Patents Assigned to D
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Patent number: 11427806Abstract: The present invention provides a method for producing dopaminergic neuron progenitor cells from pluripotent stem cells, which method comprises the steps of: (i) performing adherent culture of pluripotent stem cells on an extracellular matrix in a medium containing a reagent(s) selected from the group consisting of BMP inhibitor, TGF? inhibitor, SHH signal-stimulating agent, FGF8, and GSK3? inhibitor; (ii) collecting Corin- and/or Lrtm1-positive cells from the cells obtained in Step (i) using a substance which binds to Corin and/or a substance which binds to Lrtm1; and (iii) performing suspension culture of the cells obtained in Step (ii) in a medium containing a neurotrophic factor.Type: GrantFiled: September 4, 2014Date of Patent: August 30, 2022Assignees: Kyoto University, Osaka University, Eisai R&D Management Co., Ltd.Inventors: Jun Takahashi, Daisuke Doi, Bumpei Samata, Kiyotoshi Sekiguchi, Yuichi Ono
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Patent number: 11427621Abstract: The invention relates to a polypeptide comprising or consisting of the polypeptide of SEQ ID NO: 1 wherein the residue X at position 89 of SEQ ID NO: 1 is not a cysteine, or a functionally equivalent variant of said polypeptide wherein the residue X at position 89 of SEQ ID NO: 1 is not a cysteine and their use in medicine, particularly in the prevention and/or treatment of cancer.Type: GrantFiled: July 17, 2017Date of Patent: August 30, 2022Assignees: INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS, FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL HEBRONInventors: Laura Soucek, Toni Jauset González, Marie-Eve Beaulieu
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Patent number: 11427836Abstract: An RNA interference (RNAi) strategy is provided based on use of artificial microRNA (amiR) to reduce NKCC1 expression. In particular, a method is provided that achieves neuron-specific expression of specific amiR against NKCC1 by using a human Synapsin promoter to drive transgene expression.Type: GrantFiled: April 11, 2018Date of Patent: August 30, 2022Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITE D'EVRY-VAL-D'ESSONNE, GENETHON, FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, FONDAZIONE TELETHONInventors: Federico Mingozzi, Giuseppe Ronzitti, Andrea Contestabile, Laura Cancedda
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Patent number: 11427546Abstract: A stable crystal of a salt of N—[(R)-1-{(S)-2-hydroxy-2-phenylpropylamino}propan-2-yl]isoquinoline-6-sulfonamide may have desirable properties for a pharmaceutical drug substance, and more specifically N—[(R)-1-{(S)-2-hydroxy-2-phenylpropylamino}propan-2-yl]isoquinoline-6-sulfonamide dihydrochloride anhydride. A crystal of the anhydride may have characteristic peaks at 2? angles of 6.8±0.1°, 10.0±0.1°, 12.7±0.1°, 14.6±0.1°, 14.8±0.1°, 16.2±0.1°, 17.4±0.1°, 17.8±0.1°, 19.5±0.1°, 20.0±0.1°, 21.6±0.1°, 24.7±0.1°, 25.5±0.1°, 25.8±0.1°, 29.8±0.1°, 39.5±0.1°, and/or 44.9±0.1° in powder X-ray diffraction spectrum.Type: GrantFiled: December 16, 2019Date of Patent: August 30, 2022Assignee: D. WESTERN THERAPEUTICS INSTITUTE, INC.Inventors: Hiroyoshi Hidaka, Kengo Sumi, Takashi Izuhara
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Patent number: 11426341Abstract: Composition based on fatty alcohols and on alkyl polyrhamnosides; process for the preparation thereof; cosmetic or pharmaceutical composition comprising same; and use thereof as an emulsifier.Type: GrantFiled: December 4, 2018Date of Patent: August 30, 2022Assignee: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPICInventors: Georges Manuel Dacosta, Stéphane Dessilla, Jerome Guilbot, Virginie Pommery
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Publication number: 20220267174Abstract: A water treatment system includes an actinic radiation reactor and at least one ultraviolet (UV) lamp disposed within a quartz tube within the actinic radiation reactor. The at least one UV lamp includes a lamp tube including a gas that emits ultraviolet light responsive to electrical excitation, a first pinch extending from a first end of the lamp tube and a second pinch extending from a second end of the lamp tube, and a first end cap coupled to the first pinch and a second end cap coupled to the second pinch. The first end cap and second end cap are dimensioned to center the lamp tube coaxially within the quartz tube.Type: ApplicationFiled: July 31, 2020Publication date: August 25, 2022Applicant: ATG UV R&D LimitedInventors: George Foster, Richard Joshi
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Publication number: 20220267393Abstract: The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using animal serum. The present invention relates to a method for producing active HGFA without using animal serum. The method is characterized in that it comprises a step of obtaining a culture supernatant comprising pro-HGFA by culturing mammalian cells expressing inactive hepatocyte growth factor activator (pro-HGFA) in a medium without serum, and a step of adjusting the culture supernatant comprising pro-HGFA obtained in the above step to weakly acidic to convert pro-HGFA into active HGFA. The present invention also relates to a method for producing active HGF with HGFA produced by said method.Type: ApplicationFiled: May 5, 2022Publication date: August 25, 2022Applicant: Eisai R&D Management Co., Ltd.Inventors: Masashi Shimizu, Toshitaka Sato, Yoshihisa Arita
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Publication number: 20220265785Abstract: Disclosed in the present invention is use of lysozyme in the preparation of a drug for preventing or treating a uric acid-related disease, a drug for reducing uric acid, and a drug for promoting uric acid excretion. Also disclosed in the present invention are a pharmaceutical composition for preventing or treating a uric acid-related disease, a pharmaceutical composition for reducing uric acid, and a pharmaceutical composition for promoting uric acid excretion, and a method for preventing or treating a uric acid-related disease, reducing uric acid and promoting uric acid excretion.Type: ApplicationFiled: July 17, 2020Publication date: August 25, 2022Applicants: GUANGZHOU CENTURY CLINICAL RESEARCH CO., LTD, GUANGZHOU XIN-CHUANGYI BIOPHARMACEUTICAL CO., LTD, GUANGZHOU WELMAN NEW DRUG R&D CO., LTD., XIANGBEI WELMAN PHARMACEUTICAL CO., LTD, NANJING KANGFUSHUN PHARMACEUTICAL CO., LTDInventors: Mingjie SUN, Tianyu SUN, Juanyan JIANG
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Publication number: 20220266505Abstract: The method for manufacturing a three-dimensional object or for modifying the surface state of a preformed object by local polymerisation of monomers or oligomers, the polymerisation being initiated by mono-photon or multi-photon absorption in an area to be polymerised, includes: —introducing into a vessel with light-transparent walls a reaction medium comprising polymerisable monomers or oligomers, a polymerisation inhibitor, an indicator of the amount of the inhibitor and a photochemical polymerisation initiator; —initiating the polymerisation of the monomers or oligomers; —indicating the amount of inhibitor present in the reaction medium; —controlling the amount of light emitted by the irradiation system relative to the amount of inhibitor indicated by the indicator; and —switching to a following zone to be polymerised by moving the object and/or the focused light beam.Type: ApplicationFiled: July 22, 2020Publication date: August 25, 2022Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE D'AIX-MARSEILLE (AMU), ECOLE CENTRALE DE MARSEILLEInventors: Claude Amra, Jean-Claude André, Laurent Gallais-During, Myriam Zerrad
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Publication number: 20220270458Abstract: Systems and methods for tracking locations of movable assets within a space are disclosed. The systems include at least one tag configured for attachment to at least one movable asset and a plurality of anchors configured for measuring location data of the tag within the space. The tag and the anchors each include a transceiver module operable to measure location using, for example, ultrawide band or the global positioning system (GPS). The systems further include a listener in wireless communication with a communications portal or a mobile application on a mobile device, the listener is configured to receive location data from the tag and anchors and to transmit the location data to the communications portal or the mobile application. The systems also allow a user to create barriers for each of the tags within the space and alert the user when a tag moves beyond a barrier.Type: ApplicationFiled: February 24, 2022Publication date: August 25, 2022Applicant: J Mann 8, LLC d/b/a Lilatech SystemsInventors: Johnny MANN, Steffen Sullivan
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Patent number: 11419632Abstract: Systems, devices, and methods are provided for transseptal access of septa within a patient. The device can be advanced to a septum, e.g., towards a fossa ovalis. Instead of applying positive pressure to “tent” the septum, a negative pressure is applied to a lumen within a sheath, e.g., within an elongated member slidable within the sheath, via a negative pressure source such as a syringe on the proximal end of the sheath. This results in the septum pulling inward. The sheath employs a stationary needle-like central core component contained within the lumen of the sheath that punctures the septum when the same is pulled passed it by the negative pressure. The stationary needle-like central core component may be hollow and may form a portion of the elongated member or may be coupled to a distal end thereof.Type: GrantFiled: June 3, 2019Date of Patent: August 23, 2022Assignee: Mark D. Wieczorek, P.C.Inventor: Mark D. Wieczorek
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Patent number: 11422958Abstract: A quantum processor performs input and output which may be performed synchronously. The quantum processor executes a problem to generate a classical output state, which is read out at least partially by an I/O system. The I/O system also transmits a classical input state to by the I/O system, which may include the same qubit-proximate devices used for read-out. The classical input state is written to the qubits, and the quantum processor executes based on the classical input state (e.g., by performing reverse annealing to transform the classical input state to quantum state).Type: GrantFiled: May 12, 2020Date of Patent: August 23, 2022Assignee: D-WAVE SYSTEMS INC.Inventors: Kelly T.R. Boothby, Andrew J. Berkley, Christopher B. Rich
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Patent number: 11420980Abstract: Salts of the compound represented by formula (I) or crystals thereof have a potential use as drug substances for pharmaceuticals.Type: GrantFiled: September 15, 2020Date of Patent: August 23, 2022Assignee: Eisai R&D Management Co., Ltd.Inventors: Kenshi Yoshida, Yoshiaki Ohashi, Tamaki Hoshikawa, Nobuaki Sato, Ikuo Kushida
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Patent number: 11423115Abstract: Systems, devices, articles, methods, and techniques for advancing quantum computing by removing unwanted interactions in one or more quantum processor. One approach includes creating an updated plurality of programmable parameters based at least in part on a received value for the characteristic magnetic susceptibility of the qubit in the at least one quantum processor, and returning the updated plurality of programmable parameters. Examples programmable parameters include local biases, and coupling values characterizing the problem Hamilton.Type: GrantFiled: August 31, 2020Date of Patent: August 23, 2022Assignee: D-WAVE SYSTEMS INC.Inventor: Trevor Michael Lanting
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Patent number: 11419633Abstract: Systems, devices, and methods are provided for transseptal access of septa within a patient. The device can be advanced to a septum, e.g., towards a fossa ovalis. Instead of applying positive pressure to “tent” the septum, a negative pressure is applied to a lumen within a sheath, e.g., within an elongated member slidable within the sheath, via a negative pressure source such as a syringe on the proximal end of the sheath. This results in the septum pulling inward. The sheath employs a stationary needle-like central core component contained within the lumen of the sheath that punctures the septum when the same is pulled passed it by the negative pressure. The stationary needle-like central core component may be hollow and may form a portion of the elongated member or may be coupled to a distal end thereof.Type: GrantFiled: September 21, 2021Date of Patent: August 23, 2022Assignee: Mark D. Wieczorek, PCInventor: Christopher Gerard Kunis
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Patent number: 11424521Abstract: A superconducting circuit may include a transmission line having at least one transmission line inductance, a superconducting resonator, and a coupling capacitance that communicatively couples the superconducting resonator to the transmission line. The transmission line inductance may have a value selected to at least partially compensate for a variation in a characteristic impedance of the transmission line, the variation caused at least in part by the coupling capacitance. The coupling capacitance may be distributed along the length of the transmission line. A superconducting circuit may include a transmission line having at least one transmission line capacitance, a superconducting resonator, and a coupling inductance that communicatively couples the superconducting resonator to the transmission line. The transmission line capacitance may be selected to at least partially compensate for a variation in coupling strength between the superconducting resonator and the transmission line.Type: GrantFiled: February 20, 2019Date of Patent: August 23, 2022Assignee: D-WAVE SYSTEMS INC.Inventors: Jed D. Whittaker, Loren J. Swenson, Mark H. Volkmann
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Patent number: 11420965Abstract: The invention provides a compound of formula (I): or a pharmaceutically-acceptable salt thereof, that is an inhibitor of JAK kinases. The invention also provides pharmaceutical compositions comprising such compound, a crystalline form, methods of using such compound to treat inflammatory skin diseases and other diseases, and processes and intermediates useful for preparing such compound.Type: GrantFiled: March 30, 2021Date of Patent: August 23, 2022Assignee: THERAVANCE BIOPHARMA R&D IP, LLCInventors: Jennifer Kozak, Ryan Hudson, Gary E. L. Brandt, Robert Murray McKinnell
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Patent number: 11420714Abstract: A personal flotation system provides a horseshoe shaped float that is buoyant and can be used in a number or positions to float a person on the water and retain a beverage. The horseshoe shaped flotation device has a left and right armrest that extend out from an arced shaped closed end and dual cup holder, on the extended end of the armrest, has an cup cylinder to retain a beverage in the vertical orientation and an end cup holder to retain a beverage in an orthogonal orientation to the cup cylinder. The flotation device may have an extending strap that couples the left and right armrests together to secure the horseshoe shaped float around a person's torso.Type: GrantFiled: October 26, 2020Date of Patent: August 23, 2022Assignee: D and M Asset Management, LLCInventor: Douglas J. Masi
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Publication number: 20220262515Abstract: The method for determining an onset time and an excitability of a brain region that is not observed as recruited or not recruited in a seizure activity of an epileptic patient brain includes: providing a dynamical model of a propagation of an epileptic seizure in the brain networks; providing a statistical model which defines the probability of generating sets of observations of the state of the brain networks by said dynamical model; training the dynamical model of the propagation of an epileptic seizure using the statistical model and the data set of observations of the training cohort; and inverting the trained dynamical model and inferring the onset time and excitability of a third region from the onset time that is observed for the first and second regions using the statistical model.Type: ApplicationFiled: July 22, 2020Publication date: August 18, 2022Applicants: UNIVERSITÉ D'AIX-MARSEILLE (AMU), INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALEInventors: Viktor Jirsa, Viktor Sip
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Publication number: 20220259624Abstract: The present invention relates to a selective process for preparing sulfoxides from sulfides by enzymatic catalysis, and to a composition comprising a symmetrical sulfide, an oxidoreductase enzyme catalyzing the oxidation of said symmetrical sulfide to symmetrical sulfoxide; optionally at least one cofactor C of said enzyme E; and an oxidant, which allows in particular the implementation of said process.Type: ApplicationFiled: June 12, 2020Publication date: August 18, 2022Applicants: Arkema France, Centre National de la Recherche Scientifique (CNRS), Universite d'Aix-MarseilleInventors: Georges Fremy, Hugo Brasselet, Véronique Alphand, Katia Duquesne