Abstract: Disclosed is a composition based on a polyol of formula: HO—CH2—(CHOH)m—CH2—OH and on alkyl polyrhamnosides of formula: HO—CH2—(CHOH)m—CH2—O-(Rham)x-H; process for preparing same, and cosmetic or pharmaceutical composition including same.

Abstract: A sprung balance type mechanical timekeeper, includes a spiral spring (10), a balance (20) and an escapement mechanism (30) connected by a point of attachment (12) to the spiral spring and arranged to sustain an oscillation of the balance. The escapement mechanism (30) is connected to the point of attachment (12) of the spiral spring by a chassis (40) pivoted about the axis (A) of the balance. An outer end (12) of the spiral spring (10) is attached to this transverse pert (40) at a location located on one side of the balance axis (A). The chassis (40) includes two branches extending on either side of the axis of the balance (20) and forming a rotary plate whose axis of rotation is coincident with the axis of oscillation of the balance (20). The escapement mechanism (30) is located on the other side of the balance axis (A) and acts on the pivoted chassis (40) so as to free its rotation and thus make the attached end (12) of the spiral spring rotate.

Abstract: We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of use of those compounds and formulations for treatment of cancer.

Abstract: The present invention relates to a face mask comprising (a) a mask body portion configured to surround the mouth and at least part of the nose of a wearer; (b) a sealed compressible cushion formed on the inner face of said mask body portion wherein the middle of said cushion is placed in close proximity to the middle of the superior perimeter of said mask body portion, and wherein said cushion is at least partially filled with a fluid.

Abstract: The present invention relates to an improved process for the preparation of 3?,7?-dihydroxy6?-ethyl-5?-cholan-24-oic acid compound of formula-1, represented by the following structural formula: Formula-1 The present invention also relates to process for the preparation of ethylene diamine and tertiary butyl amine salts of 3?,7?-dihydroxy6?-ethyl-5?-cholan-24-oic acid which are useful in the preparation of pure 3?,7?-dihydroxy6?-ethyl-5?-cholan-24-oic acid.

Abstract: An apparatus for removing goods from a two-part carton having a base and a lid, the base being formed with side walls having external gussets secured against external side faces of the carton, the apparatus including: a lid removal module for engaging the lid and removing it from the carton; expansion members configured to be advanced between the gussets and the external side faces of the carton to remove the gussets from the side faces; engagement members for engaging side walls of the base and drawing them away from the goods and holding them in a position away from the goods; and a goods transfer module for engaging the goods and removing them from the carton.

Abstract: An air purifier comprising at least one removable particulate filter, a fan or impeller and a motor for driving said fan or impeller, a top and, opposite thereto, a base and means for elevating said base from the ground, at least one side surface connecting said top and base, a base air intake disposed on said base and facing the ground in a working configuration a top air intake on said top and facing away from the ground in a working configuration and an air outlet located on said side surface.

Abstract: This invention discloses diagnosis of risk of chemotherapy-induced cardiotoxicity by measurement of increased expression of soluble epoxide hydrolase in vitro and in vivo in cells, tissues or animals including measurement of increased levels of soluble epoxide hydrolase metabolites, e.g., 14,15-DHET and 11,12-DHET, in biological fluids. This invention also includes diagnosis of risk of chemotherapy-induced cardiotoxicity by measuring increased levels of oxidative stress in cells, tissues or animals including measurement of increased levels of oxidative stress biomarkers, e.g., 8-isoprostane, in biological fluids. Fatty acid and protein biomarkers to diagnose the risk of chemotherapy-induced cardiotoxicity are detected using various detection methods including mass spectrometry and immunoassay such as ELISA, Western blot analysis or label-free microwell and nanowell technologies.

Abstract: A continuous process for nano-emulsification that is performed by concentration phase inversion in a microfluidic reactor, including the following steps: (a) injection of an aqueous phase into a first microchannel, the first microchannel opening onto a formulation chamber, (b) injection, into a second microchannel, of a fatty phase including one or more fatty substances immiscible in the aqueous phase, and one or more surfactants, the second microchannel opening into the formulation chamber, then (c) mixing of the aqueous phase and the fatty phase in the formulation chamber, then (d) recovering, at the output of the formulation chamber, a suspension including lipid nanocapsules. Also, the lipid nanocapsules obtainable by the process, and the use of the lipid nanocapsules as nanovectors for pharmacologically active ingredients.

Abstract: A three-dimensional biomaterial including particles encapsulating at least one complement active fragment dispersed therein. Also, a process of manufacturing of the three-dimensional biomaterial with at least one biocompatible and/or resorbable polymer and the particles. The three-dimensional biomaterial is useful for tissue regeneration, especially with regards to dental pulp, dentin, periodontal and gingival tissues, as well as bones tissues.

Abstract: The invention relates to benzimidazole-carboxamide 5-HT4 receptor agonist compounds of formula (I) wherein R1 and X are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.

Abstract: Methods and devices for spoofing proof authentication of a user by voice to unlock a user device. According to one of its aspects, a method includes performing spoofing proof authentication of a user by voice. According to another aspect, a device is configured for spoofing proof authentication of a user by voice. Implementation of the method provides not only personalized access to the data, but also the highest level of security due to anti-spoofing.

Abstract: An objective of the disclosure is to provide compositions containing vegetable oils and an anti-oxidant system to prevent oxidation of the triglycerides in the vegetable oil in food products, in particular in products which are often stored for a long time. The antioxidant system should not give an undesired colour, and neither an undesired taste, to a food composition. Additionally, it should be a natural compound and/or common food ingredient, and fitting to the food composition with regard to taste and colour. This has been achieved by providing a food composition containing vegetable oil and apple cider vinegar, wherein the weight ratio of citric acid and malic acid to total organic acids in the apple cider vinegar is more than 2%.

Abstract: The present invention relates to the field of diagnostic and treatment of cancer, particularly melanoma, pancreatic cancer, kidney cancer and colon cancer. In particular, the invention relates to an antibody directed specifically to CD146-positive tumors and its applications, particularly for use as a medicament for the prevention and/or treatment of cancer, for use in a method of diagnostic or prognostic of a cancer, or for use as a radiotracer when labelled with a radioactive element.

Abstract: According to one aspect, the invention relates to a device for transporting and controlling light beams for endo-microscopic imaging without a lens on the distal side comprising a single-mode optical fibre bundle (40) on the distal side, wherein each single-mode optical fibre is intended to receive an elementary light source and to emit a light beam at a distal end; a single-mode optical fibre section (50) arranged at the distal end of the optical fibre bundle and intended to receive the light beams emitted by the single-mode optical fibres of the optical fibre bundle; an optical phase control device arranged on the side of the proximal end of the single-mode optical fibres.

Abstract: An instantaneous date control device for a timepiece, in particular for a mechanical wristwatch, including: a date disc, a gear train forming a kinematic linkage between the control device and a horological movement of said timepiece, a first mobile including a first toothed wheel driven at a speed of one turn per day and a cam mounted freely rotatably, over a limited angular range and/or in a single direction of rotation, as well as temporarily coupled in rotation to said first toothed wheel, a second mobile including a second toothed wheel driven at a speed of one turn per day, an unlocking and driving yoke carrying a feeler bearing on said cam and a driving finger which can mesh with teeth located on the date disc, an unlocking and driving spring, and a retaining means allowing to secure the angular position of the date disc between two instantaneous jumps.

Abstract: The invention relates to a polypeptide comprising or consisting of the polypeptide of SEQ ID NO: 1 wherein the residue X at position 89 of SEQ ID NO: 1 is not a cysteine, or a functionally equivalent variant of said polypeptide wherein the residue X at position 89 of SEQ ID NO: 1 is not a cysteine and their use in medicine, particularly in the prevention and/or treatment of cancer.

Abstract: The present invention provides a method for producing dopaminergic neuron progenitor cells from pluripotent stem cells, which method comprises the steps of: (i) performing adherent culture of pluripotent stem cells on an extracellular matrix in a medium containing a reagent(s) selected from the group consisting of BMP inhibitor, TGF? inhibitor, SHH signal-stimulating agent, FGF8, and GSK3? inhibitor; (ii) collecting Corin- and/or Lrtm1-positive cells from the cells obtained in Step (i) using a substance which binds to Corin and/or a substance which binds to Lrtm1; and (iii) performing suspension culture of the cells obtained in Step (ii) in a medium containing a neurotrophic factor.

Abstract: The invention relates to a drive arm for driving a wiper blade intended for a motor vehicle, the drive arm extending in a longitudinal direction (X), the drive arm comprising at least one first attachment means (224) for a first end of an elastic return device and at least one second attachment means (234) for the first end of the elastic return device, characterized in that a first distance (d1) measured parallel to the longitudinal direction (X) between the first attachment means (224) and the second attachment means (234) is not zero.