Patents Assigned to Curators of the University
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Patent number: 7853437Abstract: A system and method for detecting and identifying electronic devices based on their unintended electromagnetic emissions (“UEE”) signals is presented. During device classification, UEE signals are measured from a plurality of test devices and characteristic data is obtained from the UEE signal emitted from each test device. Using the characteristic data, a threshold value and ideal pulse template can be determined for each test device and stored in a memory. An ideal stimulation signal is also determined for each test device and stored in the memory. During device detection, the ideal stimulation signal is applied to the environment in which a target device is suspected of being located. Stimulated UEE signals are measured from the target device and processed. The processed measurement data is compared to stored power threshold values and ideal pulse templates to determine if the target device is present.Type: GrantFiled: December 1, 2008Date of Patent: December 14, 2010Assignee: The Curators of the University of MissouriInventors: Sarah A. Seguin, Daryl G. Beetner, Todd H. Hubing
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Patent number: 7825086Abstract: Dipeptide and tripeptide ester derivatives of acyclovir and its analogs are disclosed which are useful to treat herpes virus infections. Also disclosed is a method for preparing a therapeutic agent for targeted delivery to ocular tissue comprising linking the therapeutic agent to one or more groups of the formula —X—Y-Z(n)-R; wherein each X, Y and Z is independently Met, Val, Thr, Tyr, Trp, Ser, Ala or Gly; each R is independently H or an amino-protecting group; and each n is independently 0 or 1.Type: GrantFiled: August 19, 2008Date of Patent: November 2, 2010Assignee: The Curators of the University of MissouriInventor: Ashim K. Mitra
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Publication number: 20100273129Abstract: The provision of dental restorations can be improved by generating a cold atmospheric plasma inside the mouth of the patient and then applying that cold atmospheric plasma onto a dental restoration site. The dental restoration site can be composed of either or both of dentin and enamel. Further, the provision of dental restorations can also be improved by introducing a dental adhesive onto a dental restoration site and treating it with a cold atmospheric plasma.Type: ApplicationFiled: April 23, 2010Publication date: October 28, 2010Applicants: Curators of the University of Missouri Office of Intellectual Property Admin., Nanova, Inc.Inventors: Qingsong Yu, Hao Li, Meng Chen
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Patent number: 7819997Abstract: An exemplary method for making a transparent composite includes steps of combining a refractive index modifier with a precursor solution, combining glass with the precursor solution, and curing the precursor solution to create a transparent glass reinforced polymer composite. An exemplary transparent composite comprises a glass reinforced thermosetting polymer composite layer sandwiched between glass layers.Type: GrantFiled: September 17, 2004Date of Patent: October 26, 2010Assignee: The Curators of the University of MissouriInventor: Sanjeev K. Khanna
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Patent number: 7816567Abstract: A reactive-separation process converts glycerin into lower alcohols, having boiling points less than 200° C., at high yields. Conversion of natural glycerin to propylene glycol through an acetol intermediate is achieved at temperatures from 150° to 250° C. at a pressure ranging from 1 and 25 bar. The preferred applications of the propylene glycol are as an antifreeze, deicing compound, or anti-icing compound. The preferred catalyst for this process in a copper-chromium powder.Type: GrantFiled: December 22, 2009Date of Patent: October 19, 2010Assignees: The Curators of the University of Missouri, Renewable Alternatives LLCInventors: Galen J. Suppes, William Rusty Sutterlin, Mohanprasad Dasari
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Patent number: 7811994Abstract: A method for the identification of peptides having an affinity for the surface of fungi is provided as is a method for the identification of peptides capable of affecting the development of a fungus. Also provided are compositions containing peptides identified using the method of the present invention. In addition, isolated polynucleotides, vectors, expression cassettes and transformed cells capable of expressing peptides identified by the method of the present invention are provided.Type: GrantFiled: April 13, 2009Date of Patent: October 12, 2010Assignee: The Curators of the University of MissouriInventors: James T. English, Francis J. Schmidt, George P. Smith, Roy O. Morris, Sharon Bishop-Hurley
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Patent number: 7809418Abstract: Embodiments of the invention relate to an apparatus including a light source to generate a plurality of light beams with each of the plurality of light beams having a different wavelength range. The apparatus also includes a light funnel to direct the plurality of light beams to the target area, an aperture to direct the plurality of light beams emitting from the target area to a lens, the lens configured to collect the light beams emitting from the target area. Further, the apparatus includes a detector including a plurality of light-sensing devices each configured to detect a light beam and configured to generate an output signal indicative of an intensity of light detected and a processor for determining the blood characteristic as a function of each generated output signal.Type: GrantFiled: October 3, 2008Date of Patent: October 5, 2010Assignee: The Curators of The University of MissouriInventor: Zhi Xu
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Patent number: 7807358Abstract: The present invention provides a method of hybridization, differential methylation hybridization (DMH) for high throughput methylation analysis of multiple CpG island loci. DMH utilizes nucleic acid probes prepared from a cell sample to screen numerous CpG dinucleotide rich fragments affixed on a screening array. Positive hybridization signals indicate the presence of methylated sites. Methods of preparing the hybridization probes and screening array are also provided.Type: GrantFiled: July 28, 2006Date of Patent: October 5, 2010Assignee: Curators of the University of MissouriInventor: Timothy Hui-Ming Huang
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Publication number: 20100248228Abstract: The present invention provides a detecting method of detecting malignant cells in a patient's specimen or a biological sample. Specifically, the inventive method includes the steps of extracting a genomic DNA, digesting said genomic DNA with one or multiple methylation sensitive restriction enzymes, and amplifying by PCR with one or multiple selected primers. The PCR can be performed in a conventional or a real-time platform. The inventive method can detect leukemia cells in 90% ALL patients at a sensitivity of up to 10?6. The inventive method also provides broad clinical applications in cancer (including hematopoietic and solid tumors) screening and risk assessment, early detection and diagnosis confirmation, and therapeutic monitoring, minimal residual disease detection and prognostic prediction.Type: ApplicationFiled: March 27, 2009Publication date: September 30, 2010Applicant: The Curators of the University of MissouriInventors: Michael Xia Wang, Huidong Shi, Srilatha Nalluri
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Publication number: 20100233124Abstract: Herein a Bacillus exosporium antigen delivery (BEAD) system that provides a means to introduce recombinant proteins or small molecules into the exosporium of members of the B. cereus family of bacteria, i.e. B. anthracis, B. cereus, and B. thuringiensis, is disclosed. The system results in the surface display of recombinant proteins or small molecules such that they can stimulate an immune response. In addition, methods of making and using the system are described.Type: ApplicationFiled: February 23, 2009Publication date: September 16, 2010Applicant: The Curators of the University of MissouriInventors: George C. Stewart, Brian Matthew Thompson
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Patent number: 7786259Abstract: The present invention provides a process for preparing an immobilized peptide derivative of formula (Vb): comprising reacting a functionalized solid support comprising Sub-L wherein Sub is a solid support and L is a cleavable linker, with H—[NH—A—C(O)]—O(tBu), then reacting the immobilized product with compound of the formula RHN—A—C(O)OH, wherein the RHN—A—C(O) group is the residue of a N-protected ?-amino acid, in the presence of a coupling agent, to yield an immobilized peptide derivative of the formula (Vb).Type: GrantFiled: July 13, 2007Date of Patent: August 31, 2010Assignee: The Curators of the University of MissouriInventor: William G. Gutheil
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Publication number: 20100212331Abstract: A device and method suitable for the cryopreservation of all types of biological cells is described. In this method, an ultra-fast cooling/warming device system is used to achieve vitrification of individual cells or cell suspensions without cryoprotectant agents (CPA) or with a low concentration of CPAs (<1M), to attenuate the formation of intracellular ice crystal formation during cooling, and to minimize devitrification during subsequent warming. The device system applies oscillating heat pipe (OHP) and nanofluid techniques, and is built through microfabrication. Several devices may be networked to increase the total volume of cell samples that the cryopreservation system can process simultaneously.Type: ApplicationFiled: July 21, 2007Publication date: August 26, 2010Applicant: The Curators of the University of MissouriInventors: John K. Critser, Xu Han, Hongbin Ma
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Patent number: 7776898Abstract: The invention provides compounds of formula I: wherein R1 to R4 and n have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating pain and treating other conditions which involve, for example, binding opioid receptors using compounds of formula I.Type: GrantFiled: September 18, 2007Date of Patent: August 17, 2010Assignee: The Curators of the University of MissouriInventors: William J. Welsh, Seong Jae Yu, Anil Nair
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Publication number: 20100194239Abstract: Embodiments of the present invention provide a system and a method for increasing the harvested energy from a piezoelectric element exposed to environmental vibrations via a two-prong system. In a first prong, a cantilever beam is tapered and shaped so as to increase and provide an approximately uniform strain on and along the beam, thus resulting in increased voltage. In a second prong of the system and method, a voltage compensating circuit, when used with a voltage inversion circuit of the prior art, increases the harvested power by injecting current to the piezoelectric element after each voltage inversion so as to increase the voltage level.Type: ApplicationFiled: January 30, 2009Publication date: August 5, 2010Applicant: The Curators of the University of MissouriInventors: Shahab Mehraeen, Jagannathan Sarangapani
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Publication number: 20100190951Abstract: The invention provides processes for preparing soy-based oligomeric polyols or substituted oligomeric polyols, as well as urethane bioelasteromers comprising the oligomeric polyols or substituted oligomeric polyols.Type: ApplicationFiled: February 2, 2010Publication date: July 29, 2010Applicant: The Curators of the University of MissouriInventors: Galen Suppes, Zuleica Lozada, Arnold Lubguban
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Patent number: 7763432Abstract: Pregnancy-associated glycoproteins (PAGs) are structurally related to the pepsins, thought to be restricted to the hoofed (ungulate) mammals and characterized by being expressed specifically in the outer epithelial cell layer (chorion/trophectoderm) of the placenta. By cloning expressed genes from ovine and bovine placental cDNA libraries, the inventors estimate that cattle, sheep, and most probably all ruminant Artiodactyla, possess possibly 100 or more PAG genes, many of which are placentally expressed. The PAGs are highly diverse in sequence, with regions of hypervariability confined largely to surface-exposed loops. Selected PAG that are products of the invasive binucleate cells, expressed highly in early pregnancy at the time of trophoblast invasion and expressed weakly, if at all, in late gestation are useful in the early diagnosis of pregnancy. In a preferred embodiment, the invention relates to immunoassays for detecting these PAGs.Type: GrantFiled: October 24, 2006Date of Patent: July 27, 2010Assignee: The Curators of the University of MissouriInventors: Robert Michael Roberts, Jonathan Andrew Green, Sancai Xie
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Patent number: 7759419Abstract: A coating composition comprising an effective corrosion-inhibiting amount of a rare earth compound, a neutral to slightly acidic generating extender or an acidic generating extender, or combinations thereof is provided. In one embodiment, the corrosion-inhibiting components are combined with other components such as extenders, amino acids and amino acid derivatives, gelatin and gelatin derivatives, organic-based exchange resins, and combinations thereof, to enhance the corrosion resistance of the resultant coating film. The coating compositions have good adhesion to substrates such as metals, including aluminum and aluminum alloys.Type: GrantFiled: January 16, 2004Date of Patent: July 20, 2010Assignee: The Curators of the University of MissouriInventors: James Stoffer, Thomas O'Keefe, Eric Morris, Pu Yu, Scott A. Hayes
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Patent number: 7760355Abstract: A focused droplet nebulizer of the invention produces substantially uniform droplets of a predetermined size. Droplets are pushed out through a small outlet orifice by the contraction of a chamber. The droplets can be carried on a substantially non-divergent path in a drift tube. A piezo membrane micro pump acts in response to an electrical control signal to force a droplet out of the outlet orifice. The nebulizer can operate at frequencies permitting a stream of individual droplets of the predetermined size to be sent along the substantially non-divergent path in the drift tube in a preferred embodiment ELSD device.Type: GrantFiled: July 27, 2005Date of Patent: July 20, 2010Assignee: The Curators of the University of MissouriInventors: David W. Larsen, Zhi Xu
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Publication number: 20100179667Abstract: A mammalian tissue scaffold and method for making a tissue scaffold including a rigid scaffold body of biocompatible glass fibers bonded together and in special alignment to define open channels within the scaffold to allow fluid flow into and within the scaffold.Type: ApplicationFiled: January 15, 2009Publication date: July 15, 2010Applicant: The Curators of the University of MissouriInventors: Delbert E. Day, Steven B. Jung
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Patent number: 7752089Abstract: An adaptive inventory management system and method eliminates or minimizes frequency interference issues within a facility that employs a plurality of RFID readers for purposes of tracking and managing inventory. A middleware server activates and deactivates adjacent RFID readers within the facility based on the location of an item having an RFID tag. The middleware server also queries an inventory database based on the information collected from the RFID tag of the item and generates a command signal based on information retrieved from the database to control the travel route of the vehicle transporting items of inventory within the facility.Type: GrantFiled: February 26, 2008Date of Patent: July 6, 2010Assignee: The Curators of the University of MissouriInventors: Jagannathan Sarangapani, Anil Ramachandran, Can Saygin, Kainan Cha