Abstract: A crossbow de-cock mechanism may include a de-cock activator that is selectively movable from a first de-cock activator position that prevents de-cocking of a crossbow into a second de-cock activator position that permits de-cocking of the crossbow.

Abstract: A nursing pad includes an absorbent pad and an adhesive. The absorbent pad defines a first side and a second side and has a contoured shaped configured to correspond to a shape of a user's breast. The adhesive is attached to the second side of the absorbent pad and is configured to adhere the absorbent pad to the user's breast.

Abstract: The invention provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The invention also provides crystalline forms, pharmaceutical compositions comprising such compounds, methods of using such compounds to treat gastrointestinal and other inflammatory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: A combined administration of a liposomal composition comprising Eribulin or a pharmaceutically acceptable salt thereof and a PD-1 antagonist exhibits unexpected antitumor effect.

Abstract: The present disclosure is directed to can cooler for holding a can. The can cooler includes a vessel having a closed bottom end, an upper open end, a sidewall having an inner surface and an outer surface and a ring positioned about the upper open end. The ring having a plurality of ribs configured for holding the can in the vessel.

Abstract: A fluid arrangement (10) for continuous delivery of volumetrically proportioned gases or like fluids includes a valve assembly (11) and a volumetric fluid storage bank (143), which has first and second sets (144, 151) of fluid storage chambers (145, 148, 152, 155). The valve assembly (11) alternately supplies a consumer with a blend of gases from the first set (144) of fluid storage chambers while charging the second set (151) of fluid storage chambers from pressurized gas sources (158, 159), and, upon a threshold depletion of gases from the first set (144) of chambers, supplies the consumer with a blend of gases from the second set (151) of fluid storage chambers while charging the first set (144) of fluid storage chambers from the gas sources (158, 159). The valve assembly (11) again supplies mixed gases from the first set (144) of chambers while charging the second set (151) of chambers.

Abstract: An adjustable and reusable electrical assembly has an electrical unit, such as a plug unit or light unit, configured to engage with a cable. The electrical unit has a body that defines a channel connecting opposite pass-through openings. A first contact member and a second contact member are positioned with at least a portion in the body, each contact member having a piercing member. The cable is engageable with the plug unit extending through the channel with one piercing member in conductive contact with one wire and the other piercing member in conductive contact with the other wire. The cable can be disengaged from the plug unit and re-engaged at a different transverse position to change the length of the assembly.

Abstract: The present invention relates to a vessel navigation system and navigation method thereof, the method includes: (a) driving a vessel to sail along a sailing path including at least two nodes, the at least two nodes include a first node and a second node connected by a first line segment; (b) generating a first tracking point on the first line segment when a distance between the vessel and the first node being less than a first length, and driving the vessel to sail according to the first tracking point; (c) generating a second tracking point on the first line segment when a distance between the vessel and the first tracking point being less than the first length, and driving the vessel to sail according to the second tracking point; and then completing the navigation of the sailing path by repeating the step (b) and step (c) until the vessel passes through each node.

Abstract: A 3D printing system, comprising a heated chamber; a printing base plate mounted inside the heated chamber; a cooling unit mounted outside and above the heated chamber; a printing nozzle; wherein the cooling unit is configured to surround the printing nozzle's upper side outside the heated chamber for cooling the printing nozzle's upper side and wherein the printing nozzle's lower side is mounted inside the heated chamber; and a nozzle heating unit mounted inside the heated chamber and around the printing nozzle's lower side at a distance from the outer surface of the printing nozzle; the heating unit configured to heat the printing nozzle's lower side; the system configured to receive a printing material for printing a 3D model inside the heated chamber.

Abstract: A cleaning device (100), intended to spray at least one fluid towards a surface to be cleaned of a motor vehicle, such as an optical surface of a sensor of an optical detection system, said cleaning device comprising at least one conveying body (1) and a delivery ramp (2) for delivering one or more cleaning and/or drying fluids, and attachment means (101) for attaching a connecting portion (20) of the delivery ramp (2) to an end of the conveying body (1). The attachment means (101) comprise an elastic interlocking assembly (102) and a foolproofing assembly (103) formed respectively by elements carried by the conveying body (1) and complementary elements.

Abstract: A thermoplastic molding process for large parts and particularly to novel rotating elbow piping configurations used to precisely deposit prescribed amounts of thermoplastics or thermoplastic composites into large compression molds.

Abstract: Disclosed is a system and method that provide an amplitude value and a phase delay value which relate to a sinusoidal signal to be measured. For this purpose, phase values of a reference signal, at which the signal to be measured exceeds or falls below the reference signal, are collected and transmitted to a computation unit. The computation unit determines the amplitude and delay values from the collected phase values. The system can be implemented in a cost-effective manner, in particular using an ASIC circuit or an FPGA circuit.

Abstract: The present invention concerns heterocyclic naphthoquinones derivatives for use in the treatment of Cushing disease and other cancers, in particular via the inhibition of Ubiquitin Specific Proteases (USP) 8 and/or 2.

Abstract: A method for monitoring automatic mechanical devices selected from at least one of automatic doors and automatic dock equipment located at a commercial site. The method may include installing, at the commercial site, a plurality of internet-of-things (IoT) monitoring devices. Each of the IoT monitoring devices may include a plurality of connectors corresponding to respective data communication standards, and a wireless transceiver configured to transmit operational information. Electronic communication between each automatic mechanical device and one of the IoT monitoring devices may be established via one of the connectors. A device profile may be assigned for each of the automatic mechanical devices. Each device profiles defines a respective connector and combination of manufacturer and device model.

Abstract: A multi-clad optical fiber is provided. The fiber includes, concentrically and radially outwards from the center of the optical fiber, a core doped with at least one rare-earth dopant material, a pedestal cladding structure, an inner cladding and an outer cladding. The pedestal cladding structure includes a pedestal layer having a refractive index smaller than a refractive index of the core, and a raised index layer having a refractive index larger than the refractive index of the pedestal layer. The raised index layer has a thickness and a refractive index which preserve the confinement of the core mode in the core and minimize the overlap of one or more pedestal modes with the core.

Abstract: A closure (10) of the flip-top type, and a closure combined with a bottle or other container The closure comprises a cap base (12) which can be releasably fastened to a package (74), the cap base including an opening. A closing flap (16) is movably attached to the cap base and is suitable, when it is in a closed position, for preventing egress of a liquid from the package through the pot cap base opening. The closing flap has a locking flap extending therefrom, and movably attached to the closing flap. A locking flap fastener (70) is provided for releasably securing the locking flap to the cap base or to the package to prevent inadvertent opening of the closure during transport and use by the consumer. The locking flap (38) may be tucked within the closing flap during normal use and used to lock the closing flap during transport. The locking flap may be disposed in a recess (20) in the cap base.

Abstract: A method for the synthesis of diazabicyclo[6.2.0]decane compounds is provided. The synthesis proceeds by stereoselective synthesis of a chiral lactone followed by azetidine formation via a series of chemoselective reactions. Bicyclization results with the formation of diazobicyclo[6.2.0]decane related compounds.

Abstract: The present invention relates to novel crystalline polymorphs of sodium (4R,12aS)-9-{[(2,4-difluorophenyl) methyl] carbamoyl}-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1?,2?:4,5] pyrazino[2,1-b] [1,3] oxazin-7-olate represented by the following structural formula-1a and process for their preparation. The present invention further relates to novel solvated forms of sodium (4R,12aS)-9-{[(2,4-difluoro phenyl) methyl] carbamoyl}-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1?,2?:4,5] pyrazino[2,1-b][1,3] oxazin-7-olate compound of formula-1a and process for their preparation.

Abstract: Methods and materials for mitigating biological tissue adhesion are described herein. One method for mitigating adhesion to a biological tissue includes administering an effective amount of a self-assembling peptide solution to the biological tissue, wherein the self-assembling peptide is between about 7 amino acids and 32 amino acids in length and the self-assembling peptide solution forms a hydrogel under physiological conditions.

Abstract: DoorIQ is a software-as-a-service solution consisting of two core components. First, DoorIQ is an inspection app optimized for smartphone (either Apple or Android-powered smart devices) and the second is a cloud-based web application. The inspection app allows a certified automatic, fire, smoke, and/or egress door inspector to perform a best practice inspection for an automatic, fire, smoke, and/or egress door and enter that digitally on the smart device. The results of the inspection are stored in a database. The cloud-based web application allows inspectors, office managers and business owners to review prior inspections, add and manage certified inspectors to be able to use the app, and assign a form of payment for the use of the inspection app. The data, information, and results of inspections can then be distributed by email to property owners/managers and Authorities Having Jurisdiction (AHJ) to evidence compliance or non-compliance with codes and regulations.