Abstract: The present invention discloses novel indolylkojyl compounds of formula 1 The invention also provides a one pot, green chemistry method for preparation of indolylkojyl compounds. The compounds of the present invention are selectively toxic towards human breast cancer cells and inhibit tumor growth as well as lung metastasis. The compounds also potentiate the effect of anticancer drugs.

Abstract: The present invention relates to a compound of formula A useful as potential anticancer agents against human cancer cell lines and process for the preparation thereof.

Abstract: The present invention provides novel purine based compounds of formula 1, method of preparation of purine based compounds and its composition useful for inhibiting signalling through Toll-like receptors. These compounds are useful in inhibiting immune stimulation involving toll-like receptor 9 (TLR9). These can be used in treatment of autoimmune disease and inflammation where aberrant activation of TLR9 plays role.

Abstract: The present invention discloses a recombinant, modified extracellular chitinase having an amino acid sequence set forth in SEQ ID NO.4 or SEQ ID NO.5. The recombinant, modified chitinase is derived by inserting two-point mutations at positions 661 and 2158 in the native chitinase gene of Brevibacillus laterosporus LAK 1210 which results in amino acid substitution of tyrosine (Y) residue with histidine (H) at positions 221 and 720. The modified chitinase exhibits both exochitinase and endochitinase activity. The recombinant, modified enzyme is thermoactive with a temperature optimum of 55-60° C. and high thermostability (Tm of 66.7° C.), functions in a broad pH range (pH 3.0-11.0) having a pH optimum of 9.0 and also exhibits improved solubility and enhanced efficacy for control of insects and phytopathogenic fungi.

Abstract: This invention relates to a membrane and method for the preservation of agricultural produce. According to a first aspect of the invention there is provided a membrane for the preservation of agricultural produce comprising first and second outer polymeric layers, at least one of the outer polymeric layers being impregnated with a hydrophilic agent, and an inner layer dispersed in between the outer layers, the inner layer consisting of a polymer being impregnated with a carrier for incorporation of an antimicrobial volatile into the inner layer, the inner layer further including an absorptive agent, wherein in use, the membrane is placed proximate to agricultural produce to be preserved.

Abstract: The present invention disclosed a novel heterogeneous catalytic system (precatalyst), process for the preparation and use thereof for the synthesis of highly crystalline, disentangled ultra high molecular weight polyethylene (UHMWPE).

Abstract: The present invention discloses with the development of ecofriendly and biodegradable lubricant formulation useful for micro electro mechanical systems and process thereof. The new generation Mineral oil free lubricant formulations were developed by esterification of polyols such as 2,2-dimethyl, 1,3-Propanediol, 2,2-diethyl-1,3-propane diol, and aliphatic di carboxylic acids like adipic and azelaic and with mono alcohol, using heterogeneous catalyst Indion 140 with cation exchange properties. The said formulation has a viscosity in the range of 31 to 47 cSt at 40° C., a high viscosity index of 139-196, pour point of approximately <?39° C. with a multifunctional EP additive of recommended dose of 1.5-4%.

Abstract: The present invention relates to a novel peptide that exhibits effective antimicrobial activity against various gram-positive and gram-negative bacteria that are involved in food-borne pathogenesis, food spoilage and other pathogenic conditions. Therefore, this peptide can be a good candidate as antibacterial in agricultural, food and beverage industry, as well as for other medical applications and societal use.

Abstract: The present invention discloses a single step process for the synthesis of furan derivative from carbohydrate comprises stirring the reaction mixture of carbohydrate in solvent in presence of catalyst at temperature in the range of 170 to 190° C. for the period in the range of 23 to 25 hrs to afford corresponding furan derivative.

Abstract: The present invention relates to biomarkers useful for detection of types, grades and stages of human breast cancer. The present invention particularly relates to the development of these identified biomarkers as a miRNA chip for the early and accurate diagnosis of human breast cancer. This patent application highlights the novelty in the utility of these miRNAs, that they could be used as a diagnostic kit (miRNA chip) for early and accurate detection of breast cancer grades, stages and subtypes. Few to hundreds of samples can be checked within a span of 2 to 3 hrs and hence this becomes an easy, fast, robust and high throughput technology for screening program for early detection of breast cancer.

Abstract: The present invention discloses a process for recovery and regeneration of rare earth metals or salts thereof used as catalyst and which is conveniently integrated within the overall flow sheets of manufacturing dialkyl carbonates. Alkyl carbamate, alcohol and a rare earth metal salt as catalyst selected from the lanthanide series are added in a reactor to afford dialkyl carbonate. The rare earth metal catalyst is selected from samarium, cerium, lanthanum, neodymium, ytterbium, europium and gadolinium. Ammonia is added to a portion of the reaction mixture to precipitate the catalyst and the separated deactivated catalyst is dissolved in acid to afford regenerated catalyst, e.g., in triflic acid in the case of samarium triflate catalyst.

Abstract: The present invention disclosed an improved one pot, one step process for halogenation of compound of formula (II) to afford corresponding halogenated compound of formula (I) having improved yield and increased selectivity under very mild conditions.

Abstract: The present invention discloses a process for preparing a homogeneous solution of a polymer and melanin. The present invention further discloses a process for preparation of fibers and films from said homogeneous solution.

Abstract: The present invention relates to the formation of a stable dianionic ?-dimer-[TCNE]22? (TCNE-tetracyanoethylene) at ambient conditions that exhibits unusually intense white emission over the entire visible spectral range (400-800 nm) and has application in designing white light emitting devices. Particularly, the present invention relates to a process for the preparation of stable dimer in an organic solvent upon aging at room temperature, in the presence of anions such as Br?, Cl?, SCN?, which reduces the TCNE to a TCNE anion radical (TCNE.?) which subsequently dimerizes to form the stable dianionic dimer upon aging. More particularly, the dimer formed in this invention opens a new class of materials to design white light emitting devices having high intensity over the entire visible spectral range. The dimer also forms electron transfer salts used to develop new molecule-based metals, superconductors, and magnets.

Abstract: The present invention disclosed a novel squaraine linked metalloporphyrin based 2D sheet polymer catalyst of formula (I), process for preparation thereof and use of said catalyst for efficient photo- and electro-catalytic splitting of water.

Abstract: The present invention discloses elastic macro porous scaffold and a process for the preparation thereof. The present invention also provides a process for the preparation of macroporous, elastic nano particulate scaffolds comprising of coated or grafted cross linkable nanoparticles, and a crosslinker prepared by crosslinking during ice templating, wherein the modulus increases linearly with temperature.

Abstract: The present invention relates to novel crude oil demulsifier comprises a copolymer of styrene with pyridine or a carboxylic acid or its salt selected from methacrylic, acrylic, maleic or fumaric acid with molecular weight in the range of 10000 to 600000 Daltons, dose in the range of 20-1000 ppm. The invention further relates to a process for demulsification of crude oil by treating crude oil with the copolymer in the range of 20-1000 ppm in the temperature range of 25-40° C. by shaking to obtain demulsified crude oil having crude oil with <1% water, and Water <100 ppm oil.

Abstract: The present invention provides a monodispersed lanthanum based upconverting microrods comprising ?-NaYF4:Yb3+, Er3+ and ?-NaYF4:Yb3+, Tm3+, capped with oleic acid. The upconverting microrods, embedded in polymer matrices is used for making security tags and for sensing application. The process of preparation of the oleic acid capped upconverting microrods is also disclosed.

Abstract: Sulfonyl hydroxamic acid compounds have the following general formula: Ring A and B are aryl, heteroaryl, cycloalkyl, fused aryl or fused alkyl group, and R1, R2, R3, R4, R5, and R6 are hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl, aryl, heteroaryl, halogen, hydroxy, alkoxy, aryloxy, nitro, cyano, ester, or aldehyde. The compounds are HDAC inhibitors. Processes can be used for preparation of these indole-based sulfonyl hydroxamic acid derivatives.

Abstract: The present invention relates to substituted methanopyrido [2,1-a]isoindolones of formula I, wherein, R1 is selected from phenylsulfonyl or p-toluenesulfonyl; and n=1, 2, 3; their derivatives, stereoisomers, pharmaceutically acceptable salts and pharmaceutically acceptable compositions having potential muscarinic acetylcholine receptor modulator activity.