Patents Assigned to Consiglio Nazionale Delle Ricerche
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Patent number: 11672760Abstract: Provided are oil-in-water microemulsions for formulating pharmaceutically active compounds. The microemulsions contain oils, surfactants, water, and the pharmaceutical compounds, and are produced by mixing an aqueous phase and a lipid phase in which each phase contains at least one surfactant in a defined ratio whereby the resulting microemulsion has very small dispersed particles and is thermodynamically very stable.Type: GrantFiled: March 19, 2021Date of Patent: June 13, 2023Assignees: SIFI S.p.A., Consiglio Nazionale delle RicercheInventors: Elena Solfato, Ilenia Abbate, Cristina Maria Concetta Zappulla, Manuela Santonocito, Santa Viola, Sandro De Falco, Francesco Giuliano
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Publication number: 20230167453Abstract: Provided herein are RNA aptamers targeting CD5L. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.Type: ApplicationFiled: April 1, 2021Publication date: June 1, 2023Applicants: Board of Regents, The University of Texas System, Consiglio Nazionale delle RicercheInventors: Anil K. SOOD, Paola AMERO, Gabriel LOPEZ-BERESTEIN, Vittorio DE FRANCISCIS
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Patent number: 11628602Abstract: Filter made entirely with natural and biodegradable materials, for the protection of the respiratory tract of patients in the medical-surgical field and process for making it. The filter has a porosity or 80-98% and pore diameters of 100-350 micrometers and the pores have a shape of channels open at the ends, which are parallel to each other. The filter is obtained by preparing an aqueous solution of chitosan and an aqueous solution of gelatin, mixing them, pouring it into a container, keeping the container closed until obtaining a hydrogel and freeze-drying. A cross-linking step takes place by (a) adding a chemical cross-linker to the mixture of the chitosan and gelatine solutions and cross-linking before freeze-drying, or (b) subjecting the freeze-drying product to a thermal dehydration treatment.Type: GrantFiled: February 27, 2018Date of Patent: April 18, 2023Assignee: CONSIGLIO NAZIONALE DELLE RICERCHEInventors: Monica Sandri, Anna Tampieri, Simone Sprio
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Publication number: 20230051031Abstract: A multifunctional hybrid material based on sepiolite for environmental recovery and bio-remediation is described. In particular, the invention describes the design and development of suitably functionalized hybrid nanomaterials starting from sepiolite and the subsequent study of the absorbent and degrading properties in relation to aromatic hydrocarbons, by activating hydrocarbon-clastic bacteria. These nanomaterials have been prepared in order to remove hydrocarbon pollutants (e.g. oil) in natural matrices (marine environment), with potential applications in the field of environmental remediation.Type: ApplicationFiled: December 15, 2020Publication date: February 16, 2023Applicant: CONSIGLIO NAZIONALE DELLE RICERCHEInventors: Maria Rosaria Plutino, Simone Cappello
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Publication number: 20230034883Abstract: A multi-functional hybrid material based on natural clays for environmental bio-remediation and recover), is disclosed. In particular, the invention discloses the design and development of appropriately functionalized nanohybrid materials starting from nanostructured clays and the subsequent study of the absorbent properties in relation to hydrocarbons, heavy metals, chemical pollutants, oils, particulate, and microplastics. These nanomaterials were prepared in order to remove the hydrocarbon pollutants (for example oil) and metal pollutants in natural matrices (marine environment), with potential applications in the field of environmental remediation.Type: ApplicationFiled: December 15, 2020Publication date: February 2, 2023Applicants: CONSIGLIO NAZIONALE DELLE RICERCHE (60%), UNIVERSITA' DEGLI STUDI DI MESSINA (40%)Inventors: Maria Rosaria Plutino, Simone Cappello, Giuseppe Sabatino, Giulia Rando
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Patent number: 11564897Abstract: Method for the production of a polyphenolic composition from barley malt, including the fundamental steps of: grinding of the malt grains and splitting into two portions, 20% and 80%; mixing each of the two portions with water to obtain an A mixture and a B mixture, the A mixture being prepared with the 20% portion to obtain a mixture of the malt in water at a final concentration between 9.5% and 20%, the B mixture being prepared with the 80% portion to obtain a mixture of the malt in water at a final concentration between 33% and 60%; thermal cycle; separation of the liquid component from the solid component; boiling of the liquid component and the addition of hops; rapid cooling of the wort; storage; in which said thermal cycle consists of a first phase and a second phase, in which the first phase applies to the 20% portion (Mixture A) and the second phase during which Mixture B is added to Mixture A.Type: GrantFiled: August 20, 2018Date of Patent: January 31, 2023Assignees: ALIOPHARM S.R.L., Consiglio Nazionale delle RicercheInventors: Gian Luigi Russo, Fabrizio Tarricone, Idolo Tedesco
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Patent number: 11566070Abstract: The present invention relates to agents that modulate/regulate the activity of the protein TMEM230 for use in the therapeutic treatment of pathologies in which therapeutic regulation of angiogenesis is advisable or necessary.Type: GrantFiled: February 5, 2018Date of Patent: January 31, 2023Assignee: CONSIGLIO NAZIONALE DELLE RICERCHEInventors: Ileana Zucchi, Rolland Alvons Reinbold
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Patent number: 11547721Abstract: The present invention relates to magnetic nanoparticles based on iron oxide having cubic shape, suitably functionalized for the release of targeting chemotherapeutic agents, i.e. selectively in the tumors being treated The invention also relates to the pharmaceutical compositions having such nanoparticles and to their use in combined oncological therapies of hyperthermia and chemotherapy, useful in particular in the treatment of ovarian tumors.Type: GrantFiled: May 3, 2019Date of Patent: January 10, 2023Assignees: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA, FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI, FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, UNIVERSITA DEGLI STUDI DI GENOVA, CONSIGLIO NAZIONALE DELLE RICERCHEInventors: Markus Barthel, Marco Cassani, Mariangela Figini, Juan Granja, Teresa Pellegrino, Alessandra Quarta
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Patent number: 11517860Abstract: The invention relates to dense synthetic membranes made from polymerised phosphonium-based ionic liquids which were found to be particularly suitable for use in gas separation. The membranes are obtainable by copolymerization via UV-curing of a composition comprising a phosphonium-based ionic liquid monomer, a co-monomer, a cross-linker, a surfactant and a photo-initiator, the remainder of the polymerization mixture consisting of water. The invention also relates to a process of manufacturing said membranes, resulting in solid, dense and mechanically stable membranes, and to the use of the membranes so produced in the separation of gas mixtures, particularly gas mixtures containing carbon dioxide.Type: GrantFiled: March 8, 2019Date of Patent: December 6, 2022Assignees: Consiglio Nazionale Delle Ricerche, Universitá Di Pisa, Universitá Della CalabriaInventors: Alberto Figoli, Francesco Galiano, Giuseppe Barbieri, Adele Brunetti, Lidietta Giorno, Christian Silvio Pompelli, Cinzia Chiappe, Bartolo Gabriele, Raffaella Mancuso, Yujiro Itami
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Publication number: 20220380766Abstract: Provided herein are DNA aptamers targeting AXL receptor kinase. The DNA aptamers may comprise a thiophosphate backbone and be chemically modified. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.Type: ApplicationFiled: December 16, 2019Publication date: December 1, 2022Applicants: Board of Regents, The University of Texas System, Consiglio Nazionale delle RicercheInventors: Gabriel LOPEZ-BERESTEIN, Paola AMERO, Cristian RODRIGUEZ-AGUAYO, Rahul MITRA, Anil K. SOOD, Vittorio DE FRANCISCIS, David VOLK, Lokesh Ganesh L. RAO
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Patent number: 11428662Abstract: An electrochemical sensor (10) for measuring biochemical parameters in the sap (L) of a plant (P), comprising: —a channel in which the sap (L) of a plant (P) flows; —a first electrically conductive filament (11) which crosses the channel; —a control electrode (12) which crosses the channel; wherein the channel comprises a conductor vessel (C) of a trunk (D) of the plant (P), and wherein the first filament (11) comprises a textile fiber (110) coated with a layer (111) of conductive polymer.Type: GrantFiled: December 19, 2017Date of Patent: August 30, 2022Assignee: Consiglio Nazionale Delle RicercheInventors: Andrea Zappettini, Nicola Coppedè
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Publication number: 20220259075Abstract: The disclosure relates to N-alkyl-D-glucamine based macroporous polymeric cryogels with three-dimensional structure and with interconnected pores, which are used for sequestering and/or removing toxic contaminants, such as toxic metalloids and/or toxic heavy metals, for example from water and/or soil and the method for the preparation of said -alkyl-D-glucamine based macroporous polymeric cryogels.Type: ApplicationFiled: July 13, 2020Publication date: August 18, 2022Applicants: CONSIGLIO NAZIONALE DELLE RICERCHE, ALMA MATER STUDIORUM UNIVERSITA' DI BOLOGNAInventors: Sabrina Carola CARROCCIO, Francesca CUNSOLO, Tommaso MECCA, Vittorio PRIVITERA, Martina USSIA, Daniele CARETTI, Stefano SCURTI
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Patent number: 11415642Abstract: A device for sensing a magnetic field, comprising a closed superconducting loop configured to collect a magnetic field to be sensed, hereinafter external magnetic field, the closed superconducting loop having a path width (wp) and being provided with a constriction having a width (wc) narrower than the path width, the constriction generating a non-uniform magnetic field, hereinafter internal magnetic field, in response to the external magnetic field, a vibrating mechanical oscillator coupled to, or formed by the constriction and responsive to the internal magnetic field, and a detector configured to detect deflection or vibration of the mechanical oscillator and providing a signal indicative of the deflection or vibration.Type: GrantFiled: April 15, 2021Date of Patent: August 16, 2022Assignees: CONSIGLIO NAZIONALE DELLE RICERCHE, UNIVERSITA' DEGLI STUDI “G. D'ANNUNZIO” CHIETI-PESCARA, QUANTIFIED AIR BVInventors: Luca Pellegrino, Nicola Manca, Daniele Marre′, Federico Remaggi, Riccardo Bertacco, Federico Maspero, Warner Jurriën Venstra, Stefania Della Penna, Ingo Hilschenz, Alexei Kalaboukhov, Filomena Lombardi
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Patent number: 11408632Abstract: A climate generator adapted to produce a flow of air at controlled temperature and at relative humidity values (tc, ic) is described, which includes a bubbler (100) which receives a flow of air to be conditioned (Ga), heat exchangers (120) associated with the bubbler (100) to adjust the temperature of the water volume (W) of the bubbler and/or to provide an amount of latent heat of evaporation to the aforesaid volume of water (W); and heaters (180) for heating the flow of air at the dew point (Gb) exiting from the bubbler (100) to the controlled temperature value of the flow of air, wherein the temperature of the volume of water (W) is established as a function of the controlled temperature and relative humidity values (tc, ic), so that the heating of the flow of air at the dew point (Gb) from the temperature of the water volume (W) to the controlled temperature value determines a decrease in the relative humidity (ic) of the flow of air to the controlled relative humidity value.Type: GrantFiled: May 30, 2018Date of Patent: August 9, 2022Assignee: Consiglio Nazionale Delle RicercheInventors: Ottaviano Allegretti, Paolo Dionisi Vici
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Publication number: 20220216057Abstract: Method of doping a semiconductor sample in a uniform and carbon-free way, wherein said sample has a surface, comprising the following steps: A. removing oxides from at least part of the said surface; B. dip coating said at least part of the surface of the sample in a dopant based carbon-free solution of at least one dopant based carbon free substance diluted in water, wherein said at least one dopant based carbon free substance has a molecule comprising at least one dopant atom, wherein the dip coating is achieved by heating said dopant based carbon-free solution at a dip coating temperature from 65% to 100% of the boiling temperature of said dopant based carbon-free solution, thereby a self-assembled mono-layer including dopant atoms is formed; C. annealing said sample, wherein the annealing is configured to cause said dopant atoms included in said self-assembled mono-layer to be diffused into the sample.Type: ApplicationFiled: May 8, 2020Publication date: July 7, 2022Applicant: Consiglio Nazionale Delle RicercheInventors: Rosaria Anna PUGLISI, Sebastiano CACCAMO
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Publication number: 20220183961Abstract: It is described a process, starting from fishbones, for the production of a material having properties of physical type solar filter and photoprotective boosting agent, formed by particles of hydroxyapatite or hydroxyapatite substituted with metal ions, optionally mixed with calcium triphosphate and with metal oxides. Are also described the material obtained through the process and cosmetic or plant sunscreen compositions that comprise said material.Type: ApplicationFiled: March 27, 2020Publication date: June 16, 2022Applicant: CONSIGLIO NAZIONALE DELLE RICERCHEInventors: Michele IAFISCO, Alessio ADAMIANO, Clara PICCIRILLO
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Patent number: 11344499Abstract: A nanoparticle comprising a keratin polypeptide and at least one lipophilic active ingredient, wherein the at least one lipophilic active ingredient is non-covalently bound to the keratin polypeptide and can be e.g. a therapeutic or diagnostic agent, a nutraceutical, a cosmetic ingredients, a dye or a cosmeceutical, the keratin polypeptide being water-soluble; optionally, the nanoparticle further comprises at least one hydrophilic active ingredient non-covalently bound to the keratin polypeptide, which can be e.g. a therapeutic or diagnostic agent, a nutraceutical, a cosmetic ingredients, a dye or a cosmeceutical.Type: GrantFiled: June 13, 2018Date of Patent: May 31, 2022Assignee: CONSIGLIO NAZIONALE DELLE RICERCHEInventors: Annalisa Aluigi, Greta Varchi, Giovanna Sotgiu, Andrea Guerrini, Marco Ballestri
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Patent number: 11346719Abstract: A Fourier-transform hyperspectral imaging system may include an optical imaging system configured to produce an image of an object, and an adjustable birefringent common-path interferometer module comprising a movable birefringent element and configured to produce interfering replicas of an input radiation which are delayed from each other by a phase delay adjustable by the moving birefringent element. The interferometer module may be configured to produce collinear replicas for entering optical rays parallel to said optical axis. The hyperspectral imaging system further comprises a two-dimensional light detector configured to receive the replicas and provide digital images of the object depending on said adjustable phase delay. The system also includes an analysis device configured to perform a Fourier Transform of the digital images to obtain a hyperspectral representation of the object.Type: GrantFiled: July 25, 2019Date of Patent: May 31, 2022Assignees: POLITECNICO DI MILANO, CONSIGLIO NAZIONALE DELLE RICERCHEInventors: Cristian Angelo Manzoni, Giulio Cerullo, Dario Polli, Antonio Perri, Fabrizio Preda, Gianluca Valentini, Andrea Bassi
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Patent number: 11273023Abstract: An implantable medical device obtained by means of two-photon laser polymerisation of a resin to form a three-dimensional matrix, wherein: said three-dimensional matrix comprises a number of levels distributed in height; and said three-dimensional matrix comprises reference means designed to uniquely identify the height of each level from a pre-set reference, by means of a multi-photon fluorescence-excitation microscope; said implantable medical device being characterised in that said reference means comprise a solid having a cross section that varies with height.Type: GrantFiled: December 18, 2018Date of Patent: March 15, 2022Assignees: POLITECNICO DI MILANO, UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA, CONSIGLIO NAZIONALE DELLE RICERCHEInventors: Manuela Teresa Raimondi, Giulio Cerullo, Claudio Conci, Tommaso Zandrini, Roberto Osellame, Giuseppe Chirico
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Patent number: 11237375Abstract: A system and a method for measuring the focus state of an optical instrument are described. The system and the method provide for forming an image of the exit pupil of the objective of the optical instrument. Where the image of the exit pupil is formed, one or more optical elements are placed, deviating at least part of the rays coming from the exit pupil, so that rays coming from different non-overlapping portions of the pupil follow separate optical paths. The rays coming from the two portions of the pupil are then focused, in order to obtain two bidimensional images. A computer determines the mutual distance between these two bidimensional images as a mutual rigid lateral displacement between the two and, based on this distance, determines the corresponding defocus of the optical instrument.Type: GrantFiled: December 21, 2017Date of Patent: February 1, 2022Assignees: LABORATORIO EUROPEO DI SPETTROSCOPIE NON LINEARI (LENS), CONSIGLIO NAZIONALE DELLE RICERCHE-CNRInventors: Ludovico Silvestri, Marie Caroline Mullenbroich, Leonardo Sacconi, Francesco Saverio Pavone