Patents Assigned to Council of Scientific and Industrial Research
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Publication number: 20250042888Abstract: The present disclosure relates to a new, simple, two step synthesis of Indolmycin and its derivatives of formula (I), in 4-5 hours. Formula (I) wherein said process comprising the step of: 10 (a) reacting indole derivative with methyl magnesium bromide in a suitable solvent at a temperature in the range of 0-30° C. followed by adding ethyl epoxy butanone in a suitable solvent at ?20° C. for a period of 1-2 hrs and maintaining the obtained reaction mixture for 1 hr at ?20° C. to obtain a compound; and (b) passing the compound obtained at step a), base and N-methylated quinidine 15 through solid-solid continuous flow reactor for 1 minute to obtain the compound of formula (I).Type: ApplicationFiled: November 24, 2022Publication date: February 6, 2025Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN.Inventors: Syed GULAM DASTAGER, Madhukar SHYAM SAID, Abujanaid KHAN, Amol ARVIND KULKARNI
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Patent number: 12215197Abstract: The present invention relates to a crystalline, two dimensional polymer of Formula I and a process for the preparation thereof.Type: GrantFiled: April 2, 2020Date of Patent: February 4, 2025Assignee: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Santhosh Babu Sukumaran, Karayamkodath Chandran Ranjeesh
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Patent number: 12202833Abstract: The present invention provides highly efficient process for the preparation of enantiomerically enriched Sitagliptin of Formula (Ia). More particularly, a direct rhodium catalyzed asymmetric hydrogenation in the presence of bis-phosphine chiral ligand has been developed to yield enantiopure Sitagliptin product with the highest enantiomeric excess of 85-99.9%.Type: GrantFiled: December 9, 2019Date of Patent: January 21, 2025Assignee: Council of Scientific & Industrial ResearchInventors: Samir Hujur Chikkali, Kishor Vilas Khopade
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Patent number: 12201727Abstract: The present invention relates to the novel formulation for sustained or delayed release of rohitukine-rich Dysoxylum binectariferum extract/fraction and a process for preparing the same wherein the extract is wet-granulated using excipients i.e. biodegradable polymers and/or non-biodegradable polymers alone or in combination, and the said granules are either filled into a capsule or compressed into a tablet. The said formulation comprising a granulated extract/fraction of rohitukine-rich Dysoxylum binectariferum with polymers has resulted in a sustained release of the extract or fraction over a period of 16-24 hrs. The said formulations are useful in the treatment of inflammatory diseases.Type: GrantFiled: October 13, 2023Date of Patent: January 21, 2025Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Sonali Sandip Bharate, Vikas Kumar, Mehak Gupta, Sumit Gandhi, Ajay Kumar, Sandip Bibishan Bharate, Ram Vishwakarma
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Publication number: 20250009614Abstract: The current invention relates to a method for producing an alcohol-free, antimicrobial, moisturising hand sanitizer comprising (i) a polymer-based nanoemulsion including one or more active compounds selected from cyanovirin-N (CV-N), cannabidiol (CBD) and palmitic acid (PA); and (ii) an aqueous gel-like moisturizing composition comprising xanthan gum, glycerol and a preservative such as citric acid. The invention further relates to an alcohol-free, antimicrobial, moisturising hand sanitizer produced by the method of the invention, as well as to use of the hand sanitizer as an antimicrobial, in particular an antiviral agent.Type: ApplicationFiled: November 2, 2022Publication date: January 9, 2025Applicant: COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Tshepo Patric NKUNA, Michel Lonji KALOMBO, Katlego Zebedius SETSHEDI
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Patent number: 12191522Abstract: The present invention discloses a film comprising porous, amorphous polybenzimidazole (PBI) and at least one filler for use as a separator in a lithium ion battery and a process for preparation thereof.Type: GrantFiled: March 5, 2018Date of Patent: January 7, 2025Assignee: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Vikas Kumar, Swaminathan Sivaram, Ver Avadhani Chilukuri
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Patent number: 12172944Abstract: The present invention relates to a process for the preparation of tapentadol and analogs or compounds or stereoisomers of formula (I), Formula I wherein, A is aryl, heteroaryl, and cycloalkyl; R is H, OH, OR1, halogen, C1-C12 alkyl, cycloalkyl, aryl or heteroaryl; R1 is C1-C12 alkyl, cycloalkyl, aryl or heteroaryl, wherein each of these groups may further be substituted with one or more substituent selected from H, OH, halogen, CN, NO2, C1-C4 alkyl or phenyl. Further, the multi-step process involves no column chromatography purification until the very last step. This makes this process highly commercially viable and industrially useful.Type: GrantFiled: March 12, 2020Date of Patent: December 24, 2024Assignee: Council of Scientific & Industrial ResearchInventors: Chandrasekhar Srivari, Satyendra Mainkar Prathama, Kranthi Kumar Ramagonolla, Sukumar Genji
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Patent number: 12172991Abstract: The invention described herein relates to the compounds of Formula I for treating diseases and disorders for which inhibition or modulation of the topoisomerase I enzyme produces a physiologically beneficial response, in particular for the treatment of breast cancer. Also provided is the process of preparing compounds of Formula I.Type: GrantFiled: May 24, 2019Date of Patent: December 24, 2024Assignees: Council of Scientific & Industrial Research, Indian Association for the Cultivation of ScienceInventors: Arindam Talukdar, Benu Brata Das, Biswajit Kundu, Subhendu K. Das, Chowdhuri Srijita Paul, Dipayan Sarkar, Sourav Pal, Debomita Bhattacharya, Ayan Mukherjee, Subhajit Roy
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Publication number: 20240417358Abstract: The present invention provides a non-hazardous, improved continuous oxidation process for the preparation of substituted benzoic acid of formula (I) by using continuous process reactor system with improved process controls.Type: ApplicationFiled: October 3, 2022Publication date: December 19, 2024Applicant: Council of Scientific and Industrial ResearchInventors: Sunil Shankar JOSHI, Nilesh Atmaram MALI
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Publication number: 20240417381Abstract: The present invention relates to the process for the preparation of Nitazoxanide and intermediates thereof. The invention explores readily available starting materials with reaction conditions that are suitable for industrial scale applications. The present invention discloses, a single vessel process to prepare 5-nitrothiazol-2-amine starting from a very basic starting material 1,1-dimethoxy-N, N-dimethylmethanamine. Overall intermediates throughout the process is free from column chromatography and the final product Nitazoxanide is purified by precipitation. All the synthesized compounds were confirmed by various spectroscopic techniques such as Fourier transform infrared spectroscopy, 1H NMR, 13C NMR, HRMS and elemental analysis.Type: ApplicationFiled: September 21, 2022Publication date: December 19, 2024Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATEDInventors: Sasidhar Balappa SOMAPPA, Praveen Kumar VALMIKI, Basavaraja DURUGAPPA
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Publication number: 20240382509Abstract: The present invention conveys a fractionation method to isolate different bioactive Phytocannabinoids by solid phase extraction using HP-20 resins and one step method to synthesize C— and O-?-D-glycoside derivatives of Cannabinoid by using a ?-D-glucose donor (O-Glycosyl trichloroacetimidate donor) to obtain glycosidic derivatives. The novel C-glycosides of Cannabinoids displayed significant anti-proliferative properties against wide range of human cancer cell lines as compared to their respective parent molecules. Furthermore, the C— and O glycosides of Cannabinoids also showed anti-invasive and anti-migratory activities against metastatic cancer cells of breast and pancreatic origin. When applied in combination with DNA damaging agent (5-Fluorouracil) to colorectal cancer cells, the C— and O-glycosides of Cannabinoids potentiate DNA damaging property and thus augment apoptosis resulting in an increment in the efficacy of DNA damaging drugs.Type: ApplicationFiled: September 27, 2022Publication date: November 21, 2024Applicant: Council of Scientific and Industrial ResearchInventors: Anindya GOSWAMI, Asif ALI, Souneek CHAKRABORTY, Bashir Khalid MIR, Veeranjaneyulu GENNEDI, Waseem Iqbal LONE, Yedukondalu NALLI
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Patent number: 12146477Abstract: A Bidirectional, Linear and Binary, Segmented Antagonistic Servomechanism-based Shape Memory Alloy (SMA) Actuator comprising a main stroke transmitting lever (11 or 18) and a plurality of part-modules (15A or 15B) disposed in a closely spaced arrangement and adapted to undergo a reciprocal translation in a first direction. wherein, the part-modules comprising a plurality of segments having SMA elements (12). The invention provides two configurations arranged in ‘straight’ and ‘cross’ configurations of the SMA elements in the part-modules. Further above configuration are arranged in a tight close space however, the “cross” configuration provides additional 40% compactness. The configurations comprise a “S-type long tail” or “flipped F-type long tail” main stroke transmitting lever and plurality of “straight” or “cross” configurations part modules, respectively.Type: GrantFiled: October 20, 2023Date of Patent: November 19, 2024Assignee: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Bhargaw Hari Narayan, Joshi Tilak Chandra, Hashmi Syed Azhar Rasheed, Srivastava Avanish Kumar, John Pretesh
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Patent number: 12145931Abstract: The present invention relates to an antimalarial heterocyclic compound of formula I, dimers thereof and process for the preparation thereof. Further, the present invention relates to a pharmaceutical composition of heterocyclic compound of formula I, dimers thereof for treating malarial infection.Type: GrantFiled: February 19, 2019Date of Patent: November 19, 2024Assignee: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Santosh Baburao Mhaske, Jyoti Pankaj Mahajan, Shanmugam Dhanasekaran
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Patent number: 12134664Abstract: The invention is directed to Muramyl Dipeptide (MDP) derivative compounds of structural Formula-VIII, a process for synthesis, intermediates used in the synthesis and use thereof: wherein, R can be a linear or branched alkyl, an aryl, a substituted aryl, or an alkoxy alkyl. These compounds possess excellent pharmacological properties, in particular immunomodulating properties for use as adjuvant in vaccine formulations. These compounds are particularly useful as adjuvants in vaccines.Type: GrantFiled: May 24, 2021Date of Patent: November 5, 2024Assignees: Bharat Biotech International LTD., Council of Scientific and Industrial ResearchInventors: Krishna Murthy Ella, Ganneru Brunda, Halmuthur Mahabalarao Sampath Kumar, Paturu Rama Subba Reddy
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Patent number: 12100815Abstract: The present invention provides an energy storage device having high discharge capacity and high cycling ability. More particularly, the present invention provides Zn/V2O5 battery having cation selective ionomer membrane and free-standing electrode.Type: GrantFiled: February 4, 2020Date of Patent: September 24, 2024Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Meena Ghosh, Vidyanand Vijayakumar, Sreekumar Kurungot
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Publication number: 20240294473Abstract: The present invention relates to functionalized Maleimides and Isomaleimides of general Formula (I) and a process for the preparation thereof, involving [3+2] annulation of ?,?-unsaturated aldehydes with carbamoyl alkylates via an enolate pathway to afford highly functionalized compounds of Formula (I);Type: ApplicationFiled: June 9, 2022Publication date: September 5, 2024Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Santosh Baburao MHASKE, Amol Basagonda VIVEKI, Mahesh Dattatraya POL
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Publication number: 20240279176Abstract: The invention relates to substituted tricyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions wherein, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, X1, X2, X3, X4, X5 and ‘n’ defined herein. The present invention also relates to compositions which comprise a metallo-?-lactamase (MBL) inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta-lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more ?-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds.Type: ApplicationFiled: June 2, 2022Publication date: August 22, 2024Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Vinod Dinkar CHAUDHARI, Pulkit DHIMAN, Hemraj Santuji NANDANWAR, Vikas PATHANIA, Krishan Gopal THAKUR, Satyajeet DAS
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Patent number: 12060363Abstract: Embodiments of this disclosure are directed to isohexide-dioxalates compounds of formula (I), and polymerization processes that utilize diols, oxalic acid, and compounds according to formula (I): Embodiments of this disclosure also include polyoxalates compounds of formula (II), polymerization processes for the production of polymers having a general structure according to formula (II):Type: GrantFiled: July 12, 2018Date of Patent: August 13, 2024Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Samir Hujur Chikkali, Kadhiravan Shanmuganathan, Bhausaheb Rajput, Farsa Ram
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Publication number: 20240262753Abstract: The present invention discloses a novel flash sintering process for synthesis of MAX phases, namely, but not limited to Ti2SnC and Ti3SiC2 in an extremely short time. The process is a combustion synthesis where a relatively low voltage in a range of 20-60 V/cm is applied using a DC/AC power source across the compact precursor material prior to ignition. The flash event is observed with a quick rise in current flow in a range of 100-300 mA/mm2 followed by measured temperature range of 1200-1400° C. in a green compact body of different MAX phase compositions. The process of the present invention enables the synthesis of MAX phases in air by suppressing oxidation of the material because of the very short residence time of the flashing event. In addition, the present invention focuses on synthesis of MAX phase in bulk to serve as the starting material for the development of two-dimensional MXenes.Type: ApplicationFiled: May 27, 2022Publication date: August 8, 2024Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Laxmidhar BESRA, Nuwula Usha KIRAN, Bishnu CHOUDHARY, Sriparna CHATTERJEE
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Patent number: 12048727Abstract: The present invention relates to a synergistic formulation comprising the essential oils of plants from western Himalayas, which have versatile medicinal properties. The present invention also relates to a process for development of synergistic value added anti-acnes products using the essential oils from these plants of western Himalayas. The developed synergistic formulation is useful in inhibiting different P. acnes strains thereby exhibiting antibacterial activity.Type: GrantFiled: March 20, 2020Date of Patent: July 30, 2024Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Vijai Kant Agnihotri, Bipul Kumar, Hemant Kumar Gautam