Abstract: The invention provides substituted imidazo[1,2-b]pyridazine compounds, substituted imidazo[1,5-b]pyridazine compounds, related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted imidazo[1,2-b]pyridazine compounds described herein include substituted imidazo[1,2-b]pyridazine-3-carboxamide compounds and variants thereof.

Abstract: The invention relates to an assembly (5, 8) formed of an end-piece (8) and a wiper rubber (5) which constitute a wiper blade (1), the wiper rubber (5) comprising at least one heel (5a) and a friction zone (5g), the friction zone (5g) being capable of coming into contact with a surface to be wiped, the end-piece (8) comprising a first receiver (21) which is configured to receive a first end (31) of a flexible support (6) of the wiper blade (1), and a second receiver (22) into which the heel (5a) of the wiper rubber (5) extends, the two receivers (21, 22) being superposed in a plane passing through the heel (5a) and through the friction zone (5g), the end-piece (8) comprising a means of attachment (19) to the wiper rubber (5) integrally formed with the end-piece (8).

Abstract: A device for multispectral imaging in the infrared, suitable for detecting at at least one first and one second detection wavelength is provided. It comprises a detection matrix array comprising a set of elementary detectors of preset dimensions forming an image field of given dimensions; and an image-forming optic having a given aperture number (N) and a given focal length (F), which aperture number and focal length are suitable for forming, at any point of the image field, an elementary focal spot covering a set of at least two juxtaposed elementary detectors.

Abstract: A back panel of a motor vehicle seat element successively includes a layer of paint, a layer of non-expanded foam, at least one thermal device, and a layer of expanded foam.

Abstract: A removable protection member for brackets configured to support air conditioning units, wherein the support bracket includes at least two substantially “L”-shaped supports suited to be secured to a bearing wall and at least one cross member suited to be secured to the bearing wall and to connect the supports, said protection member including at least one pair of first covering members intended to cover the supports, each first covering member being substantially “L”-shaped; at least one second covering member suited to cover a corresponding cross member; quick connection members associated with the pair of first covering members and with the covering member, the quick connection members being suited to make it easier to maintain the pair of first covering members removably attached to the respective supports and the second covering member removably attached to the corresponding cross member through interference.

Abstract: A 3D printing nozzle calibration system, comprising a heated chamber; a printing base plate mounted inside the heated chamber; printing base moving means configured to move the printing base plate; a moving carriage; at least one rail on which the moving carriage is configured to slide up and down; a printing nozzle partially mounted inside the heated chamber; the printing nozzle is connected to the moving carriage; a hard stop connected to the moving carriage; a fixed part on which the hard stop is resting; and a printer controller; wherein the printing base plate is configured to move up, up to a point where the printing base plate touches the printing nozzle in a determined point of the printing base plate, thereby causing the hard stop to disconnect from the fixed part; and wherein the printer controller is configured to store a height of the printing base plate upon the disconnection.

Abstract: A nutraceutical and/or pharmaceutical composition designed to stimulate the production of type 2 beta-defensins. The composition includes as a sole active ingredient a gluco-oligosaccharide presenting the following basic oligomeric structure: for the treatment of intestinal inflammations in the quantity of 0.5 to 10 g. Application to the treatment of functional colopathy.

Abstract: A pneumatic tyre including a tread portion, wherein the tread portion has a groove which is oriented at an angle between +45 and ?45 degrees with respect to the rolling direction of the tyre, the groove having a depth extending in the radial dimension, wherein the groove includes a plurality of protrusions extending along the direction of the groove, wherein each protrusion has a length in the direction of the groove, a width perpendicular to its length and a height. Each protrusion has a length of at least 75% of the circumferential length of the tyre tread.

Abstract: The invention relates to a preform (1) for a container (2) made of plastic, wherein the preform (1) comprises a body part (3) comprising a wall having a thickness (e1) which extends along a longitudinal axis (X) and which is connected, via a periphery (8), to a closed bottom part (5) which has an apex (10). According to the invention, the bottom part (5) has ribs (11) which each extend from the apex (10) of the bottom part (5) to the periphery (8) so as to form a star, and a substantially triangular zone (12) arranged between two adjacent ribs (11) and a portion (8a) of the periphery (8) has a thickness (e3) which is less than the thickness (e1).

Abstract: The invention proposes an arm assembly comprising an arm adapter (20) comprising a distal section (20D) for supporting a wiper blade, a proximal section (20P) for housing a terminal section of a fluid delivery tube (26) and a terminal portion (21) for connecting the arm adapter (20) to a wiper arm rod (23), wherein the arm adapter (20) is provided with at least one retention device for fixedly retaining the terminal section of the fluid delivery tube with respect to said arm adapter, for example in the form of a retaining clip (32) attached to the proximal section (20P).

Abstract: A system for supplying power to at least one power distribution and data hub using a portable battery pack including a battery enclosed by a wearable and replaceable pouch or skin is disclosed, wherein the pouch or skin can be provided in different colors and/or patterns. Further, the pouch or skin can be MOLLE-compatible. The battery comprises a battery element housed between a battery cover and a back plate, wherein the battery element, battery cover, and back plate have a slight curvature or contour. Further, the battery comprises flexible leads.

Abstract: An apparatus for automatically preparing baked waffle cone sheets, for use in preparing a waffle cone to be filled with a frozen confectionery product, from waffle cone batter, the apparatus comprising a baking station, the baking station comprising a plurality of baking plate locations onto which the waffle cone batter is to be deposited, each baking plate location comprising an essentially planar baking surface comprising a characteristic waffle region comprising a first array of parallel linear grooves, so as to produce a characteristic waffle pattern in the baked waffle sheet from the resulting parallel linear protrusions in the baked waffle sheet; wherein each baking plate location also comprises a graphical region, the graphical region being located within the characteristic waffle region and comprising grooves corresponding to a graphical image, and also comprising at least one linear groove, each linear groove being contiguous with, dimensionally similar to and collinear with a groove in the character

Abstract: The invention relates to a method of producing an onion flavour composition, said method comprising: providing onion component selected from fresh onion, dehydrated onion and combinations thereof; providing onion juice concentrate having a dry matter content of 40-95 wt. %; mixing the onion component with the onion juice concentrate in a weight ratio, calculated on a dry matter basis, of 100 parts by weight of dry matter from onion component with 60 to 1000 parts by weight of dry matter from onion juice concentrate, to produce an onion mix; subjecting the onion mix to a heat treatment at a temperature of more than 100° C. for at least 5 minutes; and drying the onion mix to a water content of less than 10 wt. % simultaneous with and/or after the heat treatment. This method yields a shelf-stable onion flavour composition that has an intense flavour, and that can suitably be used to impart the flavour of sautéed onion to a wide variety of edible products.

Abstract: The invention provides a detergent composition for the non-oxidative laundering of fabric stains, the composition comprising: (a) from 0.1 to 10% (by weight based on the total weight of the composition) of one or more deferoxamines and/or acid addition salts thereof; and (b) from 3 to 80% (by weight based on the total weight of the composition) of one or more detersive surfactants. The invention also provides a method for the non-oxidative laundering of fabric stains, comprising diluting a dose of the detergent composition defined above to obtain a wash liquor, and washing the stained fabric with the wash liquor so formed.

Abstract: Newborn screening for primary immunodeficiencies, cystinosis, and Wilson disease is described. The newborn screening can detect these disorders from dried blood spots already routinely collected at the time of birth. Early detection of these disorders will greatly improve patient outcome as each of them can be fatal once symptoms emerge.

Abstract: The invention relates to a method of producing an onion flavour compositions, said method comprising: providing onion juice concentrate having a dry matter content of 40-95 wt. %; providing onion component selected from fresh onion, dehydrated onion and combinations thereof; mixing the onion juice concentrate with the onion component in a weight ratio, calculated on a dry matter basis, of 100 parts by weight of dry matter from onion juice concentrate with 4 to 80 parts by weight of dry matter from onion component, to produce an onion mix having a dry matter content of 20-80 wt. %; subjecting the onion mix to a heat treatment at a temperature of at least 90° C. for at least 15 minutes; optionally mixing the heat treated onion mix with additional onion component and/or additional onion juice concentrate to produce an onion blend; drying the heat treated onion mix or the onion blend to produce a dried onion composite having a water content of less than 10 wt. %.

Abstract: The present invention relates to new borondifluoride complexes of curcuminoid compounds with an enhanced fluorescence quantum yield and emission, and their uses as fluorophore in various fields such as bioimaging, therapeutics, theranostics, display and telecommunication technologies, photovoltaics. The preparation said compounds is also described.

Abstract: A vehicle leveler which includes a first portion with a leading edge and a trailing edge, the trailing edge is disposed further from the driveway than the leading edge. The leveler also includes a second portion with a leading edge and a trailing edge, the leading edge of the second portion is removably attached to the trailing edge of the first portion and the leading edge of the second portion is disposed further from the driveway than the trailing edge of the second portion. The second portion also includes an extension portion. The vehicle leveler has opposing side portions which have a top surface that forms a walkway. The vehicle leveler having a power unit and a hydraulic system that provides power and allows movement of the first portion and second portion.

Abstract: Machine learning classification models which are robust against label noise are provided. Noise may be modelled explicitly by modelling “label flips”, where incorrect binary labels are “flipped” relative to their ground truth value. Distributions of label flips may be modelled as prior and posterior distributions in a flexible architecture for machine learning systems. An arbitrary classification model may be provided within the system. The classification model is made more robust to label noise by operation of the prior and posterior distributions. Particular prior and approximating posterior distributions are disclosed.

Abstract: A compound represented by the following formula (1) is an excellent near-infrared emitter. R1 to R6 are H or a substituent and R7 is represented by the following formula (2). Ar11 is an aryl group, R11 is a substituent other than an aryl group and n11 is 1 or more.