Abstract: Disclosed is a method for searching a MTPA curve of a vehicle permanent magnet synchronous motor based on a DC power, which includes a current closed-loop adjuster, a current command generator, a current command angle generator, an active power calculator, an active power storage and comparison processor and a current given vector corrector. According to the present disclosure, the tedious manual calibration is relieved, the optimal angle is automatically searched, and the production efficiency is improved; according to the present disclosure, the step size can be arbitrarily set according to the calibration requirements, so as to achieve a higher calibration accuracy.

Abstract: An automatic insertion device and method of using the same is provided. A vibrator and an extender are connected to a penetrating member and are both in electrical communication with a controller. A detector identifies a subcutaneous target for insertion and the insertion angle, distance and trajectory for the penetrating member are calculated. The vibrator provides vibrations to the penetrating member and the extender advances the penetrating member for insertion. The vibrator and extender are in electrical communication with one another during the insertion process and adjustments to the insertion speed are made based on feedback of vibrational load encountered by the vibrator during insertion, and adjustments to the vibrations are made based on feedback of insertion load encountered by the extender during insertion. Iterative samples are taken to constantly adjust the operation of one motor based on the operations and feedback from the other motor.

Abstract: Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g.

Abstract: Disclosed are a root canal fluid filling device and method. The root canal fluid filling device includes a root canal filling device box, including an upper box body and a lower box body which are arranged in upper and lower partitions and detachable; a positive and negative pressure generating apparatus, arranged in the lower box body; an air pressure monitoring apparatus, arranged in the lower box body and connected to the positive and negative pressure generating apparatus; an air pressure recovery apparatus, arranged in the lower box body; an auxiliary positioning apparatus, including an auxiliary positioning crown which is respectively connected to the positive and negative pressure generating apparatus, the air pressure monitoring apparatus and the air pressure recovery apparatus and is to be sleeved outside and cemented to a tooth to be subjected to root canal therapy; a control display apparatus; and a power supply apparatus.

Abstract: A method for fabricating a multianalyte detection device. The multianalyte detection device includes a substrate having a plurality of graphene field effect transistor devices each having a source, a drain, and a side gate located thereon. A graphene layer deposited on the substrate to form a plurality of graphene active regions between the source electrode and the drain electrode of each of the plurality of graphene field effect transistors for detection of an analyte therein. A plurality of graphene windows are located on the graphene active regions for receiving a liquid for detecting of the analyte therein. One or more passivation layers are positioned on the substrate to protect the source electrode and the drain electrode for each of the plurality of graphene field effect transistor devices from the liquid received in the plurality of graphene windows.

Abstract: Embodiments of the present disclosure pertain to a composition that includes: silica nanofibers; and one or more detection particles associated with the silica nanofibers. Additional embodiments of the present disclosure pertain to methods of sensing one or more analytes and/or one or more environmental conditions from a sample by associating the sample with a composition of the present disclosure; detecting a change in a property of the detection particles; and correlating the change in the property of the detection particles to a presence or absence of one or more analytes, one or more environmental conditions, or combinations thereof. Further embodiments of the present disclosure pertain to methods of making the compositions of the present disclosure by growing silica nanofibers from at least one precursor material; and associating one or more detection particles with the silica nanofibers.

Abstract: A flow cell for reducing carbon dioxide may include a first chamber having a gold coated gas diffusion layer working electrode, a reference electrode, and a water-in-salt electrolyte comprising a super concentrated aqueous solution of lithium bis-(trifluoromethanesulfonyl)imide (LiTFSI). A second chamber adjacent the first chamber has a gold coated gas diffusion layer counter electrode and the water-in-salt electrolyte. The second chamber being separated from the first chamber by a proton exchange membrane. A reservoir coupled to each of the first and the second chambers with a pump contains a volume of the water-in-salt electrolyte and a head space.

Abstract: A method of producing a carbon nanotube may include heating a convergent flow nozzle and a flow chamber of a carbon nanotube reactor, flowing a vaporized reactant stream through the nozzle and collecting a carbon nanotube product from an outlet of a heated flow chamber disposed downstream of the heated convergent flow nozzle. The vaporized reactant stream may include a carbon nanotube nucleation carbon source, a carbon nanotube growth carbon source, and a carbon nanotube catalyst precursor. The nozzle may have a nozzle contraction ratio of from 3:1 to 300:1.

Abstract: A previously uncharacterized gene and gene product are disclosed herein that increase blood glucose clearance independent of insulin. Also described is a methodology for enriching for mRNAs transcribing excreted and membrane bound proteins as well as a non-human animal expressing a labeled SEC61b protein.

Abstract: A laser system for generating a narrow linewidth semiconductor light beam includes a substrate, a gain chip affixed on the substrate and configured to amplify light beam, and an optical feedback photonic chip affixed on the substrate, optically coupled to the gain chip, and configured to output light beam, which has a narrow linewidth around a resonant frequency of the optical feedback photonic chip, to the gain chip.

Abstract: Disclosed herein are adiponectin receptor agonists and methods of using the same for the treatment of inflammation or bone loss in a subject.

Abstract: A textile actuator worn by a user comprises a textile envelope that defines a chamber made fluid-impermeable by a fluid-impermeable bladder contained in the textile envelope and/or a fluid-impermeable structure incorporated into the textile envelope. The textile envelope has a pre-determined geometry that produces an equilibrium state at a non-180-angle displacement and that stops further displacement upon pressurization of the chamber and prevents over-extension the joint. A fluid is delivered into or out of the chamber to displace the textile envelope primarily by transitioning from an uninflated state to the pre-determined geometry due to displacement of the textile envelope rather than via stretching or contraction of the textile envelope. When actuated, the textile actuator (a) displaces a body segment of the user and/or (b) supports and holds the body segment of the user in place.

Abstract: Disclosed herein are agents that enhance muscle stem cell engraftment, as well as methods and compositions using the same.

Abstract: Methods are provided for producing differentiated cells from stem cells, including producing hepatocytes. Compositions thereof are also provided, as are methods of treating a liver disorder.

Abstract: Disclosed are compositions and methods comprising one or more recombinant influenza viruses. Recombinant influenza viruses with mutated polymerases and/or rearranged genomes are disclosed. Constructs comprising different influenza nucleic acid sequences are also provided. Methods of inducing protecting immunity with the recombinant influenza viruses are disclosed. Also disclosed are methods of plasmid-free production of influenza virus comprising amplicons comprising one or more of influenza genes.

Abstract: A nanopore sensor includes a nanopore disposed in a support structure with a nanopore diameter and having a nanopore fluidic resistance, RPore. A fluidic passage, is disposed in fluidic connection between a first fluidic reservoir of ionic concentration solution and the nanopore, and includes a passage length having a fluidic passage width, along at least a portion of a fluidic passage length, that is greater than the diameter of the nanopore and less than the fluidic passage length. The fluidic passage has a fluidic passage fluidic resistance, RFP, of at least about 10% of the nanopore fluidic resistance, RPore, and no more than about 10 times the nanopore fluidic resistance, RPore. The nanopore is disposed in fluidic connection between the fluidic passage and a second fluidic reservoir of ionic concentration solution. At least one transistor is operatively connected electrically to sense electrical potential local to the fluidic passage.

Abstract: Provided herein are pluripotent stem cells comprising particular combinations of transcription factor for the production of oligodendrocyte progenitor cells (OPCs). Also provided herein are methods of producing the pluripotent stem cells and methods of using the pluripotent stem cells to produce (OPCs) and oligodendrocytes.

Abstract: The present invention provides novel compounds (e.g., compounds of Formulae (I), (II), (III), (IV)) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or pharmaceutically acceptable salts thereof, optionally in a pharmaceutically acceptable carrier, and a medical uses thereof.

Abstract: The present disclosure provides an accelerated AD model system for use in the diagnosis and prognosis of Alzheimer's disease (AD). The AD accelerated model system may also be used in screening assays for identifying therapeutic agents that correct, or alleviate, one or more of the cell culture phenotypes associated with the development of AD. Such phenotypes include, for example, increased tau phosphorylation, amyloid plaque accumulation, elevated levels of A?42 to A?40 ratio, increased cell death and cell cycle re-entry. The methods and compositions provided herein are based on the discovery that exogenously expressed progerin in neural progenitor cells leads to a robust and accelerated AD phenotype in said cells as they differentiate and that the modified and differentiated cells surprisingly produce factors which generate an aged environment (“aging factors”) for all the cells in their vicinity.

Abstract: The technology described herein is directed to a gene regulatory element, e.g., enhancer, vectors comprising the same, adeno-associated vectors comprising the same and cells comprising said vectors. In another aspect, described herein are methods of treating a motor neuron disease or disorder comprising administration of said vectors, e.g., AAV vectors. In another aspect, described herein are nucleic acid compositions comprising the gene regulatory element as described herein.