Abstract: The present disclosure provides hCG variant proteins, nucleic acid molecules encoding the same, vectors comprising nucleic acid molecules, compositions comprising the same, and methods of treating cancer.

Abstract: Disclosed is a modular serviceable cartridge assembly for a respirator exhalation unit that is simple in construction and that allows quick-connect of an exhalation valve cartridge in a mask to minimize the need for reconfiguration when changing personal protective equipment, and that allows for easy removal and breakdown for servicing and/or replacement of individual components of the exhalation valve without modifying or replacing other elements of the protective mask. The assembly may be convertible from a negative pressure valve assembly to a positive pressure valve assembly, and vice versa, and a grill may be provided on an outlet side of the cartridge assembly, the rotation of which converts the assembly from a negative pressure valve to a positive pressure valve.

Abstract: The present invention provides a use of a GABA(A)R, GABA(A)R fragment, or homolog thereof or a cell expressing the GABA(A)R, GABA(A)R fragment, or homolog thereof for the prognosis, diagnosis or treatment of an autoimmune disease in a subject, methods of prognosticating, diagnosing or treating an autoimmune disease, an autoantibody binding to a GABA(A)R, GABA(A)R fragment, or homolog thereof, a method for isolating an antibody binding to a GABA(A)R, GABA(A)R fragment, or homolog thereof, and a test kit, pharmaceutical composition and medical or diagnostic device comprising a GABA(A)R, GABA(A)R fragment, or homolog thereof.

Abstract: A wheeled work vehicle (1) comprises a forward chassis part (4) and a rearward chassis part (5) pivotally connected about a substantially vertically extending primary pivot axis (7) for steering thereof. A pair of forward ground engaging wheels (29) are carried on a forward suspension unit (32), and a pair of rearward ground engaging wheels (30) are carried on a rearward suspension unit (33). The forward suspension unit (32) is pivotally connected to the forward chassis part (4) by a pair of main forward transverse pivot shafts (63) pivotally coupled to the forward chassis part (4) by corresponding main forward pivot mountings (65). The main forward transverse pivot shafts (63) defines a main forward transverse pivot axis (59) about which the forward suspension unit (32) is pivotal relative to the forward chassis part (4).

Abstract: A computational system can include digital circuitry and analog circuitry, for instance a digital processor and a quantum processor. The quantum processor can operate as a sample generator providing samples. Samples can be employed by the digital processing in implementing various machine learning techniques. For example, the computational system can perform unsupervised learning over an input space, for example via a discrete variational auto-encoder, and attempting to maximize the log-likelihood of an observed dataset. Maximizing the log-likelihood of the observed dataset can include generating a hierarchical approximating posterior. Unsupervised learning can include generating samples of a prior distribution using the quantum processor. Generating samples using the quantum processor can include forming chains of qubits and representing discrete variables by chains.

Abstract: A vehicle seat having a seat with a seat frame, a backrest with a backrest frame, the backrest frame being pivotally mounted relative to the seat frame around a first transverse axis between at least one deployed position for receiving a seat occupant and a folded position in which the backrest frame is folded opposite the seat frame. The seat further includes on each side of the seat a first and a second connecting rod intended to be fixed on a support of the seat so as to be pivotable about a respective transverse axis to lift the backrest frame relative to the seat support.

Abstract: The invention relates to a connection unit (20) for a wiper motor (100) for windshield wiper systems with a plug connector element (22) for receiving electric connection lines (24) which are configured for the at least indirect contacting of a commutator (6) of an electric motor (1), with a carrier element (26) on which connection elements (40) for contacting the commutator (6) and/or at least one component of an electric circuit are arranged, and with a carbon brush holder plate (30), wherein the carrier element (26) is formed as a pre-mountable construction unit (32) with the carbon brush holder plate (30) formed as separate component.

Abstract: A system for measuring the distance of an obstacle, in which an optical flow is measured radially while rotating along a circle in a plane intersecting the obstacle; and the distance of the obstacle is determined according to the amplitude of the optical flow, the radius of the circle, and the speed of rotation.

Abstract: Flexible implant for electrically recording or stimulating a nerve structure, said flexible implant comprising: a first layer of electrically insulating diamond; an electrode of electrically conductive doped diamond, in contact with the first layer of electrically insulating diamond; an electrically conductive layer in contact with the electrode and the first layer, so as to define a conductive track for the electrode; and a second layer of electrically insulating diamond, at least in contact with the electrically conductive layer and a remaining portion of the first layer, all of the above arranged such that: electrically insulating diamond/electrically conductive doped diamond sealing is provided at the electrode (3) by resumption of epitaxial growth; and the electrically conductive layer is encapsulated by the electrode (3), the first layer and the second layer, at the electrode and over the entirety of the remaining surface thereof except over an area defining an electrical contact.

Abstract: The invention provides compounds which are prodrugs of a JAK inhibitor agent for the targeted delivery of the JAK inhibitor to the gastrointestinal tract of a mammal. The invention also provides pharmaceutical compositions comprising the compounds, methods of using the compounds to treat gastrointestinal inflammatory diseases, and processes and intermediates useful for preparing the compounds.

Abstract: Disclosed herein is a method for treating tumor, comprising administering a liposomal composition comprising eribulin or a pharmaceutically acceptable salt thereof and a PD-1 antagonist to a patient in need thereof.

Abstract: The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of JAK kinases. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat inflammatory bowel diseases, and processes and intermediates useful for preparing such compounds.

Abstract: Method of operating an energy system, said energy system comprising: a local common transmission bus; at least one local energy connected to said bus; at least one local load connected to said bus; an energy store connected to said bus; a controllable interface arranged to exchange energy between said bus and an external distribution network external to said energy system; a controller adapted to control said interface so as to carry out said exchange of energy. According to the invention, the controller defines three modes based on the state of charge of the energy store which determine if, and how, energy is exchanged with the external network so as to optimize self-consumption and to perform ramp-rate reduction and peak shaving as appropriate.

Abstract: The invention relates to a tag to secure a string of a tea bag to a handle of a teapot, the tag being flexible and resilient and comprising at least two adjacent areas separated by a cut that are partially separable from the tag.

Abstract: The present disclosure is directed to a compact wrist rotator and flexor mechanism for use with a prosthetic hand. The wrist rotator and flexor uses a set of motors to provide a driven mechanism having two degrees of freedom, a wrist rotation and a wrist flexion. The rotator uses a motor with an inverted shaft gearbox combined with a worm gear and a face gear transmission to generate continuous and non-backdrivable rotation. The rotator is integrated into a flexor that uses a lead screw acting as a linear actuator to provide strong non-backdrivable flexion and extension. Due to the arrangement of the drives, the resulting wrist rotator and flexor mechanism has a low and compact profile.

Abstract: The present disclosure provides pladienolide compounds, pharmaceutical compositions containing such compounds, and pladienolide compounds for use in methods of medical treatment. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are pladienolide compounds for use in methods of treating cancers by administering at least one pladienolide compound disclosed herein and at least one additional therapy.

Abstract: The present disclosure relates to a method and a device for measuring at least one atmospheric parameter (gas, temperature). The method includes implementing steps of acquiring spectral images in the ultraviolet and/or the visible and/or the infrared range and scanning according to a tomographic principle. The spectral images are acquired using a network of optical systems such as infrared cameras, and are used to estimate the air quality and/or meteorological and/or climate parameters in a geographic area, for example an urban agglomeration.

Abstract: The present invention provides an apparatus for coating an edible receptacle the apparatus comprising a nozzle for applying a fat-based coating material to the internal surface of the edible receptacle and a gas-dosing element with an external surface shape corresponding to the internal shape of the edible receptacle wherein the gas dosing element has at least one aperture suitable for the introduction of cooled gas into the edible receptacle.

Abstract: The present invention relates to an oral complex preparation comprising: a capsule containing a fat-soluble first drug; and a solid preparation containing a second drug, the solid preparation being embedded into the capsule and including an oil-proof material coating layer on the surface thereof The oral complex preparation of the present invention prepared by embedding the solid preparation including the oil-proof material coating layer on the surface thereof and containing the second drug into the capsule containing the fat-soluble first drug enables two types of drug ingredients to be simultaneously administered.

Abstract: The present invention provides an infrared detector pixel structure and manufacturing method thereof.