Abstract: Provided herein are biosynthetic methods for producing brazzein and related compositions. Uses (e.g., as sweeteners) of the brazzein produced using the methods are also provided.

Abstract: The present disclosure provides polymers prepared by a method comprising reacting a polymerization mixture comprising one or more types of hydroxy/amino-oximes, one or more types of diols, one or more types of polyols (e.g., triols), one or more types of isocyanates, and optionally one or more types of oximes. At least one instance of =N—OH of at least one instance of the hydroxy/amino-oximes may react with —NCO of the isocyanates to form ?N—O—C(?O)—NH— bonds. The polymers may be a thermoset under ambient conditions. At elevated temperatures, the polymers may undergo a transition from a cross-linked state to a lightly cross-linked or un-crosslinked state (e.g., at least in part because at least one instance of the =N—O—C(?O)—NH— bonds may be cleaved (e.g., to form ?N—OH and —NCO)). The transition may be reversable (e.g., by changing the temperature). The polymers of the present disclosure may be useful as hot melt adhesives.

Abstract: The present disclosure provides polymers prepared by a method comprising reacting a polymerization mixture comprising one or more types of diols, one or more types of polyols, and one or more types of isocyanates, wherein at least one type of the diols and/or at least one type of the polyols are phenols, wherein each of the phenols is independently a diol or polyol, wherein one or more instances of —OH, —NH2, and/or —NH— are aryl-bound. At least one instance of C—OH of at least one instance of the diols or polyols may react with —NCO of the isocyanates to form C—O—C(?O)—NH— bonds. The polymers may be a thermoset under ambient conditions. At elevated temperatures, the polymers may undergo a transition from a cross-linked state to a lightly cross-linked or un-crosslinked state (e.g., at least in part because at least one instance of the C—O—C(?O)—NH— bonds may be cleaved (e.g., to form C—OH and —NCO)). The transition may be reversable (e.g., by changing the temperature).

Abstract: The present disclosure provides polymers prepared by a method comprising reacting a polymerization mixture comprising one or more types of oximes, one or more types of diols, one or more types of polyols, and one or more types of isocyanates. At least two instances of ?N—OH of at least one instance of the oximes may react with —NCO of the isocyanates to form ?N—O—C(?O)—NH— bonds. The polymers may be a thermoset under ambient conditions. At elevated temperatures, the polymers may undergo a transition from a cross-linked state to a lightly cross-linked or un-crosslinked state (e.g., at least in part because at least one instance of the ?N—O—C(?O)—NH— bonds may be cleaved (e.g., to form ?N—OH and —NCO)). The transition may be reversable (e.g., by changing the temperature). The polymers of the present disclosure may be useful as hot melt adhesives. The present disclosure also provides compositions, kits, methods of preparation, methods of bonding, and methods of de-bonding.

Abstract: The present disclosure provides esters of a retinoid and bakuchiol, such as esters of Formula (I?). The present disclosure also provides compositions and kits comprising the esters, methods of producing the esters, methods of using the esters (e.g., for treating or preventing a skin disease, slowing the ageing of the skin, improving the appearance of the skin, or modulating a retinoid receptor).

Abstract: The present disclosure relates, at least in part, to the production of delta-lactones and gamma-lactones from fatty acid substrates (e.g., fatty acid substrates of C16-C25) via a batch fermentation method in an engineered microbe using a recombinant cytochrome P450 monooxygenase.

Abstract: The present disclosure relates, at least in part, to the production of delta-lactones from fatty acid substrates via a batch fermentation method in an engineered microbe using a recombinant cytochrome P450 monooxygenase.

Abstract: The present invention relates to engineered microbial host cells comprising exogenous genes coding for proteins responsible for converting histidine and cysteine into ergothioneine in greater efficiency than the wild-type cells. Also provided in this invention are methods for producing ergothioneine using the engineered microbial host cells of the present invention.

Abstract: The present invention relates to novel steviol glycosides rebaudioside R6-5, rebaudioside R6-6, and rebaudioside R7-5 and the production of these novel steviol glycosides, such as through enzymatic bioconversion.

Abstract: Provided herein are biosynthetic methods for producing lactones, such as macrocyclic lactones, from fatty acids. The lactones produced using and/or during the biosynthetic methods are also provided.

Abstract: The present invention relates to the production of steviol glycoside rebaudiosides D4, WB1 and WB2 and the production of rebaudioside M from Reb D4.

Abstract: The present invention relates to the production of steviol glycoside rebaudiosides D4, WB1 and WB2 and the production of rebaudioside M from Reb D4.

Abstract: The present invention relates to the production of capsaicinoid compounds including Capsaicin and Nonivamide via microbial fermentation.

Abstract: The present invention provides a novel biosynthetic production process which converts L-galactose into 2?-fucosyllactose via four enzymatically catalyzed reaction steps. The present process is designed such that co-factors required by the process are regenerated within the four reaction steps, hence making the process cost-effective and efficient. The process can be performed in vitro in a cell-free system. The present invention also provides mutant enzymes that can be used to increase production levels of 2?-fucosyllactose, whether using the novel pathway described herein or the mannose-dependent pathway known in the art.

Abstract: Provided herein are methods for making gamma lactones comprising reacting a carboxylic acid substrate with a heterologous cytochrome P450 (CYP450) protein with carboxylic acid 4-hydroxylase activity.

Abstract: The present disclosure is generally directed to orally consumable products, such as foodstuffs and beverages, containing rebaudioside E present in, e.g., about 5 ppm to about 100 ppm, and to methods for preparing such orally consumable products.

Abstract: The present invention relates to microbial production of nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), and nicotinamide adenine dinucleotide (NAD) using a genetically modified bacterium.

Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).

Abstract: The present disclosure generally relates to novel polynucleotide molecules for use in regulating gene expression in recombinant cells, such as labyrinthulomycetes cells. The disclosure further relates to nucleic acid constructs, such as vectors and expression cassettes, containing a regulatory element operably linked to a heterologous nucleotide sequence. The disclosure further relates to methods for stably transforming a host cell, such as a labyrinthulomycetes cell with transgenes. Stably transformed recombinant cells, progeny, biomaterials derived therefrom, and methods for preparing and using the same are also provided.

Abstract: The present invention relates to a compound of Formula (I) and/or a physiologically acceptable salt, enantiomer, or solvate thereof. Said compound can be used in combination with one or more sweeteners to enhance their individual sweet taste or the overall sweet taste of a composition comprising said one or more sweeteners.