Abstract: Disclosed herein is a photonic material for reducing transmission of ultraviolet light. The photonic material has spherical scatterers in a matrix material. The spherical scatterers have an amorphous arrangement in the matrix material and are configured to scatter ultraviolet light traveling in the matrix material. The amorphous arrangement of the spherical scatterers causes multiple scattering of the ultraviolet light. Absorbing material is disposed within the matrix material or the spherical scatterers and absorbs the ultraviolet light traveling in the matrix material.

Abstract: A novel network of tumorigenic prognostic factors is identified that plays a critical role in advanced pancreatic cancer (PC) pathogenesis. This interactome is interconnected through a central tumor suppressive microRNA, miR-198, which is able to both directly and indirectly modulate expression of the various members of this network to alter the molecular makeup of pancreatic tumors, with important clinical implications. When this tumor signature network is intact, miR-198 expression is reduced and patient survival is dismal; patients with higher miR-198 present an altered tumor signature network, better prognosis and increased survival. Further, according to the present disclosure, MiR-198 replacement reverses tumorigenicity in vitro and in vivo.

Abstract: Disclosed is a method for increasing susceptibility of cancer cells to ionizing radiation by delivering to the cells a radiosensitizing agent that has one of the following properties: (a) it perturbs the process of chromosome segregation thereby increasing chromosome missegregation; or (b) it is an inhibitor of an agent that promotes faithful chromosome segregation induces numeric chromosome instability in said cells and this instability is induced substantially simultaneously with or closely prior to or closely after irradiating the cells. Examples of such radiosensitizing agent include inhibitors of one or more of the following: Kif2b, MCAK, MPS1, Eg5/Kinesin-5 5, Polo-like kinase 4, MCAK, Bub1 and Hec1. Such agents specifically target proteins involved in maintaining or promoting faithful chromosome segregation.

Abstract: Disclosed are compounds of formula (I) below: wherein each of the variables A, B, X, W, V, R1-R5, and m is defined herein. Also disclosed are pharmaceutical compositions containing a nanocomplex, wherein the nanocomplex is formed of one of the compounds, and a protein, a nucleic acid, or a small molecule; and methods of treating a medical condition with one of the pharmaceutical compositions.

Abstract: A method of modulating some or all copies of a gene in a cell is provided including introducing into a cell one or more ribonucleic acid (RNA) sequences that comprise a portion that is complementary to all or a portion of each of the one or more target nucleic acid sequences, and a nucleic acid sequence that encodes a Cas protein and maintaining the cells under conditions in which the Cas protein is expressed and the Cas protein binds and modulates the one or more target nucleic acid sequences in the cell.

Abstract: The present disclosure is directed to electrolyte membrane compositions, electrolyte membranes, batteries utilizing said electrolyte membranes, and methods of assembling said batteries. The electrolyte membranes disclosed herein provide membranes and electrolytes for sustainable and more robust batteries.

Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.

Abstract: The present disclosure relates to the field of hydrogel technology, and specifically relates to a small molecule melphalan hydrogel and a preparation method thereof. The small molecule melphalan hydrogel is made of melphalan drug or melphalan hydrochloride as raw materials, and it is formed at room temperature or physiological condition by means of making the melphalan drug in a hydrophilic solvent. The hydrophilic solvent includes any one of physiological saline, pure water, and phosphate buffered saline solution. The small molecule melphalan hydrogel provided by the present disclosure is an injectable hydrogel of 100% pure melphalan drug, the gel only contains small molecule melphalan drug, which solves the problems of containing a large amount of carrier materials and having a low drug loading rate in the field of hydrogel.

Abstract: Provided herein are therapeutic agents having specificity for human CLPTM1L/CRR9 polypeptide, including therapeutic agents comprising one or more CLPTM1L-targeting agents, compositions comprising such therapeutic agents, and methods of using such compositions for treating or preventing a cancer, pre-cancerous lesion, or other disease condition associated with CLPTM1L/CRR9 protein dysfunction (e.g., pathogenic production, modification, or function). In particular, provided herein are fully human monoclonal antibodies against human CLPTM1L/CRR9 protein and methods of using such antibodies for treating or preventing a cancer, pre-cancerous lesion, or other disease condition associated with CLPTM1L/CRR9 protein dysfunction (e.g., pathogenic production, modification, or function).

Abstract: The present invention discloses an adjusting apparatus for improving an anti-cavitation effect of a water pump. The adjusting apparatus comprises a centrifugal impeller (10), a volute (20), an adjusting device (30), a jet device (40), a pressure and/or flow monitoring device, and a controller. The centrifugal impeller comprises a rear side labyrinth seal (15) and a front side labyrinth seal (16), and the volute comprises a first sealing portion (21), a first pressure adjusting cavity (22), a second sealing portion (23) and a second pressure adjusting cavity (24), where the position of the first sealing portion is provided with the first pressure adjusting cavity, the position of the second sealing portion is provided with the second pressure adjusting cavity, the second pressure adjusting cavity is in communication with the first pressure adjusting cavity through the first pipeline.

Abstract: A privacy protection method and system for financial data sharing based on federated learning are provided. In recent years, due to the restrictions of data security and privacy protection laws and regulations, it is difficult to share data across institutions or departments. In order to make data transfer and transaction between different entities can be achieved without violating the national laws on data privacy and data security, the privacy protection method and system for financial data sharing based on federated learning is provided. A privacy collection intersection technology is adopted, so that two institutions, which may have many differences in business, but most of their customer groups are the same, jointly train a learning model.

Abstract: Aspects of the disclosure relate to compositions and methods for treating hereditary hearing loss and/or vision loss, for example, due to Usher syndrome, Type 3A. In some embodiments, the disclosure provides a recombinant adeno-associated virus comprising: (i) an AAV-S capsid protein, and (ii) an isolated nucleic acid comprising a transgene (e.g., a transgene for expressing a clarin-1 protein). The present disclosure also provides methods of treating hereditary hearing loss and/or vision loss (e.g., Usher Syndrome, Type 3A) using the same.

Abstract: Gene editing can be performed by introducing gene-editing components into a cell by mechanical cell disruption. Related apparatus, systems, techniques, and articles are also described.

Abstract: The invention provides methods and compositions for distinguishing breast cancer.

Abstract: Embodiments disclosed herein provide methods, systems, and computer program products that utilize long-range phase information to detect subtle chromosome imbalances in genotype data. Clonal expansions result from mutation followed by selective proliferation, and the embodiments disclosed herein may be used to somatic structural variant events (SVs) predictive or diagnostic of cancer and other diseases.

Abstract: The invention relates to a method of producing a tendon neotissue from a population of adipose-derived stem cells (ASCs) subjected to mechanical and biological stimulations in a bioreactor system. The tendon neotissues are effective as implants to treat tendon or ligament injury in a subject. The invention also relates to a customized bioreactor useful for producing a tri-dimensional engineered tissue.

Abstract: The present invention teaches increasing the efficiency of a dye-sensitive solar cell by increasing the surface area of the DSSC photoanode. A thin film titanium oxide is deposited in trapezoidal shaped wells etched in the DSSC substrate. The thin-film titanium oxide is anodized to produce titanium oxide nanotubes on the inner surface of the trapezoidal shaped wells to further increase the surface area and incidence of light being temporarily trapped within the wells. A sensitized dye overlays the titanium oxide nanotubes to increase quantity of light absorbed by the titanium oxide nanotubes. A photoactive layer such as Cs2O may be deposited to enhance electron current contribution. A compatible transparent metal contact layer is deposited. This layer may be followed by a high-refractive index droplet over the well to act as a convex lens waveguide for incoming light. Electrical connections are then made to the frontside and backside metal contacts.

Abstract: A multi-correction analysis method for correcting a result of analyzing a large number of object substances contained in a sample using a chromatograph, includes: grouping at least a part of a large number of object substances possibly contained in a sample to be analyzed into groups based on changes in the measured values of the part of the object substances obtained by performing chromatographic analysis of the sample under different analysis conditions, and determining a surrogate substance for each of the groups; and adding the surrogate substance to the sample as an internal standard substance common to the object substances contained in each group, and correcting a measured value of each of the large number of object substances obtained from a result of chromatographic analysis of the sample with a measured value of the internal standard substance corresponding to the group to which the object substance belongs.

Abstract: An apparatus for estimating bio-information of a user may include a first sensor configured to measure a first signal from the user; a second sensor configured to measure a second signal from the user; and a processor configured to obtain a first characteristic point from the first signal; obtain a second characteristic point from the second signal based on the first characteristic point and a pre-defined probability distribution function; and estimate the bio-information of the user based on the second characteristic point.

Abstract: An antiviral agent is provided, having a phosphorodiamidate morpholino oligomer with an antisense sequence to a portion of a genome of a strain of a coronavirus. The coronavirus may be SARS-CoV-2 or another ?CoV. The antiviral agent finds many uses, such as in a pharmaceutical composition, a method of treating coronavirus-mediated disease, a method of preventing coronavirus-mediated disease, a method of reducing or preventing the replication of coronavirus in a host cell, a method of controlling the spread of coronavirus in donated tissue, a treated tissue sample, and in the manufacture of a medicament for the treatment or prevention or coronavirus-mediated disease.