Patents Assigned to D
-
Publication number: 20220259677Abstract: The present application relates to the field of cancer, particular to hypoxic tumors. It was found that hypoxia is an important driver for hypermethylation of (promoters of) tumor suppressor genes. As this hypermethylation is a stable signature that is also present in circulating tumor DNA in peripheral blood, detecting this methylation pattern is a surrogate marker for tumor hypoxia. This can be used to adapt therapy as well.Type: ApplicationFiled: April 25, 2022Publication date: August 18, 2022Applicants: VIB VZW, Katholieke Universiteit Leuven, K.U. Leuven R&D, Life Sciences Research Partners VZWInventors: Diether LAMBRECHTS, Bernard THIENPONT
-
Publication number: 20220262515Abstract: The method for determining an onset time and an excitability of a brain region that is not observed as recruited or not recruited in a seizure activity of an epileptic patient brain includes: providing a dynamical model of a propagation of an epileptic seizure in the brain networks; providing a statistical model which defines the probability of generating sets of observations of the state of the brain networks by said dynamical model; training the dynamical model of the propagation of an epileptic seizure using the statistical model and the data set of observations of the training cohort; and inverting the trained dynamical model and inferring the onset time and excitability of a third region from the onset time that is observed for the first and second regions using the statistical model.Type: ApplicationFiled: July 22, 2020Publication date: August 18, 2022Applicants: UNIVERSITÉ D'AIX-MARSEILLE (AMU), INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALEInventors: Viktor Jirsa, Viktor Sip
-
Publication number: 20220259624Abstract: The present invention relates to a selective process for preparing sulfoxides from sulfides by enzymatic catalysis, and to a composition comprising a symmetrical sulfide, an oxidoreductase enzyme catalyzing the oxidation of said symmetrical sulfide to symmetrical sulfoxide; optionally at least one cofactor C of said enzyme E; and an oxidant, which allows in particular the implementation of said process.Type: ApplicationFiled: June 12, 2020Publication date: August 18, 2022Applicants: Arkema France, Centre National de la Recherche Scientifique (CNRS), Universite d'Aix-MarseilleInventors: Georges Fremy, Hugo Brasselet, Véronique Alphand, Katia Duquesne
-
Publication number: 20220257671Abstract: Recombinant, alive and metabolically active bacteria including a heterologous prokaryotic biomineralized ferritin. In particular, the inventors have shown that naturally non-magnetic Escherichia coli may be engineered to become magnetic by the expression and the biomineralization of the ferritin of Pyrococcus furiosus. Moreover, the inventors have shown that a fixed number of magnetic E. coli strains keep their magnetic properties through cell division by asymmetrical division. The inventors have also shown that magnetic bacteria according to the invention may be of use in both non-therapeutic and therapeutic uses, such as, e.g., the biosensing of target substance, the depollution of complex environments, the display of antibodies, nanobodies and antigens, the delivery of therapeutic substance to target cells, the targeting and infection of target cells.Type: ApplicationFiled: July 24, 2020Publication date: August 18, 2022Applicants: PARIS SCIENCES ET LETTRES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, MUSÉUM NATIONAL D'HISTOIRE NATURELLE (MNHN)Inventors: Zoher GUEROUI, Mary AUBRY, Wei-An WANG, François GUYOT
-
Publication number: 20220256899Abstract: The present invention relates to a method for the preparation of a flavouring, comprising the steps of (i) providing a reaction mixture comprising yeast extract comprising at least 0.5 wt. %, by weight of dry matter of yeast extract, glycosylamine and/or derivatives thereof and at least 1.0 wt. %, by weight of dry yeast extract, thiol containing compounds; at least 2 wt. %, by weight of the reaction mixture, acid; at least 10 wt. %, by weight of the reaction mixture, water; (ii) heating the reaction mixture at a temperature in the range of 90-160° C.; wherein the heated reaction mixture has an acidity such that a 1 wt. % dilution in demineralised water has a pH of in the range of 3.5 and 6 at 20° C. and (ii) optionally drying the product.Type: ApplicationFiled: October 15, 2019Publication date: August 18, 2022Applicant: Conopco Inc., d/b/a UNILEVERInventors: Amir Maximiliaan Batenburg, Jacoba Carolina van Hoek, Jean Hypolites Koek
-
Publication number: 20220258365Abstract: A razor head includes a frame, elongated blades arranged on an inner side of the frame, and two bridge walls each extending between two points of the frame in an interior of the frame, the bridge walls each including projections arranged in an arrangement direction of the blades. Each of the blades is held between adjacent ones of the projections of the bridge walls. Each of the projections includes a first flat surface and a second flat surface. In each of the bridge walls, the first flat surface and the second flat surface are shifted from each other in a longitudinal direction of the blades so as not to overlap each other, and the first flat surfaces and the second flat surfaces are located on the same position as viewed in the arrangement direction. Each of the projections has a horizontal cross-sectional shape of a parallelogram.Type: ApplicationFiled: September 10, 2019Publication date: August 18, 2022Applicant: KAI R&D CENTER CO., LTD.Inventor: Kengo Hashimoto
-
Patent number: 11415642Abstract: A device for sensing a magnetic field, comprising a closed superconducting loop configured to collect a magnetic field to be sensed, hereinafter external magnetic field, the closed superconducting loop having a path width (wp) and being provided with a constriction having a width (wc) narrower than the path width, the constriction generating a non-uniform magnetic field, hereinafter internal magnetic field, in response to the external magnetic field, a vibrating mechanical oscillator coupled to, or formed by the constriction and responsive to the internal magnetic field, and a detector configured to detect deflection or vibration of the mechanical oscillator and providing a signal indicative of the deflection or vibration.Type: GrantFiled: April 15, 2021Date of Patent: August 16, 2022Assignees: CONSIGLIO NAZIONALE DELLE RICERCHE, UNIVERSITA' DEGLI STUDI “G. D'ANNUNZIO” CHIETI-PESCARA, QUANTIFIED AIR BVInventors: Luca Pellegrino, Nicola Manca, Daniele Marre′, Federico Remaggi, Riccardo Bertacco, Federico Maspero, Warner Jurriën Venstra, Stefania Della Penna, Ingo Hilschenz, Alexei Kalaboukhov, Filomena Lombardi
-
Patent number: 11418738Abstract: The present invention discloses an image sensor for real-time calibration of dark current, including a pixel array comprises at least a pixel unit, the pixel unit includes a pixel photosensitive portion, a pixel dark shielding portion and a subtraction circuit, photodiodes in the pixel photosensitive portion and the pixel dark shielding portion are isolated by deep trench isolations, the pixel dark shielding portion are covered by a dark shielding layer; both of the pixel photosensitive portion and the pixel dark shielding portion adopt a same voltage and sequential control, a light ambient voltage signal and a non-light ambient voltage signal are generated and connected to both ends of a subtraction circuit to realize subtraction and dark current calibration.Type: GrantFiled: August 29, 2018Date of Patent: August 16, 2022Assignees: SHANGHAI IC R&D CENTER CO., LTD, CHENGDU IMAGE DESIGN TECHNOLOGY CO., LTD.Inventors: Jiebin Duan, Chen Li, Pengfei Wang, Tao Zhou
-
Patent number: 11415702Abstract: A terminal to calculate a position and detect spoofing, the terminal includes a receiver of first signals, notably signals of a GNSS type, from first sources, to compute a first information relative to its position, as for instance a pseudo range measurement, an ephemeris, a navigation message, spatial coordinates or temporal coordinates, and to calculate a position; a receiver of a second signal of a non-RF and non-GNSS type from a second source, notably from an optical display, the second signal comprising a second information transmitted using a predetermined encoding format to retrieve said second information; a processing logic configured to detect spoofing by comparing the first and second information. The associated transmitters, authentication server and spoofing detection methods are also provided.Type: GrantFiled: November 23, 2018Date of Patent: August 16, 2022Assignee: CENTRE NATIONAL D'ETUDES SPATIALES (CNES)Inventor: François-Xavier Marmet
-
Patent number: 11415708Abstract: A positioning device includes a first GNSS receiver; a communication link configured to receive a spatial position, code measurements and carrier phase measurements of a second GNSS receiver; an input interface to a processing logic, the processing logic being configured to: calculate a position of the first positioning device from communicated data; and to estimate one or more parameters representative of multipath at the position of the first positioning device; wherein the communication link is configured to communicate to a second positioning device the parameters representative of multipath at the position of the first positioning device. Described developments comprise the use of multipath severity indicators, the determination of relative distances between receivers, validity conditions in time and/or space of multipath, various embodiments in a train or in a group of vehicles. Software aspects are discussed.Type: GrantFiled: December 21, 2018Date of Patent: August 16, 2022Assignee: CENTRE NATIONAL D'ETUDES SPATIALES (CNES)Inventors: Cédric Rouch, Denis Laurichesse, François-Xavier Marmet
-
Patent number: 11416095Abstract: An electronic device described herein includes a touch screen for a touch sensitive display carried by a portable housing. The electronic device is configured to operate in a high detection threshold mode to determine whether an object is in contact with the touch sensitive display, and operate in a low detection threshold mode to determine whether the object is adjacent to the touch sensitive display, based on lack of detection of the object being in contact with the touch sensitive display. The electronic device is further configured to determine whether the object is in contact with a peripheral edge of the portable housing by determining whether the object is adjacent opposite sides of the touch sensitive display, based on detection of the object being adjacent to the touch sensitive display.Type: GrantFiled: May 10, 2016Date of Patent: August 16, 2022Assignees: STMicroelectronics Asia Pacific Pte Ltd, STMicroelectronics (Beijing) R&D Co. LtdInventors: Tae-gil Kang, Hang Yin, Cam Chung La
-
Patent number: 11413517Abstract: A nose clip and a tail clip for a splitboard ski assembly may each comprise at least three hooks. The nose clip and the tail clip may be adaptable to various splitboard ski designs. A stretcher for a skin assembly may be configured to interface with the tail clip. The tail clip may comprise at least two elongated apertures defining a rail. The stretcher may be configured to interface with the rail via friction and/or secure a skin assembly to a splitboard ski assembly.Type: GrantFiled: January 25, 2021Date of Patent: August 16, 2022Assignee: SPARK R&D IP HOLDINGS, LLCInventor: William J. Ritter
-
Publication number: 20220255246Abstract: An electrical grounding assembly includes an electrically conductive metal grounding substrate that is electrically connectable to a structure to be electrically grounded. A corrosion-protective jacket is on the grounding substrate. The jacket is electrically conductive and water impermeable, and includes a polymeric matrix and a particulate carbonaceous material dispersed in the polymeric matrix.Type: ApplicationFiled: April 26, 2022Publication date: August 11, 2022Applicant: SHORE ACRES ENTERPRISES INC. (D/B/A SAE INC.)Inventors: BRIEN TODD SIROLA, CHRISTOPHER PAUL BERNI, CAITLIN EMMA MORRISSEY HUGHES, DONALD BRIEN SIROLA
-
Publication number: 20220251052Abstract: The present invention relates to process for the preparation of 2-(3,5-dichlorophenyl)-1,3- benzoxazole-6-carboxylic acid of formula (I), its pharmaceutically acceptable salts and polymorphs thereof which are used in the treatment of cardiomyopathy of wild type or hereditary transthyretin-mediated amyloidosis.Type: ApplicationFiled: July 4, 2020Publication date: August 11, 2022Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTERInventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Venkat Reddy GHOJALA, Rajeshwar Reddy SAGYAM, Markandeya BEKKAM
-
Publication number: 20220248670Abstract: An aqueous fabric spray composition, comprising: a. 0.0001-10 wt. % free perfume. b. 0.001 to 2 wt. % quaternary ammonium biocide.Type: ApplicationFiled: July 24, 2020Publication date: August 11, 2022Applicant: Conopco, Inc., d/b/a UNILEVERInventor: Christopher BOARDMAN
-
Publication number: 20220251232Abstract: Novel anti-CD25 antibodies and antigen-bind fragments thereof that do not inhibit the binding of interleukin-2 (IL-2) to CD25, and the use thereof for treating cancer or an infectious disease. Also, fusion proteins including the antibodies and antigen-bind fragments, nucleic acids encoding the antibodies and antigen-bind fragments, and an expression vectors including the nucleic acids. Further, pharmaceutical compositions including the fusion proteins or the antibodies and antigen-bind fragments.Type: ApplicationFiled: May 20, 2020Publication date: August 11, 2022Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), INSTITUT JEAN PAOLI & IRENE CALMETTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ D'AIX MARSEILLE, UNIVERSITE DE PARIS, ALDERAAN BIOTECHNOLOGY, UNIVERSITE PARIS EST CRETEIL VAL DE MARNEInventors: Daniel OLIVE, Armand BENSUSSAN, Jérôme GIUSTINIANI, Arnaud FOUSSAT
-
Publication number: 20220248840Abstract: A thermally insulated container for storing and serving frozen confectionery items, wherein the container is preferably arranged to be removably mounted within a service cart, such as an inflight service cart.Type: ApplicationFiled: May 11, 2020Publication date: August 11, 2022Applicant: Conopco, Inc., d/b/a UNILEVERInventors: Leonie Martine DIKS-WARMERDAM, Johannes KRIEG, René Joachim BUTER
-
Publication number: 20220249344Abstract: Personal care topical compositions at skin-tolerant pH with cystine which is solubilized or has small crystal size below 20 microns. A process of making the composition is also described.Type: ApplicationFiled: April 27, 2022Publication date: August 11, 2022Applicant: Conopco, Inc., d/b/a UNILEVERInventors: Maria BUCHALOVA, Teanoosh Moaddel, Qiang Qiu
-
Publication number: 20220249167Abstract: The method of identifying a potentially surgically operable target zone in an epileptic patient's brain includes: providing a computerized platform modelling various zones of a primate brain and connectivity between said zones; providing a model of an epileptogenic zone and a model of the propagation of an epileptic discharge from an epileptic zone to a propagation zone; obtaining a patient's personalized computerized platform; deriving the potential target zones based on modularity analysis; evaluating the target zones' effectiveness by simulating epileptic seizures propagation in the personalized patient's computerized platform; evaluating the target zones' safety by simulating spatiotemporal brain activation patterns in a defined state condition and comparing the simulated spatiotemporal brain activation patterns obtained before removal of the target zone with the spatiotemporal brain activation patterns obtained after removal of the target zone; identifying the target zones which satisfy both effectivenesType: ApplicationFiled: May 27, 2020Publication date: August 11, 2022Applicants: UNIVERSITÉ D'AIX-MARSEILLE (AMU), INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALEInventors: Sora An, Viktor Jirsa
-
Publication number: 20220252660Abstract: The present invention provides a method for detecting failed back-drills in PCBs in the process of fabricating a PCB so that the failed back-drill can be screened out or repaired. The present invention accomplishes this by adding a short to ground connection for every back-drill via that will be cut when the back-drill removes the via stub. If the back-drill is bad or failed the short to ground will fail the subsequent electrical tests. The PCB can be repaired by re-drilling the hole or via. The present invention allows for detecting failed back-drills with easy detection in the manufacturing stage using standard equipment and test procedures. This process creates a simple pass-fail measurement that uses an existing common test process to catch failed back drills in the PCB fabrication facility. This allows for easy and cost-effective repair and guarantees back-drill failures do not pass into the field.Type: ApplicationFiled: February 11, 2021Publication date: August 11, 2022Applicant: R & D Circuits, Inc.Inventors: Donald Eric Thompson, Thomas Smith