De Bettignies, Carine De Bettignies, Sylvain Julien
  • Patent number: 12274694
    Abstract: The present invention relates to compounds of formula (I): for use as peripheral NMDA receptor antagonists.
    Type: Grant
    Filed: April 6, 2023
    Date of Patent: April 15, 2025
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ PARIS-SACLAY, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS (APHP), HOPITAL MARIE LANNELONGUE
    Inventors: Sylvia Cohen-Kaminsky, Marc Humbert, Sebastien Dumas, Gilles Bru-Mercier, Samir Messaoudi, Jean-Daniel Brion, Mouad Alami, Gilles Galvani
  • Patent number: 12269000
    Abstract: The present invention relates to a method for producing a colloid comprising functionalised liquid colloidal particles. The invention also relates to such a colloid and to the uses thereof.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: April 8, 2025
    Assignees: Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite
    Inventors: Jacques Fattaccioli, Lea Pinon, Lorraine Montel
  • Patent number: 12269848
    Abstract: The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.
    Type: Grant
    Filed: April 8, 2024
    Date of Patent: April 8, 2025
    Assignees: Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay
    Inventors: Aurélie Albertini, Yves Gaudin, Hélène Raux, Laura Belot, Jovan Nikolic
  • Patent number: 12269837
    Abstract: Disclosed are chelates resulting from the complexation of bifunctional do2pa derivatives ligands of formula (I), wherein the substituents R1, R1?, R2, R2?, R3, R3?, L1, L1?, L2 and L2? are defined as in the claims, with metallic cations, especially Pb(II) and Bi(III). Also disclosed are bifunctional do2pa derivatives ligands of formula (I), as well as the use of chelates in nuclear medicine and the use of ligands in cations detection or epuration of effluents.
    Type: Grant
    Filed: January 24, 2022
    Date of Patent: April 8, 2025
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ DE BRETAGNE OCCIDENTALE
    Inventors: Fatima Oukhatar, Maryline Beyler, Raphaël Tripier
  • Patent number: 12264180
    Abstract: The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.
    Type: Grant
    Filed: April 8, 2024
    Date of Patent: April 1, 2025
    Assignees: Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay
    Inventors: Aurélie Albertini, Yves Gaudin, Hélène Raux, Laura Belot, Jovan Nikolic
  • Publication number: 20250101147
    Abstract: The present invention relates to a process for preparing a crosslinked polymer composition containing exchangeable pending links and exchangeable crosslinks, by boronic ester metathesis reactions, said process implementing a thermoplastic polymer comprising pending boronic ester groups, and an additive as crosslinking agent that melts, and thus crosslinks, in the polymer matrix at a temperature, called temperature of dissociation, higher that the processing temperature. Said temperature of dissociation is reached in the later curing step only.
    Type: Application
    Filed: September 13, 2024
    Publication date: March 27, 2025
    Applicants: ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Renaud NICOLAY, Nathan Jay VAN ZEE, Georges Jacques Marie FORMON, Jonathan JAYARATNAM
  • Patent number: 12256992
    Abstract: Disclosed is a device including a detector producing a signal depending on variations of the pupil diameter of an eye of a subject, a display for presenting, to the subject, a light pattern subdivided into a plurality of regions, and an analyzer receiving the signal of the detector and analyzing the frequential content thereof. The display is controlled such that each region has a light intensity modulated at a respective modulation frequency, the modulation frequencies being different from one region to the next.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: March 25, 2025
    Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
    Inventors: Jean Lorenceau, Suzon Ajasse
  • Patent number: 12257103
    Abstract: Method for non-invasively characterizing a heterogeneous medium using ultrasound, comprising a step of generating a series of incident ultrasonic waves, a step of recording an experimental reflection matrix Rui(t) defined between the input emission basis (i) and an output reception basis (u), a step of determining a response REP(r,?r) of the medium between an input virtual transducer (TVin) calculated based on an input focusing of the experimental reflection matrix that creates an input focal spot around a first point (P1), and an output virtual transducer (TVout) calculated based on an output focusing of the experimental reflection matrix that creates an output focal spot around a second point (P2), said response being expressed as a function of a central point (PC) of spatial position (r) in the medium located midway between the first and second points (P1, P2).
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: March 25, 2025
    Assignees: SUPERSONIC IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris
    Inventors: William Lambert, Alexandre Aubry, Mathias Fink, Laura Cobus
  • Patent number: 12258400
    Abstract: The present invention relates to antibodies having specificity for BTN2A and uses thereof, in particular for the treatment of cancer.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: March 25, 2025
    Assignees: IMCHECK THERAPEUTICS SAS, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS—, INSTITUT JEAN PAOLI & IRENE CALMETTES, UNIVERSITÉ D'AIX-MARSEILLE
    Inventors: Etienne Foucher, Carla Cano, Kieu Suong Le, Christine Pasero, Daniel Olive
  • Patent number: 12259308
    Abstract: A medical analysis device with cellular impedance signal processing features a memory arranged to receive pulse data sets, with each pulse data set including impedance value data that are associated each time with a time marker. The pulse data sets together represent a curve of cellular impedance values that are measured as a cell passes through a polarised opening. The device further includes a classifier in communication with the memory. The classifier may feature a convolutional neural network that receives the pulse data sets as input. The classifier is provided with at least one convolutional layer, which convolutional layer has a depth greater than or equal to 3, and at least two fully connected layers, in addition to an output layer rendering a cell classification from which a pulse data set is derived.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: March 25, 2025
    Assignees: HORIBA ABX SAS, UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Pierre Taraconat, Damien Isebe, Simon Mendez, Franck Nicoud
  • Patent number: 12251258
    Abstract: Disclosed is a method for characterising an object, comprising: emission of ultrasonic waves that enter an object by passing through an external interface, then reflect off an internal interface, then exit the object by passing through the external interface again, the ultrasonic waves comprising first waves having a mode that varies according to a first variation during their propagation in the object, and second waves having a mode that varies according to a second variation during their propagation in the object; reception of echo signals comprising first signals representing echoes of the first waves, and second signals representing echoes of the second waves, construction of a plurality of images showing the object, the plurality of images being constructed from the echo signals, under the assumption that two characteristics of the object are equal to two candidate values, and comprising a first image constructed from the first signals, and a second constructed from the second signals; construction of a
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: March 18, 2025
    Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventor: Guillaume Renaud
  • Patent number: 12250944
    Abstract: The present invention relates to the long-term preservation of biological material. More specifically, it concerns a preservation container comprising: a biological container for containing biological material, a first shield configured for absorbing gamma-rays, a second shield configured for absorbing ambient neutrons, said second shield surrounding the biological container, the preservation container being of low-radioactivity background materials, and a method for preserving a biological material, comprising: a) providing a biological material in a confinement container, b) providing the preservation container of the invention, c) placing the confinement container containing the biological material into said preservation container, d) storing said preservation container containing the biological material in a room located under a material attenuating cosmic rays and induced particles, said material having a thickness equivalent to 1 m to 7000 m of water, for attenuating cosmic rays.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: March 18, 2025
    Assignees: Centre National de la Recherche Scientifique (CNRS), Institut Pasteur, Université Paris Cité, Groupe Hospitalier Universitaire Paris—Psychiatrie et Neurosciences
    Inventors: Maurice Chapellier, Fabrice Chretien, Fabrice Piquemal, Pierre Rocheteau, Guillaume Warot, Michel Zampaolo