Abstract: The invention provides a compound of formula 1 or a pharmaceutically-acceptable salt thereof, that is useful as a JAK inhibitor. The invention also provides pharmaceutical compositions comprising the compound, methods of using the compound to treat diseases amenable to a JAK inhibitor, and processes useful for preparing the compound.

Abstract: The invention is in the field of hard surface cleaning compositions. There is need for compositions that foam copiously during the washing/cleaning stage. However, during the rinse stage, the foam should rinse-off as quickly as possible in minimum number of rinses-cycles so that the process becomes sustainable. Disclosed is an aqueous cleaning composition, having a pH of 6.5 or lower, comprising (i) 3.0 to 25.0% by weight alkyl ethoxy sulphate; (ii) 1.0 to 5.0% by weight amphoteric surfactant; (iii) 0.1 to 1.0% by weight fatty acids being saturated non-hydroxy C8-12 fatty acid and a saturated non-hydroxy C14-18 fatty acid, where ratio of amount of said C8-12 fatty acid to that of said C14-18 fatty acid is from 1:0.1 to 1:10 parts by weight; and (iv) 0.5 to 5% by weight non-ionic surfactant, wherein (iii) and (iv) together an antifoaming system, and wherein amount of non-alkoxylated anionic surfactant in said composition in less than 1.0% by weight.

Abstract: Disclosed is a skin care kit comprising (a) a freeze-dried cosmetic composition comprising a cosmetic active, and (b) an aqueous cosmetic composition comprising an acrylic polymeric thickener.

Abstract: A lycorine derivative of Formula (I), and a pharmaceutically acceptable salt, a preparation method, a pharmaceutical composition and use thereof wherein the lycorine derivative has obvious antiviral activity and is useful in the treatment of viral diseases such as hand-foot-mouth disease.

Abstract: Disclosed is a method for diagnosing allergy in a human or animal patient, wherein the level of species-specific lipocalin, especially lipocalin 2 in a human patient, is measured in a sample of said patient and wherein a lowered level of said lipocalin compared to the level of said lipocalin in the corresponding sample of a human or animal that has no allergy, is indicative of an allergy, as well as a kit for performing this method, and a kit for quality control of allergen molecules or extracts used for immunotherapy of allergy by determining its siderophore-iron ligand load and thus immunomodulatory potency. Further, lipocalin proteins for use in treatment or prevention of allergies are provided, preferably complexed with siderophore-iron ligands.

Abstract: The inventions relates to compounds of (I) and therapeutic uses thereof: (I) The terms Z, Y, and R1 are as defined in the claims.

Abstract: A system for providing mobile content to a mobile communication device includes a first computing system including one or more servers to cause a graphical user interface to be displayed at a second computing system, the graphical user interface (i) enabling a user of the second computing system to at least one of create, edit, or select the mobile content and (ii) enabling the user of the second computing system to provide a phone number associated with the mobile communication device, the mobile communication device being separate and remote from the first computing system and the second computing system.

Abstract: A modular desktop organizer and system including a rectangular base with a tall superstructure and shallow side trays. The superstructure includes a U-slot for holding an upright smartphone with an inductive charger, and a deep cup for holding pens, scissors, and accessories. The base includes a channel-shaped tablet holder at the back. The base is electrically powered and includes USB ports. The modular components have a self-centering bias by way of a bottom bulge with a rounded periphery that nests within the top of another modular component having a complementary rounded lip. The modular components can be stacked to two, three or more levels high in an aligned and neat fashion due to the self-centering bias.

Abstract: A vertical fall arrest safety device travels along a rail of a vertical track and is configured for quick attachment and detachment anywhere along the rail. The device has a mounting body having side rail engagements configured for slidably engaging behind the edges of a rail of the vertical track in use. The engagements are spaced and staggered so as to receive the rail therebetween when the mounting body is at an angle, and then slidably attach to the rail when the mounting body is twisted into alignment with the rail. The device also has a lever pivotally coupled to the mounting body at a fulcrum. As such, when a downward force is applied to a connection point of a distal end of the lever, an opposite distal end of the lever frictionally engages the rail.

Abstract: A thermal radiation detector is disclosed that includes a substrate, a platform suspended above the substrate, a support structure holding the platform, and a temperature sensor disposed on the platform and having an electrical parameter that varies in accordance with the temperature of the temperature sensor. The detector also includes a carbon-nanotube-based optical absorber in thermal contact with the temperature sensor and configured to absorb electromagnetic radiation to generate heat to change the temperature of the temperature sensor. The optical absorber may include a carbon nanotube film, for example, obtained by spray coating. The detector further includes a passivation layer structure disposed over the optical absorber, which may be made of a metal compound, for example, titanium or aluminum oxide. The thermal radiation detector may be a microbolometer detector, a thermocouple/thermopile detector, or a pyroelectric detector.

Abstract: The application relates to antimicrobial agents against Gram-negative bacteria, in particular to fusion proteins composed of an enzyme having the activity of degrading the cell wall of Gram-negative bacteria and a peptide stretch fused to the enzyme at the N- or C-terminus, as well as pharmaceutical compositions comprising the same. Moreover, it relates to nucleic acid molecules encoding such a fusion protein, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid molecules or said vectors. In addition, it relates to such a fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means or as cosmetic substance. The application also relates to the treatment or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries.

Abstract: A temperature-resistant calcium-resistant water-based drilling fluid for oil and gas reservoir protection and a use thereof is provided. The water-based drilling fluid contains a filtrate reducer and a plugging agent, wherein the filtrate reducer is a copolymer that contains structural units represented by formula (1), structural units represented by formula (2), and structural units represented by formula (3), wherein, the mass ratio of the structural units represented by formula (1) to the structural units represented by formula (2) to the structural units represented by formula (3) is (0.1-0.2):1:(0.05-0.1), and the number-average molecular weight of the copolymer is 10,000-100,000, the plugging agent is acrylamide-diallyldimethylammonium chloride copolymer modified graphene.

Abstract: It is an object of the present invention to provide a pharmaceutical composition comprising an anti-fractalkine antibody that provides therapeutically effective improvement to Crohn's disease, after the administration thereof to a human subject, and a method for treating Crohn's disease. Provided is a pharmaceutical composition for treating Crohn's disease. The present pharmaceutical composition comprises an anti-fractalkine antibody and a pharmaceutically acceptable excipient, and is used, such that the anti-fractalkine antibody is intravenously administered to a human at a dose of at least 10 mg/kg of human body weight in a method for treating Crohn's disease.

Abstract: A micro-fluidic device is described. The micro-fluidic device includes a semiconductor substrate; at least one micro-reactor in the semiconductor substrate; one or more micro-fluidic channels in the semiconductor substrate, connected to the at least one micro-reactor; a cover layer bonded to the semiconductor substrate for sealing the one or more micro-fluidic channels; and at least one through-substrate trench surrounding the at least one micro-reactor and the one or more micro-fluidic channels.

Abstract: Disclosed is an in vitro method to diagnose or determine the risk of developing a neurodegenerative disease in a subject based on the determination of the methylation pattern in certain regions of mitochondrial DNA from the subject or the determination of the nucleotide at the polymorphic position 16519 in the mitochondrial DNA of the subject. Also, disclosed are nucleic acids suitable for the in vitro method to diagnose or determine the risk of developing a neurodegenerative disease in a subject.

Abstract: The present invention relates to a method for removal of large contaminants, such as virus, in a chromatographic process for purification of a target molecule, preferably monoclonal antibodies, mAbs, by using a specifically designed chromatographic bead having a thin outer layer and a core functionalized with a ligand adsorbing the mAbs or parts thereof.

Abstract: A dental zirconia system to produce translucent zirconia sintered bodies comprises at least two separate zirconia green bodies. At least one zirconia green body comprises zirconium oxide and a lower content of at least one other oxide summing to between 6.5 wt % to 20 wt % based on a total weight percent of the zirconia green body. At least another zirconia green body comprises zirconium oxide and a higher content of at least one other oxide summing to between 7.5 wt % to 20 wt % based on a total weight percent of the zirconia green body. The at least two zirconia green bodies each have at least some particles with a diameter of 100 nanometers to 1000 nanometers. The at least two zirconia green bodies have different amounts of the at least one other oxide with respect to one another.

Abstract: Methods for embedding photocatalytic titanium dioxide in asphalt surfaces to reduce pollutants via photocatalytic reactions are provided herein. One method includes applying an amount of an asphalt surface treatment compound to an upper surface of the asphalt surface, the asphalt surface treatment compound including a mixture of a liquid carrier compound with a titanium dioxide (TiO2) photocatalyst.

Abstract: A series of pyrazolo[3,4-d]pyrimidine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.