Abstract: A portable dock plate which includes a planar ramp that has opposing side members, the ramp also has a top end and a bottom end, the top end includes a lip portion. The dock plate has a wheel assembly and a opposing wheel assembly. The wheel assembly includes a wheel, wheel lock linkage, a first locking pin with corresponding first locking pin holes, a lip-lowering apparatus and a lip-raising apparatus. The opposing wheel assembly has a wheel and a opposing locking pin with corresponding opposing locking pin holes. The dock plate also includes opposing handrails which are connected to the opposing side members, each handrail includes a moveable lever-handle for movement and placement of the dock plate.
Type:
Application
Filed:
March 23, 2021
Publication date:
May 26, 2022
Applicant:
Leum Engineering, Inc. d/b/a Dockzilla Co.
Abstract: The vehicle leveler includes a first portion which has a leading edge and a trailing edge, the trailing edge is disposed further from the driveway than the leading edge. The embodiment also includes a second portion which has a leading edge and a trailing edge, the leading edge of the second portion is attached to the trailing edge of the first portion and the leading edge of the second portion is disposed further from the driveway than the trailing edge of the second portion. The device has opposing side portions and a walkway. The opposing side portions include at least one or more lights which illuminate the leveler and the walkway.
Type:
Application
Filed:
February 1, 2022
Publication date:
May 26, 2022
Applicant:
Leum Engineering, Inc. d/b/a Dockzilla Co.
Abstract: A portable dock plate which includes a planar ramp that has opposing side members, the ramp also has a top end and a bottom end, the top end includes a lip portion. The dock plate has a first wheel assembly and a second wheel assembly. The first wheel assembly includes a wheel, wheel lock linkage, a first locking pin with corresponding first locking pin holes, a lip-lowering apparatus and a lip-raising apparatus. The second wheel assembly has a wheel and a second locking pin with corresponding second locking pin holes. The dock plate also includes opposing handrails which are connected to the opposing side members, each handrail includes a moveable lever-handle for movement and placement of the dock plate.
Type:
Application
Filed:
November 23, 2020
Publication date:
May 26, 2022
Applicant:
Leum Engineering, Inc. d/b/a Dockzilla Co.
Abstract: The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3? or GSK3?) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychiatric disorders, metabolic disorders, and cancer.
Type:
Application
Filed:
June 10, 2021
Publication date:
May 26, 2022
Applicants:
The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc., The General Hospital Corporation d/b/a Massachusetts General Hospital
Inventors:
Florence Fevrier Wagner, Jennifer Q. Pan, Sivaraman Dandapani, Andrew Germain, Edward Holson, Benito Munoz, Partha P. Nag, Michael C. Lewis, Stephen J. Haggarty, Joshua A. Bishop, Kimberly Stegmaier, Michel Weiwer, Versha Banerji
Abstract: A method for tracking a user across multiple website domains over a computerized network, the method comprising sending a first first-party user identifier to a collector in response to a user accessing a first website; generating a first user prompt in response to the user accessing the first website; receiving a first input from the user in response to the first user prompt; redirecting the user to a centralized domain; sending a second first-party user identifier associated with the user and the centralized domain to the collector; correlating the first first-party user identifier with the second first-party user identifier to determine that the user is associated with both the first first-party user identifier and the second first-party user identifier; and displaying a webpage of the centralized domain or a landing page in response to the correlation.
Abstract: A multi-cell inflatable jack includes a plurality of jack elements. Each of the plurality of jack elements includes a body having a predetermined perimeter shape and defining a perimeter chamber and a central chamber. A valve is coupled to the body and configured to provide air flow to one of the perimeter chamber or the central chamber. A plurality of flow control stringers are located between the first chamber portion and the second chamber portion and are configured to control an air flow rate into each of the perimeter chamber and the central chamber. At least one fastener is formed on the body and configured to attach the jack element to at least one additional jack element in a multi-cell stack.
Type:
Application
Filed:
December 6, 2021
Publication date:
May 26, 2022
Applicant:
D.T. Davis Enterprises, Ltd. (d/b/a Hovertech International)
Abstract: A cap system for a refill capsule for a container for concentrated cleaning fluid is described. The cap system comprises a cap assembly (200) comprising a conduit (203) sealed by a closure member (208), frangibly connected to an inner surface of the conduit (203). The frangible connection extends in a first plane, which is orthogonal to the longitudinal axis (A) of the conduit (203). The cap system further comprises a plug (300), disposed at least partially within the conduit (203), the plug comprising an abutment surface (305) for bearing against the closure member (208), to break the frangible connection (210). The abutment surface (305) extends in a second plane, which is parallel to the first plane in which the frangible connection (210) extends.
Type:
Application
Filed:
May 22, 2020
Publication date:
May 26, 2022
Applicant:
Conopco Inc., d/b/a UNILEVER
Inventors:
Sebastiaan Wilhemus Josephus den Boer, Matthijs Lucas Bookelmann, Sjoerd Bastiaan Zwartkruis
Abstract: The present invention provides a composition comprising one or more deoxyribonucleosides for use in the treatment of a mitochondrial DNA depletion and/or multiple deletions syndrome provided that the syndrome is not caused by a defect in the deoxyribonucleoside triphosphate (dNTP) metabolism. With the use of the invention there is a recovery in mitochondrial DNA levels independently from the severity of the patient's disease, which confers a great therapeutic value to the invention.
Type:
Grant
Filed:
June 3, 2016
Date of Patent:
May 24, 2022
Assignees:
FUNDACIÓ HOSPITAL UNIVERSITARI VALL D'HEBRON-INSTITUT DE RECERCA, CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED
Inventors:
Ramon Martí Seves, Emiliano González Vioque, Cora Blázquez Bermejo, Javier Torres Torronteras, Raquel Cabrera Pérez, Yolanda Cámara Navarro
Abstract: The invention relates to a Myc dominant negative mutant, called Omomyc, for use in medicine and for use in the prevention and/or treatment of cancer. The invention also refers to a fusion protein comprising Omomyc and pharmaceutical composition thereof and their use in medicine and, in particular, for treatment of cancer.
Type:
Grant
Filed:
June 6, 2019
Date of Patent:
May 24, 2022
Assignees:
FUNDACIÓ PRIVADA INSTITUT D'INVESTIGACIÓ, ONCOLÓGICA DE VALL HEBRON
Abstract: Composition based on a polyol of formula HO—CH2-CHOH—CH2-OH and on alkyl polyrhamnosides of formula HO—CH2-CHOH—CH2-O-(Rham)x-H; process for preparing same, and cosmetic or pharmaceutical composition comprising same.
Type:
Grant
Filed:
November 27, 2018
Date of Patent:
May 24, 2022
Assignee:
SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC
Inventors:
Georges Manuel Dacosta, Jérome Guilbot, Stéphane Dessilla, Laetitia Cattuzzato
Abstract: The disclosure provides thiol-containing alkyl fatty acid compound formulations for intravenous, parenteral or oral administration. The compositions of the present technology have optimal controlled bioavailability and are useful for treating metabolic dysfunctions such as pre-diabetes, Metabolic Syndrome and diabetes. Also provided are methods of treatment comprising the daily administration of the disclosed thiol-containing alkyl fatty acid formulations.
Abstract: A dynamic joint structure (DJS) for movably connecting a wheel set to a chassis of a vehicle, and a vehicle including a front such DJS and a rear such DJS. The DJS includes an upper suspension plate having at least one upper recess with an upper opening; a middle suspension plate having at least one middle recess with a middle opening; and at least one connector assembly including: (i) an elongated bolt defining an insert axis “Zi” along its longer side; and (ii) a restriction unit configured to restrict the movement of the bolt over an XiYi plane that is perpendicular to Zi, for enhancing translation of tilting movements of the chassis of the vehicle into steering movements of the vehicle's wheels set to which the DJS connects.
Abstract: The present disclosure discloses a support for household appliance and a household appliance. The support for household appliance comprises a fixed part and a moving part, a hollow chamber is formed between the fixed part and the moving part and the hollow chamber is provided with a hydraulic medium. At least two household-appliance-used supports communicate with one another through high-pressure pipes; and the hydraulic medium circulates among the household-appliance-used supports under action of pressure to drive the moving part to extend and retract to achieve automatic leveling. Liquid outlet nozzles communicating with the hollow chamber are arranged on the fixed part, the high-pressure pipes are in sealed connection with the liquid outlet nozzles through snap-in connecting members, and the snap-in connecting members have reinforcing aprons which are fit with the fixed part.
Abstract: A vehicle seat having a pivoting function about a vertical axis, the seat comprising a pivoting assembly) with a base, a rotating ring mounted on the base by means of a hinge mechanism interposed between the base and the rotating ring, a seating portion frame connected to the rotating ring, directly or via a raising mechanism and/or longitudinal rails, the hinge mechanism allowing rotation, about a vertical main axis, of the rotating ring relative to the base and blocking any substantial movement in the other degrees of freedom, namely the other two rotations and the three translations in an orthogonal reference system.
Abstract: The invention provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat gastrointestinal and other inflammatory diseases.
Type:
Grant
Filed:
October 23, 2020
Date of Patent:
May 24, 2022
Assignee:
Theravance Biopharma R&D IP, LLC
Inventors:
Robert Murray McKinnell, Erik Fenster, Tom M. Lam, Anthony Francesco Palermo
Abstract: Method for processing a sequence of digital signal samples including a first sub-sequence and a second sub-sequence. Forming a first block of samples comprising the first sub-sequence and a second block of samples comprising header samples followed by the second sub-sequence. Demodulating the first block of samples through a digital demodulator to produce a first block of symbols, and the second block of digital signal samples through a second digital demodulator to produce a second block of symbols. The second demodulator implementing a carrier synchronisation or symbol rate synchronisation starting with the header samples, which comprise samples in a number adapted in such a way that the synchronisation is effective before the second demodulator demodulates the second sub-sequence. Reconstructing a sequence of symbols by concatenating the first symbol block with the second symbol block.
Type:
Grant
Filed:
June 21, 2019
Date of Patent:
May 24, 2022
Assignees:
SAFRAN DATA SYSTEMS, CENTRE NATIONAL D'ETUDES SPATIALES
Abstract: Disclosed herein are microfluidic actuators for selecting objects in a fluid stream comprising a plurality of objects. In some embodiments, the actuator comprises an object detection means adapted for, upon arrival of an object, identifying whether an object is an object of interest. It further comprises a heater adapted for generating a jet flow for deflecting an object of interest from the fluid stream and a controller for activating the heater as function of the detection of an object of interest using a nucleation signal. The controller is adapted for obtaining temperature information of the heater and for adjusting a nucleation signal for the heater taking into account the obtained temperature information. Also disclosed are microfluidic systems and diagnostic devices comprising the microfluidic actuators of the disclosure, as well as methods of use thereof.
Type:
Grant
Filed:
December 26, 2017
Date of Patent:
May 24, 2022
Assignees:
IMEC VZW, KATHOLIEKE UNIVERSITEIT LEUVEN, KU LEUVEN R&D
Inventors:
Koen Johannes Hubertus Gerardus de Wijs, Chengxun Liu