Patents Assigned to Conagen Inc.
  • Method for the microbial production of specific natural capsaicinoids
    Patent number: 11459591
    Abstract: The present invention relates to the production of capsaicinoid compounds including Capsaicin and Nonivamide via microbial fermentation.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: October 4, 2022
    Assignee: Conagen Inc.
    Inventors: Hui Chen, Xiaodan Yu, LanLan Zhou, Hongxue Wang, Min Wang
  • Non-caloric sweeteners and methods for synthesizing
    Patent number: 11453692
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: September 27, 2022
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • Biosynthetic production of steviol glycoside rebaudioside I via variant enzymes
    Patent number: 11447808
    Abstract: The present invention relates, at least in part, to the production of steviol glycoside rebaudioside I through the use of variant UGT enzymes having activity to transfer a glucosyl group from UDP-glucose to rebaudioside A to produce rebaudioside I.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: September 20, 2022
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Michael Batten, Xiaodan Yu
  • Biosynthetic production of steviol glycosides rebaudioside J and rebaudioside N
    Patent number: 11441165
    Abstract: The present disclosure relates to the production of steviol glycosides rebaudioside J and rebaudioside N through the use of rebaudioside A as a substrate and a biosynthetic pathway involving various 1,2 RhaT-rhamnosyltransferases.
    Type: Grant
    Filed: December 2, 2020
    Date of Patent: September 13, 2022
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Michael Batten, Phillip Hunt, Oliver (Xiaodan) Yu
  • BIOSYNTHETIC PRODUCTION OF STEVIOL GLYCOSIDE REBAUDIOSIDE D4 FROM REBAUDIOSIDE E
    Publication number: 20220282297
    Abstract: The present invention relates, in some aspects, to the production of steviol glycoside rebaudioside D4 through the use of rebaudioside E. In some aspects, the invention relates to mutant CP1 enzymes, mutant HV1 enzymes as well as host cells and methods utilizing such enzymes, such as to produce rebaudioside D4.
    Type: Application
    Filed: March 17, 2022
    Publication date: September 8, 2022
    Applicant: Conagen Inc.
    Inventors: Guohong Mao, Jacob Edward Vick, Michael Batten, Yang Luo, Yilin Wu, Xiaodan Yu
  • PLASMID ADDICTION SYSTEM TO DRIVE DESIRED GENE EXPRESSION
    Publication number: 20220275379
    Abstract: The present invention relates to a Plasmid Addiction System for the stabilization of expression plasmids encoding proteins of interest. The invention uses a succinate cycle optimization to ensure the expression of plasmid(s) of interest. By ensuring that plasmids of interest contain genes necessary in the succinate cycle, the system ensures that the passage of the plasmid to daughters and therefore improves the efficiency of production and expression of genes and/or products of interest.
    Type: Application
    Filed: July 16, 2018
    Publication date: September 1, 2022
    Applicant: Conagen Inc.
    Inventors: Matthew de la Pena Mattozzi, Daniel Kim, Sonya Clarkson
  • Plasmid addiction system to drive desired gene expression
    Patent number: 11421239
    Abstract: The present invention relates to a Plasmid Addiction System for the stabilization of expression plasmids encoding proteins of interest. The invention uses a succinate cycle optimization to ensure the expression of plasmid(s) of interest. By ensuring that plasmids of interest contain genes necessary in the succinate cycle, the system ensures that the passage of the plasmid to daughters and therefore improves the efficiency of production and expression of genes and/or products of interest.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: August 23, 2022
    Assignee: Conagen Inc.
    Inventors: Matthew de la Pena Mattozzi, Daniel Kim, Sonya Clarkson
  • Hydrolysis of steviol glycosides by beta-glucosidase
    Patent number: 11414689
    Abstract: The present disclosure relates to the use of beta-glucosidase to enhance the production efficiency of desired steviol glycosides, such as rebaudioside M (reb M).
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: August 16, 2022
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Jacob Edward Vick, Michael Batten, Oliver Yu
  • BIOCONVERSION OF 4-COUMARIC ACID TO RESVERATROL
    Publication number: 20220243230
    Abstract: The present invention relates, at least in part, to the production of resveratrol from 4-coumaric acid. The production can be mediated in a transgenic Saccharomyces cell.
    Type: Application
    Filed: April 21, 2022
    Publication date: August 4, 2022
    Applicant: Conagen Inc.
    Inventors: Grace Park, Ernesto Simon
  • BIOSYNTHETIC PRODUCTION OF STEVIOL GLYCOSIDE REBAUDIOSIDE I VIA VARIANT ENZYMES
    Publication number: 20220205007
    Abstract: The present invention relates, at least in part, to the production of steviol glycoside rebaudioside I through the use of variant UGT enzymes having activity to transfer a glucosyl group from UDP-glucose to rebaudioside A to produce rebaudioside I.
    Type: Application
    Filed: January 7, 2022
    Publication date: June 30, 2022
    Applicant: Conagen Inc.
    Inventors: Guohong Mao, Michael Batten, Xiaodan Yu
  • NON-CALORIC SWEETENERS AND METHODS FOR SYNTHESIZING
    Publication number: 20220162248
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Application
    Filed: November 29, 2021
    Publication date: May 26, 2022
    Applicant: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • Biosynthetic production of steviol glycoside rebaudioside D4 from rebaudioside E
    Patent number: 11306340
    Abstract: The present invention relates, in some aspects, to the production of steviol glycoside rebaudioside D4 through the use of rebaudioside E. In some aspects, the invention relates to mutant CP1 enzymes, mutant HV1 enzymes as well as host cells and methods utilizing such enzymes, such as to produce rebaudioside D4.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: April 19, 2022
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Jacob Edward Vick, Michael Batten, Yang Luo, Yilin Wu, Xiaodan Yu
  • BIOSYNTHESIS OF VANILLIN FROM ISOEUGENOL
    Publication number: 20220112526
    Abstract: The present invention relates to the production of vanillin via the bioconversion of isoeugenol. The bioconversion can be mediated in a cellular system (e.g., an Escherichia coli bacterium), or in an enzymatic reaction mixture without a cellular system.
    Type: Application
    Filed: October 29, 2021
    Publication date: April 14, 2022
    Applicant: Conagen Inc.
    Inventors: Rui Zhou, Junying Ma, Oliver Yu
  • BIOSYNTHESIS OF VANILLIN FROM ISOEUGENOL
    Publication number: 20220112525
    Abstract: The present invention relates to the production of vanillin via the bioconversion of isoeugenol. The bioconversion can be mediated in a cellular system (e.g., an Escherichia coli bacterium), or in an enzymatic reaction mixture without a cellular system.
    Type: Application
    Filed: October 29, 2021
    Publication date: April 14, 2022
    Applicant: Conagen Inc.
    Inventors: Rui Zhou, Junying Ma, Oliver Yu
  • BIOSYNTHETIC PRODUCTION OF GAMMA- AND DELTA-LACTONES USING CYTOCHROME P450 ENZYMES HAVING SUBTERMINAL HYDROXYLASE ACTIVITY
    Publication number: 20220106618
    Abstract: Provided herein are methods for making lactones comprising incubating a cellular system expressing a heterologous cytochrome P450 (CYP450) protein with a medium comprising straight chain fatty acids to produce subterminal hydroxy fatty acids, and incubating a yeast cell culture with the subterminal hydroxy fatty acids to produce lactones.
    Type: Application
    Filed: September 21, 2021
    Publication date: April 7, 2022
    Applicant: Conagen Inc.
    Inventors: Hui Chen, Xiaodan Oliver Yu
  • BIOSYNTHETIC PRODUCTION OF UDP-RHAMNOSE
    Publication number: 20220090158
    Abstract: The present disclosure relates to the biosynthesis of UDP-Rhamnose and recombinant polypeptides having enzymatic activity useful in the relevant biosynthetic pathways for producing UDP-Rhamnose. The present invention also provides a method for preparing a steviol glycoside composition comprising at least one rhamnose-containing steviol glycoside.
    Type: Application
    Filed: September 28, 2021
    Publication date: March 24, 2022
    Applicant: Conagen Inc.
    Inventors: Guohong Mao, Phillip James Hunt, Michael James Batten, Timothy Joseph Hanley, Oliver Yu
  • BIOSYNTHESIS PRODUCTION OF STEVIOL GLYCOSIDES AND PROCESSES THEREFORE
    Publication number: 20220042060
    Abstract: The present invention relates to the production of steviol glycoside rebaudiosides D4, WB1 and WB2 and the production of rebaudioside M from Reb D4.
    Type: Application
    Filed: July 28, 2021
    Publication date: February 10, 2022
    Applicant: Conagen Inc.
    Inventors: Guohong Mao, Jacob Edward Vick, Michael Batten, Yang Luo, Yilin Wu, Beihua Zhang, David Byun, Xiaodan Yu
  • BIOSYNTHETIC PRODUCTION OF VARIANT STEVIOL GLYCOSIDES
    Publication number: 20210381019
    Abstract: The present invention relates to novel steviol glycosides R6-1, R6-2A, R6-2B, R6-4A, R6-4B and R7-2 and the production of these novel steviol glycosides, such as through enzymatic bioconversion. The use of these novel steviol glycosides as sweeteners and in orally consumable products are also provided.
    Type: Application
    Filed: June 11, 2021
    Publication date: December 9, 2021
    Applicant: Conagen Inc.
    Inventors: Guohong Mao, Michael Batten, Yang Luo, Oliver Yu
  • Non-caloric sweeteners and methods for synthesizing
    Patent number: 11186604
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: November 30, 2021
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • CONTROLLABLE PROTEIN DEGRADATION VIA ENGINEERING DEGRADATION TAG VARIANTS IN CORYNEBACTERIUM HOST CELLS
    Publication number: 20210277405
    Abstract: The present invention relates to the creation of a control system within a host cell to limit or eliminate degradation of key specified products at certain times during fermentation and to redirect the metabolic flux of the cell toward higher production of same key specified products.
    Type: Application
    Filed: March 18, 2021
    Publication date: September 9, 2021
    Applicants: Conagen Inc., Sumitomo Chemical Co., Ltd.
    Inventors: Ilya Tikh, Sonya Clarkson, Brendon Dusel, Jacob Edward Vick, Xiaodan Yu, Bryan Salas-Santiago