Abstract: Provided herein are compounds useful for the treatment of cancer.

Abstract: An IV system can include a first flow regulator configured to restrict flow through a tube and a second flow regulator configured to restrict flow through the tube downstream of the first flow regulator. The first flow regulator can compress the tube a fixed amount to set an initial flow rate through the tube, while the second flow regulator includes a user-adjustable mechanical compression device that compresses the tube to a variable degree to fine-tune the flow rate through to a more precise flow rate that is lower than the initial flow rate. The flow regulators can utilize a purely mechanical means such that electricity is not required. Such systems can provide a simple, low-cost, and low-power way to provide precise flow control to patients, especially neonatal patient, in any environment. Systems can also include flow rate monitoring, alerting, and shutoff components.

Abstract: Multiple emulsions comprising an internal phase which is an oil continuous nanoemulsion are described. The multiple emulsions are water continuous, stable, provide moisturizing benefits and can comprise a high concentration of water soluble actives.

Abstract: The invention provides a frozen confection product comprising oil bodies and from 2 to 35 wt % total fat; at most 15 wt % protein; and from 5 to 40 wt % sugars; wherein at least 25 wt % of the fat is present as oil bodies; and wherein the oil in the oil bodies has an iodine value of less than 100 and comprises at least 45% C18:1 fatty acids.

Abstract: The systems and methods for assembling and installing multiple wind turbines from a single vessel are provided. Generally, the different embodiments use wind turbine components on the vessel that include blades, a nacelle assembly having a rotating hub, and a tower. A Turbine Installation Gantry System (T.I.G.S.) embodiment uses a gantry system having a truss sub-structure and at least one bridge crane on the elevated vessel for assembling the wind turbine blades on board to the nacelle hub supported above the seabed. A Skidding Turbine Installation Crane (S.T.I.C.) embodiment has a rotatable crane mounted on a skidding pedestal or cantilever structure to provide full access to the vessel deck and the blades outboard of the vessel for assembling each of the blades with the assembled nacelle assembly outboard. A Turbine Assembly and Positioning System (T.A.P.S.

Abstract: Compounds of formula (I): wherein R1, R2, R3, B, W, Z, m and n are as defined in the description.

Abstract: A rail lifting head (10) comprises a head gate member (20) defining a gate aperture (22), a rail support member (24) removably secured to the gate member (20) and adapted to support a rail vertically within the gate aperture (22), and a head cartridge (100) which is removably secured to the head gate member (20). The head cartridge (100) includes two opposed vertical rollers (128) which support a rail laterally within the gate aperture and a fixing (112) which secures the head cartridge (100) to the head gate member (20). The rail support member (24) is removable from the head gate member (20).

Abstract: A FeFET and a method of its manufacture are provided, the FeFET having a ferroelectric whose film thickness (dr) is made small and so nanofine as to range in: 59 nm<dr<150 nm, without impairing the data retention property of not less than 105 seconds and the data rewrite endurance property of not less than 108 times, of those that have hitherto been developed, and the FeFET allowing a memory window of 0.40 V or more when a sweep amplitude of the gate voltage is not more than 3.3 V.

Abstract: A tunable microwave system includes at least two elements, each element being chosen from a propagating guide, an evanescent guide, a resonator, and at least one coupling device arranged between the two elements and configured to couple the two elements to each other, the coupling device having a holder having an aperture and having at least one elongate element the shape of which is elongate in a polarization direction contained in a plane of the aperture, the elongate element being securely fastened to the perimeter of the aperture at at least one end, the coupling device being configured to be rotatable about an axis substantially perpendicular to the plane of the aperture so as to modify a value of the polarization direction and so that the coupling between the two elements is dependent on the value of the polarization direction.

Abstract: A seat suspension with suspension strands which comprises a fan grille of plastic provided with anchoring points overmolded on at least some of the suspension strands.

Abstract: The invention relates to identification of synaptogyrin-3 as a target for treating or inhibiting progression of tauopathies or symptoms of tauopathies. In particular, synaptogyrin-3 inhibitors for use as a medicament in general, and for treating or inhibiting progression of tauopathies or symptoms of tauopathies are envisaged. The invention further relates to methods for identification of or for screening for inhibitors of synaptogyrin-3.

Abstract: A captive screw spray nozzle comprising a screw for holding the spray nozzle on a support, the screw comprising a screw head engaging with a holding member, secured to the spray nozzle, and forming a stop for retaining the captive screw on the spray nozzle.

Abstract: A method for manufacturing an optical metasurface is configured to operate in a given working spectral band. The method comprises: obtaining a 2D array of patterns, each comprising one or more nanostructures forming dielectric elements that are resonant in said working spectral band, said nanostructures being formed in at least one photosensitive dielectric medium; exposing said 2D array to a writing electromagnetic wave having at least one wavelength in said photosensitivity spectral band, said writing wave having a spatial energy distribution in a plane of the 2D array that is a function of an intended phase profile, so that each pattern of the 2D array produces on an incident electromagnetic wave having a wavelength in the working spectral band, a phase variation corresponding to a refractive index variation experienced by said pattern during said exposure.

Abstract: A combination panel assembly includes a vehicle panel and a leg system. The vehicle panel includes a first panel side defining a vehicle appearance surface, and an opposing second panel side. The leg system is attached to the second panel side and includes a plurality of legs movable between a stowed position and a deployed position. The combination panel assembly is movable between a vehicle position and a table position. In the vehicle position and with the plurality of legs in the stowed position, the vehicle panel encloses a compartment opening of a vehicle compartment of a vehicle. In the table position and with the plurality of legs is in the deployed position, the combination panel assembly is fully detached from the vehicle and operable as a freestanding table including a table surface defined by the vehicle appearance surface and supported at a table height by the leg system.

Abstract: An apparatus for the preparation of frozen confectionery products comprising a filling head (1) comprising one or more frozen confection inlets (3) connectable to a source of one or more frozen confections comprising one or more inclusions, a mixing chamber (4) and an outlet (2), a first housing (5) comprising a nozzle (6) is connectable to, and rotatable in relation to, the filling head outlet (2), and the outlet of the nozzle (7) has a cross section comprising a central section (8) and peripheral sections (9), wherein an annular shape (24) can be superimposed on the central section (8) and the diameter of the annular shape (24) has a ratio of from 3:1 to 6:1 of the longest length of the one or more inclusions, and the longest length of the one or more inclusions is from 2 mm to 10 mm. A process for the preparation of a frozen confection product comprising the foregoing apparatus and a product prepared according to the process.

Abstract: Novel coated bulking agent particles for reduction of calories in fat-based food products comprising sugar. A coated bulking agent particle comprising from 2 wt % to 70 wt % bulking agent and from 30 wt % to 98 wt % coating composition comprising sugar and surface active agent; wherein the ratio of sugar to surface active agent in the composition is from 2000:1 to 4:1 and from 50 wt % to 100 wt % of the sugar is in crystalline form; wherein the bulking agent is coated with the coating composition; an agglomerated coated bulking agent particle; a process of preparing the particles and a fat-based confection composition comprising the coated bulking agent particles.

Abstract: The present invention provides a solid oral pharmaceutical composition comprising a pharmaceutically effective amount of living microorganisms and one or more pharmaceutically acceptable water absorbing excipient(s), wherein the composition has a water content, determined according to European Pharmacopoeia 9.4, section 2.5.12., from 0.5 to 30% with respect the total weight of the composition. The invention also provides processes for its preparation as well as it use in therapy. The live-cell based composition of the invention is stable at mild conditions.

Abstract: A process for etching glass includes: loading a piece of glass on a flatbed digital printer; applying a selected pre-coat solution to the glass to prevent the ink from permanently adhering to the glass; printing a mask having a selected pattern on the glass with the digital printer; sandblasting the masked glass; stripping away the mask from the glass to reveal the etched glass; and cleaning any residual mask and/or pre-coat solution from the glass.