Abstract: An system for emptying at least one reservoir containing a pressurized fluid, including, for each reservoir, a vent for discharging the fluid out of the reservoir and a discharge valve for connecting the reservoir to the vent, the emptying system additionally including, for each discharge valve, a return member for returning the discharge valve to its closed configuration, and a fluid control system for controlling the movement of each discharge valve to its open configuration by action of an operating fluid on the discharge valve, the control system including an operating station arranged outside a danger zone around each reservoir, and, for each discharge valve, a fluid pipe fluidically connecting the operating station to the discharge valve, the operating station including at least one reversible free connection for connecting to each fluid pipe of a device for supplying the control system with operating fluid.

Abstract: The invention provides compounds of formula (I): or pharmaceutically-acceptable salts thereof, that are inhibitors of Janus kinases. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat inflammatory and autoimmune skin diseases.

Abstract: The invention relates to a geared motor (1) for a motor-vehicle wiping system comprising an electric motor (2) comprising a rotor (20) including magnetic elements, a stator (21) having the electromagnetic excitation windings of the rotor, a rotary shaft (22) rigidly connected to the rotor, a reduction gear (3) linking the rotary shaft (22) and an output shaft of the geared motor, a casing (4) forming a protective envelope for said reduction gear, or the electric motor (2), and in which said reduction gear (3) includes a worm screw and worm wheel gear, the worm screw (30) being rigidly connected to the rotary shaft of the rotor (22), the worm wheel (31) rigidly connected to an output shaft (8) of the geared motor, bearing means (23, 24) for guiding the rotary shaft of the rotor (22) in rotation in relation to the casing (4), and potentially, a determination device for determining the angular position of the rotor including a multi-pole magnet (5) that is rigidly connected to the rotary shaft (22) of the rotor

Abstract: Apparatus for a drill powered wire puller are disclosed. In an embodiment the drill powered wire puller includes a center plate, a cradle plate, a housing, a support, the support including a receiver, and a capstan. The center plate is coupled with the cradle plate at a proximal end. The cradle plate includes a U-shaped notch and two hooks or catches which are configured to couple the cradle plate with a powered rotary tool, such as a drill. The right side of the center plate is coupled with a housing, the left side of the center plate is coupled with a support. The left side of the support is coupled with a capstan. The support laterally offsets the receiver to align a longitudinal axis of the receiver with a radially curved portion of the capstan.

Abstract: The present disclosure relates to biguanide derivatives of formula (I) and their rearrangement products. The present disclosure also relates to the use of these compounds in a method for treating cancer, in particular melanoma.

Abstract: A neural network circuit for providing a threshold weighted sum of input signals comprises at least two arrays of transistors with programmable threshold voltage, each transistor storing a synaptic weight as a threshold voltage and having a control electrode for receiving an activation input signal. Additionally, for each array of transistors, a reference network associated therewith, which provides a reference signal to be combined with the positive or negative weight current components of the transistors of the associated array, the reference signal having opposite sign compared to the weight current components of the associated array, thereby providing the threshold of the weighted sums of the currents. Further, at least one bitline is configured to receive the combined positive and/or negative current components, each combined with their associated reference signals.

Abstract: The invention relates to a co-granule of xanthan gum and acacia gum having an average diameter of between 50 ?m and 1000 ?m.

Abstract: The disclosure provides a panel of biomarkers that individually or in combination can indicate the presence of sepsis as distinguishable from other non-infection related inflammatory conditions. The disclosed biomarkers and related reagents and kits provide strategies for detecting, treating, and monitoring sepsis in subjects. In aspect, the disclosure provides a method for detecting sepsis, comprising contacting a biological sample obtained from the subject with an affinity reagent that specifically binds to one or more of the disclosed novel biomarkers, and detecting differential expression of the one or more biomarkers by detecting binding of the affinity reagent to the biomarker. The method can incorporate use of additional known biomarkers. The method can further comprise treating a subject determined to have sepsis. In some embodiments, the subject is a human subject less than 20 years old.

Abstract: The present description relates according to a first aspect to a method for measurement of optical properties of at least one particle in a sample (10) and permits, for example, quantitative determination of the complex dipolar polarizability of at least one particle present in a sample. The optical characterization method comprises the illumination of said sample (10) using a light beam, the sample (10) being positioned in the object space of an optical system (120); the acquisition of at least one phase image and at least one intensity image of said at least one particle illuminated by the light beam, the acquisition being carried out in an analysis plane arranged in the image space of the optical system (120); and the determination of at least one optical property of said at least one particle from said at least one phase image and at least one intensity image.

Abstract: The invention relates to a mounting bracket (5) for a pipe (4) supplying fluid to a driving arm (1) of a motor vehicle wiper system (100), the driving arm (1) comprising at least one spring (14), the mounting bracket (5) comprising at least one sleeve (51) configured to hold the supply pipe (4). The mounting bracket (5) according to the invention comprises a substantially hollow cylindrical body (50) linked to the sleeve (51) and configured to be inserted into a space (141) surrounded by the spring (14) of the driving arm (1). The invention also relates to a driving arm (1) comprising such a mounting bracket (5) and to a method for assembling such a driving arm (1), comprising a preliminary step of inserting the body (50) of such a mounting bracket (5) into at least part of the aforementioned space (141).

Abstract: Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35-80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. The aimed of the inventors was to characterize the natural history of AAV infection in the liver. Viral DNA was thus quantified in tumor and non-tumor liver tissues of 1461 patients. Presence of episomal form and viral mRNA expression were analyzed using a DNAse/TaqMan based assay and quantitative RT-PCR. In silico analyses using viral capture data explored viral variants and new clonal insertions. AAV DNA was detected in 21% of the patients equally distributed in 2 major viral subtypes: one similar to AAV2, the other hybrid between AAV2 and AAV13 sequences. Thus the inventors provided an integrated analysis of the wild type AAV infection in the liver with the identification of viral genotypes, molecular forms, helper virus relationship and viral integrations.

Abstract: A novel compound is disclosed. Skin lightening composition comprising said compound and method of skin lightening is disclosed too. In addition, method of synthesizing said novel compound is disclosed.

Abstract: The present invention relates to a plant-based frozen confection comprising: fat in an amount of 1 to 15 wt %; sugars in an amount of 10 to 30 wt %; and pulse protein in an amount of 0.4 to 10 wt %; wherein the pulse protein comprises soy protein and fava bean protein in a weight ratio of 1:1 to 1:4.

Abstract: The present invention relates to a process for the preparation of amorphous Selexipag from Selexipag crystalline salts using a solvent.

Abstract: An accessory for a tag device and a RFID tagging device using the accessory. The accessory includes a tag holder defining with a slot arranged to receive the tag device and to removably secure the tag device in a predetermined position; and an antenna provided on the tag holder, wherein the antenna has a radiator arranged to couple to a feeder of the tag device when the tag device is positioned in the predetermined position within the slot.

Abstract: A method for producing a plastic-coated loudspeaker housing comprises the putting together of a loudspeaker housing from a plurality of housing wall elements. The put-together loudspeaker housing is placed in a mold. This is followed by a surface coating of the put-together loudspeaker housing by introducing a liquid, curable plastic into the mold.

Abstract: Method of manufacturing a micromechanical component intended to cooperate with another micromechanical component, the method comprising the steps of providing a substrate, forming a mould on said substrate, said mould defining sidewalls arranged to delimit said micromechanical component, providing particles on at least said sidewalls, depositing a metal in said mould so as to form said micromechanical component, and liberating said micromechanical component from said mould and removing said particles.

Abstract: Razor head includes a razor cartridge (10) and a razor blade (20). The razor cartridge (10) contains a front side wall (11), a rear side wall (12), a left side wall (13), and a right side wall (14) which enclose an accommodating space (15) to receiving the razor blade (20). The front side wall (11) has multiple protective ribs (30) protruding upward and arranged at intervals along the length direction of the razor cartridge (10); each protective rib (30) extends along the width direction of the razor cartridge (10) and contains a flexible protective rib (30a) and a rigid protective rib which (30b) which are joined, the rigid protective rib (30b) is located in front of the razor blade (20) and arranged adjacent to the razor blade (20), and a guide groove (31) is enclosed between the two adjacent protective rib (30). The razor head has good shaving performance and good comfort.

Abstract: A sprung balance type mechanical timekeeper, includes a spiral spring (10), a balance (20) and an escapement mechanism (30) connected by a point of attachment (12) to the spiral spring and arranged to sustain an oscillation of the balance. The escapement mechanism (30) is connected to the point of attachment (12) of the spiral spring by a chassis (40) pivoted about the axis (A) of the balance. An outer end (12) of the spiral spring (10) is attached to this transverse pert (40) at a location located on one side of the balance axis (A). The chassis (40) includes two branches extending on either side of the axis of the balance (20) and forming a rotary plate whose axis of rotation is coincident with the axis of oscillation of the balance (20). The escapement mechanism (30) is located on the other side of the balance axis (A) and acts on the pivoted chassis (40) so as to free its rotation and thus make the attached end (12) of the spiral spring rotate.