Abstract: Provided herein is a combination therapy useful for the treatment breast cancer. The combination comprises an ER-alpha inhibitor and a CDK 4/6 inhibitor.

Abstract: The present invention provides a polymorph of a benzamide compound and a preparation method and applications thereof. The shown benzamide compound is 3-Bromo-N-[2,4-dichloro-6-[(methylamino)carbonyl]phenyl]-1-(3,5-dichloro-2-pyridinyl)-1H-pyrazole-5-carboxamide. The application of the polymorph of the compound in the preparation of the formulation exhibits excellent effect. The advantages of the polymorph A in aspects such as chemical stability, filterability, solubility, hygroscopicity, melting point, solid density and flowability can have a significant impact on the developments of the production method and a formulation and on the quality and efficacy of a plant treating agent.

Abstract: A solid-state thermochromic device and method for producing the device, the device including: a stack successively including, from a rear face to a front face exposed to solar radiation: a) a solid substrate of an inorganic material resistant up to a temperature of 550° C.; b) an infrared-reflective layer of an electronically conductive material; c) electronically insulating interface layers; d) an electronically insulating inorganic dielectric layer transparent to infrared radiation, of cerium oxide CeO2, with a thickness between 400 and 900 nm; e) electronically insulating interface layers; f) a layer of an infrared-active thermochromic material, an n-doped VO2 vanadium oxide, and crystallized in a monoclinic or rutile phase, with a thickness between 30 and 50 nm; and g) a solar-protective coating, transparent to infrared radiation.

Abstract: A headrest device comprises: a headrest support that is pivotable relative to a backrest frame of a vehicle seat, about a first transverse axis; a headrest frame that is pivotable relative to the headrest support about a second transverse axis; and a tilt compensation device for the headrest frame. The compensation device comprises a connecting element in two parts that are pivotable relative to one another, and first and second pivotable guide pins respectively received in a first guide path in the headrest support and in a second guide path formed by the headrest frame. The second part of the connecting element is guided in translation relative to the headrest support in a direction perpendicular to the first axis.

Abstract: A system of tracing a dental prosthesis, the prosthesis including an electrical power source coupled with a radio-communications signals transmitter capable of assuming a weakly active state in which it periodically sends out signals at a first transmission frequency, and a highly active state in which it periodically sends out signals at a second, higher transmission frequency, and a presence sensor for sensing presence of the prosthesis in a mouth of a user, capable of delivering information on absence of the prosthesis in the mouth. The transmitter is configured to pass from the weakly active state to the highly active state when the sensor delivers information on absence of the prosthesis in the mouth. The system also includes a base forming a support of the dental prosthesis when not worn by a user, and the transmitter assumes the weakly active state on detecting the prosthesis in proximity to the base.

Abstract: A throwing star target is provided, in which a throwing star easily sticks and which has excellent durability. A throwing star target 1 which holds a thrown throwing star 2 includes a board 10, and a plurality of pins 20 arranged on a target surface 10A of the board 10. Each of the plurality of pins 20 has a polygonal XY cross section, is formed to be tapered, and has flat surfaces 20U, 20V, and 20W which come into contact with a front side 2A or a back side 2B of the throwing star 2 that is in a state in which of being held.

Abstract: A panel assembly includes a multilayer load bearing panel configured to enclose an opening to an interior compartment by positioning the panel in the opening. The panel has opposing first and second appearance layers and is reversible in the opening between first and second positions. In the first position, the first appearance layer is outwardly facing in the opening and the second appearance layer faces inwardly to the compartment. In the second position, the second appearance layer is outwardly facing in the opening and the first appearance layer faces inwardly to the compartment. One of the appearance layers is made of a protective polymeric coating such as a thermosetting polyurethane-based coating or thermoset polyurea coating. The other appearance layer is made of one of a laminate structure which can include a wood veneer, a textile, or a carpeting material. A method for making the multilayer panel is provided.

Abstract: Method of forming a metallic plating (9) on a substrate (1), comprising the steps of: —providing a substrate (1) comprising a hydrocarbon-based polymer containing C—C and either or both of C—H and N—H bonds; —covalently bonding an azide-containing primer compound (3) to said substrate (1) by C—H and/or N—H insertion, said primer compound (3) comprising molecules each having at plurality of C—H and/or C—N insertion sites; —in the absence of in-situ polymerisation, covalently bonding a pre-synthesised chelating polymer (5) to said primer compound (3) by C—H and/or N—H insertion, said chelating polymer (5) being capable of forming ligand bonds with metal atoms or ions; —dispersing a plating catalyst (7) in said pre-synthesised polymer (5); —forming said metallic plating (9) on said pre-synthesised polymer (5) by means of electroless plating or electroplating

Abstract: A process for the production of sotol by the fermentation of Dasylirion wheeleri, Dasylirion leophyllum or Dasylirion texanum using a novel methodology and apparatus is disclosed. The sotol is prepared by the process of cutting away spiky and thorn covered leaves from hearts of the harvested sotol plants; splitting and roughly shredding the hearts of the sotol plants; steaming the split and shredded hearts of the sotol plants under pressure; squeezing the steamed sotol hearts using a press to obtain an aqueous extract; and fermenting the aqueous extract to obtain sotol. The manufacturing process of the present invention provides a steady, manageable and predictable heat source, thereby allowing consistent replication of process conditions from batch to batch.

Abstract: A method for preparation of a composition in the form of an oil-in-water emulsion includes providing caramel, one or more phenolic compounds, vegetable oil and vinegar. The caramel is prepared from one or more monosaccharides and/or one or more disaccharides and water, and heated for a time period. The method includes mixing the caramel with one or more phenolic compounds with vegetable oil.

Abstract: The process involves feeding a base aerated frozen confection having an overrun of from 20-150% from a freezer to a static mixer, feeding a viscous flavorant or other ingredient having a free oil level of at least 10% to the static mixer to combine with the base frozen confection, and mixing them in the static mixer to obtain a frozen confection including the viscous flavorant or other ingredient which is homogeneous to the eye and taste and which preferably has fewer crystalline fat structures per air bubble, which means greater stability of the air bubbles. The invention is also reflected in reduced standard deviation in product fill weight and an improved distribution of air bubbles. The invention also is directed to the frozen is aerated confection.

Abstract: A seat element having a cover and padding configured to serve as support for a user, and having a ventilation and thermal control system that includes a thermoelectric module, a blower, and a conduit delimiting a passage for air connecting the blower and the thermoelectric module. The ventilation and thermal control system is configured for passing a flow of air coming from the cover towards the blower, and the thermoelectric module is configured for cooling and/or heating the airflow.

Abstract: This solar panel includes a structure in contact with an ambient environment and at least two photovoltaic cells each defining a lateral contact face and including a base element, a grid of electric conductors and a protective element made from transparent material, the grid including at least one conductive wire extending along the lateral contact face. The two cells are arranged on the structure such that at least part of each of the lateral contact faces is arranged regarding the other part while forming a panel surface and such that the shortest path passing through the ambient environment between the opposite parts of the lateral faces of the two cells is equal to at least about 20 mm.

Abstract: The present disclosure concerns a broadband hyperspectral imaging spectrophotometer configured to analyze an object and includes an illumination assembly having a source for emitting a light beam and configured so that the light beam scans line by line the object to be analyzed, a focusing mirror, a first mirror folding, and a planar scanning mirror movable in rotation. The illumination assembly, the focusing mirror, the first folding mirror and the planar mirror are arranged to bring the light beam to the object along a line which will be displaced on the object via the scanning mirror. The imaging spectrophotometer further includes two measuring sensors by a distance between the object and the scanning mirror. The focusing mirror is movable in translation to adapt the imager to the measured distance by the measuring sensors.

Abstract: The present disclosure relates to a seat member comprising a first shell, a second shell fixed to the first shell, and a padding covering the second shell such that the second shell is sandwiched between the first shell and the padding, the padding being configured to support a user, and a ventilation system comprising a fan and a duct, the duct being defined by the first shell and the second shell and forming an air passage placing the fan and padding in communication via holes in the second shell. The duct comprises a housing able to receive the fan, and the first shell comprises a door through which the fan can be placed in the housing, the fan having a first orifice for the passage of air between the exterior and the fan, the door having a hole located facing the first orifice.

Abstract: A method of generating frequency combs composed of a predetermined number of rays, wherein the method includes the modulation of a main ray generated by a laser source (20), by a first radiofrequency signal at a first frequency value, by a second radio frequency signal at a second frequency value, and by a third radio frequency signal at a third frequency value. The second frequency value is equal to twice the first frequency value. The third frequency value is equal to three times the first frequency value.

Abstract: The present invention relates to a device 3 for protecting an optical sensor 13 for an automotive vehicle that is intended to be attached to the optical sensor, characterized in that the device includes:—a transparent optical element 9 exhibiting rotational symmetry and being rotatably mounted about an axis of rotation, configured to be positioned upstream of the optical sensor 13 so that the axis of rotation of the optical element 9 is merged with the optical axis 15 of the optical sensor 13; and—an actuator 5 that is coupled to the optical element 9 so as to rotate the optical element 9 in order to allow soiling to be removed by a centrifugal effect.

Abstract: Methods, compositions, and systems for treating subject(s) in need of plasma Factor VIII, particularly a subject having preexisting anti-FVIII inhibitory antibodies, are provided. The methods involve administering to the subject a therapeutically effective amount of an inflammation suppressor, a therapeutically effective amount of a CD8+ T cell depleting agent, and a therapeutically effective amount of a composition comprising a lentiviral vector (LV) comprising an optimized FVIII expression cassette expressibly linked to a megakaryocyte-specific promoter. Such methods, compositions, and systems are useful to treat subjects with blood clotting disorder(s), such as hemophilia A.