Patents Assigned to Conagen Inc.
  • Methods of using O-methyltransferase for biosynthetic production of pterostilbene
    Patent number: 10370683
    Abstract: A biosynthetic method of making pterostilbene including expressing a 4-coumaratexoenzyme A ligase (4CL) in a cellular system, expressing a stilbene synthase (STS) in the cellular system, expressing a resveratrol O-methyltransferase (ROMT) in the cellular system, feeding p-coumaric acid to the cellular system, growing the cellular system in a medium, and producing pterostilbene.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: August 6, 2019
    Assignee: Conagen Inc.
    Inventors: Mohammad Wadud Bhuiya, Yechun Wang, Xiaodan Yu
  • Recombinant production of steviol glycosides
    Patent number: 10253344
    Abstract: Recombinant polypeptides having UDP-glycosyltransferase activities, including a 1,2-19-O-glucose glycosylation activity and a 1,2-13-O-glucose glycosylation activity for synthesizing of steviol glucosides, are provided. A method of producing a steviol glycoside composition using such recombinant polypeptide is also provided. Also disclosed are steviol glycosides referred to as rebaudioside Z1 and rebaudioside Z2.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: April 9, 2019
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • BIOSYNTHESIS OF ERIODICTYOL FROM ENGINEERED MICROBES
    Publication number: 20190048374
    Abstract: The present invention relates to the production of eriodictyol via bioconversion.
    Type: Application
    Filed: July 11, 2018
    Publication date: February 14, 2019
    Applicant: Conagen, Inc.
    Inventors: Rui zhou, Xiaodan Yu, Steven Chen
  • PLASMID ADDICTION SYSTEM TO DRIVE DESIRED GENE EXPRESSION
    Publication number: 20190024097
    Abstract: The present invention relates to a Plasmid Addiction System for the stabilization of expression plasmids encoding proteins of interest. The invention uses a succinate cycle optimization to ensure the expression of plasmid(s) of interest. By ensuring that plasmids of interest contain genes necessary in the succinate cycle, the system ensures that the passage of the plasmid to daughters and therefore improves the efficiency of production and expression of genes and/or products of interest.
    Type: Application
    Filed: July 16, 2018
    Publication date: January 24, 2019
    Applicant: Conagen Inc.
    Inventors: Matthew de la Pena Mattozzi, Daniel Kim, Sonya Clarkson
  • METHODS OF MAKING CAPSINOIDS BY BIOSYNTHETIC PROCESSES
    Publication number: 20190010522
    Abstract: Provided herein are methods of making capsinoids including providing a capsiate synthase in a mixture or cellular system, feeding 8-methyl-6-nonenoyl-CoA, 6E-8-methylnonenoic acid or 8-methylnonanoic acid into the mixture or cellular system, feeding vanillyl alcohol into the mixture or cellular system, and collecting capsinoids from the mixture or cellular system.
    Type: Application
    Filed: January 6, 2017
    Publication date: January 10, 2019
    Applicant: Conagen Inc.
    Inventors: Hui Chen, Xiaodan Yu
  • Non-caloric sweeteners and methods for synthesizing
    Patent number: 10160781
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: December 25, 2018
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • Non-caloric sweetener
    Patent number: 10138263
    Abstract: Disclosed is a steviol glycoside referred to as rebaudioside D2. Rebaudioside D2 has five ?-D-glucosyl units connected to the aglycone steviol. Also disclosed are methods for producing rebaudioside D2, a UDP-glycosyltransferase fusion enzyme, and methods for producing rebaudioside D and rebaudioside E.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: November 27, 2018
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Venkata Sai Prakash Chaturvedula, Oliver Yu
  • Recombinant production of steviol glycosides
    Patent number: 10081826
    Abstract: Recombinant polypeptides having UDP-glycosyltransferase activities, including a 1,2-19-O-glucose glycosylation activity and a 1,2-13-O-glucose glycosylation activity for synthesizing of steviol glucosides, are provided. A method of producing a steviol glycoside composition using such recombinant polypeptide is also provided. Also disclosed are steviol glycosides referred to as rebaudioside Z1 and rebaudioside Z2.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: September 25, 2018
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • NON-CALORIC SWEETENERS AND METHODS FOR SYNTHESIZING
    Publication number: 20180258126
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Application
    Filed: May 21, 2018
    Publication date: September 13, 2018
    Applicant: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • NON-CALORIC SWEETENERS AND METHODS FOR SYNTHESIZING
    Publication number: 20180258124
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Application
    Filed: May 21, 2018
    Publication date: September 13, 2018
    Applicant: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • NON-CALORIC SWEETENERS AND METHODS FOR SYNTHESIZING
    Publication number: 20180258125
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Application
    Filed: May 21, 2018
    Publication date: September 13, 2018
    Applicant: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • NON-CALORIC SWEETENER
    Publication number: 20180244709
    Abstract: Disclosed is a steviol glycoside referred to as rebaudioside D2. Rebaudioside D2 has five ?-D-glucosyl units connected to the aglycone steviol. Also disclosed are methods for producing rebaudioside D2, a UDP-glycosyltransferase fusion enzyme, and methods for producing rebaudioside D and rebaudioside E.
    Type: Application
    Filed: April 30, 2018
    Publication date: August 30, 2018
    Applicant: Conagen Inc.
    Inventors: Guohong Mao, Venkata Sai Prakash Chaturvedula, Xiaodan Yu
  • Non-caloric sweeteners and methods for synthesizing
    Patent number: 10059732
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: August 28, 2018
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • Non-caloric sweeteners and methods for synthesizing
    Patent number: 10023604
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: July 17, 2018
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • Non-caloric sweeteners and methods for synthesizing
    Patent number: 10010099
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: July 3, 2018
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • Non-caloric sweeteners and methods for synthesizing
    Patent number: 10010101
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: July 3, 2018
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • Non-caloric sweetener
    Patent number: 9988414
    Abstract: Disclosed is a steviol glycoside referred to as rebaudioside D3. Rebaudioside D3 has five ?-D-glucosyl units connected to the aglycone steviol. Also disclosed are methods for producing rebaudioside D3, a UDP-glycosyltransferase fusion enzyme, and methods for producing rebaudioside D and rebaudioside E.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: June 5, 2018
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Venkata Sai Prakash Chaturvedula, Xiaodan Yu
  • Methods of using capsaicin synthase for the microbial production of capsaicinoids
    Patent number: 9951358
    Abstract: A biosynthetic method of making a capsaicinoid including expressing a first gene product of CS/AT3/Pun1 in a cellular system, growing the cellular system in a medium, and collecting the capsaicinoid. The biosynthetic method further includes expressing a second gene product of ACS1 and expressing a third gene product of pAMT in the cellular system.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: April 24, 2018
    Assignee: Conagen Inc.
    Inventors: Hui Chen, Hongxue Wang, Oliver Yu
  • PRODUCTION OF NON-CALORIC SWEETENERS USING ENGINEERED WHOLE-CELL CATALYSTS
    Publication number: 20180080055
    Abstract: Disclosed are whole-cell catalysts, methods of making the whole-cell catalysts, and methods of using the whole-cell catalysts to produce steviol glycosides.
    Type: Application
    Filed: April 14, 2016
    Publication date: March 22, 2018
    Applicant: Conagen Inc.
    Inventors: Guohong Mao, Jacob Edward Vick, Shi-Yan Li, Xiaodan Yu
  • Non-caloric sweeteners and methods for synthesizing
    Patent number: 9908913
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: March 6, 2018
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu