Patents Assigned to D
  • SALTS OF COMPOUNDS AND CRYSTALS THEREOF
    Publication number: 20210198282
    Abstract: The present invention provides crystals of (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-Difluoro-34,39-bis(sulfanyl)-2,33,35,38, 40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34?5,39?5-diphosphaoctacyclo[28.6.4.13,36.128,31.04,8.07,12.019,24.023,27]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene-34,39-dione (Compound (I)) ammonium salts, Compound (I) sodium salts, or Compound (I), possessing a potential to be used as drug substance in pharmaceuticals.
    Type: Application
    Filed: August 14, 2019
    Publication date: July 1, 2021
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Jun NIIJIMA, Hirofumi KURODA, So YASUI, Yoko ITO, Ikuo KUSHIDA
  • Use of Syncytin for Targeting Drug and Gene Delivery to Lung Tissue
    Publication number: 20210198636
    Abstract: The invention relates to a pharmaceutical composition for targeting drug delivery including gene delivery to lung tissue, comprising at least a therapeutic drug or gene associated to a syncytin protein, and its use in the prevention and/or treatment of lung diseases, in particular in gene therapy of said diseases using lentiviral vector particles or lentivirus-like particles pseudotyped with syncytin protein.
    Type: Application
    Filed: October 19, 2018
    Publication date: July 1, 2021
    Applicants: Genethon, Institut National de la Santé et de la Recherche Médicale, Université d'Evry val d'Essonne
    Inventors: Anne Galy, Youna Coquin, Maxime Ferrand
  • DEEP-SEA FUNGUS-DERIVED ANTHRAQUINONE COMPOUND AND USE THEREOF IN PREPARING ANTI-ALLERGIC DRUGS
    Publication number: 20210198272
    Abstract: An anthraquinone compound and the use thereof in preparing anti-allergic drugs. The anthraquinone compound has a structure according to formula (I) and can be used to prepare anti-allergic drugs.
    Type: Application
    Filed: December 25, 2019
    Publication date: July 1, 2021
    Applicants: Third Institute of Oceanography, Ministry of Natural Resources, China Ocean Mineral Resources R&D Association
    Inventors: Xianwen YANG, Cuiping XING, Jinmei XIA
  • OIL-IN-WATER EMULSION CONTAINING WHEAT FLOUR AND PHYSICALLY MODIFIED STARCH
    Publication number: 20210195909
    Abstract: The present invention relates to a composition in the form of an oil-in-water emulsion, containing wheat flour and physically modified starch. The invention also relates to a method for preparation of the composition. The invention further relates to the use of a wheat flour and physically modified starch to reduce syneresis in an oil-in-water emulsion.
    Type: Application
    Filed: March 12, 2021
    Publication date: July 1, 2021
    Applicant: Conopco Inc., d/b/a UNILEVER
    Inventors: Zaida Maria Salazar, Jurek Woller, Nicole Zwets
  • LDPC coding with differentiated protection
    Patent number: 11050439
    Abstract: A new unequal-error-protection method that is based on using a particular parity-check-matrix structure for LDPC codes.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: June 29, 2021
    Assignees: THALES, CENTRE NATIONAL D'ETUDES SPATIALES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE, TESA TELECOM SPATIALES AERONAUTIQUES
    Inventors: Lorenzo Ortega Espluga, Charly Poulliat, Hanaa Al Bitar, Marie-Laure Boucheret, Marion Aubault
  • Substituted piperidines for the treatment of cancer
    Patent number: 11046681
    Abstract: Compounds of formula (I): wherein R1, R2, R3, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: June 29, 2021
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: András Kotschy, Csaba Wéber, Attila Vasas, Balázs Molnár, Árpád Kiss, Alba Macias, James Brooke Murray, Elodie Lewkowicz, Olivier Geneste, Maïa Chanrion, Didier Demarles
  • Hydroalcoholic extract of , cosmetic compositions comprising the same and cosmetic uses thereof
    Patent number: 11045669
    Abstract: The invention relates to a hydroalcoholic extract of the aerial parts of Schinus molle. The invention is characterised in that it comprises predominantly quercitrin and miquelianin among the extracted polyphenols, in a concentration, respectively, of at least 0.04% of quercitrin by weight of the total weight of the extract, and of at least 0.02% of miquelianin by weight of the total weight of the extract, the other extracted polyphenols, considered independently of one another, being present in trace form. The invention also relates to a method for preparing an extract of Schinus molle according to the invention and to cosmetic compositions comprising an effective amount of the extract according to the invention as protective active agent, and the cosmetic use of such compositions to improve the barrier function of the skin and to protect the skin against atmospheric pollutants.
    Type: Grant
    Filed: April 5, 2016
    Date of Patent: June 29, 2021
    Assignees: ISP INVESTMENTS LLC, JAFER ENTERPRISES R&D, S.L.
    Inventors: Isabelle Imbert, Nouha Domloge, Jean Marie Botto, Rémi Laville, Sébastien Garnier
  • Laser source apparatus and method for generating temporal dissipative cavity solitons
    Patent number: 11048144
    Abstract: A laser source apparatus (100) for generating temporal dissipative cavity solitons (1) comprises an input source-device (10), being configured for providing an input light field (2), and an optical resonator device (20) with a resonator (21) having a third order optical Kerr non-linearity and being coupled with the input source device (10) for generating the cavity solitons (1) by the driving input light field (2), wherein the input source device (10) is configured for providing the input light field (2) as a pulse train of laser pulses (3). Preferably, the pulse repetition rate of the input laser pulses (2) is adapted to the free spectral range of the resonator (21) and the carrier envelope offset frequency of the input laser pulses (2) is adapted to one of the resonant frequencies of the resonator (21). Furthermore, a method of generating temporal dissipative cavity solitons (1) is described.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: June 29, 2021
    Assignee: CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA—RECHERCHE ET DÉVELOPPEMENT
    Inventors: Tobias Herr, Steve Lecomte, Ewelina Obrzud
  • Memory device having variable impedance memory cells and time-to-transition sensing of data stored therein
    Patent number: 11049553
    Abstract: The present disclosure relates to circuits, systems, and methods of operation for a memory device. In an example, a memory device includes a plurality of memory cells, each memory cell having a variable impedance that varies in accordance with a respective data value stored therein; and a read circuit configured to read the data value stored within a selected memory cell based upon a variable time delay determination of a signal node voltage change corresponding to the variable impedance of the selected memory cell.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: June 29, 2021
    Assignee: R&D 3 LLC
    Inventor: Ravindraraj Ramaraju
  • INFLATABLE MATTRESS WITH LONGITUDINALLY ORIENTED STRINGERS
    Publication number: 20210186780
    Abstract: A transfer mattress includes a top panel, a bottom panel, an outer stringer and an inner stringer. The top panel has a perimeter including a proximal edge and a distal edge, wherein a central longitudinal axis extends from the proximal edge to the distal edge. The bottom panel has a plurality of perforations and a perimeter including a proximal edge and a distal edge coupled to the perimeter of the top panel. The outer stringer and inner stringer each have a superior edge coupled to the top panel and an inferior edge coupled to the bottom panel and a longitudinal portion that is substantially parallel to the central longitudinal axis. The inner stringer is positioned between the central longitudinal axis and the outer stringer.
    Type: Application
    Filed: October 18, 2018
    Publication date: June 24, 2021
    Applicant: D.T. DAVIS ENTERPRISES, LTD. (d/b/a HOVERTECH INTERNATIONAL)
    Inventor: David T. Davis
  • MACHINE LEARNING-BASED DIGITAL EXCHANGE PLATFORM
    Publication number: 20210192620
    Abstract: Obtaining a plurality of different digital asset types, at least a first digital asset type of the plurality of different digital asset types comprising a predefined digital asset type, and at least a second digital asset type of the plurality of different digital asset types comprising a dynamically defined digital asset type. Converting the first digital asset type to a first digital asset object based on the predefined digital asset type and an object model. Converting the second digital asset type to a second digital asset object based on the dynamically defined digital asset type and the object model. Identifying, based on machine learning, a first candidate set of users of a plurality of users to potentially be issued first digital asset units associated with a first brand, each the first digital asset units comprising a corresponding instance of the first digital asset object.
    Type: Application
    Filed: December 18, 2020
    Publication date: June 24, 2021
    Applicant: EdenLedger, Inc. d/b/a FanVestor
    Inventor: Mikhail Golomb
  • PEPTIDES OF USE IN THE PREVENTIVE AND CURATIVE TREATMENT OF ALOPECIA
    Publication number: 20210188911
    Abstract: The object of the present invention relates to a novel family of peptide conjugates of formula (I): A-X1—X2-Pro-Ala-X—B ??(I) wherein: A represents a hydrogen atom, a C6 to C20 acyl group or a cholesterol residue; X1 represents a covalent bond, an alanine or a proline; X2 represents an arginine, a lysine, or an alanine; X represents a lysine, an alanine, or a phenylalanine; and B represents a hydroxyl or an amine; or one of its preferentially pharmaceutically, dermatologically or cosmetically acceptable salts, as well as their synthesis processes and their uses for reducing hair loss and stimulating hair growth.
    Type: Application
    Filed: January 27, 2021
    Publication date: June 24, 2021
    Applicants: Institut Europeen de Biologie Cellulaire, Centre de Recherches Biologiques et d'Experimentations Cutanees, Centre National de la Recherche Scienfitique (CNRS)
    Inventors: Michel Hocquaux, Stéphanie Almeida Épouse Scalvino, Elian Lati, Joanna Bakala
  • IMPROVED SAFETY CATHETER NEEDLE
    Publication number: 20210187249
    Abstract: A safety catheter needle having a cannula removably inserted in a catheter and associated with a cannula holder is provided. The cannula has a proximal extremity attached to the cannula holder and a distal extremity close to a deformed part, with provision for a protection device associated with the catheter holder movably containing the cannula and moving within the catheter holder when the cannula is drawn out from the catheter. The protection device has a principal body containing a moving body rotating about an axis (M) at right angles to a longitudinal axis (W) of the cannula and capable of interacting with a fixed part of the catheter holder-while the cannula is being drawn out, bringing about rotation of the rotating moving body within the principal body and immobilizing the distal extremity of the cannula within the former.
    Type: Application
    Filed: December 12, 2018
    Publication date: June 24, 2021
    Applicant: SOL-MILLENNIUM SWISS R&D CENTER SA
    Inventors: Matteo LAGANA', Dario DE ZOLT
  • FUSED PYRIMIDINE PYRIDINONE COMPOUNDS AS JAK INHIBITORS
    Publication number: 20210188844
    Abstract: The disclosure provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The disclosure also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat gastrointestinal inflammatory diseases.
    Type: Application
    Filed: November 24, 2020
    Publication date: June 24, 2021
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Robert Murray McKinnell, Erik Fenster, Tom M. Lam, Diana Jin Wang, Anthony Francesco Palermo, Luke Boralsky, Breena Fraga
  • DEVICE FOR CLEANING AN OPTICAL DETECTION SYSTEM OF A MOTOR VEHICLE
    Publication number: 20210188218
    Abstract: The invention concerns a cleaning device (5) for an optical sensor (9) module (3) of a motor vehicle comprising a housing (7), an optical sensor (9) housed in the housing (7), characterised in that the cleaning device (5) comprises a cylindrical flange (21) having first snap-fastening members (23) shaped to engage with second snap-fastening members (25) carried by the sensor (9) module (3), the first (23) and second (25) snap-fastening members being configured such that, in the mounted state, the axis of the cylindrical flange (21) merges with the optical axis (A) of the optical sensor (9), and at least one pipe (35; 37) having spray openings (350; 370) is attached to the inner wall (33) of the cylindrical flange (21), the spray openings (350; 370) being turned towards the optical sensor (9).
    Type: Application
    Filed: January 31, 2017
    Publication date: June 24, 2021
    Applicant: Valeo Systèmes d'Essuyage
    Inventors: Julien Carrion, Christophe Chassaing, Grégory Kolanowski, Chantal Marquet
  • NOVEL POLYMORPHS OF 4-[3-CHLORO-4-(N'-CYCLOPROPYL UREIDO)PHENOXY]-7-METHOXYQUINOLINE-6-CARBOXAMIDE, ITS SALTS AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20210188778
    Abstract: The present invention relates to novel polymorphs of 4-[3-chloro-4-(N?-cyclopropyl ureido) phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate represented by following structural formula-1a and process for preparation thereof. Further, the present invention relates to an improved process for the preparation of 4-[3-chloro-4-(N?-cyclopropylureido) phenoxy]-7-methoxyquinoline-6-carboxamide compound of formula-1 or its salts and its intermediates thereof.
    Type: Application
    Filed: December 8, 2018
    Publication date: June 24, 2021
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Venkata Panakala Rao GOGULAPATI, Rajeshwar Reddy SAGYAM, Pavan Kumar Reddy BANDLA, Srinivasulu RANGINENI
  • UV-RESISTANT AND ALKALINE-RESISTANT BOROSILICATE GLASS AND USE THEREOF
    Publication number: 20210188697
    Abstract: Disclosed is a type of borosilicate glass, the composition of which, based on oxides, contains the following components by weight percentage (wt %): 2.0 wt %-5.0 wt % of TiO2, 0.25 wt %-2.5 wt % of CeO2 and 0.25 wt %-3.0 wt % of Y2O3, and does not contain any iron compound, such as ferric oxide. The glass has better UV resistance and alkaline resistance properties, and a better light transmission rate, and is particularly suitable for use in the field of pharmaceutical packaging materials.
    Type: Application
    Filed: October 19, 2018
    Publication date: June 24, 2021
    Applicant: DONGGUAN HEC PHARM R&D CO., LTD.
    Inventors: Weiqiang HONG, Xinqian HE, Yong JIANG, Zhengshang ZHOU, Lianying ZHU, Zhiyong LI, Fangfang HUANG
  • MACROCYCLIZATION REACTIONS AND INTERMEDIATES AND OTHER FRAGMENTS USEFUL IN THE SYNTHESIS OF ANALOGS OF HALICHONDRIN B
    Publication number: 20210188867
    Abstract: The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.
    Type: Application
    Filed: March 1, 2021
    Publication date: June 24, 2021
    Applicants: EISAI R&D MANAGEMENT CO., LTD., EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Francis G. FANG, Dae-Shik KIM, Hyeong-Wook CHOI, Charles E. CHASE, Jaemoon LEE
  • COMPOSITION COMPRISING A STRUCTURED AQUEOUS PHASE AND SERICIN
    Publication number: 20210186843
    Abstract: The invention relates to a composition comprising 5 to 100 wt. % of a structured aqueous phase wherein the composition contains 0.1 to 10 wt. % sericin by weight of water, said sericin having a proportion of beta-sheet in the secondary structure that exceeds 80%. It was found that sericin having a proportion of beta-sheet in the secondary structure that exceeds 80% is an excellent water structurant and can suitably be used to structure the aqueous phase of a wide range of products, such as cosmetic products, pharmaceutical products, food products and detergent compositions.
    Type: Application
    Filed: October 9, 2018
    Publication date: June 24, 2021
    Applicant: Conopco, Inc., d/b/a UNILEVER
    Inventors: Nivedita Jagdish PATIL, Siva Rama Krishna PERALA, Janhavi Sanjay RAUT, Jyoti Kumar TIWARI
  • Emulsified food composition
    Publication number: 20210186072
    Abstract: A food composition in the form of an emulsion comprising a continuous water phase which comprises a water-in-oil emulsion which is emulsified in the continuous water phase, and oil droplets without an internal water phase emulsified in the continuous water phase, polyglycerol polyricinoleate, and an oil-in-water emulsifier.
    Type: Application
    Filed: May 15, 2019
    Publication date: June 24, 2021
    Applicant: Conopco, Inc., d/b/a UNILEVER
    Inventors: Gerrit NEIMAN, Sabrina SILVA PAES, Stephan Georg SCHUMM, Evelien Maria Mathilda VANDEVENNE