Patents Assigned to Curators of the University
  • Identifying geographic-areas based on change patterns detected from high-resolution, remotely sensed imagery
    Patent number: 8001115
    Abstract: A method, system, and medium are provided for identifying terrestrial objects that have changed in a certain manner. One embodiment of the method includes receiving a query that includes one or more inputs, which are related to 1) a first terrestrial object (“first object”) and 2) source change-detection information that describes change associated with the first object; applying the query to a dataset that includes indexed information that describes the imagery; based on the one or more inputs, receiving a query result by identifying a set of regions in the dataset that are respectively associated with change information that is similar to that of the source change-detection information; and presenting on a presentation device indications of at least a portion of the identified set of regions.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: August 16, 2011
    Assignee: The Curators of the University of Missouri
    Inventors: Curtis Herbert Davis, Matthew Nicholas Klaric, Grant Jason Scott, Chi-Ren Shyu
  • Plant artificial chromosome platforms via telomere truncation
    Patent number: 7993913
    Abstract: The invention provides engineered plant minichromosomes generated by telomere mediated truncation of native chromosomes. These minichromosomes are faithfully transmitted from one generation to the next and provide an ideal platform for breeding genes into desired plant varieties with out problems, such as linkage drag, associated with standard breeding methods.
    Type: Grant
    Filed: May 9, 2007
    Date of Patent: August 9, 2011
    Assignee: The Curators of the University of Missouri
    Inventors: Weichang Yu, Juan M. Vega, James Birchler
  • Method of identifying compounds using a transgenic pig model of cystic fibrosis
    Patent number: 7989675
    Abstract: The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of using such animal models in the identification and characterization of therapies for the diseases and conditions.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: August 2, 2011
    Assignees: University of Iowa Research Foundation, The Curators of the University of Missouri
    Inventors: Michael J. Welsh, Christopher S. Rogers, Randall Prather, John Engelhardt, Ziying Yan
  • Fluorescent sensors for cellular amines
    Patent number: 7977120
    Abstract: The invention provides compounds of formulas I, II, and III, methods of making them, and methods of their use. The compounds of the invention can be used as fluorescent sensors, for example, to detect an amine-containing analyte in a biological sample. The compounds can be selective for one type of amine over others and the amount of fluorescence can be correlated with the concentration of the amine in the sample.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: July 12, 2011
    Assignee: The Curators of the University of Missouri
    Inventors: Timothy Glass, Kristen Secor
  • Photo-acoustic detection device and method
    Patent number: 7968347
    Abstract: An example method for detecting an analyte in a sample of a bodily fluid comprises the steps of exposing the bodily fluid sample to electromagnetic energy to cause a thermoelastic expansion in the analyte, and detecting a photoacoustic signal in the sample that results from the thermoelastic expansion.
    Type: Grant
    Filed: July 11, 2007
    Date of Patent: June 28, 2011
    Assignee: The Curators of the University of Missouri
    Inventors: John A. Viator, Paul S. Dale, Ryan M. Weight, Peter Sutovsky
  • Optical device components
    Patent number: 7961305
    Abstract: Embodiments of the invention relate to an internal reflection light funnel, including an internal reflection cone having a first diameter at an entrance end and a second diameter at an exit end, the first diameter being greater than the second diameter; and a light source embedded within the cone. The funnel has a half angle of less than about 25 degrees.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: June 14, 2011
    Assignee: The Curators of the University of Missouri
    Inventors: Zhi Xu, Robert D. Rosenthal
  • Optical device components
    Patent number: 7961304
    Abstract: Embodiments of the invention relate to a light illumination funnel. The funnel includes a first opening positioned to receive an incoming light source, a second opening positioned opposite the first opening and with a diameter smaller than the first opening and inner reflective walls, in contact with the first opening and second opening. The funnel has a half angle of less than 25 degrees. Embodiments also relate to a light collection funnel and an apparatus utilizing both a light illumination funnel and light collection funnel.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: June 14, 2011
    Assignee: The Curators of the University of Missouri
    Inventor: Zhi Xu
  • Stereochemically defined dipeptide esters of antiviral agents for enhanced ocular treatment
    Patent number: 7951774
    Abstract: Stereochemically defined dipeptide esters of nucleoside-analogous antiviral agents including acyclovir and ganciclovir are provided. Certain of these stereochemically defined dipeptide esters are found to have unexpectedly enhanced delivery to and uptake by ocular tissues, crossing the blood-ocular barrier more effectively than other stereochemically defined dipeptide esters. For example, (L-Val)-(D-Val)-acyclovir was found to be taken up more effectively into corneal tissue than were underivatized acyclovir, monoesters (L-Val)-acyclovir or (D-Val)-acyclovir, or diester (L-Val)-(L-Val)-acyclovir.
    Type: Grant
    Filed: November 25, 2008
    Date of Patent: May 31, 2011
    Assignee: The Curators of the University of Missouri
    Inventors: Ashim K. Mitra, Swapan K. Samanta, Ravi S. Talluri
  • Synthesis of poly(ethylene amine) on an oxide support
    Patent number: 7947345
    Abstract: Methods of polymerizing polyethylene-based polymers on a support, and supports coated with polyethylene-based polymers. The coated supports may be used to improve the ink fixation properties of an ink-jet printing medium. The coated supports may also be useful for highly tailored chromatographic separations.
    Type: Grant
    Filed: November 7, 2003
    Date of Patent: May 24, 2011
    Assignees: Hewlett-Packard Development Company, L.P., The Curators of the University of Missouri
    Inventors: Eric L Burch, James O. Stoffer, Thomas Schuman
  • Supported molecular biofluid viscosity sensors for in vitro and in vivo use
    Patent number: 7943390
    Abstract: A device and a method for measuring viscosity that includes attaching molecular rotors to a solid surface, exposing the solid surface to a fluid having a viscosity to be measured, and taking optical measurements to determine viscosity. The solid surface is preferably quartz, polystyrene or silicate glass, such as a fiber optic probe or a glass cuvette. The molecular rotors are of the type that includes an electron-donor group and electron-acceptor group that are linked by a single bond so that the groups may rotate with respect to one another, and that exhibit a fluorescence emission when rotation is hindered.
    Type: Grant
    Filed: April 20, 2009
    Date of Patent: May 17, 2011
    Assignees: The Curators of the University of Missouri, The Regents of the University of California, La Jolla Bioengineering Institute
    Inventors: Mark A. Haidekker, Sheila Grant, Emmanuel Theodorakis, Marcos Intaglietta, John A. Frangos
  • Method of producing lower alcohols from glycerol
    Patent number: 7943805
    Abstract: A reactive-separation process converts glycerin into lower alcohols, having boiling points less than 200° C., at high yields. Conversion of natural glycerin to propylene glycol through an acetol intermediate is achieved at temperatures from 150° to 250° C. at a pressure ranging from 1 and 25 bar. The preferred applications of the propylene glycol are as an antifreeze, deicing compound, or anti-icing compound. The preferred catalyst for this process in a copper-chromium powder.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: May 17, 2011
    Assignee: The Curators Of The University Of Missouri
    Inventors: Galen J. Suppes, William Rusty Sutterlin, Mohanprasad Dasari
  • Modulating levels of RNA-binding proteins for the treatment of breast cancer
    Publication number: 20110110896
    Abstract: The present invention relates to methods of using RNA-binding protein modulating agents to treat of cancer, particularly patients that are susceptible to or diagnosed with estrogen receptor-negative breast cancer, such as methods of inhibiting the growth or metastasis of cancer cells comprising contacting cells with a therapeutically-effective amount of an HuR-modulating agent. The invention also relates to compositions comprising therapeutically-effective amounts of an HuR-modulating agent.
    Type: Application
    Filed: October 8, 2010
    Publication date: May 12, 2011
    Applicant: The Curators of the University of Missouri
    Inventors: Ulus Atasoy, Matthew Michael Gubin, Robert Calaluce
  • Ordered nanoenergetic composites and synthesis method
    Patent number: 7927437
    Abstract: A structured, self-assembled nanoenergetic material is disclosed that includes a nanostructure comprising at least one of the group consisting of a fuel and an oxidizer and a plurality of substantially spherical nanoparticles comprising at least the other of the group consisting of a fuel and an oxidizer. The spherical particles are arranged around the exterior surface area of said nanorod. This structured particle assures that the oxidizer and the fuel have a high interfacial surface area between them. Preferably, the nanostructure is at least one of a nanorod, nanowire and a nanowell, and the second shaped nanoparticle is a nanosphere.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: April 19, 2011
    Assignee: The Curators of the University of Missouri
    Inventors: Shubhra Gangopadhyay, Rajesh Shende, Senthil Subramanian, Keshab Gangopadhyay, Shameem Hasan
  • Peptidyl prodrugs that resist P-glycoprotein mediated drug efflux
    Patent number: 7910553
    Abstract: A method of treating a patient for a condition wherein the bioactive agent of choice is DRUG, wherein DRUG is a substrate that is effluxed by the P-gp transporter, is provided, the method comprising administering to the patient an effective amount of a compound of formula (I): DRUG-X—Y(n)—Z(n?)—Z?(n?)—R??(I) wherein each X, Y, Z, and Z? is independently Met, Val, Thr, Tyr, Trp, Ser, Ala, or Gly; R is H or an amino-protecting group; n is 1, and each n?, or n? is independently 0 or 1; or a pharmaceutically acceptable salt thereof, with the proviso that DRUG is not acyclovir or ganciclovir and that DRUG is non-peptidyl.
    Type: Grant
    Filed: February 22, 2007
    Date of Patent: March 22, 2011
    Assignee: The Curators of the University of Missouri
    Inventors: Ashim K. Mitra, Soumyajit Majumdar, Ritesh Jain, Yasser Nashed
  • Ultra-low refractive index high surface area nanoparticulate films and nanoparticles
    Patent number: 7907809
    Abstract: Nanoparticles having a mean particle size of less than about 25 nanometers and a mean pore size of less than 10 nanometers, and a mean surface area of at least 500 m2/g; nanoporous films of such nanoparticles; and composites and devices containing such nanoparticles and nanoporous films.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: March 15, 2011
    Assignee: The Curators of the University of Missouri
    Inventors: Venumadhav Korampally, Shubhra Gangopadhyay, Luis Polo-Parada, Sangho Bok, Keshab Gangopadhyay
  • Noise cancellation in fourier transform spectrophotometry
    Patent number: 7903252
    Abstract: Increasing signal to noise ratio in optical spectra obtained by spectrophotometers. An interferometer introduces interference effects into a source light beam. A dual beam configuration splits the source beam having the interference effects into a reference beam and a sample beam. The reference beam interacts with a reference substance and is detected by a reference detector. The sample beam interacts with a sample substance and is detected by a sample detector. An optical spectra of the sample is based on the difference between the detected reference beam and the detected sample beam.
    Type: Grant
    Filed: August 27, 2007
    Date of Patent: March 8, 2011
    Assignee: The Curators of the University of Missouri
    Inventors: David W. Larsen, Zhi Xu
  • Inhibitors of macromolecular activity
    Patent number: 7888005
    Abstract: The present invention relates generally to methods, kits, compositions, and combinations to identify anti-infective or anti-pathogenic agents. The present invention also relates to methods, kits, compositions, and combinations directed to identifying elements of RNA metabolism related to pathogen propagation, monitoring of these RNA metabolic events, and to agents capable of interrupting RNA metabolism in a pathogen-specific fashion.
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: February 15, 2011
    Assignee: The Curators of the University of Missouri
    Inventors: Francis J. Schmidt, Farahnaz Rahmatpanah
  • Rapid heating with nanoenergetic materials
    Patent number: 7879721
    Abstract: The present process for rapidly heating and cooling a target material without damaging the substrate upon which it has been deposited. More specifically, target material is coated onto a first substrate. A self-propagating nanoenergetic material is selected that combusts at temperatures sufficient to change the target material and creates a flame front that propagates sufficiently quickly that the first substrate is not substantially heated. The nanoenergetic material is deposited on the target material, such that the target material and the nanoenergetic material is sandwiched between the substrate and the target material. The nanoenergetic material is ignited and the flame front of the nanoenergetic material is allowed to propagate over the second substrate and change the target material.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: February 1, 2011
    Assignee: The Curators of the University of Missouri
    Inventors: Shubhra Gangopadhyay, Maruf Hossain, Keshab Gangopadhyay, Rajesh Shende
  • Soybean variety SN97-6946
    Patent number: 7880061
    Abstract: A soybean variety designated SN97-6946, the plants and seeds of soybean variety SN97-6946, methods for producing a soybean plant produced by crossing the variety SN97-6946 with itself or with another soybean plant, and hybrid soybean seeds and plants produced by crossing the variety SN97-6946 with another soybean line or plant, and the creation of variants by mutagenesis or by transformation of variety SN97-6946. This invention also relates to methods for producing other soybean varieties or breeding lines derived from soybean variety SN97-6946 and to soybean varieties or breeding lines produced by those methods.
    Type: Grant
    Filed: February 25, 2003
    Date of Patent: February 1, 2011
    Assignee: The Curators Of The University Of Missouri
    Inventors: David A. Sleper, Prakash R. Arelli
  • SCAFFOLD FOR TISSUE REGENERATION IN MAMMALS
    Publication number: 20110014261
    Abstract: A three-dimensional scaffold with interconnected pores for repair of tissue comprising a scaffold body for structural support of the tissue scaffold, where the scaffold body comprises scaffold body components bonded to each other and made from component materials comprising about 40 to about 90 wt % B2O3, and two or more other oxides, wherein the scaffold body has a porosity between about 15 and about 90 vol %.
    Type: Application
    Filed: July 16, 2009
    Publication date: January 20, 2011
    Applicant: The Curators of the University of Missouri
    Inventors: Delbert E. Day, Steven B. Jung, Roger F. Brown