Patents Assigned to CNRS
  • Compositions useful in the diagnostic of latently infected
    Patent number: 11448656
    Abstract: The present invention concerns a composition comprising at least three peptides derived from Mycobacterium tuberculosis antigen Rv2626c, its use in the diagnostic of latently infected Mycobacterium tuberculosis (LTBI) subjects, corresponding methods of use and kits.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: September 20, 2022
    Assignees: CNRS, CONICET, INSTITUT JEAN PAOLI & IRENE CALMETES, UNIVERSITE D' AIX-MARSEILLE, INSERM
    Inventors: Juan Iovanna, Virginia Pasquinelli, Maria Madgalena Gherardi, Hector Eduardo Chuluyan, Ana Inès Rovetta, Delfina Pena, Véronica Edith Garcia
  • ELASTOMER COMPOSITION
    Publication number: 20220280683
    Abstract: A composition based on triblock copolymers of the ABA type, including two styrene thermoplastic terminal blocks A, and an elastomer central block B which is a saturated olefin, and at least one polyisobutene having a very low molecular weight and optionally a diblock copolymer of AB. The present composition exhibits advantageous properties which are similar to those of silicone elastomers. Also, a dressing including such an elastomeric composition.
    Type: Application
    Filed: July 30, 2020
    Publication date: September 8, 2022
    Applicants: URGO RECHERCHE INNOVATION ET DEVELOPPEMENT, UNIVERSITE DE PAU ET DES PAYS DE L'ADOUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -
    Inventors: Christophe DERAIL, Armelle RONCIN, Xavier CALLIES, Christelle Marie Aline GUILLAMAUD, Anne-Sophie DANEROL, Marie DAUX
  • PROTEIN HYDROLYSATE DERIVED FROM BLUE-BACKED FISH
    Publication number: 20220279814
    Abstract: A protein hydrolysate obtained from at least one protein source from bluefish having (i) a degree of hydrolysis (DH) of at least 10%, (ii) at least 80% water-soluble protein with a molecular weight of less than 1000 Da, (iii) at least 0.3% phospholipids, and (iv) at least 0.5% DHA and EPA.
    Type: Application
    Filed: July 31, 2020
    Publication date: September 8, 2022
    Applicants: SPECIALITES PET FOOD, UNIVERSITE DE BORDEAUX, UNIVERSITÉ DE BRETAGNE OCCIDENTALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD), INSTITUT POLYTECHNIQUE DE BORDEAUX, ABYSS INGREDIENTS, INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER - IFREMER, INSTITUT NATIONAL DE LA RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
    Inventors: Fabienne GUERARD, Cloé OROY, Anne LEPOUDERE, Mathilde CHATAIGNER, Patrick ALLAUME, Anne-Laure DINEL, Corinne JOFFRE, Véronique PALLET, Fabienne LE GRAND
  • NOVEL DIZOCILPINE DERIVATIVES AS PERIPHERAL NMDA RECEPTOR ANTAGONISTS
    Publication number: 20220280498
    Abstract: The present invention relates to compounds of formula (I): for use as peripheral NMDA receptor antagonists.
    Type: Application
    Filed: May 26, 2022
    Publication date: September 8, 2022
    Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS SUD, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (APHP), HOPITAL MARIE LANNELONGUE
    Inventors: Sylvia COHEN-KAMINSKY, Marc HUMBERT, Sebastien DUMAS, Gilles BRU-MERCIER, Samir MESSAOUDI, Jean-Daniel BRION, Mouad ALAMI, Gilles GALVANI
  • ENZYMATIC BIOCATHODE, METHOD FOR PRODUCING IT AND FUEL BIOCELL AND BIOSENSOR COMPRISING THIS ENZYMATIC BIOCATHODE
    Publication number: 20220275420
    Abstract: A biomass-based enzymatic biocathode based on glucose, monosaccharide, ketone or aldehyde includes a collector conductor support, conductive particles disposed on and bound to said collector conductor support, and an aldose reductase disposed on said conductive particles, being bound thereto by adsorption and accessible at the surface of the monosaccharide, ketone or aldehyde reagent that is to be reduced when the biocathode is operational.
    Type: Application
    Filed: July 27, 2020
    Publication date: September 1, 2022
    Applicants: UNIVERSITÉ GRENOBLE ALPES, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE - INSERM, GRENOBLE INP (INSTITUT NATIONAL POLYTECHNIQUE), CNRS - CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Abdelkader ZEBDA, Philippe CINQUIN, Donald MARTIN, Thomas SORANZO
  • PROCESS FOR POLYMERIZING A COMPOSITION IN THE PRESENCE OF A BLOCK COPOLYMER
    Publication number: 20220275136
    Abstract: The present invention relates to a process for the polymerization of a composition in the presence of at least one block copolymer, and also to the products obtained by this polymerization process. The present invention also relates to the use of the products obtained using the polymerization process which is a subject matter of the invention.
    Type: Application
    Filed: May 19, 2020
    Publication date: September 1, 2022
    Applicants: Arkema France, Centre National De La Recherche Scientifique - CNRS, UNIVERSITE DE PAU ET DES PAYS DE L'ADOUR
    Inventors: Sylvain Bourrigaud, Anne-Laure Brocas, Sylvie Cazaumayou, Laura Garcia Andujar, Maud Save, Christophe Derail, Laurent Rubatat
  • METHOD FOR MANUFACTURING A THREE-DIMENSIONAL OBJECT OR FOR MODIFYING THE SURFACE STATE OF A PREFORMED OBJECT BY PHOTO-POLYMERIZATION
    Publication number: 20220266505
    Abstract: The method for manufacturing a three-dimensional object or for modifying the surface state of a preformed object by local polymerisation of monomers or oligomers, the polymerisation being initiated by mono-photon or multi-photon absorption in an area to be polymerised, includes: —introducing into a vessel with light-transparent walls a reaction medium comprising polymerisable monomers or oligomers, a polymerisation inhibitor, an indicator of the amount of the inhibitor and a photochemical polymerisation initiator; —initiating the polymerisation of the monomers or oligomers; —indicating the amount of inhibitor present in the reaction medium; —controlling the amount of light emitted by the irradiation system relative to the amount of inhibitor indicated by the indicator; and —switching to a following zone to be polymerised by moving the object and/or the focused light beam.
    Type: Application
    Filed: July 22, 2020
    Publication date: August 25, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE D'AIX-MARSEILLE (AMU), ECOLE CENTRALE DE MARSEILLE
    Inventors: Claude Amra, Jean-Claude André, Laurent Gallais-During, Myriam Zerrad
  • SELECTIVE BCRP/ABCG2 TRANSPORTER INHIBITORS AS AGENTS TO ABOLISH RESISTANCE TO ANTI-CANCER AGENTS
    Publication number: 20220267289
    Abstract: A compound of formula (I): or pharmaceutically acceptable enantiomer, salt or solvate thereof, or a mixture thereof, the ring A, and the substituents Z, Y and R1 being as defined herein.
    Type: Application
    Filed: June 1, 2020
    Publication date: August 25, 2022
    Applicants: UNIVERSITE GRENOBLE ALPES, CNRS - CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Ahcène BOUMENDJEL, Pierre FALSON, Alexis MORENO, Basile PERES, Emile ROUSSEL
  • Process For Preparation Of Bioorganic Nylon Polymers And Their Use As Antibacterial Material
    Publication number: 20220267522
    Abstract: The present invention relates to new biopolymer, i.e. bioorganic nylons incorporating peptidic blocks obtained by a process of polymerization of amino peptidic blocks. The process of the invention comprises the steps of mixing amino peptidic blocks with or without a diaminoalcane and reacting the mixture according to polycondensation with a diacyl chloride in homogeneous or heterogeneous media.
    Type: Application
    Filed: March 8, 2022
    Publication date: August 25, 2022
    Applicants: Universite De Montpellier, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Jean Martinez, Ahmad Mehdi, Gilles Subra, Saïd Jebors
  • SELECTIVE PROCESS FOR PREPARING SULFOXIDES BY ENZYMATIC CATALYSIS
    Publication number: 20220259624
    Abstract: The present invention relates to a selective process for preparing sulfoxides from sulfides by enzymatic catalysis, and to a composition comprising a symmetrical sulfide, an oxidoreductase enzyme catalyzing the oxidation of said symmetrical sulfide to symmetrical sulfoxide; optionally at least one cofactor C of said enzyme E; and an oxidant, which allows in particular the implementation of said process.
    Type: Application
    Filed: June 12, 2020
    Publication date: August 18, 2022
    Applicants: Arkema France, Centre National de la Recherche Scientifique (CNRS), Universite d'Aix-Marseille
    Inventors: Georges Fremy, Hugo Brasselet, Véronique Alphand, Katia Duquesne
  • Method for rejuvenating cells
    Patent number: 11414649
    Abstract: The invention relates to a method for reprogramming cells from aged donors or senescent cells to pluripotent cells that have lost marks of senescence. In particular, the invention relates to an ex vivo method for preparing induced pluripotent stem cells (iPSCs) from a target cell population comprising cells from aged donors or senescent cells, said method comprising the steps of culturing said target cell population under appropriate conditions for reprogramming said cells into iPSCs, wherein said appropriate conditions comprises increasing expression in said target cells, of at least the following reprogramming factors: Oct4, Klf4, Sox2, c-Myc, Lin28 and, optionally Nanog.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: August 16, 2022
    Assignees: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE MONTPELLIER I, UNIVERSITE MONTPELLIER II
    Inventors: Alexandre Prieur, Ollivier Milhavet, Jean-Marc Lemaitre, Laure Lapasset
  • Hydrazone derivatives for preventing or treating EBV-related cancers
    Patent number: 11406631
    Abstract: The present invention relates to novel bis-hydrazone derivatives of formula (I): wherein Ar1 and Ar2 may be identical or different and are each independently selected from the group consisting of groups of formula (II) and (III): Y1 and Z1 are independently CH or NRc+, provided that al least one of Y1 and Z1 is NRc+ and at least one of Y1 and Z1 is CH, and Ra, Rb, Rc, X2? and L as defined in the claims, or a hydrate or a solvate thereof. Compositions and kits comprising same are also described. Said bis-hydrazone derivatives of formula (I), compositions and kits are useful as drugs, in particular for treating or preventing cancers associated with the Epstein-Barr Virus.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: August 9, 2022
    Assignees: Centre National de la Recherche Scientifique (CNRS)
    Inventors: Marc Blondel, Alicia Quillevere, Cécile Voisset, Maria José Lista, Robin Fahraeus, Chrysoula Daskalogianni, Rodrigo Prado-Martins, Marie-Paule Teulade-Fichou, Anton Granzhan, Claire Beauvineau, Oksana Reznichenko
  • METHOD FOR PREPARING A MONOLITHIC NANOPOROUS SILICATE SOL-GEL MATERIAL
    Publication number: 20220242739
    Abstract: A method for preparing a monolithic nanoporous silicate sol-gel material for modulating the pore size distribution for one single starting composition without the addition of a structuring agent. The method includes the following steps: a) synthesising a gel from at least one organosilylated precursor, the synthesis being carried out in an aqueous medium, optionally including an organic solvent and without a structuring agent, and b) drying the gel obtained in step a) at a temperature between 10° C. and 70° C., preferably between 15° C. and 55° C. and more preferably between 20° C. and 40° C., in a gas flow in a drying chamber to obtain a monolithic nanoporous silicate sol-gel material and a residual relative humidity in the drying chamber of between 0.1 and 20%, preferably between 0.5 and 10% and more preferably about 5%.
    Type: Application
    Filed: October 4, 2019
    Publication date: August 4, 2022
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, ECOLE NATIONALE SUPERIEURE MINES-TELECOM LILLE-DOUAI
    Inventors: Clarisse TRAN, Thu-Hoa TRAN-THI, Sabine CRUNAIRE, Jean-Luc WOJKIEWICZ
  • METHOD FOR MANUFACTURING A PART MADE OF A MONOCRYSTALLINE SUPERALLOY
    Publication number: 20220243312
    Abstract: The invention concerns a method for manufacturing an aircraft part, the part comprising a monocrystalline nickel-based superalloy substrate, the method consecutively implementing the steps of moulding the part at a moulding temperature greater than the melting temperature of the superalloy, and cooling the part, such that the monocrystalline superalloy has a ? phase and a ? phase, solution heat treatment of the part at a first temperature between the solves temperature of the ?? phase and the melting temperature of the superalloy, homogenising the crystalline structure or the part, cooling the part to ambient temperature, first tempering and second tempering.
    Type: Application
    Filed: June 26, 2020
    Publication date: August 4, 2022
    Applicants: Safran Aircraft Engines, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NATIONALE SUPERIEURE DE MECANIQUE ET D'AEROTECHNIQUE DE POITIERS, UNIVERSITE DE POITIERS
    Inventors: Satoshi UTADA, Joël DELAUTRE, Sarah HAMADI, Jonathan CORMIER, Patrick VILLECHAISE, Jérémy RAME
  • Atomic Force Microscope
    Publication number: 20220236301
    Abstract: The present invention relates to an atomic force microscope for evaluating a surface of a sample, comprising a sample holder, having a first zone suitable for receiving the sample mounted in a stationary manner, a probe having a tip able to be positioned facing the surface of the sample, the microscope being configured to allow an adjustment of a position of the tip relative to the surface, and a support, the sample holder having at least one second zone, separate from the first zone and stationary relative to the support, the sample holder being deformable so as to allow a relative movement of the first zone with respect to the second zone, and the microscope comprising a detector able to detect a movement of the first zone relative to the second zone.
    Type: Application
    Filed: July 16, 2020
    Publication date: July 28, 2022
    Applicants: Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite, Université de Paris
    Inventors: Antoine Niguès, Alessandro Siria
  • SURGICAL SYSTEM WITH NAVIGATION
    Publication number: 20220233250
    Abstract: Systems, instruments, and methods are provided verifying the surgery is being performed in accordance with a surgical plan, wherein a surgical tool having a sensor outputs a data signal that enables the trajectory of the surgical tool to be displayed as an overlay on an image of an anatomical portion of a patient and a visual or audible signal that confirms the surgical tool is penetrating the anatomical portion in accordance with the surgical plan and/or that issues an alert indicating that the surgical tool is not being inserted into the anatomical portion according to the surgical plan.
    Type: Application
    Filed: April 13, 2022
    Publication date: July 28, 2022
    Applicants: SpineGuard, INSERM (Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique - CNRS
    Inventors: Stephane BETTE, Maurice BOURLION, Thibault CHANDANSON
  • NOVEL COMPOUNDS, FUNCTIONALISED DIOXABOROLANE OR DIOXABORINANE DERIVATIVES, METHOD FOR PREPARING SAME AND USES THEREOF
    Publication number: 20220227790
    Abstract: The invention relates to functionalised dioxaborolane or dioxaborinane derivatives of formula (I), wherein R1 is covalently bonded to the boron atom by a carbon atom; one of R2, R3, R?3 or R4 is a radical of formula —X; or one of R1, R2, R3, R?3 or R4 is a radical of formula —X; and X is a functionalised radical. The invention relates to the method for preparing same and the uses thereof.
    Type: Application
    Filed: January 6, 2022
    Publication date: July 21, 2022
    Applicants: ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Ludwik LEIBLER, Renaud NICOLAY
  • Method for producing a microfluidic device
    Patent number: 11389793
    Abstract: The present invention relates to a method for producing a microfluidic device, in particular, a sol-gel method for producing a microfluidic device in hybrid silica glass. The invention also relates to a microfluidic device obtainable by the method as described above and to microfluidic device in hybrid silica glass comprising at least one microchannel having a depth of at least 1 ?m, preferably between 1 ?m and 1 mm, and more preferably between 10 and 100 ?m.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: July 19, 2022
    Assignees: TOTAL SA, ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS-, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Michael Levant, Denis Bartolo, Stéphane Parola, Denis Chateau
  • Method for forming spacers of a transistor
    Patent number: 11393689
    Abstract: A method for forming spacers on a gate pattern includes deposition of a first dielectric layer having basal portions on an active layer and side portions of the edges of the pattern; anisotropic modification of only the basal portions of the first layer, so as to obtain modified basal portions; deposition of a second dielectric layer on the first layer, also having basal and side portions; anisotropic etching of only the basal portions of the second layer, so as to remove these basal portions while conserving the side portions; and removal of the modified basal portions while conserving the first and second non-modified side portions, by selective etching of the modified dielectric material vis-à-vis the non-modified dielectric material.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: July 19, 2022
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE GRENOBLE ALPES
    Inventors: Nicolas Posseme, Marceline Bonvalot, Ahmad Chaker, Christophe Vallee
  • Modified oligonucleotides comprising thiol functions and use thereof for detecting nucleic acids
    Patent number: 11390643
    Abstract: The present invention relates to a modified oligonucleotide having two or more thiol functions, which can be immobilized on a gold surface or on a grafted surface, in particular a surface comprising at least one carbon-carbon double bond or carbon-carbon triple bond or haloacetamide functions, preferably maleimide or acrylamide functions. The invention also relates to a method for detecting a nucleic acid in a biological sample comprising a step of detecting hybridization between a modified oligonucleotide and a target nucleic acid amplified from the biological sample. The invention relates more particularly to a method for detecting, genotyping or sequencing a pathogenic organism, preferably a virus.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: July 19, 2022
    Assignees: ETABLISSEMENT FRANÇAIS DU SANG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE MONTPELLIER, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Chantal Fournier-Wirth, Myriam Lereau, Jean-François Cantaloube, Jean-Jacques Vasseur, François Morvan, Albert Meyer, Julie Mayen, Carole Chaix, Carole Farre