Patents Assigned to CNRS
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Patent number: 12557437Abstract: A method for growing a III-V material may include forming at least one layer on a stack including a crystalline layer made of III-V material, a first masking layer surmounting the germination layer, the first masking layer having at least one first opening; depositing a second masking layer covering an upper face of the sacrificial layer; forming at least one second opening in the second masking layer; removing the sacrificial layer selectively at the first masking layer and at the second masking layer; epitaxially growing a material made of the III-V material from the germination layer; forming al least one third opening in the second masking layer; and epitaxially growing at least one material made of the III-V material from the first epitaxial layer.Type: GrantFiled: November 2, 2022Date of Patent: February 17, 2026Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CNRSInventors: Matthew Charles, Yvon Cordier
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Patent number: 12338423Abstract: A method to provide a microfluidic flow comprising a central flow and at least one outer flow, such that the central flow includes a first material and the at least one outer flow comprises a second material. One of the first material and the second material has cells and the other of the first material and the second material has solid particles. The method involves injection of a first suspension including the first material through a central inlet with a flow rate Q2 and injection of a second suspension comprising the second material through a pair of side inlets with a flow rate Q2, whereby the ratio of the flow rate Q2 over the flow rate Q1 is at least 4. A device provides such microfluidic flow and a method is provided to alter biological cells.Type: GrantFiled: April 30, 2020Date of Patent: June 24, 2025Assignees: UNIVERSITEIT GENT, CNRS, ISEN YNCRÉA HAUTS-DE-FRANCE, UNIVERSITÉ DE LILLE, UNIVERSITÉ POLYTECHNIQUE HAUTS-DE-FRANCE, CENTRALE LILLE INSTITUTEInventors: Kevin Braeckmans, Ranhua Xiong, Majid Layachi, Anthony Treizebre, Francois Anquez, Quentin Thommen, Emmanuel Courtade
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Publication number: 20240426624Abstract: The method (P1) for detecting a boundary (L1, L2, L3) of a traffic lane (VC1, VC2) for a motor vehicle (1) involves: (E1) detecting the boundary by a vehicle environment detection means (3), the boundary being defined by a function, in particular a polynomial function, (E4) determining a plurality of first vectors (MXi) characterizing the boundary on the basis of map data and on the basis of data on the current position and orientation of the vehicle, (E6) determining a plurality of second vectors (Fj) characterizing the boundary, each second vector being determined by an orthogonal projection of a first vector onto said function, and (E8) calculating Mahalanobis distances between each first vector and each second vector.Type: ApplicationFiled: October 10, 2022Publication date: December 26, 2024Applicants: AMPERE S.A.S., CNRS, UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE (UTC)Inventors: Federico Camarda, Véronique Cherfaoui, Franck Davoine, Bruno Durand
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Publication number: 20240162460Abstract: A method may activate a fuel cell including a plurality of electrochemical cells in a stack, the fuel cell being intended to operate, during at least one nominal operating phase, as an electric generator. Such a method may include, during an activation phase by electrolysis, prior to the at least one nominal operating phase: electrically supplying the fuel cell by an external electric generator, the electric supply being configured to apply an activation voltage greater than the voltage of the cell in an open circuit (OCV); fluid supplying a humid gas fluid at a first electrode and/or a second electrodes. The humid gas may have a relative humidity (RH) such that 40%?RH<100%. The fuel cell may operate in electrolysis during the activation phase called by electrolysis.Type: ApplicationFiled: November 9, 2023Publication date: May 16, 2024Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, INSTITUT POLYTECHNIQUE DE GRENOBLE, UNIVERSITE SAVOIE MONT BLANC, CNRS, UNIVERSITE GRENOBLE ALPESInventors: Eric PINTON, Yann BULTEL, Timothée DRUGEOT, Fabrice MICOUD
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Patent number: 11904004Abstract: Described herein are anti-CD277 antibodies which: activates or inhibit the cytolytic function of V?9/V?2 T cells, and/or costimulates T cells together with CD3-TCR, and/or costimulates T cells in addition to CD28-B7 costimulation, and/or increases the activity and/or survival of monocytes and dendritic cells. The use of said antibodies in therapy is also described.Type: GrantFiled: June 9, 2020Date of Patent: February 20, 2024Assignees: INSERM, UNIVERSITE D'AIX-MARSEILLE, INSTITUT JEAN PAOLI & IRENE CALMETTES, CNRS, UNIVERSITE DE NANTESInventors: Daniel Olive, Marc Bonneville, Emmanuel Scotet, Christelle Harly, Yves Guillaume
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Patent number: 11761884Abstract: An integrated photoacoustic transducer, sensing system and method for assisting in sensing a concentration of a species in a fluid such that the integrated photoacoustic transducer includes a waveguide structure. The waveguide structure has an optical resonance spectrally overlapping a spectral absorption line or band of the species. The photoacoustic transducer includes at least one acoustic cavity formed in a portion of the waveguide structure and configured for receiving the fluid for sensing comprising the species. The at least one acoustic cavity has an acoustic resonance spectrally overlapping with a harmonic of a modulation frequency. At least one acoustic transducer comprising a deformable mechanical portion is included in the photoacoustic transducer.Type: GrantFiled: January 27, 2020Date of Patent: September 19, 2023Assignees: VMICRO SAS, UNIVERSITEIT GENT, CNRSInventors: Bart Kuyken, Mathias Vanwolleghem, Mattias Verstuyft, Benjamin Walter, Jean-Francois Lampin
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Publication number: 20230136949Abstract: A method for growing a III-V material may include forming at least one layer on a stack including a crystalline layer made of III-V material, a first masking layer surmounting the germination layer, the first masking layer having at least one first opening; depositing a second masking layer covering an upper face of the sacrificial layer; forming at least one second opening in the second masking layer; removing the sacrificial layer selectively at the first masking layer and at the second masking layer; epitaxially growing a material made of the III-V material from the germination layer; forming al least one third opening in the second masking layer; and epitaxially growing at least one material made of the III-V material from the first epitaxial layer.Type: ApplicationFiled: November 2, 2022Publication date: May 4, 2023Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CNRSInventors: Matthew CHARLES, Yvon CORDIER
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Patent number: 11572409Abstract: The present invention relates to antibodies having specificity for BTN2 and uses thereof, in particular for the treatment of cancer.Type: GrantFiled: September 21, 2018Date of Patent: February 7, 2023Assignees: IMCHECK THERAPEUTICS SAS, INSERM, INSTITUT JEAN PAOLI & IRENE CALMETTES, UNIVERSITÉ D'AIX-MARSEILLE, CNRSInventors: Daniel Olive, Christine Pasero
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Publication number: 20220405448Abstract: A computer-implemented method of machine-learning. The method comprises providing a dataset of 3D modeled objects each representing a mechanical part. Each 3D modeled object comprises a specification of a geometry of the mechanical part. The method further comprises learning a set of parameterization vectors each respective to a respective 3D modeled object of the dataset and a neural network configured to take as input a parameterization vector and to output a representation of a 3D modeled object usable in a differentiable simulation-based shape optimization. The learning comprises minimizing a loss that penalizes, for each 3D modeled object of the dataset, a disparity between the output of the neural network for an input parameterization vector respective to the 3D modeled object and a representation of the 3D modeled object. The representation of the 3D modeled object is usable in a differentiable simulation-based shape optimization.Type: ApplicationFiled: June 1, 2022Publication date: December 22, 2022Applicants: DASSAULT SYSTEMES, ECOLE POLYTECHNIQUE, CNRSInventors: Mariem MEZGHANNI, Théo BODRITO, Malika BOULKENAFED, Maks OVSJANIKOV
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Patent number: 11448656Abstract: The present invention concerns a composition comprising at least three peptides derived from Mycobacterium tuberculosis antigen Rv2626c, its use in the diagnostic of latently infected Mycobacterium tuberculosis (LTBI) subjects, corresponding methods of use and kits.Type: GrantFiled: July 17, 2018Date of Patent: September 20, 2022Assignees: CNRS, CONICET, INSTITUT JEAN PAOLI & IRENE CALMETES, UNIVERSITE D' AIX-MARSEILLE, INSERMInventors: Juan Iovanna, Virginia Pasquinelli, Maria Madgalena Gherardi, Hector Eduardo Chuluyan, Ana Inès Rovetta, Delfina Pena, Véronica Edith Garcia
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Patent number: 11351156Abstract: PI3K signalling is the most increased pathway in human cancers. The four isoforms of PI3K are thought to be activated by different redundant mechanisms leading to a common downstream signalling. The inventors questioned this concept, by mapping differential isoform-specific downstream signalling in response to their constant selective inhibition in pancreatic cancer, a disease currently without therapy. They identified common and specific signals activated by each PI3K isoform. These data make the rational for the development of highly selective PI3K isoform drugs used in combination, instead of compounds inhibiting all PI3Ks. In particular, the inventors showed that combined p110a and 110? inhibition is the most efficient strategy for pancreatic cancer patients.Type: GrantFiled: October 12, 2018Date of Patent: June 7, 2022Assignees: INSERM, Université Paul Sabatier Toulouse III, CNRS, Klinikum Rechts der Isar der Technischen Universität MünchenInventors: Julie Guillermet-Guibert, Maximillian Reichert, Célia Cintas
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Patent number: 11278543Abstract: The present invention relates to the general field of treatment and prevention of diseases involving an inflammatory condition, namely sepsis or infectious or viral diseases as well as diseases requiring for the treatment of immunosuppressive activity namely autoimmune diseases and graft rejection. In particular, the invention relates to an inhibitor of the activity or the formation of the PP1/GADD34 complex for the treatment of a condition requiring an immunosuppressive activity or an anti-inflammatory activity.Type: GrantFiled: December 15, 2015Date of Patent: March 22, 2022Assignees: INSERM, UNIVERSITE D'AIX MARSEILLE, CNRSInventor: Philippe Pierre
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Patent number: 11191744Abstract: The invention relates to an active pharmaceutical ingredient consisting exclusively of the combination of (1S,3R,4R,5R)-3-{[(2E)-3-(3,4-)dihydroxyphenyl)-2-propenoyl]oxy}-1,4,5-trihydroxycyclohexanecarboxylic acid and of methyl (2S,3E,4S)-4-{2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl}-3-ethylidene-2-(?-D-glucopyranosyloxy)-3,4-dihydro-2H-pyran-5-carboxylate for use as a drug or veterinary product, particularly in the prevention and/or treatment of pathological disorders of carbohydrate and/or lipid metabolism.Type: GrantFiled: February 13, 2018Date of Patent: December 7, 2021Assignees: VALBIOTIS, UNIVERSITE CLERMONT AUVERGNE, UNIVERSITE DE LA ROCHELLE, CNRSInventors: Sebastien Peltier, Vivien Chavanelle, Florian Le Joubioux, Pascal Sirvent, Thierry Maugard
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Patent number: 10918647Abstract: The invention provides antifungal compounds, antifungal compositions, and intermediates for the preparation of antifungal compounds and antifungal compositions. The invention also provides methods of inhibiting fungi and methods of treating fungal infections, for example, with a compound or composition described herein. The antifungal compositions can include antifungal adjuvants such as essential oils or essential oil extracts, which adjuvants further improve the antifungal activity of the compositions.Type: GrantFiled: July 26, 2017Date of Patent: February 16, 2021Assignees: University of Southern California, CNRS, Universite Grenoble Alpes, INSERMInventors: Charles E. McKenna, Carlo Petosa, Jerome Govin, Boris A. Kashemirov, Elena Ferri, Flore Mietton
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Patent number: 10736930Abstract: A composition comprising at least: a single extract obtained from a mixture of at least two plants selected from Chrysanthellum indicum, Cynara scolymus, Vaccinium myrtillus, Piper and Olea europaea. This composition is particularly useful as a nutritional product or health product for preventing and/or combating carbohydrate and/or fat metabolism disorders in humans and animals.Type: GrantFiled: October 30, 2018Date of Patent: August 11, 2020Assignees: VALBIOTIS, UNIVERSITE CLERMONT AUVERGNE, UNIVERSITE DE LA ROCHELLE, CNRSInventors: Sebastien Peltier, Pascal Sirvent, Thierry Maugard
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Publication number: 20190240232Abstract: The invention provides antifungal compounds, antifungal compositions, and intermediates for the preparation of antifungal compounds and antifungal compositions. The invention also provides methods of inhibiting fungi and methods of treating fungal infections, for example, with a compound or composition described herein. The antifungal compositions can include antifungal adjuvants such as essential oils or essential oil extracts, which adjuvants further improve the antifungal activity of the compositions.Type: ApplicationFiled: July 26, 2017Publication date: August 8, 2019Applicants: University of Southern California, CNRS, Universite Grenoble Alpes, INSERMInventors: Charles E. MCKENNA, Carlo PETOSA, Jerome GOVIN, Boris A. KASHEMIROV, Elena FERRI, Flore MIETTON
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Patent number: 10232005Abstract: A composition comprising at least a mixture of molecules obtained at least from: Chrysanthellum indicum, Cynara scolymus, and Vaccinium myrtillus and wherein the mixture of molecules also comprises piperine. The composition is particularly useful as a nutritional product or health product for preventing and/or combating carbohydrate and/or fat metabolism disorders in humans and animals.Type: GrantFiled: October 18, 2016Date of Patent: March 19, 2019Assignees: Universite Clermont Auvergne, Valbiotis, Universite De La Rochelle, CNRSInventors: Sebastien Peltier, Pascal Sirvent, Thierry Maugard
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Publication number: 20190056373Abstract: A method for determination of the behavior of a reactive mixture intended for obtaining a geopolymer. The reactive mixture comprises at least one aluminosilicate material. The method includes determining a proportion of amorphous phase of the at least one aluminosilicate material and determining a degree of wettability of the at least one aluminosilicate material. If the proportion of amorphous phase is greater than 45% and if the degree of wettability is situated in a range between 300 ?g/l and 1400 ?g/l, then the reactive mixture, formed by the reaction of the at least one aluminosilicate material with an alkaline solution, forms a geopolymer.Type: ApplicationFiled: October 27, 2016Publication date: February 21, 2019Applicants: UNIVERSITE DE LIMOGES, CNRSInventors: Ameni Gharzouni, Laëticia Vidal, Sylvie Rossignol, Elodie Prud'Homme, Alexandre Autef, Emmanuel JOUSSEIN
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Patent number: 10008334Abstract: An electrochemical capacitor includes a first electrode connected to a positive terminal of a power source during the charge of the electrochemical capacitor and a second electrode connected to a negative terminal of a power source during the charge of the electrochemical capacitor. The first and the second electrodes each have a carbon material. The electrochemical capacitor further includes a porous separator to separate the first and second electrodes and to be impregnated with an almost neutral aqueous electrolyte situated between the two electrodes. The neutral aqueous electrolyte has a salt formed by a metallic cation and an anion.Type: GrantFiled: September 18, 2013Date of Patent: June 26, 2018Assignees: CNRS, Universite D'OrleansInventors: Francois Beguin, Laurent Demarconnay, Encarnacion Raymundo-Pinero
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Patent number: 9993807Abstract: The invention concerns a composition comprising a mixture of zinc sulphide (ZnS) and molybdenum sulphide (MoSx), in which the Mo/Zn molar ratio is in the range 0.01 to 1.9. The invention also pertains to a process for its preparation as well as to its application in photocatalysis and more particularly to its application in photocatalysis for the production of dihydrogen from water (H2O) and/or hydrogen sulphide (H2S) and/or any other source of protons in the presence of a source emitting in the ultraviolet and/or visible spectrum.Type: GrantFiled: June 19, 2013Date of Patent: June 12, 2018Assignees: CNRS, IFP Energies nouvellesInventors: Antoine Fecant, Denis Uzio, Dina Lofficial, Eric Puzenat, Elodie Blanco, Pavel Afanasiev, Gilles Berhault