Patents Assigned to Curators of the University
  • Patent number: 8252961
    Abstract: This invention relates generally to a process for value-added processing of fats and oils to yield glycerol and glycerol derivatives. More particularly, the process converts glycerol to acetol and then acetol to propylene glycol to produce a propylene glycol with ultra-low amounts of ethylene glycol. The propylene glycol thus produced may be used as an antifreeze, deicing compound, or anti-icing compound.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: August 28, 2012
    Assignee: The Curators of The University of Missouri
    Inventor: Galen J. Suppes
  • Patent number: 8252954
    Abstract: A method for the preparation of calix[n]arene derivatives, in particular phosphonated calix[n]arenes. The present invention also relates to nano-structures of phosphonated calix[n]arenes.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: August 28, 2012
    Assignees: The Curators of The University of Missouri, The University of Western Australia
    Inventors: Colin L. Raston, Mohamed Makha, Thomas Edward Clark, Jerry L. Atwood
  • Patent number: 8250481
    Abstract: A method, system, and medium are provided for presenting aspects of change associated with a geographic area that has been captured by high-resolution, remotely sensed imagery.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: August 21, 2012
    Assignee: The Curators of the University of Missouri
    Inventors: Matthew Nicholas Klaric, Curtis Herbert Davis, Grant Jason Scott, Chi-Ren Shyu, Brian Christopher Claywell
  • Patent number: 8247440
    Abstract: The present disclosure relates to pharmaceutical compositions comprising omeprazole, lansoprazole and at least one buffering agent.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: August 21, 2012
    Assignee: Curators of the University of Missouri
    Inventor: Jeffrey O. Phillips
  • Patent number: 8243997
    Abstract: A method, system, and medium are provided for detecting change in a geographic area. One embodiment includes receiving a set of remotely sensed imagery that depicts the geographic area, automatically identifying changes in physical features of the geographic area by comparing, without user intervention, the set of remotely sensed imagery to a dataset of previously stored remotely sensed imagery that also depicts the geographic area, and deriving a change-quality measurement associated with the set of remotely sensed imagery, wherein the change-quality measurement quantifies a suitability of comparison of the set of remotely sensed imagery to the previously stored remotely sensed imagery.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: August 14, 2012
    Assignee: The Curators of the University of Missouri
    Inventors: Curtis Herbert Davis, Brian Christopher Claywell, James Michael Keller, Matthew Nicholas Klaric, Grant Jason Scott, Chi-Ren Shyu
  • Patent number: 8241393
    Abstract: An example embodiment of a method for making gold nanoparticles includes steps of reacting a gold salt with a phosphino amino acid. Example phosphino amino acids include trimers, with a particular example being a trimeric amino acid conjugate containing one phosphino group. In an example method of the invention, the gold nanoparticles may be produced in timer periods of less than about 3 minutes, and at temperatures of less than about 30° C. Other methods of the invention are directed to methods for stabilizing gold nanoparticles, and to methods for making gold nanochains.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: August 14, 2012
    Assignee: The Curators of the University of Missouri
    Inventors: Kannan Raghuraman, Kattesh K. Katti, Kavita K. Katti, Henry W. White, Cathy S. Cutler
  • Patent number: 8241905
    Abstract: A composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises centrifuging a cell suspension to form a pellet, extruding the pellet through an orifice, and cutting the extruded pellet into pieces. Apparatus for making cell aggregates comprises an extrusion system and a cutting system. In a method of organ printing, a plurality of cell aggregates are embedded in a polymeric or gel matrix and allowed to fuse to form a desired three-dimensional tissue structure. An intermediate product comprises at least one layer of matrix and a plurality of cell aggregates embedded therein in a predetermined pattern. Modeling methods predict the structural evolution of fusing cell aggregates for combinations of cell type, matrix, and embedding patterns to enable selection of organ printing processes parameters for use in producing an engineered tissue having a desired three-dimensional structure.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: August 14, 2012
    Assignees: The Curators of the University of Missouri, MUSC Foundation for Research Development
    Inventors: Gabor Forgacs, Karoly Jakab, Adrian Neagu, Vladimir Mironov
  • Patent number: 8212573
    Abstract: Analyzing a device under test (“DUT”) at higher frequencies. A phase shifter varies the phase of a standing wave on a transmission line coupled to the DUT. The standing wave magnitude is sampled at each of the phase shifts and one or more DUT characteristics are determined as a function of the sampled magnitudes and phase shifts. Further aspects include a related phase shifter comprising a waveguide having a plurality of sub-resonant slots formed therein and having active elements for loading the slots to control the phase shift applied to the signal.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: July 3, 2012
    Assignee: The Curators of the University of Missouri
    Inventors: Mohamed Ahmed AbouKhousa, Reza Zoughi, Sergiy Kharkivskiy
  • Patent number: 8213471
    Abstract: A thermal management apparatus and method for a thin disk laser system enabling the laser system to have near isothermal temperatures across and throughout a thin disk comprising a mechanically controlled oscillating heat pipe having effective thermal conductivity of 10-20,000 W/m*K that promotes near isothermal conditions in lasing of the thin disk, a thin disk lasing crystal or ceramic bonded to the mechanically controlled oscillating heat pipe, and a supporting structure including a surface bonded to the thin disk that matches the CTE (coefficient of thermal expansion) of both materials.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: July 3, 2012
    Assignees: Integral Laser Solutions, LLC, The Curators of the University of Missouri
    Inventors: LaVerne Arthur Schlie, Hongbin Ma, Douglas E. Smith, Vitaly Gruzdev
  • Patent number: 8208680
    Abstract: A method for determining the yield loss of a crop using remote sensor data is described. The yield loss is determined using the reflectivity of green light by the crop canopy measured from remote sensor data such as an aerial photograph that is digitized and spatially referenced to the field's longitude and latitude. Green pixel values from the aerial photograph, expressed relative to green pixel values from well-fertilized areas of the field, are transformed to yield losses using a linear transformation that was developed using empirical data. A similar method is described to determine recommended nitrogen fertilization rates for the crop fields. The yield loss data is useful for nitrogen fertilization management, as it allows a producer of crops to weigh the expense of fertilization against the loss of revenue due to yield loss.
    Type: Grant
    Filed: November 7, 2007
    Date of Patent: June 26, 2012
    Assignee: The Curators of the University of Missouri
    Inventors: Peter Clifton Scharf, Victoria Cacnio Hubbard
  • Patent number: 8202408
    Abstract: A sensor electrode for the detection of nucleotides in a biological sample is described. The sensitivity of the electrode is enhanced by the nanostructured sensor architecture that increases the available surface area of the electrode. The electrode detects nucleotides using standard electrochemical methods.
    Type: Grant
    Filed: March 9, 2009
    Date of Patent: June 19, 2012
    Assignee: The Curators of the University of Missouri
    Inventors: Charles A. Carson, Hao Li, Qingsong Yu
  • Patent number: 8192946
    Abstract: Disclosed are methods and compositions for detecting pregnancy in an animal by means of assaying peptidase activity of one or more Pregnancy Associated Glycoproteins (PAGs). In certain aspects, methods also comprising use of an antibody that binds immunologically to a PAG that displays proteolytic activity are provided. Substrates of proteolytic PAGs are also provided, as are kits, and methods of use. Further, methods of purifying PAGs based on their proteolytic activity are also provided.
    Type: Grant
    Filed: April 10, 2009
    Date of Patent: June 5, 2012
    Assignee: The Curators of The University of Missouri
    Inventors: Jonathan Green, Bhanu Prakash Telugu
  • Publication number: 20120134918
    Abstract: The invention provides a cancer therapeutic and imaging agent comprising a solution containing Gum Arabic coated 198Au nanoparticles. The Gum Arabic coated 198Au nanoparticles have been demonstrated experimentally shown to have a surprising efficacy for a single dose direct injection, reducing tumors in analog mice by 82% over a short period of time. The particles of the invention have a believed optimal size for therapy and imaging applications, and can be used as a theranostic agent in the treatment of needle accessible cancers. The invention also provides a method for forming Gum Arabic coated 198Au nanoparticles. A gold foil is irradiated to produce 198Au foil. The foil is dissolved to form radioactive gold salt. The salt is dried, and then reconstituted to form a 198Au nanoparticle precursor. The precursor is reduced with a reducing agent in an aqueous solution including Gum Arabic to form Gum Arabic coated 198Au nanoparticles.
    Type: Application
    Filed: November 10, 2011
    Publication date: May 31, 2012
    Applicant: The Curators of the University of Missouri
    Inventors: Kattesh V. Katti, Raghuraman Kannan, Cathy S. Cutler
  • Patent number: 8187439
    Abstract: Mixed-metal automotive vehicle bodies-in-white comprising ferrous metal surfaces, zinc surfaces, aluminum alloy surfaces, and magnesium alloy surfaces are cleaned and immersed in an aqueous bath comprising an adhesion promoter and an aqueous electrocoat bath (the adhesion promoter may be in the electrocoat bath. The adhesion promoter, which may be a cerium salt, is selected to react with each metal in the body surfaces to form an oxide layer that provides corrosion resistance for the surface and adherence for the deposited polymeric paint coating. The body is cathodic in the electrocoat deposition.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: May 29, 2012
    Assignees: GM Global Technology Operations LLC, Curators of The University of Missouri
    Inventors: Yar-Ming Wang, Hong-Hsiang Kuo, Matthew J. O'Keefe, Surender Maddela, Thomas J. O'Keefe, Jane G. O'Keefe, legal representative
  • Patent number: 8182999
    Abstract: Pregnancy-associated glycoproteins (PAGs) are structurally related to the pepsins, thought to be restricted to the hoofed (ungulate) mammals and characterized by being expressed specifically in the outer epithelial cell layer (chorion/trophectoderm) of the placenta. By cloning expressed genes from ovine and bovine placental cDNA libraries, the inventors estimate that cattle, sheep, and most probably all ruminant Artiodactyla, possess possibly 100 or more PAG genes, many of which are placentally expressed. The PAGs are highly diverse in sequence, with regions of hypervariability confined largely to surface-exposed loops. Selected PAG that are products of the invasive binucleate cells, expressed highly in early pregnancy at the time of trophoblast invasion and expressed weakly, if at all, in late gestation are useful in the early diagnosis of pregnancy. In a preferred embodiment, the invention relates to immunoassays for detecting these PAGs.
    Type: Grant
    Filed: June 28, 2010
    Date of Patent: May 22, 2012
    Assignee: The Curators of the University of Missouri
    Inventors: Robert Michael Roberts, Jonathan Andrew Green, Sancai Xie
  • Patent number: 8178593
    Abstract: The invention provides B-sides of urethane formulations, wherein the B-sides comprise both alcohol and epoxy moieties. Also provided are urethane formulations comprising the B-side of the invention, as well as A-sides comprising isocyanate molecules.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: May 15, 2012
    Assignee: The Curators of the University of Missouri
    Inventors: Galen Suppes, Fu-Hung Hsieh, Yuan-Chan Tu, Pimphan Kiatsimkul
  • Patent number: 8173077
    Abstract: A DNA amplification device utilizing a polydimethylsiloxane (PDMS) and silicon substrate coated with spin-on glass (SOG) is provided. This PDMS layer is irreversibly bonded to the SOG layer of the silicon substrate using oxygen plasma. The amplification device is an inexpensive, microfluidic device, which can be utilized as a portable thermo-cycler to perform PCR amplification of DNA in the field.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: May 8, 2012
    Assignee: The Curators of the University of Missouri
    Inventors: Venumadhav Korampally, Shubhra Gangopadhyay, Keshab Gangopadhyay, Sheila A. Grant, Steven B. Kleiboeker, Shantanu Bhattacharya, Yuanfang Gao
  • Patent number: 8173154
    Abstract: A method and compositions for wound care management comprising a dressing comprising a three-dimensional body of glass-based fibers comprising 40 to 80 weight % B2O3, wherein at least 25 wt. % of the fibers have a diameter between 200 nm and 4000 nm, and a length:width aspect ratio of at least 10. The glasses may also be used for wound care as fibers formed into sutures, as particles in surgical glue to close a wound, or as particles in an ointment or cream to apply to a wound. The compositions may comprise glass formers P2O5 and/or SiO2; alkali oxides selected from Li2O, Na2O, K2O, and Rb2O; and/or alkaline earth oxides selected from MgO, SrO, BaO and CaO. The compositions may further comprise 0.05 to 10 wt. % of one or more trace elements selected from Ag, Cu, F, Fe, Mn, Mo, Ni, Sr, and Zn.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: May 8, 2012
    Assignee: The Curators of the University of Missouri
    Inventors: Steven B. Jung, Delbert E. Day
  • Publication number: 20120093994
    Abstract: Analog meat compositions produced from vegetable protein and processes for producing the analog meat compositions are described. The compositions are produced with high moisture content, low vegetable protein content, carbohydrate, and, optionally, an edible lipid material and provides a product that simulates the fibrous structure of animal meat and has a desirable meat-like moisture, texture, mouthfeel, flavor and color.
    Type: Application
    Filed: October 13, 2011
    Publication date: April 19, 2012
    Applicant: The Curators of the University of Missouri
    Inventors: Fu-hung Hsieh, Harold E. Huff
  • Patent number: 8153118
    Abstract: The invention is related to a method of altering the metabolism of a plant by carrying out the steps of treating seeds of the plant with non-genetically engineered selected mutant pink-pigmented facultative methylotroph having a plant altering capability, and growing the plants from the treated seeds, wherein the plants that grow from such treated seeds exhibit an altered characteristic relative to non-treated plants.
    Type: Grant
    Filed: February 6, 2006
    Date of Patent: April 10, 2012
    Assignees: Salisbury University, The Curators of the University of Missouri
    Inventors: Mark A. Holland, Joseph C. Polacco