Abstract: The present invention relates to a process for the production of fiber-reinforced composite materials with an ultra-refractory, high tenacity, high ablation resistant matrix with self-healing properties, prepared from highly sinterable slurries. The composite material is produced using techniques of infiltration and drying at ambient pressure or under vacuum, and consolidated by sintering with or without the application of gas or mechanical pressure.
Abstract: The present invention relates to a ring-down spectrometry apparatus in absorption saturation condition, for measuring the concentration of a gas through a measurement of the spectrum of a molecular transition of said gas. The apparatus includes a laser source, an adjuster for varying the wavelength of said radiation emitted by said laser, and a resonant cavity. A photodetector is adapted to detect an electromagnetic radiation beam and is adapted to generate a decay signal. An electronic circuit receives the signal from the photodetector and is adapted to convert it to a processor. A processor is adapted to receive said decay signal from the photodetector and perform interpolation to obtain a concentration of said gas.
Type:
Grant
Filed:
April 15, 2014
Date of Patent:
October 16, 2018
Assignee:
CONSIGLIO NAZIONALE DELLE RICERCHE
Inventors:
Giovanni Giusfredi, Iacopo Galli, Pablo Cancio Pastor, Davide Mazzotti, Paolo De Natale
Abstract: The present invention is relative to a method of ring-down spectroscopy in saturated-absorption condition, for measuring a first concentration of a gas through a measurement of the spectrum of a molecular transition of said gas.
Type:
Application
Filed:
September 30, 2016
Publication date:
September 27, 2018
Applicant:
CONSIGLIO NAZIONALE DELLE RICERCHE - CNR
Inventors:
Davide Mazzotti, Pablo Cancio Pastor, Iacopo Galli, Paolo De Natale, Giovanni Giusfredi
Abstract: An integrated optofluidic device to illuminate, along an irradiation direction, a fluidic sample containing an object to be analysed, the device comprising: a substrate comprising an entry surface and being made of a material transparent to a light beam incident through the entry surface along the irradiation direction; a microfluidic channel formed in the substrate and having a channel portion intercepting the irradiation direction and extending along a longitudinal axis transverse to the irradiation direction, the microfluidic channel comprising a first flow inlet port for loading a fluidic sample therein, and an elongated lens cavity for an optofluidic cylindrical lens, the cavity being formed in the substrate and being arranged along the beam irradiation direction between the entry surface and the microfluidic channel, wherein the lens cavity is in fluid communication with a lens inlet port for loading a lens fluid.
Type:
Application
Filed:
September 27, 2016
Publication date:
September 27, 2018
Applicants:
POLITECNICO DI MILANO, CONSIGLIO NAZIONALE DELLE RICERCHE
Inventors:
Andrea Bassi, Petra Paiè, Roberto Osellame, Francesca Bragheri
Abstract: The present invention places in the field of the maintenance of aeration, conditioning, air-conditioning, etc. plants, and in particular the present invention relates to a method for evaluating the cleaning state of a plant, with particular reference to the atmospheric particulate.
Type:
Grant
Filed:
September 30, 2014
Date of Patent:
August 7, 2018
Assignees:
CONSIGLIO NAZIONALE DELLE RICERCHE, TAGLIAFERRI S.R.L.
Inventors:
Domenico Vitulano, Daniela De Canditiis, Vittoria Bruni, Sante Tagliaferri, Fabio Buccolini, Elisa Rossi, Daniele Pigozzi
Abstract: It is disclosed a biocomposite of hydroxyapatite on graphene oxide sheets and its use for bone tissue engineering applications, such as bone repair, bone augmentation, as well as coating of biomedical implants. Processes for preparing said biocomposites are also described.
Type:
Application
Filed:
July 26, 2016
Publication date:
August 2, 2018
Applicants:
CONSIGLIO NAZIONALE DELLE RICERCHE, JOINTHERAPEUTICS S.R.L.
Inventors:
Luigi Ambrosio, Maria Grazia Raucci, Angela Longo, Gianfranco Carotenuto, Daniela Giugliano
Abstract: The T cells specific to human collagen type II, one of the possible autoantigens, have a crucial role in the development of rheumatoid arthritis in the context of HLA-DR4. The protein-protein interactions between the T cell receptor (TCR) and the type II collagen linked to the allele MHC of class II HLA-DR4 may thus represent the target for the development of new drugs against rheumatoid arthritis. Using computational virtual screening techniques, families of pharmacologically active molecules have been identified that interfere with the TCR/collagen II-MHCII interaction. The compounds identified here open up new possibilities in the treatment of rheumatoid arthritis.
Type:
Grant
Filed:
March 24, 2017
Date of Patent:
June 12, 2018
Assignees:
CONSIGLIO NAZIONALE DELLE RICERCHE, UNIVERSITÀ CATTOLICA DEL SACRO CUORE
Inventors:
Maria Cristina De Rosa, Francesco Ria, Bruno Giardina, Gianfranco Ferraccioli, Davide Pirolli, Chiara Nicolo′
Abstract: A new therapeutic use of botulinum neurotoxin serotype A (Bont/A) is described, therapeutic treatment of paralysis caused by spinal cord injury.
Type:
Application
Filed:
April 21, 2016
Publication date:
May 24, 2018
Applicant:
Consiglio Nazionale Delle Ricerche
Inventors:
Sara Marinelli, Flaminia Pavone, Siro Luvisetto, Valentina Vacca
Abstract: The present invention concerns a device constituted by a planar optical antenna which allows to beam and collect light emitted from various light sources, including light-emitting devices (LEDs), fluorescent markers and single-photon sources. By considering the light source as a light receiver and using reciprocity, the device can also be used to improve the absorption of light by various receivers, including molecules. This device is in particular suitable for in-vitro diagnostics (IVD).
Type:
Application
Filed:
April 13, 2016
Publication date:
May 10, 2018
Applicant:
Consiglio Nazionale Delle Ricerche
Inventors:
Mario AGIO, Costanza TONINELLI, Simona CHECCUCCI, Fabrizio SGRIGNUOLI, Sahrish RIZVI, Pietro Ernesto LOMBARDI
Abstract: Self-assembled block copolymer films having two or more blocks are manufactured by distributing a solution containing at least one block copolymer onto the substrate so as to partially coat a substrate surface, obtaining an intermediate product. A block copolymer is self-assembled by heating the intermediate product. The self-assembling step includes Rapid Thermal Processing, which is performed by heating the intermediate product up to a first target temperature, ranging from a glass transition temperature to an order-disorder transition temperature of the block copolymer, through a temperature rising ramp having a rate of temperature change not lower than 5° C./second; maintaining the intermediate product at the target temperature for a time interval not longer than 60 minutes, whereby a sample is obtained on the surface of which a self-assembled film of the block copolymer has been made; and cooling the sample down to the ambient temperature through a temperature descending ramp.
Abstract: Low-noise current source, configured to be supplied by at least one DC main supply (Vss) and to deliver an output current (IL), the source comprising one or more current generator modules (G1, G2, . . . GN) operating in parallel each one of which is configured to deliver a respective output current (Ii), whereby the output current (IL) of the source is equal to the sum of the output currents (Ii) of said one or more current generator modules (G1, G2, . . . GN), each current generator module (G1; G2; . . . GN) comprising a regulator component (Q1), configured to deliver the output current (Ii) of the current generator module (G1; G2; . . .
Type:
Grant
Filed:
October 29, 2015
Date of Patent:
April 10, 2018
Assignees:
CONSIGLIO NAZIONALE DELLE RICERCHE, UNIVERSTÀ DEGLI STUDI DI FIRENZE
Inventors:
Saverio Bartalini, Alessio Montori, Marco De Pas, Mauro Giuntini, Paolo De Natale
Abstract: A photochemical reactor (1) having a hollow container body (10) having a side wall (11) made of a material arranged to contain an excited luminous plasma with electromagnetic fields and defining a closed excitation chamber (12) in which, in use, an excitable material (15) is present in such a way to obtain a discharge of the excited luminous plasma by microwave irradiation. The hollow container body (10) is provided with at least a hollow (20) that protrudes into the excitation chamber (12) and at least a microwave radiation source positioned, in use, in the hollow (20), and arranged to emit radiations in such a way to excite the excitable material (15) producing a luminous plasma.
Type:
Application
Filed:
March 17, 2016
Publication date:
April 5, 2018
Applicant:
CNR - CONSIGLIO NAZIONALE DELLE RICERCHE
Abstract: A video-confocal microscopy method for creating an image of an optical section (?) of a sample (99), provides, in one aspect of the invention, illuminating the sample (99) with illumination beams (19) concentrated on spots (x,y) arranged in an illumination pattern (18) in an illumination plane (?0) at the optical section (?); translationally parallel moving the pattern (18) of spots (x,y) to a plurality of positions in the illumination plane; it also provides for each position (u,v) of the illumination pattern (18), receiving light (21) returned by the sample (99) by reflection and/or transmission and/or phosphorescence, and detecting raw images (52), each having a light intensity distribution Iu,v(x,y) on said image detector.
Abstract: A process for the conversion of a feedstock containing one or more fatty acid triglycerides to a mixture containing one or more fatty acid alkyl esters and t-alkyl glycerols, including reacting the feedstock with a compound of formula (I): R—O—RI??(I) wherein: RI is an alkyl, alkenyl or alkynyl having 1-18 carbon atoms; R is H or a tertiary alkyl group, wherein the reaction takes place in the presence of an acid transesterification catalyst by irradiation with microwaves and/or ultrasound and/or radio waves.
Type:
Grant
Filed:
February 4, 2014
Date of Patent:
January 23, 2018
Assignee:
CONSIGLIO NAZIONALE DELLE RICERCHE
Inventors:
Giovanni Nicolosi, Carmelo Drago, Leonarda Francesca Liotta, Valeria La Parola, Maria Luisa Testa
Abstract: A system for monitoring a building structure is described. The system comprises a laser source which emits an infrared radiation and an interferometric arrangement which divides the radiation into an object beam and a reference beam. The object beam irradiates the building structure and is scattered by it, while the reference beam interferes with the scattered object beam so as to create a hologram of the building. The system also comprises a sensor which detects a sequence of holograms and a processing unit which reconstructs the evolution in time of deformations or displacements of the building by numerically processing the sequence of holograms. The system—being based on digital holography—offers various advantages compared to known monitoring techniques, for example techniques which make use of seismometers (possibility of remote monitoring, substantial space-time continuity of the monitoring, capacity for detecting a wider range of deformations and displacements).
Type:
Application
Filed:
January 28, 2016
Publication date:
January 4, 2018
Applicants:
CONSIGLIO NAZIONALE DELLE RICERCHE - CNR, UNIVERSITA DEGLI STUDI Dl FIRENZE
Inventors:
Massimiliano LOCATELLI, Pasquale POGGI, Eugenio PUGLIESE, Giorgio LACANNA
Abstract: A method and system for converting mechanical energy from a generator operated by a turbine into electric energy to be input into an electric network, comprising the following: (A) supplying a power electronic converter connectable to input of the generator and to output of the electric network; (B) supplying an electrical power outputting the generator to the power electronic converter; (C) adapting the electrical power using the power electronic converter to input the electrical power to the electric network by the following substeps: (C1) calculating rotation speed of the turbine; (C2) calculating wind speed moving the turbine; (C3) calculating reference rotation speed, corresponding to the maximum point of power input to the electric network, using a Maximum Power Point Tracking algorithm; the method comprising substep (C1) implemented by an algorithm carrying out a virtual encoder, and substep (C2) implemented by training a neural network implementing a virtual anemometer.
Type:
Grant
Filed:
May 5, 2014
Date of Patent:
January 2, 2018
Assignee:
CONSIGLIO NAZIONALE DELLE RICERCHE
Inventors:
Gianpaolo Vitale, Marcello Pucci, Massimiliano Luna
Abstract: A method is disclosed for realizing a liquid crystal tri-dimensional aligned structure, including: providing a first substrate having a first surface; forming a liquid crystal layer in contact to said first surface, said liquid crystal layer including a polymerizable liquid crystal compound; realizing a first aligning formation within said liquid crystal layer by irradiating a first portion of said liquid crystal layer with electromagnetic or electron beam radiation according to a given first pattern, so that said first portion of liquid crystal compound becomes polymerized and said first aligning formation is made of said polymerized liquid crystal compound according to said given first pattern, said first aligning structure defining a first aligning axis; locally orienting optical axes of molecules of said liquid crystal layer along said first aligning axis.
Type:
Application
Filed:
December 23, 2014
Publication date:
December 28, 2017
Applicants:
Consiglio Nazionale delle Ricerche - CNR, Laboratorio Europeo di Spettroscopie Non Lineari (LENS)
Inventors:
Hao ZENG, Piotr Jan WASYLCZYK, Diederik Sybolt WIERSMA, Camilla PARMEGGIANI, Chih-Hua HO
Abstract: Low-noise current source, configured to be supplied by at least one DC main supply (Vss) and to deliver an output current (IL), the source comprising one or more current generator modules (G1, G2, . . . GN) operating in parallel each one of which is configured to deliver a respective output current (Ii), whereby the output current (IL) of the source is equal to the sum of the output currents (Ii) of said one or more current generator modules (G1, G2, . . . GN), each current generator module (G1; G2; . . . GN) comprising a regulator component (Q1), configured to deliver the output current (Ii) of the current generator module (G1; G2; . . .
Type:
Application
Filed:
October 29, 2015
Publication date:
November 2, 2017
Applicants:
CONSIGLIO NAZIONALE DELLE RICERCHE, UNIVERSITÀ DEGLI STUDI DI FIRENZE
Inventors:
Saverio BARTALINI, Alessio MONTORI, Marco DE PAS, Mauro GIUNTINI, Paolo DE NATALE
Abstract: The present invention relates to a derivative of carnosine (?-alanyl-L-histidine) having formula (1), obtained by the functionalization of hyaluronic acid with carnosine.
Type:
Application
Filed:
July 30, 2015
Publication date:
August 31, 2017
Applicants:
CONSIGLIO NAZIONALE DELLE RICERCHE, FIDIA FARMACEUTICI S.P.A.
Abstract: The present invention relates to the use of an enzymatic method for treating flour, semolina and protein extracts derived from cereals known to stimulate a pathological immune response in patients affected by Celiac Disease (CD). Said treatment drastically reduces or completely eliminates the toxicity of gluten or similar products derived from other cereals. The method uses the catalytic activity of microbial transglutaminase and, in particular, its ability to bind proteins in cereal flour or semolina to an alkylated (C1-C4) derivative of lysine. After the treatment said proteins extracted from flour show a substantially lowered immuno-stimulatory activity in celiac patients T lymphocytes.
Type:
Grant
Filed:
October 29, 2007
Date of Patent:
August 15, 2017
Assignee:
Consiglio Nazionale Delle Ricerche
Inventors:
Mauro Rossi, Carmela Gianfrani, Rosa Anna Siciliano